GREMLIN Database
EUTP - Ethanolamine utilization protein EutP
UniProt: P76556 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14191
Length: 159 (140)
Sequences: 321 (263)
Seq/√Len: 22.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_D128_N5.8691.00
125_F141_Y4.6531.00
112_R126_E4.3771.00
69_I97_V3.2361.00
19_N28_A2.9320.99
112_R116_L2.8580.99
42_I65_V2.7210.99
136_Q140_D2.5740.98
18_F41_D2.4050.98
32_Q43_D2.2880.97
31_T43_D2.2660.96
101_T126_E2.1660.95
73_G76_D2.0160.93
86_L90_V1.9660.92
15_T43_D1.9030.91
55_Y85_L1.8970.91
52_P82_P1.7290.86
85_L90_V1.6670.84
41_D60_T1.6340.83
72_H82_P1.6230.82
3_R126_E1.6180.82
98_I126_E1.5770.81
60_T63_Q1.5620.80
71_V81_L1.5580.80
31_T46_G1.5390.79
19_N26_T1.5260.78
131_D134_S1.5230.78
84_G142_L1.5180.78
109_A112_R1.5050.77
4_I69_I1.4280.73
7_V137_Q1.4190.73
3_R101_T1.4070.72
62_L88_I1.3940.72
36_F84_G1.3690.70
30_K43_D1.3670.70
16_T31_T1.3570.69
44_T58_L1.3260.68
109_A126_E1.3150.67
12_A20_A1.3000.66
98_I124_M1.2670.64
51_H55_Y1.2500.63
112_R117_E1.2440.63
9_S76_D1.2310.62
15_T31_T1.2290.62
51_H56_H1.2160.61
5_A18_F1.2080.60
68_L92_K1.2070.60
128_N134_S1.1830.59
46_G99_S1.1760.58
48_Y113_K1.1710.58
74_A106_A1.1640.57
14_K46_G1.1260.55
36_F63_Q1.1200.54
104_P107_D1.1020.53
48_Y77_P1.0970.53
123_P141_Y1.0720.51
38_D124_M1.0590.50
63_Q93_R1.0580.50
49_F107_D1.0480.49
7_V57_A1.0470.49
75_N105_D1.0430.49
138_L141_Y1.0390.49
9_S91_S1.0310.48
9_S65_V1.0290.48
100_K135_V1.0250.48
110_A144_S1.0220.48
21_L138_L1.0200.48
77_P107_D1.0110.47
55_Y100_K1.0010.46
75_N99_S0.9970.46
5_A55_Y0.9920.46
31_T102_D0.9540.43
6_F83_A0.9370.42
47_E57_A0.9370.42
23_G139_V0.9240.41
21_L139_V0.9200.41
43_D46_G0.9170.41
101_T127_L0.9160.41
72_H81_L0.9140.40
10_V51_H0.9000.40
5_A65_V0.8980.39
52_P97_V0.8970.39
112_R140_D0.8930.39
94_Q119_G0.8780.38
98_I137_Q0.8740.38
15_T46_G0.8700.38
48_Y59_I0.8570.37
62_L96_A0.8550.37
7_V113_K0.8540.37
41_D82_P0.8470.36
112_R123_P0.8450.36
111_T133_Q0.8440.36
58_L142_L0.8430.36
34_V42_I0.8430.36
58_L138_L0.8380.36
2_K95_I0.8350.35
3_R22_Q0.8200.34
9_S36_F0.8170.34
48_Y79_S0.8160.34
59_I88_I0.8120.34
20_A129_S0.8100.34
14_K43_D0.8070.34
53_R57_A0.8030.33
29_R35_E0.8010.33
50_N99_S0.7850.32
49_F80_R0.7760.32
33_A61_T0.7750.32
104_P108_V0.7690.31
62_L90_V0.7560.31
61_T68_L0.7490.30
44_T57_A0.7440.30
55_Y61_T0.7420.30
12_A73_G0.7380.30
51_H80_R0.7300.29
16_T41_D0.7260.29
26_T30_K0.7210.29
99_S117_E0.7210.29
16_T43_D0.7140.28
26_T142_L0.7140.28
7_V10_V0.7140.28
5_A36_F0.7140.28
17_L102_D0.7110.28
87_D111_T0.7090.28
23_G40_G0.7050.28
10_V80_R0.7020.28
36_F60_T0.7000.27
56_H60_T0.6990.27
12_A117_E0.6950.27
32_Q46_G0.6930.27
20_A23_G0.6900.27
116_L123_P0.6880.27
22_Q64_D0.6860.27
100_K103_M0.6830.27
62_L124_M0.6830.27
74_A104_P0.6800.26
79_S114_L0.6780.26
137_Q140_D0.6760.26
20_A104_P0.6750.26
106_A114_L0.6740.26
25_Y133_Q0.6730.26
9_S84_G0.6700.26
111_T139_V0.6640.26
51_H128_N0.6510.25
32_Q47_E0.6490.25
10_V50_N0.6420.24
25_Y143_A0.6330.24
52_P69_I0.6300.24
7_V135_V0.6280.24
49_F119_G0.6270.24
98_I111_T0.6260.24
30_K61_T0.6160.23
98_I108_V0.6160.23
68_L114_L0.6140.23
98_I139_V0.6130.23
56_H82_P0.6130.23
50_N62_L0.6130.23
35_E90_V0.6130.23
110_A114_L0.6130.23
31_T100_K0.6120.23
14_K17_L0.6090.23
24_N71_V0.6090.23
62_L73_G0.6050.23
57_A76_D0.6040.23
20_A133_Q0.6030.22
20_A93_R0.5960.22
48_Y57_A0.5930.22
13_G31_T0.5930.22
34_V61_T0.5890.22
16_T75_N0.5790.21
95_I141_Y0.5780.21
101_T129_S0.5760.21
51_H79_S0.5740.21
77_P87_D0.5740.21
69_I95_I0.5650.21
135_V140_D0.5620.21
107_D116_L0.5580.20
96_A115_L0.5510.20
100_K134_S0.5500.20
28_A52_P0.5490.20
16_T129_S0.5490.20
18_F91_S0.5480.20
58_L80_R0.5470.20
17_L43_D0.5460.20
31_T128_N0.5450.20
25_Y117_E0.5410.20
3_R60_T0.5410.20
28_A31_T0.5410.20
51_H73_G0.5400.20
9_S78_E0.5390.20
77_P140_D0.5380.20
5_A44_T0.5380.20
113_K135_V0.5340.19
85_L95_I0.5330.19
16_T73_G0.5330.19
98_I121_E0.5280.19
45_P96_A0.5270.19
109_A117_E0.5220.19
31_T47_E0.5220.19
15_T19_N0.5160.19
66_D93_R0.5160.19
84_G91_S0.5150.19
22_Q41_D0.5130.18
3_R50_N0.5120.18
30_K47_E0.5090.18
99_S123_P0.5060.18
33_A55_Y0.5040.18
44_T82_P0.5040.18
5_A90_V0.5030.18
46_G102_D0.5010.18
54_W138_L0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zo1I 1 0.9686 99.7 0.71 Contact Map
3wbiA 1 0.8679 99.7 0.711 Contact Map
4tmxA 1 0.956 99.7 0.715 Contact Map
4n3sA 1 0.9182 99.7 0.717 Contact Map
3j4jA 1 0.9623 99.7 0.717 Contact Map
1g7sA 1 0.956 99.7 0.718 Contact Map
4kjzA 1 0.956 99.7 0.718 Contact Map
4n3nA 2 0.9245 99.7 0.719 Contact Map
2dykA 1 0.8616 99.7 0.719 Contact Map
4b43A 1 0.9057 99.7 0.72 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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