GREMLIN Database
EUTG - Ethanolamine utilization protein EutG
UniProt: P76553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14183
Length: 395 (367)
Sequences: 10271 (7062)
Seq/√Len: 368.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
367_Q384_L3.8701.00
363_G388_V3.8441.00
246_P345_E3.5181.00
308_E340_S3.2951.00
100_A104_E3.1871.00
359_S392_A3.0341.00
247_K254_D2.7921.00
251_Y254_D2.7911.00
98_A125_V2.7481.00
93_T173_A2.7361.00
67_A71_R2.5661.00
244_S260_S2.5641.00
383_S386_Q2.5021.00
199_E255_L2.3911.00
362_Y388_V2.3851.00
283_M391_Y2.3651.00
85_C97_A2.3281.00
34_P196_A2.3131.00
358_T361_H2.3051.00
236_G239_A2.2591.00
51_H79_A2.2571.00
217_A237_A2.2491.00
39_S42_Q2.2301.00
351_R354_D2.1871.00
388_V392_A2.1861.00
193_L262_L2.1631.00
49_L109_G2.1171.00
52_L109_G2.1141.00
35_G196_A2.1051.00
231_D317_R2.0861.00
341_E345_E2.0781.00
213_A241_I2.0671.00
36_S39_S2.0641.00
214_L238_I2.0071.00
119_L153_A1.9561.00
206_T258_R1.9001.00
310_N378_N1.9001.00
366_A388_V1.8931.00
110_V122_A1.8901.00
102_L149_L1.8811.00
284_A298_A1.8611.00
81_T105_S1.8321.00
208_M297_L1.8231.00
384_L388_V1.7971.00
70_T74_T1.7931.00
59_F63_A1.7781.00
365_W391_Y1.7471.00
87_V94_D1.7441.00
102_L129_V1.7061.00
366_A384_L1.6811.00
242_G325_L1.6801.00
67_A70_T1.6751.00
301_M355_V1.6621.00
338_A341_E1.6591.00
327_T332_D1.6451.00
322_G335_A1.6381.00
198_T258_R1.6281.00
238_I321_I1.5991.00
172_D175_S1.5921.00
363_G384_L1.5871.00
57_D60_L1.5751.00
308_E393_A1.5671.00
50_K108_D1.5651.00
34_P255_L1.5571.00
246_P250_G1.5521.00
41_G72_S1.5491.00
94_D97_A1.5481.00
112_A151_L1.5471.00
389_G393_A1.5381.00
96_C134_S1.5331.00
61_H84_P1.5311.00
210_G245_L1.5241.00
250_G345_E1.5121.00
203_S207_A1.5081.00
81_T101_Q1.5041.00
337_N341_E1.4971.00
256_A260_S1.4941.00
38_S68_G1.4871.00
97_A100_A1.4811.00
81_T107_C1.4791.00
204_H297_L1.4741.00
235_I320_Q1.4651.00
29_V43_Q1.4621.00
101_Q105_S1.4601.00
95_V170_I1.4471.00
71_R75_V1.4441.00
308_E333_R1.4381.00
44_A109_G1.4221.00
34_P259_E1.4191.00
389_G392_A1.4121.00
74_T80_M1.4081.00
210_G261_M1.4051.00
43_Q46_T1.4001.00
235_I324_A1.3951.00
283_M302_L1.3941.00
206_T252_G1.3931.00
307_M339_V1.3801.00
344_A350_K1.3771.00
293_I298_A1.3651.00
290_A364_A1.3611.00
361_H364_A1.3601.00
196_A255_L1.3511.00
364_A368_A1.3431.00
70_T80_M1.3371.00
198_T262_L1.3351.00
52_L111_I1.3341.00
211_I343_I1.3201.00
247_K251_Y1.3041.00
328_K332_D1.3001.00
102_L107_C1.3001.00
92_I96_C1.2901.00
311_R333_R1.2901.00
254_D257_A1.2891.00
112_A122_A1.2741.00
152_I190_V1.2711.00
133_D137_A1.2691.00
55_M125_V1.2681.00
99_V128_L1.2631.00
31_L43_Q1.2621.00
386_Q389_G1.2601.00
211_I348_I1.2581.00
126_T148_R1.2551.00
87_V91_C1.2521.00
43_Q190_V1.2521.00
101_Q104_E1.2471.00
68_G196_A1.2451.00
135_T138_E1.2411.00
203_S249_V1.2401.00
95_V121_A1.2371.00
93_T174_V1.2291.00
130_T147_P1.2281.00
51_H81_T1.2271.00
30_T266_C1.2271.00
367_Q371_E1.2231.00
96_C100_A1.2171.00
133_D138_E1.2081.00
109_G152_I1.2051.00
244_S247_K1.1961.00
243_K260_S1.1951.00
333_R337_N1.1921.00
321_I335_A1.1791.00
158_A206_T1.1721.00
309_F386_Q1.1661.00
51_H55_M1.1651.00
241_I261_M1.1591.00
279_L382_A1.1551.00
385_E388_V1.1541.00
91_C94_D1.1511.00
100_A103_R1.1491.00
110_V126_T1.1471.00
51_H105_S1.1461.00
244_S257_A1.1421.00
364_A367_Q1.1381.00
122_A151_L1.1351.00
102_L125_V1.1331.00
56_A60_L1.1331.00
55_M86_P1.1271.00
33_G36_S1.1271.00
71_R74_T1.1211.00
196_A199_E1.1201.00
36_S192_I1.1201.00
283_M387_I1.1121.00
220_A271_A1.1101.00
201_V205_V1.1031.00
58_S62_Q1.1001.00
235_I239_A1.1001.00
37_V154_I1.0961.00
53_F107_C1.0811.00
206_T248_A1.0791.00
312_M380_R1.0781.00
203_S250_G1.0751.00
236_G240_M1.0721.00
31_L39_S1.0621.00
44_A152_I1.0611.00
59_F62_Q1.0611.00
35_G38_S1.0561.00
217_A268_A1.0521.00
99_V103_R1.0491.00
53_F102_L1.0461.00
291_L361_H1.0441.00
280_C303_L1.0431.00
282_A375_L1.0421.00
232_S236_G1.0401.00
385_E389_G1.0381.00
52_L55_M1.0371.00
34_P199_E1.0371.00
40_C69_L1.0341.00
58_S84_P1.0341.00
69_L113_F1.0331.00
280_C299_N1.0321.00
207_A249_V1.0321.00
91_C173_A1.0261.00
92_I173_A1.0221.00
153_A188_P1.0201.00
239_A324_A1.0171.00
53_F101_Q1.0161.00
195_A259_E1.0141.00
362_Y392_A1.0081.00
56_A61_H1.0071.00
320_Q324_A1.0041.00
167_V182_A1.0001.00
164_T266_C0.9991.00
237_A268_A0.9991.00
313_V380_R0.9941.00
55_M122_A0.9911.00
370_L384_L0.9851.00
37_V68_G0.9761.00
86_P121_A0.9741.00
231_D234_A0.9741.00
112_A153_A0.9721.00
247_K256_A0.9711.00
89_E292_H0.9691.00
51_H106_G0.9651.00
58_S85_C0.9571.00
305_T393_A0.9571.00
87_V97_A0.9551.00
45_Q76_K0.9461.00
284_A288_G0.9421.00
211_I300_A0.9411.00
164_T191_A0.9401.00
42_Q76_K0.9401.00
150_P189_D0.9371.00
204_H208_M0.9351.00
309_F380_R0.9301.00
221_Y320_Q0.9251.00
54_V70_T0.9211.00
252_G258_R0.9171.00
214_L241_I0.9141.00
247_K257_A0.9131.00
56_A59_F0.9131.00
54_V80_M0.9101.00
52_L108_D0.9061.00
35_G194_D0.9041.00
320_Q323_R0.9021.00
99_V125_V0.9021.00
242_G338_A0.9021.00
290_A368_A0.9011.00
319_S323_R0.9001.00
74_T79_A0.8991.00
119_L155_P0.8991.00
321_I339_V0.8981.00
52_L78_I0.8981.00
220_A231_D0.8921.00
363_G367_Q0.8881.00
208_M294_P0.8871.00
286_Q391_Y0.8861.00
241_I264_A0.8851.00
60_L63_A0.8821.00
54_V66_T0.8811.00
153_A191_A0.8801.00
218_I238_I0.8801.00
279_L306_V0.8791.00
248_A252_G0.8781.00
218_I321_I0.8771.00
240_M260_S0.8741.00
199_E253_H0.8731.00
158_A262_L0.8731.00
239_A243_K0.8691.00
56_A84_P0.8681.00
176_G292_H0.8661.00
215_T303_L0.8621.00
366_A370_L0.8621.00
248_A257_A0.8591.00
29_V46_T0.8581.00
91_C292_H0.8531.00
121_A125_V0.8531.00
249_V347_G0.8511.00
44_A49_L0.8421.00
334_D337_N0.8411.00
232_S239_A0.8331.00
126_T149_L0.8321.00
37_V196_A0.8301.00
112_A119_L0.8301.00
119_L162_S0.8281.00
309_F382_A0.8251.00
83_W98_A0.8241.00
37_V197_L0.8231.00
99_V129_V0.8221.00
151_L189_D0.8211.00
41_G75_V0.8171.00
305_T308_E0.8151.00
127_L186_L0.8141.00
307_M318_F0.8131.00
66_T70_T0.8131.00
68_G197_L0.8101.00
249_V346_V0.8091.00
126_T151_L0.8071.00
340_S344_A0.8061.00
247_K250_G0.8061.00
350_K354_D0.8051.00
240_M264_A0.8041.00
131_N146_Q0.8021.00
263_L267_M0.8001.00
198_T206_T0.8001.00
129_V149_L0.7991.00
40_C154_I0.7951.00
220_A234_A0.7941.00
60_L66_T0.7931.00
166_N184_A0.7931.00
221_Y235_I0.7931.00
95_V124_A0.7921.00
214_L218_I0.7901.00
55_M118_V0.7901.00
38_S72_S0.7881.00
349_G354_D0.7871.00
68_G72_S0.7791.00
281_H295_H0.7781.00
33_G39_S0.7761.00
243_K246_P0.7751.00
286_Q368_A0.7701.00
37_V194_D0.7701.00
334_D338_A0.7671.00
222_S307_M0.7661.00
207_A348_I0.7641.00
226_A317_R0.7601.00
368_A371_E0.7601.00
50_K79_A0.7591.00
279_L387_I0.7571.00
83_W97_A0.7561.00
256_A259_E0.7531.00
31_L36_S0.7511.00
285_H372_D0.7511.00
363_G366_A0.7511.00
244_S261_M0.7491.00
68_G71_R0.7461.00
203_S252_G0.7451.00
51_H108_D0.7441.00
307_M335_A0.7431.00
217_A234_A0.7421.00
201_V209_T0.7371.00
311_R315_R0.7371.00
212_D295_H0.7361.00
315_R319_S0.7351.00
302_L390_L0.7331.00
246_P249_V0.7321.00
233_L267_M0.7321.00
344_A354_D0.7291.00
225_N276_G0.7201.00
39_S43_Q0.7191.00
349_G355_V0.7181.00
370_L387_I0.7181.00
239_A320_Q0.7181.00
226_A231_D0.7171.00
56_A82_L0.7171.00
70_T82_L0.7171.00
308_E336_I0.7161.00
49_L52_L0.7130.99
52_L80_M0.7130.99
224_L381_T0.7120.99
32_C259_E0.7100.99
287_P298_A0.7070.99
203_S347_G0.7030.99
93_T97_A0.7020.99
44_A111_I0.7000.99
341_E344_A0.7000.99
210_G346_V0.6980.99
193_L266_C0.6930.99
242_G246_P0.6920.99
236_G267_M0.6920.99
244_S256_A0.6910.99
284_A299_N0.6880.99
304_P343_I0.6860.99
72_S75_V0.6850.99
158_A198_T0.6840.99
57_D63_A0.6830.99
297_L349_G0.6820.99
96_C99_V0.6810.99
24_F267_M0.6810.99
61_H66_T0.6800.99
37_V72_S0.6780.99
43_Q47_R0.6760.99
64_G67_A0.6730.99
309_F383_S0.6710.99
134_S137_A0.6710.99
58_S61_H0.6700.99
53_F105_S0.6700.99
215_T299_N0.6670.99
124_A168_T0.6670.99
293_I355_V0.6650.99
238_I325_L0.6650.99
168_T181_L0.6640.99
307_M336_I0.6640.99
37_V69_L0.6630.99
112_A118_V0.6620.99
61_H67_A0.6620.99
221_Y317_R0.6600.99
45_Q50_K0.6590.99
382_A390_L0.6560.99
134_S138_E0.6550.99
287_P391_Y0.6530.99
95_V125_V0.6530.99
248_A261_M0.6520.99
215_T280_C0.6510.99
308_E337_N0.6490.99
97_A101_Q0.6480.99
61_H70_T0.6430.99
165_T269_G0.6420.99
243_K247_K0.6380.99
155_P193_L0.6360.99
89_E117_S0.6350.99
244_S248_A0.6350.99
238_I242_G0.6340.99
272_F277_L0.6340.99
342_L346_V0.6330.99
164_T270_M0.6330.99
38_S196_A0.6330.99
308_E311_R0.6320.99
42_Q46_T0.6300.99
44_A78_I0.6290.99
67_A74_T0.6270.99
218_I335_A0.6270.99
339_V343_I0.6260.99
255_L259_E0.6250.99
152_I192_I0.6250.99
130_T149_L0.6200.99
223_A377_S0.6200.99
382_A386_Q0.6170.99
282_A374_C0.6150.99
300_A343_I0.6150.99
226_A230_T0.6140.99
34_P256_A0.6130.98
41_G44_A0.6130.98
96_C128_L0.6120.98
287_P352_L0.6120.98
362_Y391_Y0.6110.98
38_S75_V0.6110.98
169_V212_D0.6100.98
102_L110_V0.6090.98
216_H268_A0.6080.98
74_T77_G0.6070.98
41_G76_K0.6070.98
357_A362_Y0.6060.98
132_P138_E0.6050.98
222_S318_F0.6040.98
218_I303_L0.6000.98
340_S350_K0.6000.98
294_P297_L0.5990.98
131_N148_R0.5970.98
166_N273_S0.5960.98
210_G241_I0.5960.98
211_I346_V0.5960.98
382_A387_I0.5960.98
135_T140_S0.5930.98
32_C263_L0.5930.98
283_M369_A0.5930.98
380_R386_Q0.5910.98
40_C72_S0.5910.98
276_G377_S0.5900.98
178_K295_H0.5900.98
299_N302_L0.5880.98
315_R318_F0.5880.98
127_L144_V0.5870.98
288_G298_A0.5870.98
337_N340_S0.5860.98
297_L348_I0.5860.98
30_T191_A0.5860.98
300_A348_I0.5850.98
53_F83_W0.5840.98
65_M113_F0.5840.98
48_G108_D0.5830.98
221_Y231_D0.5830.98
353_G359_S0.5820.98
31_L190_V0.5820.98
316_E319_S0.5810.98
136_L172_D0.5810.98
155_P265_S0.5790.98
244_S264_A0.5790.98
53_F81_T0.5790.98
136_L140_S0.5780.98
195_A255_L0.5760.98
373_I376_R0.5760.98
212_D281_H0.5730.98
352_L357_A0.5730.98
60_L65_M0.5730.98
245_L342_L0.5700.98
323_R332_D0.5690.98
42_Q45_Q0.5690.98
290_A365_W0.5690.98
279_L282_A0.5680.98
278_G285_H0.5670.97
216_H295_H0.5620.97
124_A170_I0.5620.97
314_C318_F0.5610.97
47_R152_I0.5610.97
359_S362_Y0.5600.97
89_E288_G0.5590.97
218_I307_M0.5590.97
147_P185_S0.5590.97
101_Q107_C0.5580.97
41_G45_Q0.5570.97
65_M197_L0.5560.97
87_V292_H0.5550.97
124_A181_L0.5550.97
69_L72_S0.5550.97
148_R189_D0.5550.97
51_H107_C0.5550.97
55_M98_A0.5540.97
215_T278_G0.5540.97
369_A391_Y0.5540.97
224_L377_S0.5530.97
44_A73_L0.5520.97
301_M352_L0.5510.97
73_L80_M0.5490.97
31_L192_I0.5440.97
301_M348_I0.5440.97
285_H288_G0.5430.97
96_C135_T0.5410.97
225_N228_P0.5400.97
66_T113_F0.5390.97
304_P340_S0.5360.96
327_T334_D0.5360.96
132_P135_T0.5340.96
278_G377_S0.5340.96
63_A66_T0.5330.96
222_S278_G0.5320.96
38_S71_R0.5310.96
55_M121_A0.5310.96
321_I325_L0.5300.96
246_P342_L0.5280.96
167_V180_V0.5280.96
205_V209_T0.5270.96
343_I348_I0.5260.96
135_T139_M0.5260.96
279_L378_N0.5240.96
128_L132_P0.5230.96
199_E258_R0.5230.96
246_P338_A0.5210.96
240_M267_M0.5210.96
45_Q78_I0.5200.96
309_F390_L0.5200.96
304_P336_I0.5190.96
111_I152_I0.5190.96
53_F98_A0.5180.96
222_S306_V0.5180.96
366_A387_I0.5160.96
240_M244_S0.5160.96
110_V125_V0.5160.96
103_R132_P0.5150.96
94_D121_A0.5140.96
130_T148_R0.5130.96
305_T390_L0.5110.95
336_I340_S0.5110.95
61_H82_L0.5090.95
161_G265_S0.5040.95
102_L105_S0.5040.95
154_I192_I0.5030.95
83_W94_D0.5030.95
302_L306_V0.5000.95
77_G80_M0.5000.95
54_V82_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9519 100 0.148 Contact Map
3bfjA 5 0.9494 100 0.152 Contact Map
1rrmA 2 0.9468 100 0.164 Contact Map
4fr2A 2 0.9494 100 0.171 Contact Map
1vljA 2 0.962 100 0.178 Contact Map
3zdrA 2 0.9443 100 0.192 Contact Map
4qgsA 2 0.9266 100 0.206 Contact Map
1o2dA 1 0.9038 100 0.21 Contact Map
3iv7A 2 0.8658 100 0.245 Contact Map
3w5sA 2 0.8709 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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