GREMLIN Database
YPFH - Esterase YpfH
UniProt: P76561 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14195
Length: 232 (195)
Sequences: 4070 (3098)
Seq/√Len: 221.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_I131_V3.7401.00
114_A136_G3.3931.00
164_L185_I3.1471.00
114_A133_A3.0081.00
29_P52_G2.9901.00
134_F201_A2.8361.00
186_V200_F2.7311.00
66_F137_R2.7191.00
168_V185_I2.6451.00
17_Q46_A2.4511.00
132_I201_A2.4231.00
19_L48_V2.3811.00
157_G187_E2.3091.00
106_A205_L2.3001.00
106_A130_R2.2401.00
22_F87_F2.2221.00
27_D31_A2.2181.00
182_T207_Y2.1731.00
171_Q175_I2.0781.00
108_I132_I2.0301.00
117_V131_V1.9991.00
154_I197_S1.9611.00
184_D200_F1.9551.00
92_R96_K1.9291.00
18_L94_W1.8521.00
160_P190_G1.8261.00
189_L194_D1.8151.00
167_A183_L1.7901.00
88_I120_S1.7721.00
77_Q81_D1.7541.00
17_Q104_A1.7501.00
157_G185_I1.7101.00
84_M119_E1.6061.00
101_G104_A1.5931.00
172_E175_I1.5901.00
95_Q105_T1.5901.00
118_L133_A1.5881.00
153_L171_Q1.5801.00
202_L206_R1.5801.00
15_A18_L1.5801.00
118_L153_L1.5231.00
164_L168_V1.5221.00
88_I124_E1.4721.00
133_A153_L1.4571.00
172_E176_S1.4361.00
24_G111_S1.4321.00
95_Q102_A1.4281.00
116_M136_G1.4231.00
121_I149_T1.4191.00
11_P15_A1.4111.00
55_E61_A1.4011.00
165_A168_V1.3801.00
133_A136_G1.3701.00
52_G63_R1.3691.00
88_I92_R1.3671.00
171_Q181_V1.3461.00
195_N199_Q1.3441.00
85_P89_E1.3221.00
49_V94_W1.3141.00
165_A169_A1.2911.00
155_H167_A1.2811.00
106_A208_T1.2521.00
20_L91_V1.2241.00
94_W98_S1.2101.00
173_A177_A1.1931.00
56_P82_A1.1851.00
135_N197_S1.1811.00
152_H200_F1.1711.00
118_L170_A1.1711.00
32_M193_I1.1701.00
16_Q45_D1.1461.00
111_S191_H1.1431.00
89_E93_Y1.1411.00
115_I137_R1.1411.00
151_I179_G1.1401.00
168_V183_L1.1211.00
92_R127_L1.1181.00
56_P64_Q1.1171.00
157_G188_D1.1081.00
28_N31_A1.1031.00
171_Q183_L1.1011.00
152_H184_D1.0971.00
47_L94_W1.0911.00
164_L183_L1.0871.00
157_G164_L1.0851.00
27_D193_I1.0761.00
16_Q104_A1.0731.00
19_L46_A1.0681.00
144_T147_T1.0601.00
135_N155_H1.0591.00
87_F116_M1.0571.00
18_L49_V1.0541.00
76_R79_R1.0521.00
56_P63_R1.0501.00
92_R124_E1.0451.00
84_M120_S1.0421.00
92_R95_Q1.0211.00
173_A176_S0.9881.00
51_V87_F0.9871.00
85_P88_I0.9841.00
87_F120_S0.9831.00
18_L47_L0.9741.00
154_I186_V0.9721.00
86_T89_E0.9711.00
153_L181_V0.9711.00
158_E188_D0.9701.00
152_H186_V0.9631.00
203_D207_Y0.9631.00
21_L108_I0.9491.00
204_H208_T0.9491.00
102_A126_G0.9291.00
30_V52_G0.9271.00
130_R150_T0.9240.99
51_V90_T0.9230.99
119_E123_A0.9200.99
88_I128_A0.9060.99
104_A129_S0.9040.99
174_L179_G0.9010.99
11_P14_P0.9000.99
162_I166_H0.8990.99
18_L100_V0.8940.99
100_V105_T0.8860.99
131_V151_I0.8810.99
58_G62_G0.8800.99
69_Q74_D0.8790.99
111_S159_D0.8770.99
117_V136_G0.8750.99
90_T94_W0.8750.99
163_D166_H0.8740.99
21_L32_M0.8730.99
38_W195_N0.8690.99
91_V128_A0.8630.99
103_N127_L0.8570.99
92_R126_G0.8550.99
151_I174_L0.8530.99
106_A129_S0.8510.99
168_V172_E0.8500.99
200_F203_D0.8430.99
40_A44_P0.8400.99
199_Q202_L0.8370.99
20_L107_L0.8310.99
81_D84_M0.8270.99
64_Q68_V0.8140.99
115_I162_I0.8120.99
93_Y96_K0.8070.99
169_A172_E0.7960.98
15_A47_L0.7960.98
31_A34_E0.7920.98
81_D119_E0.7900.98
91_V105_T0.7880.98
36_G48_V0.7800.98
186_V189_L0.7790.98
186_V197_S0.7780.98
54_A86_T0.7750.98
186_V194_D0.7670.98
40_A46_A0.7630.98
36_G40_A0.7590.98
80_V119_E0.7510.98
53_G65_W0.7500.98
55_E63_R0.7480.98
192_A195_N0.7450.98
21_L36_G0.7420.98
186_V196_R0.7420.98
152_H197_S0.7410.98
155_H162_I0.7340.97
100_V104_A0.7320.97
134_F193_I0.7320.97
84_M123_A0.7300.97
70_G74_D0.7300.97
35_I38_W0.7270.97
30_V33_G0.7240.97
80_V116_M0.7240.97
118_L131_V0.7220.97
167_A170_A0.7210.97
88_I127_L0.7190.97
25_V112_Q0.7160.97
28_N63_R0.7160.97
155_H164_L0.7130.97
108_I134_F0.7110.97
29_P51_V0.7090.97
28_N52_G0.7050.97
168_V171_Q0.7020.97
189_L192_A0.6970.97
33_G48_V0.6970.97
38_W198_M0.6970.97
154_I200_F0.6960.97
33_G50_S0.6950.96
91_V120_S0.6920.96
47_L98_S0.6890.96
146_S179_G0.6890.96
132_I152_H0.6880.96
40_A202_L0.6860.96
130_R208_T0.6850.96
13_K45_D0.6850.96
152_H204_H0.6740.96
150_T180_D0.6720.96
169_A173_A0.6710.96
34_E37_N0.6710.96
22_F116_M0.6710.96
27_D161_V0.6690.96
194_D197_S0.6680.96
115_I139_A0.6660.96
89_E92_R0.6660.96
35_I40_A0.6640.95
110_F135_N0.6640.95
159_D191_H0.6620.95
122_K179_G0.6570.95
148_A180_D0.6560.95
25_V115_I0.6550.95
91_V94_W0.6540.95
20_L94_W0.6530.95
57_S71_I0.6460.95
75_N140_S0.6360.94
158_E190_G0.6350.94
25_V58_G0.6340.94
134_F197_S0.6330.94
75_N119_E0.6290.94
153_L167_A0.6270.94
77_Q140_S0.6270.94
153_L170_A0.6180.93
39_F202_L0.6180.93
107_L117_V0.6150.93
29_P50_S0.6140.93
84_M116_M0.6130.93
47_L100_V0.6130.93
79_R83_I0.6110.93
138_Y170_A0.6090.93
25_V68_V0.6090.93
93_Y98_S0.6030.93
37_N40_A0.6010.92
150_T208_T0.5990.92
32_M50_S0.5980.92
110_F193_I0.5890.92
68_V112_Q0.5890.92
88_I126_G0.5880.92
107_L121_I0.5870.92
203_D206_R0.5860.91
140_S143_E0.5850.91
50_S108_I0.5820.91
12_D15_A0.5800.91
156_G189_L0.5790.91
22_F117_V0.5770.91
121_I151_I0.5770.91
156_G188_D0.5730.91
129_S150_T0.5610.90
134_F152_H0.5600.90
82_A85_P0.5600.90
118_L138_Y0.5580.89
78_A81_D0.5570.89
133_A167_A0.5560.89
146_S149_T0.5530.89
87_F90_T0.5520.89
64_Q112_Q0.5510.89
53_G112_Q0.5490.89
184_D196_R0.5470.88
70_G73_E0.5470.88
25_V53_G0.5460.88
25_V64_Q0.5460.88
107_L128_A0.5440.88
78_A82_A0.5390.88
122_K139_A0.5390.88
49_V57_S0.5370.88
17_Q101_G0.5350.87
88_I125_P0.5320.87
108_I201_A0.5320.87
68_V79_R0.5310.87
119_E139_A0.5300.87
134_F154_I0.5280.87
12_D16_Q0.5270.87
77_Q143_E0.5250.86
25_V28_N0.5250.86
68_V83_I0.5250.86
57_S62_G0.5250.86
124_E128_A0.5230.86
122_K174_L0.5210.86
39_F48_V0.5190.86
35_I193_I0.5170.85
96_K126_G0.5170.85
36_G39_F0.5140.85
35_I198_M0.5130.85
27_D110_F0.5110.85
122_K177_A0.5100.85
157_G168_V0.5100.85
48_V52_G0.5100.85
153_L183_L0.5070.84
19_L108_I0.5070.84
75_N141_L0.5060.84
135_N162_I0.5050.84
20_L105_T0.5040.84
27_D33_G0.5000.84
138_Y153_L0.5000.84
156_G191_H0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5eA 2 0.8621 100 0.476 Contact Map
1fj2A 2 0.9009 100 0.483 Contact Map
3u0vA 1 0.8879 100 0.487 Contact Map
1auoA 2 0.8879 100 0.488 Contact Map
3og9A 1 0.8621 100 0.493 Contact Map
2r8bA 1 0.8621 100 0.503 Contact Map
2h1iA 3 0.8707 100 0.507 Contact Map
3cn9A 1 0.8621 100 0.517 Contact Map
4f21A 1 0.8966 100 0.525 Contact Map
1ycdA 1 0.8103 100 0.531 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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