GREMLIN Database
EUTA - Ethanolamine utilization protein EutA
UniProt: P76551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14181
Length: 467 (462)
Sequences: 241 (201)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_I158_A8.3401.00
132_G163_F6.2491.00
53_F75_Q4.3270.99
170_G251_P3.8730.98
71_L75_Q3.7440.98
130_I319_T3.7420.98
99_K175_N3.5290.96
53_F71_L3.4910.96
230_V293_H3.3090.95
339_L406_L3.2930.95
222_T226_A3.2060.94
59_K62_G3.1880.94
24_R45_E3.1660.93
175_N313_I2.9500.91
67_E70_T2.8980.90
5_Q24_R2.8400.89
21_I49_Q2.6350.85
226_A230_V2.5480.83
341_V440_A2.4510.80
90_A117_F2.2760.75
181_L221_V2.2580.74
74_E77_H2.2400.73
124_P130_I2.2040.72
226_A293_H2.2010.72
218_L285_L2.1490.70
120_A180_L2.1450.70
223_R289_A2.1120.69
173_C246_Q2.1080.69
39_Y44_R2.1020.68
27_L450_L2.0720.67
149_L160_Y2.0700.67
192_A200_V2.0540.66
8_S23_S2.0490.66
120_A171_T2.0440.66
34_S414_G2.0330.66
230_V382_Y2.0200.65
137_A148_V2.0050.64
19_Q173_C2.0010.64
260_T302_Q1.9890.64
79_A374_L1.9850.64
119_V307_T1.9560.62
15_T37_P1.9480.62
188_R394_D1.9090.60
112_Q464_A1.9090.60
16_T132_G1.9000.60
372_L414_G1.8850.59
223_R397_A1.8800.59
7_L153_I1.8450.58
426_Q429_P1.8200.57
175_N246_Q1.8140.56
48_W75_Q1.8050.56
84_E345_I1.7830.55
59_K148_V1.7610.54
44_R306_Q1.7500.54
176_V193_H1.7390.53
408_V433_I1.7220.52
45_E256_P1.7200.52
77_H201_D1.6800.50
52_V371_V1.6800.50
140_L260_T1.6780.50
76_Y412_D1.6680.50
62_G101_R1.6430.49
86_V374_L1.6370.49
372_L438_V1.6270.48
173_C453_G1.6130.48
172_A459_T1.6010.47
49_Q385_V1.6000.47
16_T181_L1.5960.47
176_V408_V1.5950.47
188_R212_S1.5810.46
16_T175_N1.5770.46
99_K313_I1.5710.46
54_F135_A1.5710.46
231_E238_S1.5600.45
133_H307_T1.5590.45
149_L462_S1.5590.45
290_L318_H1.5570.45
8_S174_L1.5540.45
111_S124_P1.5400.44
205_G279_F1.5290.44
449_P453_G1.5280.44
385_V459_T1.5240.44
9_V25_L1.5240.44
287_A308_V1.5240.44
141_S412_D1.5230.44
19_Q119_V1.5220.44
114_L306_Q1.5150.43
159_N441_G1.5010.43
69_K81_I1.4980.42
208_T407_V1.4890.42
164_D431_A1.4880.42
162_L430_L1.4720.41
180_L316_G1.4720.41
407_V444_I1.4550.41
33_V40_E1.4540.41
158_A308_V1.4450.40
266_G287_A1.4440.40
16_T39_Y1.4420.40
345_I349_D1.4360.40
208_T211_R1.4350.40
313_I319_T1.4340.40
86_V334_L1.4310.40
158_A435_E1.4310.40
270_R416_A1.4250.39
106_A380_V1.4150.39
24_R421_L1.4150.39
29_N36_V1.4140.39
268_C296_L1.4110.39
104_R341_V1.4070.39
169_S339_L1.4040.38
106_A174_L1.4030.38
230_V295_R1.4020.38
44_R382_Y1.3920.38
28_V175_N1.3870.38
132_G453_G1.3830.38
29_N307_T1.3820.38
93_I376_A1.3760.37
162_L250_L1.3700.37
22_F42_I1.3640.37
16_T171_T1.3630.37
125_H247_T1.3580.37
44_R462_S1.3470.36
98_A159_N1.3440.36
241_A249_L1.3440.36
7_L111_S1.3380.36
58_D291_H1.3250.35
22_F68_L1.3220.35
143_Q398_R1.3190.35
161_A436_V1.3150.35
20_V76_Y1.3140.35
132_G168_I1.3090.35
72_I366_K1.3020.34
390_N424_Q1.3000.34
222_T282_I1.2900.34
260_T419_M1.2880.34
19_Q266_G1.2860.34
19_Q175_N1.2840.34
184_D460_V1.2700.33
72_I218_L1.2660.33
246_Q313_I1.2650.33
345_I401_N1.2600.33
68_L346_D1.2600.33
20_V68_L1.2600.33
162_L290_L1.2560.32
124_P128_S1.2490.32
10_G14_G1.2470.32
433_I436_V1.2440.32
8_S88_S1.2430.32
135_A138_Q1.2420.32
96_E180_L1.2410.32
316_G415_K1.2390.32
97_S441_G1.2270.31
15_T441_G1.2250.31
141_S166_G1.2210.31
119_V159_N1.2150.31
15_T18_T1.2080.31
15_T36_V1.2050.31
173_C267_E1.2020.30
96_E178_G1.2020.30
99_K342_A1.2000.30
37_P97_S1.1980.30
93_I316_G1.1960.30
419_M462_S1.1960.30
128_S173_C1.1920.30
267_E287_A1.1910.30
357_A440_A1.1840.30
192_A207_G1.1800.30
279_F354_W1.1790.30
224_R436_V1.1610.29
368_D396_V1.1610.29
147_R164_D1.1400.28
19_Q36_V1.1360.28
267_E307_T1.1360.28
16_T304_P1.1280.28
64_K67_E1.1270.28
176_V287_A1.1270.28
159_N316_G1.1270.28
99_K118_V1.1240.28
151_I414_G1.1230.28
15_T159_N1.1220.27
52_V100_T1.1200.27
307_T453_G1.1160.27
9_V118_V1.1120.27
6_L145_L1.1110.27
334_L433_I1.1100.27
319_T424_Q1.1090.27
16_T412_D1.1080.27
202_E363_L1.1020.27
49_Q408_V1.1000.27
200_V205_G1.0990.27
15_T97_S1.0950.27
19_Q99_K1.0950.27
37_P462_S1.0890.26
146_C257_E1.0890.26
308_V435_E1.0880.26
339_L397_A1.0880.26
266_G304_P1.0860.26
347_E374_L1.0850.26
184_D188_R1.0840.26
66_A70_T1.0830.26
52_V199_I1.0790.26
267_E453_G1.0770.26
153_I353_A1.0750.26
132_G170_G1.0750.26
100_T316_G1.0720.26
86_V192_A1.0700.26
357_A360_Q1.0700.26
172_A233_I1.0690.26
82_E176_V1.0690.26
174_L270_R1.0680.26
16_T413_F1.0640.25
93_I415_K1.0630.25
206_A211_R1.0600.25
410_G429_P1.0570.25
63_L375_P1.0530.25
15_T163_F1.0520.25
116_D119_V1.0490.25
158_A452_G1.0470.25
336_L406_L1.0470.25
29_N44_R1.0450.25
299_M339_L1.0430.25
75_Q419_M1.0420.25
82_E221_V1.0410.25
316_G441_G1.0390.25
191_Y287_A1.0380.25
6_L87_D1.0380.25
39_Y306_Q1.0350.25
197_Q249_L1.0340.24
46_I214_T1.0300.24
196_G433_I1.0280.24
19_Q158_A1.0270.24
316_G376_A1.0220.24
240_L430_L1.0160.24
46_I204_F1.0160.24
178_G338_N1.0140.24
208_T390_N1.0050.24
6_L353_A1.0040.24
181_L436_V1.0030.23
192_A209_D0.9980.23
223_R292_D0.9960.23
130_I280_A0.9940.23
358_L407_V0.9900.23
331_G359_I0.9860.23
173_C307_T0.9820.23
339_L352_G0.9820.23
133_H173_C0.9810.23
128_S318_H0.9800.23
194_K256_P0.9780.23
84_E291_H0.9710.22
51_P350_L0.9710.22
377_S384_A0.9670.22
175_N435_E0.9670.22
280_A380_V0.9650.22
42_I459_T0.9610.22
160_Y380_V0.9600.22
90_A327_I0.9600.22
315_A441_G0.9580.22
123_G445_D0.9570.22
128_S246_Q0.9560.22
151_I182_E0.9550.22
75_Q114_L0.9550.22
160_Y266_G0.9520.22
214_T256_P0.9510.22
203_C224_R0.9490.22
209_D259_I0.9480.22
293_H296_L0.9450.22
93_I159_N0.9440.22
99_K182_E0.9400.22
68_L80_G0.9340.21
41_F432_V0.9300.21
382_Y386_L0.9280.21
36_V119_V0.9270.21
118_V218_L0.9260.21
28_V313_I0.9240.21
259_I289_A0.9230.21
19_Q22_F0.9220.21
382_Y423_P0.9210.21
15_T119_V0.9160.21
269_Y290_L0.9150.21
8_S13_I0.9140.21
149_L233_I0.9140.21
131_A138_Q0.9120.21
7_L106_A0.9100.21
231_E235_G0.9090.21
197_Q291_H0.9060.21
158_A173_C0.9060.21
212_S352_G0.9050.20
123_G315_A0.9040.20
343_I373_A0.9040.20
172_A380_V0.9020.20
106_A246_Q0.9010.20
77_H212_S0.9010.20
46_I77_H0.8980.20
183_T194_K0.8970.20
107_V222_T0.8960.20
29_N124_P0.8950.20
225_M465_F0.8930.20
17_T312_V0.8890.20
321_S341_V0.8880.20
5_Q26_E0.8850.20
125_H248_G0.8840.20
196_G431_A0.8800.20
189_V208_T0.8770.20
189_V218_L0.8770.20
15_T307_T0.8760.20
83_P200_V0.8760.20
129_V455_V0.8690.19
77_H153_I0.8690.19
106_A329_L0.8670.19
13_I42_I0.8670.19
346_D349_D0.8630.19
37_P159_N0.8530.19
19_Q287_A0.8530.19
126_L415_K0.8530.19
392_L405_L0.8520.19
26_E334_L0.8510.19
96_E313_I0.8500.19
200_V204_F0.8490.19
51_P244_L0.8480.19
19_Q308_V0.8460.19
68_L284_P0.8440.19
321_S435_E0.8430.19
171_T257_E0.8430.19
160_Y172_A0.8430.19
15_T316_G0.8420.19
76_Y432_V0.8400.19
173_C277_F0.8390.19
366_K414_G0.8380.19
6_L176_V0.8360.19
148_V363_L0.8350.19
126_L316_G0.8340.19
57_V159_N0.8340.19
37_P307_T0.8330.18
296_L408_V0.8330.18
52_V289_A0.8280.18
29_N130_I0.8240.18
341_V438_V0.8230.18
339_L416_A0.8230.18
148_V225_M0.8180.18
124_P319_T0.8170.18
256_P337_R0.8170.18
221_V460_V0.8160.18
259_I383_A0.8150.18
13_I50_S0.8150.18
172_A250_L0.8120.18
72_I111_S0.8110.18
15_T178_G0.8100.18
336_L429_P0.8100.18
293_H456_V0.8070.18
5_Q22_F0.8030.18
93_I119_V0.8030.18
212_S374_L0.8010.18
130_I199_I0.7980.18
190_V208_T0.7980.18
354_W411_Q0.7970.18
34_S438_V0.7970.18
15_T57_V0.7960.18
183_T199_I0.7950.17
196_G203_C0.7950.17
325_S453_G0.7940.17
136_G141_S0.7940.17
268_C391_A0.7930.17
37_P441_G0.7890.17
111_S342_A0.7870.17
332_V383_A0.7850.17
392_L446_I0.7850.17
51_P75_Q0.7850.17
351_V401_N0.7840.17
22_F435_E0.7830.17
188_R208_T0.7830.17
110_L124_P0.7780.17
90_A123_G0.7780.17
271_H397_A0.7760.17
239_P242_Q0.7760.17
48_W86_V0.7730.17
159_N307_T0.7720.17
25_L449_P0.7710.17
358_L446_I0.7700.17
69_K385_V0.7690.17
416_A420_L0.7690.17
171_T180_L0.7660.17
148_V214_T0.7650.17
228_L244_L0.7640.17
182_E287_A0.7630.17
110_L178_G0.7630.17
199_I341_V0.7600.17
53_F431_A0.7560.17
158_A175_N0.7510.16
129_V438_V0.7500.16
290_L421_L0.7500.16
334_L421_L0.7480.16
97_S316_G0.7470.16
126_L129_V0.7460.16
276_P285_L0.7430.16
184_D408_V0.7420.16
376_A462_S0.7420.16
37_P178_G0.7410.16
117_F123_G0.7400.16
16_T38_R0.7400.16
32_A68_L0.7370.16
20_V432_V0.7360.16
126_L432_V0.7360.16
49_Q306_Q0.7350.16
401_N431_A0.7340.16
8_S320_L0.7330.16
88_S270_R0.7320.16
51_P222_T0.7320.16
313_I329_L0.7320.16
133_H171_T0.7310.16
77_H292_D0.7290.16
29_N119_V0.7280.16
221_V289_A0.7270.16
97_S159_N0.7270.16
432_V462_S0.7230.16
160_Y414_G0.7200.16
239_P274_A0.7190.16
15_T29_N0.7190.16
334_L361_L0.7190.16
68_L88_S0.7170.16
8_S75_Q0.7170.16
315_A445_D0.7140.16
318_H380_V0.7120.15
219_V383_A0.7110.15
158_A440_A0.7080.15
368_D431_A0.7070.15
74_E192_A0.7060.15
187_G300_N0.7060.15
339_L394_D0.7050.15
219_V359_I0.7040.15
88_S174_L0.7030.15
117_F445_D0.7010.15
129_V424_Q0.7010.15
406_L446_I0.6990.15
64_K420_L0.6990.15
57_V210_A0.6990.15
181_L207_G0.6980.15
432_V459_T0.6970.15
180_L443_Y0.6970.15
186_H349_D0.6960.15
23_S136_G0.6960.15
239_P346_D0.6960.15
18_T133_H0.6950.15
111_S413_F0.6940.15
140_L172_A0.6940.15
96_E123_G0.6930.15
75_Q334_L0.6900.15
176_V282_I0.6900.15
81_I202_E0.6880.15
28_V99_K0.6880.15
38_R309_R0.6880.15
195_P200_V0.6860.15
266_G308_V0.6860.15
363_L385_V0.6860.15
7_L200_V0.6850.15
369_A433_I0.6820.15
16_T61_G0.6820.15
130_I307_T0.6820.15
116_D146_C0.6800.15
205_G430_L0.6780.15
259_I381_R0.6780.15
358_L395_F0.6780.15
125_H458_V0.6780.15
172_A421_L0.6770.15
217_Q220_Q0.6770.15
99_K173_C0.6770.15
19_Q317_A0.6750.15
313_I435_E0.6740.15
414_G450_L0.6740.15
11_I36_V0.6730.15
201_D394_D0.6720.15
75_Q325_S0.6720.15
211_R239_P0.6700.15
22_F228_L0.6700.15
19_Q116_D0.6690.14
348_T372_L0.6680.14
396_V405_L0.6660.14
27_L341_V0.6660.14
167_K198_M0.6660.14
354_W395_F0.6660.14
356_Q387_T0.6650.14
197_Q212_S0.6640.14
202_E240_L0.6640.14
43_K214_T0.6630.14
74_E82_E0.6630.14
185_S206_A0.6620.14
60_Q385_V0.6600.14
217_Q433_I0.6580.14
308_V464_A0.6570.14
26_E36_V0.6550.14
188_R352_G0.6540.14
119_V415_K0.6480.14
185_S353_A0.6480.14
207_G210_A0.6470.14
19_Q118_V0.6450.14
348_T352_G0.6450.14
340_P441_G0.6450.14
261_L290_L0.6430.14
319_T452_G0.6430.14
11_I37_P0.6430.14
246_Q318_H0.6420.14
16_T229_I0.6420.14
198_M400_P0.6410.14
9_V76_Y0.6410.14
118_V285_L0.6410.14
123_G136_G0.6410.14
150_N334_L0.6400.14
54_F280_A0.6390.14
198_M227_E0.6380.14
192_A241_A0.6370.14
130_I362_D0.6350.14
172_A284_P0.6340.14
93_I412_D0.6320.14
12_D17_T0.6320.14
14_G17_T0.6320.14
10_G17_T0.6320.14
233_I331_G0.6300.14
97_S318_H0.6300.14
97_S386_L0.6300.14
130_I328_W0.6290.14
406_L455_V0.6280.14
53_F410_G0.6280.14
247_T459_T0.6270.14
119_V419_M0.6270.14
407_V417_L0.6260.14
136_G445_D0.6250.14
163_F453_G0.6240.14
334_L429_P0.6240.14
316_G443_Y0.6240.14
287_A357_A0.6230.14
97_S110_L0.6230.14
13_I129_V0.6220.13
250_L444_I0.6190.13
18_T307_T0.6180.13
189_V402_P0.6170.13
37_P75_Q0.6170.13
111_S350_L0.6160.13
265_V277_F0.6160.13
25_L322_L0.6150.13
132_G449_P0.6150.13
160_Y287_A0.6120.13
130_I435_E0.6110.13
9_V328_W0.6110.13
273_P429_P0.6110.13
246_Q267_E0.6110.13
322_L419_M0.6100.13
112_Q319_T0.6090.13
289_A292_D0.6090.13
232_V308_V0.6090.13
200_V456_V0.6060.13
148_V171_T0.6060.13
5_Q330_E0.6050.13
184_D363_L0.6020.13
159_N376_A0.6020.13
99_K308_V0.6020.13
214_T271_H0.6020.13
18_T178_G0.6020.13
19_Q29_N0.6010.13
174_L385_V0.6000.13
279_F374_L0.5990.13
111_S200_V0.5990.13
180_L421_L0.5970.13
21_I137_A0.5950.13
66_A202_E0.5950.13
124_P316_G0.5950.13
36_V44_R0.5940.13
393_V430_L0.5920.13
39_Y88_S0.5920.13
162_L176_V0.5910.13
9_V381_R0.5910.13
306_Q419_M0.5910.13
37_P133_H0.5910.13
61_G205_G0.5890.13
15_T462_S0.5890.13
169_S392_L0.5870.13
133_H267_E0.5870.13
133_H456_V0.5860.13
43_K337_R0.5850.13
172_A247_T0.5850.13
37_P119_V0.5850.13
8_S136_G0.5840.13
68_L407_V0.5840.13
36_V329_L0.5840.13
42_I62_G0.5840.13
68_L247_T0.5840.13
15_T132_G0.5840.13
294_P305_A0.5830.13
280_A326_T0.5830.13
149_L170_G0.5820.13
38_R194_K0.5810.13
77_H236_T0.5800.13
300_N368_D0.5780.13
90_A445_D0.5780.13
352_G356_Q0.5760.13
305_A345_I0.5750.13
37_P316_G0.5750.13
162_L190_V0.5740.13
277_F435_E0.5730.13
20_V147_R0.5730.13
231_E290_L0.5710.12
26_E52_V0.5710.12
307_T325_S0.5700.12
215_G236_T0.5690.12
73_L77_H0.5690.12
196_G381_R0.5680.12
57_V75_Q0.5670.12
99_K200_V0.5670.12
83_P225_M0.5660.12
275_D290_L0.5650.12
318_H435_E0.5640.12
77_H300_N0.5640.12
260_T318_H0.5620.12
144_R385_V0.5620.12
86_V222_T0.5610.12
111_S130_I0.5610.12
129_V439_R0.5610.12
384_A402_P0.5590.12
147_R244_L0.5590.12
132_G313_I0.5590.12
261_L269_Y0.5580.12
104_R313_I0.5560.12
86_V446_I0.5550.12
372_L428_L0.5520.12
116_D163_F0.5500.12
182_E329_L0.5500.12
38_R158_A0.5500.12
83_P388_V0.5500.12
210_A275_D0.5500.12
407_V427_Q0.5480.12
347_E372_L0.5480.12
45_E194_K0.5460.12
65_E391_A0.5440.12
98_A321_S0.5430.12
71_L174_L0.5410.12
99_K247_T0.5400.12
117_F316_G0.5400.12
207_G398_R0.5400.12
273_P339_L0.5400.12
6_L299_M0.5390.12
19_Q435_E0.5380.12
119_V124_P0.5380.12
178_G441_G0.5370.12
139_T337_R0.5370.12
131_A428_L0.5370.12
123_G180_L0.5360.12
99_K246_Q0.5330.12
99_K306_Q0.5320.12
22_F71_L0.5300.12
54_F325_S0.5300.12
270_R304_P0.5290.12
189_V385_V0.5280.12
287_A325_S0.5270.12
9_V172_A0.5270.12
199_I203_C0.5260.12
194_K303_F0.5240.12
11_I15_T0.5240.12
174_L428_L0.5240.12
38_R318_H0.5230.12
393_V427_Q0.5230.12
322_L405_L0.5230.12
32_A149_L0.5220.12
162_L251_P0.5220.12
159_N163_F0.5220.12
135_A266_G0.5220.12
35_Q414_G0.5220.12
106_A234_D0.5220.12
173_C435_E0.5210.12
124_P307_T0.5200.12
129_V372_L0.5200.12
7_L130_I0.5190.12
135_A297_R0.5190.12
231_E240_L0.5170.11
371_V442_D0.5170.11
29_N37_P0.5150.11
293_H407_V0.5150.11
43_K293_H0.5150.11
338_N461_K0.5130.11
45_E433_I0.5130.11
411_Q420_L0.5120.11
20_V365_P0.5110.11
235_G290_L0.5110.11
135_A148_V0.5110.11
361_L460_V0.5110.11
230_V296_L0.5080.11
213_L414_G0.5070.11
13_I88_S0.5070.11
360_Q440_A0.5060.11
226_A279_F0.5060.11
257_E403_H0.5060.11
430_L436_V0.5060.11
432_V435_E0.5050.11
20_V464_A0.5030.11
261_L308_V0.5010.11
136_G412_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zgyA 2 0.591 99.9 0.884 Contact Map
3h1qA 1 0.5139 99.7 0.908 Contact Map
4a2aA 1 0.5782 99.6 0.911 Contact Map
3wt0A 1 0.6103 99.6 0.914 Contact Map
1jceA 1 0.6188 99.6 0.915 Contact Map
5afuA 5 0.6767 99.6 0.916 Contact Map
3wqtA 2 0.6039 99.5 0.917 Contact Map
4b1yB 1 0.6724 99.5 0.918 Contact Map
1k8kB 1 0.3148 99.5 0.918 Contact Map
1k8kA 1 0.7066 99.5 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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