GREMLIN Database
EUTH - Ethanolamine utilization protein EutH
UniProt: P76552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14182
Length: 408 (356)
Sequences: 261 (177)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_S293_L4.7921.00
22_R49_E3.4670.96
19_A240_A3.4220.96
84_Y97_T3.2550.94
96_G123_S3.2360.94
14_F293_L3.1990.94
312_N337_D3.1400.93
153_Y338_T3.0670.92
47_Q50_E2.9920.91
130_M168_G2.9810.91
147_E334_K2.9570.91
325_N357_D2.8740.90
220_M223_G2.8110.88
113_A120_W2.8060.88
171_A175_V2.7780.88
325_N351_A2.7440.87
96_G124_G2.6060.84
55_M281_S2.5940.84
298_F301_P2.5680.83
67_A242_A2.5500.83
106_F365_N2.4790.81
329_M344_N2.3750.78
101_C362_A2.3390.77
343_I385_I2.3340.77
115_G118_A2.2210.73
150_D341_K2.2040.72
294_L355_L2.1590.71
287_A291_V2.1450.70
77_G112_L2.0930.68
358_H373_M2.0550.67
178_Y194_L2.0430.66
315_A340_G2.0420.66
101_C125_L2.0400.66
351_A357_D2.0240.65
217_P290_M2.0140.65
49_E232_V1.9850.64
24_L42_E1.9810.64
19_A363_A1.9690.63
101_C129_S1.9250.61
374_I385_I1.9220.61
242_A246_F1.9170.61
170_I199_M1.8640.59
106_F366_M1.8510.58
124_G129_S1.7960.56
89_A130_M1.7920.56
14_F287_A1.7750.55
241_A253_I1.7740.55
216_I219_K1.7530.54
24_L44_S1.7500.54
318_G344_N1.7390.53
304_S308_V1.7320.53
122_Y354_A1.7260.53
107_F235_I1.7200.52
302_L317_A1.7190.52
333_M345_C1.7100.52
209_V348_A1.7060.52
158_V206_A1.7060.52
45_G289_P1.7020.52
351_A354_A1.6960.51
170_I382_V1.6840.51
160_A343_I1.6360.49
129_S325_N1.6280.48
12_M243_V1.6240.48
106_F248_L1.6010.47
83_V196_L1.5990.47
195_I290_M1.5950.47
98_L311_M1.5860.46
65_M98_L1.5790.46
43_G296_R1.5720.46
92_S301_P1.5450.45
106_F217_P1.5440.45
287_A353_F1.5410.44
57_A162_I1.5380.44
204_I382_V1.5370.44
348_A353_F1.5280.44
55_M360_G1.5250.44
284_L324_A1.5220.44
171_A379_I1.5150.43
199_M354_A1.5120.43
86_M200_I1.5090.43
125_L236_T1.4840.42
67_A246_F1.4840.42
152_R156_L1.4660.41
169_C365_N1.4580.41
322_T384_A1.4500.40
251_E256_L1.4500.40
51_G281_S1.4450.40
100_A358_H1.4420.40
113_A369_M1.4280.40
26_Q45_G1.4180.39
3_I9_Y1.4010.38
243_V285_L1.3840.38
125_L362_A1.3840.38
11_M283_V1.3770.37
126_I339_R1.3710.37
11_M15_M1.3690.37
52_F202_V1.3650.37
314_I335_Q1.3500.36
87_L165_I1.3470.36
7_I10_I1.3410.36
196_L200_I1.3390.36
132_G377_K1.3360.36
80_I204_I1.3360.36
20_V24_L1.3290.35
287_A324_A1.3090.35
374_I378_L1.3040.34
224_F353_F1.3010.34
138_S322_T1.2950.34
96_G128_G1.2940.34
325_N370_I1.2930.34
135_I352_A1.2700.33
290_M294_L1.2660.33
109_A130_M1.2610.33
200_I365_N1.2560.33
192_F374_I1.2520.32
339_R387_V1.2420.32
160_A391_L1.2420.32
14_F353_F1.2360.32
347_F352_A1.2260.31
124_G325_N1.2170.31
9_Y244_V1.2170.31
357_D370_I1.2170.31
219_K339_R1.2140.31
196_L211_L1.2130.31
68_L238_G1.2130.31
386_G390_M1.2020.30
234_L322_T1.2010.30
10_I218_E1.1930.30
14_F347_F1.1920.30
160_A385_I1.1870.30
17_I226_I1.1820.30
203_I305_V1.1770.30
14_F290_M1.1750.29
26_Q42_E1.1680.29
115_G119_A1.1680.29
170_I376_G1.1680.29
125_L366_M1.1670.29
142_A330_F1.1500.29
44_S292_L1.1490.28
332_M343_I1.1410.28
167_I383_T1.1400.28
156_L392_V1.1280.28
164_T384_A1.1180.27
52_F243_V1.1080.27
208_L223_G1.1020.27
95_A164_T1.1010.27
164_T302_L1.0980.27
287_A321_A1.0970.27
167_I380_G1.0950.27
86_M380_G1.0950.27
216_I220_M1.0930.27
10_I77_G1.0920.26
196_L343_I1.0870.26
152_R158_V1.0830.26
52_F320_V1.0810.26
152_R294_L1.0810.26
93_M362_A1.0710.26
97_T376_G1.0680.26
308_V315_A1.0670.26
47_Q205_V1.0580.25
244_V252_L1.0550.25
339_R389_M1.0540.25
49_E312_N1.0490.25
22_R163_V1.0450.25
232_V236_T1.0440.25
6_I338_T1.0410.25
101_C330_F1.0400.25
316_A351_A1.0320.24
119_A178_Y1.0300.24
15_M326_N1.0270.24
255_G258_P1.0250.24
94_F350_S1.0230.24
168_G198_N1.0190.24
92_S259_I1.0160.24
49_E276_V1.0110.24
278_G324_A0.9990.23
323_L374_I0.9980.23
99_L344_N0.9960.23
277_I343_I0.9950.23
22_R236_T0.9900.23
302_L316_A0.9870.23
96_G105_G0.9870.23
59_G202_V0.9850.23
342_V352_A0.9840.23
81_I124_G0.9830.23
242_A382_V0.9810.23
278_G284_L0.9790.23
304_S307_K0.9700.22
308_V343_I0.9660.22
144_G360_G0.9650.22
155_A315_A0.9620.22
339_R392_V0.9580.22
115_G146_I0.9570.22
133_P353_F0.9560.22
84_Y111_E0.9530.22
291_V321_A0.9520.22
212_G220_M0.9510.22
138_S353_F0.9420.22
106_F290_M0.9420.22
231_L235_I0.9410.22
96_G357_D0.9400.22
204_I390_M0.9380.21
49_E124_G0.9370.21
284_L287_A0.9340.21
358_H362_A0.9320.21
278_G287_A0.9310.21
327_I359_L0.9260.21
62_M206_A0.9250.21
148_P151_R0.9240.21
107_F276_V0.9200.21
86_M315_A0.9190.21
216_I339_R0.9180.21
26_Q192_F0.9170.21
200_I339_R0.9160.21
272_R275_E0.9160.21
12_M247_L0.9130.21
206_A302_L0.9120.21
119_A176_A0.9120.21
106_F246_F0.9110.21
16_L240_A0.9070.21
287_A347_F0.9060.21
23_I352_A0.9040.20
164_T350_S0.9020.20
77_G81_I0.8990.20
196_L237_L0.8950.20
20_V240_A0.8920.20
49_E202_V0.8900.20
354_A360_G0.8890.20
87_L195_I0.8880.20
54_A320_V0.8870.20
71_V241_A0.8830.20
204_I218_E0.8800.20
112_L191_T0.8800.20
136_V358_H0.8800.20
170_I285_L0.8790.20
318_G336_M0.8790.20
23_I237_L0.8780.20
233_A305_V0.8780.20
303_M319_M0.8750.20
88_G372_P0.8750.20
154_L206_A0.8740.20
128_G155_A0.8730.20
111_E115_G0.8730.20
67_A96_G0.8700.20
87_L355_L0.8650.19
75_V196_L0.8640.19
23_I322_T0.8630.19
210_A342_V0.8600.19
68_L256_L0.8590.19
173_G238_G0.8540.19
321_A329_M0.8530.19
203_I294_L0.8510.19
229_K349_V0.8480.19
205_V244_V0.8450.19
133_P169_C0.8440.19
324_A353_F0.8410.19
375_V379_I0.8370.19
257_D272_R0.8350.19
349_V378_L0.8290.18
274_I278_G0.8270.18
119_A194_L0.8250.18
362_A369_M0.8210.18
176_A194_L0.8210.18
79_V226_I0.8200.18
260_F275_E0.8190.18
26_Q41_I0.8190.18
352_A355_L0.8110.18
206_A252_L0.8080.18
98_L218_E0.8060.18
86_M382_V0.8050.18
69_A76_L0.8030.18
160_A329_M0.8020.18
11_M318_G0.7990.18
81_I87_L0.7980.18
44_S345_C0.7950.18
136_V385_I0.7940.17
21_D340_G0.7920.17
122_Y169_C0.7920.17
72_L227_F0.7910.17
68_L71_V0.7780.17
89_A95_A0.7740.17
165_I363_A0.7740.17
287_A330_F0.7690.17
133_P320_V0.7680.17
72_L305_V0.7660.17
9_Y250_W0.7630.17
230_F234_L0.7580.17
71_V176_A0.7570.17
162_I243_V0.7530.16
315_A339_R0.7490.16
63_V253_I0.7470.16
129_S362_A0.7460.16
211_L222_N0.7460.16
13_F20_V0.7440.16
60_L162_I0.7440.16
118_A191_T0.7440.16
151_R277_I0.7430.16
119_A363_A0.7410.16
100_A132_G0.7410.16
315_A389_M0.7410.16
99_L361_F0.7390.16
226_I333_M0.7390.16
160_A387_V0.7370.16
392_V395_E0.7360.16
155_A342_V0.7360.16
127_L365_N0.7310.16
158_V224_F0.7290.16
47_Q222_N0.7270.16
124_G202_V0.7270.16
326_N382_V0.7250.16
19_A327_I0.7250.16
164_T167_I0.7250.16
227_F334_K0.7230.16
17_I285_L0.7210.16
93_M358_H0.7180.16
14_F321_A0.7180.16
93_M357_D0.7170.16
131_M148_P0.7150.16
18_A113_A0.7150.16
299_E305_V0.7140.16
5_E52_F0.7120.15
92_S216_I0.7110.15
80_I309_L0.7090.15
10_I211_L0.7070.15
215_F256_L0.7060.15
221_I290_M0.7060.15
100_A103_M0.7040.15
117_V204_I0.7000.15
8_M333_M0.6960.15
145_I327_I0.6960.15
17_I42_E0.6950.15
362_A373_M0.6950.15
223_G227_F0.6940.15
6_I10_I0.6930.15
150_D353_F0.6930.15
292_L296_R0.6910.15
133_P328_P0.6900.15
42_E297_W0.6890.15
170_I254_P0.6890.15
4_N61_A0.6880.15
49_E360_G0.6880.15
228_A231_L0.6850.15
294_L298_F0.6830.15
67_A156_L0.6820.15
55_M343_I0.6790.15
109_A212_G0.6770.15
73_A384_A0.6760.15
19_A128_G0.6760.15
130_M376_G0.6760.15
13_F83_V0.6720.15
13_F170_I0.6700.15
205_V230_F0.6680.14
224_F287_A0.6670.14
110_K120_W0.6660.14
136_V373_M0.6660.14
120_W272_R0.6650.14
92_S131_M0.6650.14
16_L255_G0.6650.14
46_G143_L0.6640.14
343_I355_L0.6610.14
43_G91_P0.6600.14
142_A145_I0.6590.14
89_A363_A0.6580.14
303_M339_R0.6580.14
41_I120_W0.6570.14
66_T283_V0.6560.14
87_L316_A0.6540.14
313_N385_I0.6490.14
311_M337_D0.6470.14
42_E230_F0.6450.14
113_A141_V0.6450.14
80_I315_A0.6420.14
287_A352_A0.6420.14
245_K288_Y0.6410.14
288_Y345_C0.6400.14
58_L356_G0.6380.14
318_G329_M0.6350.14
89_A253_I0.6310.14
192_F335_Q0.6300.14
96_G129_S0.6280.14
25_S120_W0.6260.14
84_Y128_G0.6240.14
156_L293_L0.6230.14
237_L300_K0.6220.14
146_I300_K0.6200.13
63_V67_A0.6200.13
82_P136_V0.6200.13
65_M243_V0.6200.13
233_A371_F0.6190.13
66_T358_H0.6190.13
17_I195_I0.6180.13
135_I294_L0.6180.13
16_L307_K0.6160.13
155_A341_K0.6150.13
353_F357_D0.6150.13
43_G88_G0.6140.13
19_A47_Q0.6140.13
316_A339_R0.6100.13
112_L349_V0.6080.13
25_S177_M0.6080.13
167_I170_I0.6070.13
141_V361_F0.6060.13
319_M385_I0.6010.13
63_V259_I0.6010.13
96_G362_A0.6010.13
215_F305_V0.6000.13
70_P284_L0.5970.13
50_E212_G0.5960.13
321_A353_F0.5960.13
16_L118_A0.5940.13
17_I277_I0.5940.13
389_M393_P0.5940.13
83_V382_V0.5930.13
57_A309_L0.5930.13
103_M132_G0.5920.13
11_M22_R0.5920.13
259_I285_L0.5910.13
11_M243_V0.5910.13
165_I205_V0.5910.13
258_P272_R0.5900.13
143_L158_V0.5900.13
63_V200_I0.5900.13
71_V256_L0.5900.13
228_A372_P0.5900.13
7_I76_L0.5860.13
159_L272_R0.5850.13
306_G334_K0.5850.13
156_L342_V0.5840.13
139_I372_P0.5830.13
72_L278_G0.5830.13
96_G327_I0.5830.13
225_Q384_A0.5820.13
103_M137_F0.5820.13
174_L196_L0.5810.13
96_G370_I0.5810.13
43_G359_L0.5790.13
156_L393_P0.5780.13
134_T171_A0.5770.13
204_I216_I0.5770.13
52_F65_M0.5760.13
98_L227_F0.5730.13
119_A305_V0.5710.12
92_S251_E0.5700.12
23_I320_V0.5670.12
88_G289_P0.5670.12
41_I275_E0.5650.12
94_F139_I0.5650.12
15_M154_L0.5650.12
329_M348_A0.5640.12
94_F164_T0.5640.12
112_L372_P0.5640.12
106_F127_L0.5630.12
63_V68_L0.5630.12
205_V305_V0.5620.12
74_H135_I0.5590.12
96_G135_I0.5590.12
245_K251_E0.5580.12
126_I202_V0.5570.12
303_M389_M0.5560.12
134_T378_L0.5560.12
129_S370_I0.5550.12
80_I218_E0.5540.12
226_I334_K0.5540.12
224_F321_A0.5530.12
43_G302_L0.5510.12
11_M236_T0.5510.12
251_E255_G0.5470.12
283_V369_M0.5460.12
351_A383_T0.5440.12
163_V274_I0.5440.12
137_F353_F0.5440.12
211_L375_V0.5430.12
107_F125_L0.5430.12
227_F236_T0.5400.12
307_K393_P0.5400.12
57_A393_P0.5380.12
156_L277_I0.5370.12
210_A343_I0.5360.12
204_I294_L0.5360.12
156_L328_P0.5360.12
99_L260_F0.5360.12
22_R360_G0.5360.12
3_I290_M0.5350.12
133_P348_A0.5350.12
13_F207_I0.5340.12
342_V392_V0.5340.12
360_G364_A0.5330.12
20_V379_I0.5320.12
71_V78_P0.5320.12
67_A256_L0.5300.12
133_P383_T0.5300.12
90_N228_A0.5290.12
6_I87_L0.5290.12
350_S380_G0.5280.12
168_G276_V0.5280.12
20_V60_L0.5270.12
191_T282_C0.5250.12
16_L233_A0.5250.12
165_I380_G0.5220.12
44_S127_L0.5210.12
20_V386_G0.5190.12
63_V156_L0.5190.12
111_E375_V0.5190.12
112_L160_A0.5180.11
92_S95_A0.5180.11
57_A215_F0.5170.11
154_L295_T0.5170.11
17_I368_A0.5170.11
62_M141_V0.5150.11
147_E311_M0.5150.11
58_L119_A0.5150.11
178_Y251_E0.5150.11
163_V201_P0.5150.11
69_A78_P0.5140.11
107_F370_I0.5140.11
17_I215_F0.5140.11
154_L320_V0.5130.11
245_K255_G0.5090.11
65_M238_G0.5090.11
55_M127_L0.5090.11
320_V363_A0.5090.11
55_M59_G0.5080.11
278_G357_D0.5060.11
145_I321_A0.5060.11
244_V250_W0.5040.11
224_F347_F0.5040.11
121_L146_I0.5030.11
174_L192_F0.5030.11
151_R197_M0.5030.11
52_F362_A0.5020.11
66_T90_N0.5010.11
162_I209_V0.5010.11
46_G351_A0.5000.11
195_I249_G0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.7132 77.7 0.971 Contact Map
4x5mA 2 0.2304 62.6 0.974 Contact Map
4pd6A 3 0.5294 49.5 0.976 Contact Map
3qnqA 2 0.8088 39.1 0.977 Contact Map
4pypA 1 0.875 36.6 0.978 Contact Map
2kluA 1 0.1054 33.3 0.978 Contact Map
2kncA 1 0.1176 25.5 0.979 Contact Map
3v5uA 1 0.3088 17.4 0.981 Contact Map
4j05A 3 0.8725 17.4 0.981 Contact Map
4n7wA 2 0.723 16.4 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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