GREMLIN Database
MAO2 - NADP-dependent malic enzyme
UniProt: P76558 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14193
Length: 759 (743)
Sequences: 1170 (474)
Seq/√Len: 17.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_N114_L7.3911.00
445_V551_A6.7931.00
190_M211_L6.4831.00
227_Q243_V5.3811.00
119_F123_V4.6601.00
49_E52_K4.5071.00
184_N187_D4.3051.00
296_P314_Y4.0211.00
179_R356_H3.9011.00
510_Y543_M3.7001.00
53_D56_K3.6421.00
510_Y548_E3.6161.00
398_K402_E3.5741.00
254_I269_L3.4651.00
203_M218_V3.3020.99
280_A376_P3.2970.99
447_L747_V3.2500.99
111_V126_L3.2330.99
7_Q11_D3.2220.99
14_E59_K3.1930.99
655_V664_I3.1880.99
596_A696_V3.1730.99
124_A153_R3.1040.99
226_Y233_M3.0850.99
532_L542_I3.0100.99
551_A750_A3.0100.99
56_K59_K2.9430.99
613_T631_L2.9130.98
177_G282_M2.8980.98
605_D608_E2.8810.98
398_K413_F2.8470.98
471_I549_A2.8440.98
171_T205_L2.8390.98
298_A301_V2.8170.98
650_Q653_E2.8110.98
122_V125_A2.7990.98
118_K121_E2.7690.98
149_K152_E2.7260.98
217_V242_V2.7120.97
56_K60_Y2.7020.97
544_V549_A2.6690.97
266_P290_E2.6520.97
204_N239_A2.5590.96
675_V712_V2.5230.96
178_L185_I2.5120.96
442_P751_V2.4850.96
476_P500_N2.4770.96
271_Q300_E2.4430.95
656_R664_I2.4150.95
116_P149_K2.4150.95
446_V544_V2.4080.95
251_D276_K2.4070.95
116_P120_I2.4020.95
175_L349_R2.3960.95
117_D120_I2.3940.95
272_E275_K2.3700.94
113_E118_K2.3660.94
401_M409_P2.3620.94
540_G552_M2.3540.94
298_A303_P2.3540.94
247_K252_D2.3350.94
21_I95_G2.3070.94
119_F146_I2.2970.93
204_N240_Y2.2910.93
269_L276_K2.2900.93
47_C76_V2.2880.93
479_I498_I2.2390.92
254_I276_K2.2370.92
607_E650_Q2.2180.92
113_E125_A2.2150.92
23_V95_G2.2090.92
255_E276_K2.2030.92
665_D687_S2.1970.92
127_E155_N2.1870.92
174_I259_I2.1790.91
462_L747_V2.1700.91
55_L407_T2.1650.91
139_K142_E2.1510.91
341_E344_K2.1290.90
595_I697_M2.1200.90
222_K237_K2.1160.90
297_L300_E2.0880.89
171_T209_L2.0770.89
706_S709_L2.0760.89
298_A305_A2.0650.89
226_Y248_R2.0390.88
275_K301_V2.0390.88
228_G233_M2.0380.88
656_R687_S2.0370.88
57_A84_A2.0240.88
57_A85_L2.0130.88
221_S265_G1.9820.87
252_D255_E1.9760.87
111_V125_A1.9580.86
632_L705_I1.9570.86
435_F748_A1.9560.86
517_I545_Q1.9530.86
447_L462_L1.9470.86
609_L651_A1.9440.86
188_V211_L1.9280.85
567_V731_V1.9220.85
357_A391_K1.9200.85
199_A263_C1.9110.85
109_I126_L1.8980.84
148_Q152_E1.8930.84
48_L51_E1.8850.84
188_V259_I1.8760.84
290_E294_L1.8750.84
665_D683_M1.8730.84
603_E643_P1.8570.83
186_S212_Q1.8530.83
543_M548_E1.8400.82
473_I540_G1.8330.82
58_Y63_R1.8220.82
126_L154_M1.8070.81
116_P145_Y1.8060.81
446_V549_A1.7900.81
389_I392_I1.7900.81
217_V253_V1.7890.81
95_G106_V1.7860.80
120_I149_K1.7840.80
603_E647_K1.7810.80
123_V146_I1.7750.80
609_L648_M1.7660.80
224_V245_D1.7480.79
334_V401_M1.7440.79
271_Q275_K1.7270.78
127_E154_M1.7090.77
554_C563_H1.7070.77
208_A341_E1.6910.77
58_Y64_G1.6900.76
447_L553_I1.6900.76
221_S237_K1.6730.76
243_V246_G1.6730.76
483_I488_L1.6720.76
469_K497_E1.6700.76
513_E545_Q1.6690.76
353_E357_A1.6630.75
221_S225_I1.6610.75
260_F269_L1.6530.75
610_A654_L1.6500.75
117_D149_K1.6450.74
200_I221_S1.6380.74
6_K45_A1.6360.74
600_V724_L1.6320.74
107_F129_T1.6250.74
54_P85_L1.6230.73
228_G248_R1.6220.73
274_V301_V1.6120.73
585_A720_V1.6060.73
443_K751_V1.5860.72
200_I234_A1.5820.71
299_K307_I1.5800.71
464_T489_Q1.5780.71
111_V119_F1.5710.71
149_K153_R1.5700.71
118_K122_V1.5700.71
10_L49_E1.5700.71
226_Y232_N1.5690.71
340_N403_S1.5650.71
583_M725_M1.5640.71
170_S206_L1.5630.71
274_V283_I1.5550.70
342_E402_E1.5530.70
113_E119_F1.5520.70
46_P60_Y1.5470.70
446_V543_M1.5450.70
738_A742_R1.5410.69
445_V747_V1.5220.68
49_E60_Y1.5180.68
219_C253_V1.5140.68
353_E356_H1.5140.68
613_T694_I1.4870.67
207_V240_Y1.4780.66
113_E122_V1.4780.66
347_A392_I1.4770.66
227_Q238_A1.4770.66
462_L468_A1.4680.66
192_V203_M1.4670.65
225_I232_N1.4660.65
290_E297_L1.4630.65
594_F620_V1.4610.65
249_T252_D1.4570.65
106_V129_T1.4420.64
410_I413_F1.4400.64
115_D118_K1.4320.64
221_S232_N1.4310.63
595_I710_L1.4280.63
572_G728_A1.4270.63
242_V245_D1.4260.63
271_Q297_L1.4230.63
209_L345_L1.4230.63
211_L216_I1.4200.63
271_Q274_V1.4120.62
174_I282_M1.4110.62
492_A496_F1.4090.62
663_M689_K1.4000.62
607_E654_L1.3970.62
297_L301_V1.3930.61
225_I237_K1.3900.61
174_I284_L1.3840.61
519_K685_D1.3830.61
274_V297_L1.3820.61
191_V254_I1.3800.61
189_R247_K1.3690.60
294_L297_L1.3690.60
734_L743_I1.3690.60
655_V662_L1.3560.59
468_A747_V1.3460.59
245_D248_R1.3430.58
145_Y149_K1.3220.57
180_V379_I1.3160.57
192_V218_V1.3150.57
113_E116_P1.3150.57
221_S266_P1.3130.57
201_A207_V1.3070.56
447_L468_A1.3010.56
500_N503_S1.2980.56
461_E744_V1.2960.56
611_E658_R1.2890.55
571_F728_A1.2880.55
624_G703_A1.2790.55
732_H750_A1.2740.54
113_E121_E1.2640.54
631_L655_V1.2590.53
174_I206_L1.2510.53
213_K242_V1.2460.53
582_A599_Y1.2430.52
621_R626_E1.2400.52
402_E413_F1.2400.52
430_F585_A1.2390.52
532_L538_V1.2380.52
700_M704_R1.2360.52
177_G284_L1.2360.52
189_R414_D1.2280.52
219_C224_V1.2230.51
256_G279_R1.2230.51
155_N337_T1.2210.51
504_D539_I1.2180.51
270_T276_K1.2170.51
70_I111_V1.2120.51
217_V224_V1.2100.50
182_E275_K1.2070.50
224_V249_T1.2040.50
222_K232_N1.2030.50
653_E657_E1.2020.50
513_E546_R1.2020.50
11_D15_F1.1970.50
235_E238_A1.1970.50
121_E153_R1.1950.50
540_G731_V1.1940.50
342_E403_S1.1900.49
111_V122_V1.1870.49
266_P270_T1.1850.49
199_A218_V1.1800.49
219_C237_K1.1790.49
609_L631_L1.1760.48
234_A237_K1.1710.48
631_L664_I1.1660.48
199_A700_M1.1610.48
209_L349_R1.1580.47
211_L259_I1.1580.47
207_V216_I1.1580.47
170_S221_S1.1560.47
46_P51_E1.1560.47
132_G195_A1.1480.47
676_E680_N1.1460.47
269_L298_A1.1440.46
629_V694_I1.1430.46
190_M216_I1.1410.46
145_Y148_Q1.1410.46
46_P56_K1.1380.46
124_A150_L1.1380.46
545_Q729_K1.1370.46
283_I305_A1.1370.46
490_I496_F1.1340.46
151_R338_A1.1310.46
480_E484_Q1.1250.45
654_L658_R1.1220.45
474_G479_I1.1200.45
465_L751_V1.1070.44
568_K580_A1.1050.44
391_K417_I1.1040.44
483_I490_I1.0960.44
593_T713_S1.0960.44
205_L348_V1.0850.43
200_I225_I1.0850.43
599_Y707_Y1.0800.43
640_S645_S1.0790.43
652_L656_R1.0750.42
207_V213_K1.0730.42
446_V471_I1.0720.42
274_V298_A1.0670.42
544_V713_S1.0650.42
203_M216_I1.0640.42
513_E542_I1.0640.42
335_G408_R1.0630.42
219_C225_I1.0620.42
606_A610_A1.0620.42
628_R663_M1.0600.41
677_A681_D1.0590.41
200_I222_K1.0570.41
96_V130_F1.0530.41
178_L188_V1.0510.41
222_K225_I1.0510.41
457_H739_S1.0500.41
66_L106_V1.0490.41
641_D646_S1.0490.41
74_T114_L1.0480.41
579_T608_E1.0470.41
71_S87_G1.0460.41
295_P301_V1.0400.40
698_P705_I1.0380.40
574_R618_E1.0370.40
723_V746_M1.0350.40
173_A318_V1.0310.40
256_G702_A1.0310.40
218_V234_A1.0260.40
453_A457_H1.0260.40
179_R374_F1.0240.39
670_G705_I1.0230.39
103_G655_V1.0190.39
500_N506_R1.0190.39
271_Q301_V1.0190.39
171_T211_L1.0180.39
193_S251_D1.0160.39
299_K376_P1.0120.39
506_R539_I1.0080.38
506_R509_E1.0070.38
582_A724_L1.0040.38
271_Q298_A1.0030.38
516_Q519_K1.0020.38
294_L314_Y0.9970.38
306_I379_I0.9970.38
118_K125_A0.9950.38
500_N539_I0.9950.38
16_P109_I0.9950.38
60_Y71_S0.9930.38
60_Y87_G0.9900.37
610_A655_V0.9880.37
29_L100_K0.9870.37
233_M236_T0.9860.37
267_K314_Y0.9860.37
636_N704_R0.9810.37
537_T554_C0.9780.37
228_G232_N0.9760.37
221_S270_T0.9740.37
195_A199_A0.9730.36
242_V253_V0.9710.36
583_M620_V0.9680.36
679_R690_G0.9650.36
704_R707_Y0.9650.36
224_V253_V0.9640.36
170_S286_L0.9610.36
581_G601_N0.9610.36
620_V694_I0.9610.36
504_D508_K0.9600.36
500_N508_K0.9580.36
267_K297_L0.9580.36
29_L47_C0.9570.36
251_D254_I0.9560.36
583_M619_T0.9550.35
512_T516_Q0.9550.35
299_K303_P0.9530.35
476_P480_E0.9490.35
11_D740_V0.9460.35
663_M688_L0.9450.35
453_A485_K0.9430.35
580_A727_V0.9330.34
519_K683_M0.9320.34
146_I685_D0.9320.34
475_R478_V0.9320.34
70_I119_F0.9310.34
552_M564_F0.9310.34
601_N612_I0.9290.34
389_I696_V0.9280.34
68_A71_S0.9260.34
392_I746_M0.9250.34
654_L657_E0.9230.34
586_L719_T0.9200.34
456_L460_Q0.9190.34
101_F384_F0.9190.34
484_Q491_K0.9180.33
619_T725_M0.9170.33
169_I326_F0.9140.33
672_A678_I0.9070.33
200_I265_G0.9070.33
221_S273_M0.9060.33
286_L308_C0.9020.33
515_F519_K0.9010.33
669_H737_I0.9000.33
242_V247_K0.8980.32
623_F745_N0.8970.32
323_C327_I0.8950.32
284_L308_C0.8940.32
656_R662_L0.8940.32
228_G245_D0.8930.32
227_Q233_M0.8890.32
233_M248_R0.8890.32
167_A321_V0.8890.32
283_I295_P0.8880.32
253_V609_L0.8850.32
58_Y87_G0.8850.32
190_M261_L0.8840.32
628_R692_A0.8840.32
155_N544_V0.8840.32
347_A362_V0.8830.32
22_Q142_E0.8820.32
76_V82_I0.8800.31
282_M308_C0.8790.31
614_L655_V0.8780.31
284_L359_Q0.8780.31
121_E124_A0.8750.31
628_R690_G0.8730.31
47_C82_I0.8720.31
224_V248_R0.8720.31
448_P540_G0.8710.31
477_N502_E0.8690.31
442_P544_V0.8690.31
613_T629_V0.8690.31
510_Y544_V0.8650.31
538_V566_V0.8620.31
506_R548_E0.8610.30
401_M413_F0.8610.30
259_I697_M0.8600.30
173_A284_L0.8570.30
454_R703_A0.8570.30
200_I218_V0.8560.30
634_H701_E0.8560.30
270_T273_M0.8550.30
103_G423_F0.8540.30
179_R353_E0.8520.30
219_C268_V0.8480.30
634_H642_C0.8470.30
581_G612_I0.8470.30
17_V22_Q0.8460.30
446_V477_N0.8460.30
498_I505_P0.8460.30
584_N599_Y0.8450.30
206_L295_P0.8440.30
180_V306_I0.8430.30
364_A696_V0.8420.30
51_E56_K0.8420.30
485_K539_I0.8410.29
116_P122_V0.8410.29
246_G252_D0.8400.29
104_I225_I0.8340.29
199_A380_I0.8340.29
338_A405_V0.8320.29
193_S268_V0.8320.29
335_G407_T0.8300.29
109_I129_T0.8300.29
632_L704_R0.8290.29
560_Y582_A0.8280.29
538_V731_V0.8260.29
579_T601_N0.8260.29
651_A655_V0.8260.29
464_T501_N0.8230.29
120_I146_I0.8230.29
608_E717_G0.8230.29
261_L286_L0.8220.29
660_P664_I0.8220.29
36_A686_S0.8210.28
113_E149_K0.8210.28
626_E663_M0.8190.28
500_N568_K0.8170.28
36_A103_G0.8170.28
142_E326_F0.8160.28
436_S439_R0.8160.28
507_F511_W0.8140.28
142_E710_L0.8130.28
511_W529_Q0.8130.28
600_V670_G0.8100.28
614_L659_A0.8090.28
582_A703_A0.8080.28
189_R213_K0.8070.28
57_A345_L0.8070.28
671_D711_R0.8070.28
96_V170_S0.8060.28
49_E111_V0.8060.28
376_P379_I0.8050.28
606_A650_Q0.8040.28
296_P307_I0.8020.28
590_S593_T0.8020.28
482_R485_K0.8010.27
104_I268_V0.8000.27
376_P702_A0.7990.27
200_I232_N0.7990.27
217_V247_K0.7980.27
14_E60_Y0.7980.27
334_V752_V0.7960.27
521_R641_D0.7940.27
596_A616_A0.7940.27
208_A345_L0.7920.27
22_Q130_F0.7890.27
269_L274_V0.7880.27
632_L670_G0.7880.27
173_A742_R0.7880.27
191_V237_K0.7870.27
204_N207_V0.7860.27
236_T240_Y0.7860.27
552_M567_V0.7860.27
263_C270_T0.7860.27
632_L698_P0.7840.27
445_V553_I0.7820.27
267_K301_V0.7810.27
430_F723_V0.7810.27
543_M549_A0.7780.26
175_L209_L0.7770.26
282_M675_V0.7740.26
544_V609_L0.7740.26
610_A617_A0.7720.26
665_D686_S0.7720.26
462_L467_L0.7710.26
412_D415_V0.7710.26
414_D466_G0.7710.26
384_F545_Q0.7690.26
33_R649_R0.7680.26
81_N112_D0.7670.26
116_P139_K0.7660.26
68_A377_E0.7660.26
142_E473_I0.7650.26
479_I594_F0.7630.26
226_Y245_D0.7620.26
389_I674_L0.7610.26
252_D441_A0.7600.26
48_L52_K0.7590.26
353_E391_K0.7590.26
212_Q275_K0.7580.25
631_L648_M0.7580.25
345_L349_R0.7580.25
414_D417_I0.7570.25
57_A445_V0.7570.25
189_R224_V0.7550.25
95_G107_F0.7550.25
665_D688_L0.7530.25
68_A114_L0.7530.25
628_R676_E0.7510.25
29_L76_V0.7510.25
573_Y720_V0.7510.25
267_K290_E0.7510.25
299_K377_E0.7510.25
579_T612_I0.7500.25
119_F153_R0.7480.25
707_Y719_T0.7480.25
610_A659_A0.7470.25
230_E233_M0.7460.25
607_E653_E0.7450.25
321_V363_V0.7450.25
583_M616_A0.7430.25
358_E489_Q0.7420.25
181_V379_I0.7400.25
66_L129_T0.7390.25
95_G198_A0.7390.25
351_I392_I0.7340.24
519_K665_D0.7320.24
36_A286_L0.7320.24
581_G725_M0.7320.24
117_D121_E0.7310.24
595_I695_L0.7300.24
452_E526_E0.7300.24
267_K296_P0.7300.24
326_F382_K0.7290.24
222_K749_L0.7290.24
499_V543_M0.7260.24
6_K48_L0.7260.24
449_E609_L0.7250.24
635_S638_G0.7250.24
432_K733_V0.7240.24
183_K607_E0.7240.24
66_L107_F0.7220.24
473_I631_L0.7220.24
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599_Y694_I0.5260.16
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553_I746_M0.5100.16
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347_A363_V0.5090.16
351_I592_N0.5090.16
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266_P447_L0.5060.16
593_T710_L0.5060.16
471_I608_E0.5060.16
222_K230_E0.5060.16
218_V221_S0.5050.16
272_E725_M0.5050.16
52_K551_A0.5050.16
644_S737_I0.5050.16
542_I662_L0.5050.16
191_V253_V0.5040.16
500_N545_Q0.5040.16
222_K265_G0.5040.16
326_F586_L0.5040.16
566_V707_Y0.5040.16
104_I434_I0.5030.16
710_L716_E0.5030.16
326_F642_C0.5030.16
177_G685_D0.5020.16
286_L525_Q0.5020.16
702_A705_I0.5020.16
199_A704_R0.5020.16
438_A563_H0.5020.16
199_A203_M0.5010.16
639_S664_I0.5010.16
362_V386_P0.5010.16
36_A300_E0.5000.15
15_F445_V0.5000.15
595_I656_R0.5000.15
424_V428_N0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nv9A 2 0.5797 100 0.598 Contact Map
1vl6A 4 0.4901 100 0.652 Contact Map
1pj3A 4 0.5349 100 0.663 Contact Map
1gq2A 6 0.5428 100 0.663 Contact Map
1o0sA 4 0.5744 100 0.665 Contact Map
2a9fA 2 0.4993 100 0.688 Contact Map
2dvmA 2 0.5586 100 0.689 Contact Map
4e4rA 2 0.4295 100 0.824 Contact Map
1td9A 3 0.4256 100 0.832 Contact Map
1r5jA 4 0.4256 100 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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