GREMLIN Database
INTZ - Putative prophage CPZ-55 integrase
UniProt: P76542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14172
Length: 402 (331)
Sequences: 18511 (15568)
Seq/√Len: 855.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
339_S357_L4.8251.00
143_R152_D3.4401.00
253_W292_F3.2481.00
330_T333_G2.9671.00
149_T152_D2.9021.00
276_H358_A2.8271.00
238_L331_G2.7671.00
245_T332_H2.6731.00
261_A285_V2.6261.00
338_F356_Q2.6151.00
257_N260_D2.5471.00
242_A338_F2.4941.00
233_T291_Q2.4481.00
336_T370_Q2.4251.00
252_R299_A2.4131.00
72_R75_E2.3511.00
46_R53_E2.2361.00
264_T277_V2.1981.00
238_L248_L2.1531.00
106_K137_Y2.1181.00
109_A178_I2.1141.00
338_F342_L2.1011.00
66_L70_R2.0731.00
129_R133_E2.0671.00
157_L172_R2.0071.00
139_V159_K2.0071.00
109_A132_L1.9911.00
110_E137_Y1.9641.00
350_P365_R1.9501.00
106_K110_E1.9401.00
262_T277_V1.9351.00
253_W301_V1.9311.00
108_V182_A1.9101.00
343_N353_I1.8781.00
166_E170_K1.8771.00
279_P356_Q1.8411.00
144_S147_D1.8381.00
180_K194_A1.8321.00
181_F185_T1.8131.00
108_V145_I1.7981.00
233_T290_D1.7981.00
76_S79_L1.7931.00
285_V289_Q1.7881.00
153_V193_V1.7751.00
274_R360_V1.7641.00
75_E79_L1.7641.00
316_I320_L1.7341.00
243_L248_L1.7321.00
186_E190_R1.7191.00
113_F129_R1.7151.00
349_S352_W1.6981.00
212_P215_E1.6921.00
106_K142_K1.6861.00
48_W53_E1.6761.00
261_A282_R1.6651.00
65_T68_E1.6571.00
148_I179_F1.6281.00
131_A174_R1.6211.00
108_V181_F1.6031.00
343_N369_N1.5921.00
240_L281_S1.5911.00
78_S82_N1.5581.00
124_Y128_V1.5531.00
282_R286_E1.5461.00
247_E276_H1.5251.00
46_R55_L1.5191.00
184_I197_D1.5151.00
245_T249_R1.4991.00
255_W266_P1.4811.00
72_R76_S1.4801.00
251_C256_I1.4541.00
232_Q236_R1.4511.00
172_R176_G1.4301.00
215_E218_A1.4231.00
111_D115_T1.4171.00
361_P366_G1.4111.00
216_I239_I1.4011.00
252_R300_F1.4011.00
254_E299_A1.3841.00
239_I334_W1.3751.00
160_K171_L1.3741.00
113_F125_A1.3671.00
233_T287_L1.3641.00
154_L185_T1.3641.00
117_V125_A1.3561.00
348_Y383_D1.3361.00
234_A248_L1.3321.00
282_R382_Q1.3321.00
339_S353_I1.3311.00
363_G366_G1.3291.00
130_S134_K1.3181.00
104_G107_K1.3121.00
211_I329_A1.3121.00
342_L353_I1.3091.00
342_L348_Y1.3041.00
280_L284_A1.2961.00
352_W380_M1.2941.00
258_L289_Q1.2901.00
251_C263_I1.2831.00
154_L158_Q1.2821.00
125_A129_R1.2811.00
237_L284_A1.2801.00
257_N262_T1.2771.00
183_V188_V1.2721.00
178_I182_A1.2691.00
143_R147_D1.2691.00
216_I341_A1.2561.00
211_I219_F1.2551.00
150_A184_I1.2441.00
176_G180_K1.2421.00
351_D354_E1.2361.00
218_A222_A1.2341.00
73_A77_R1.2331.00
224_E232_Q1.2311.00
243_L265_L1.2281.00
180_K191_N1.2271.00
110_E114_A1.2221.00
75_E78_S1.2191.00
184_I195_D1.2181.00
156_L171_L1.2091.00
348_Y380_M1.2021.00
74_T81_A1.1951.00
132_L137_Y1.1901.00
364_I367_V1.1811.00
354_E362_K1.1741.00
280_L285_V1.1621.00
217_P221_K1.1551.00
122_E126_K1.1451.00
133_E137_Y1.1431.00
128_V174_R1.1411.00
337_T341_A1.1361.00
304_G307_M1.1271.00
150_A186_E1.1251.00
117_V129_R1.1251.00
211_I337_T1.1251.00
67_K71_R1.1231.00
127_Q130_S1.1151.00
140_L156_L1.1141.00
317_L320_L1.1121.00
281_S284_A1.1081.00
252_R255_W1.1031.00
283_Q385_A1.0971.00
121_S269_V1.0961.00
105_F178_I1.0951.00
263_I267_A1.0941.00
379_A383_D1.0941.00
317_L321_E1.0931.00
42_Y57_A1.0901.00
354_E365_R1.0901.00
121_S124_Y1.0871.00
71_R75_E1.0851.00
220_Y236_R1.0811.00
116_R120_W1.0791.00
359_H364_I1.0761.00
120_W128_V1.0741.00
108_V185_T1.0731.00
340_T369_N1.0661.00
361_P364_I1.0631.00
234_A302_F1.0591.00
245_T331_G1.0591.00
44_R57_A1.0531.00
164_A167_Q1.0461.00
283_Q286_E1.0381.00
79_L84_I1.0381.00
102_A146_V1.0371.00
106_K141_G1.0341.00
151_R185_T1.0281.00
70_R74_T1.0221.00
179_F192_P1.0151.00
255_W269_V1.0091.00
236_R287_L1.0051.00
172_R193_V1.0011.00
74_T77_R0.9971.00
213_I341_A0.9971.00
315_A318_K0.9971.00
351_D355_I0.9961.00
237_L248_L0.9951.00
210_W337_T0.9941.00
291_Q295_S0.9931.00
102_A144_S0.9921.00
344_E376_Q0.9801.00
110_E129_R0.9791.00
237_L263_I0.9771.00
78_S81_A0.9761.00
66_L69_A0.9751.00
213_I217_P0.9751.00
151_R155_A0.9741.00
179_F193_V0.9721.00
281_S385_A0.9701.00
126_K130_S0.9681.00
254_E298_S0.9671.00
341_A344_E0.9661.00
376_Q379_A0.9661.00
179_F188_V0.9651.00
169_R199_A0.9561.00
153_V175_I0.9531.00
236_R283_Q0.9501.00
68_E71_R0.9421.00
45_F72_R0.9421.00
120_W125_A0.9411.00
222_A322_R0.9411.00
145_I179_F0.9371.00
240_L284_A0.9331.00
160_K168_A0.9321.00
108_V178_I0.9291.00
77_R81_A0.9211.00
378_R382_Q0.9191.00
176_G194_A0.9191.00
58_I61_Y0.9181.00
170_K173_R0.9161.00
105_F109_A0.9151.00
237_L302_F0.9141.00
270_M275_P0.9121.00
223_L235_I0.9081.00
355_I377_R0.9061.00
183_V190_R0.9051.00
354_E366_G0.9051.00
253_W295_S0.9011.00
122_E125_A0.9001.00
340_T370_Q0.8981.00
354_E364_I0.8971.00
289_Q292_F0.8961.00
356_Q377_R0.8951.00
183_V195_D0.8921.00
113_F117_V0.8871.00
103_A107_K0.8861.00
255_W267_A0.8851.00
166_E169_R0.8801.00
105_F148_I0.8801.00
71_R74_T0.8761.00
109_A113_F0.8741.00
258_L285_V0.8741.00
127_Q131_A0.8741.00
152_D155_A0.8691.00
365_R369_N0.8681.00
224_E236_R0.8631.00
149_T189_T0.8601.00
105_F175_I0.8591.00
248_L331_G0.8581.00
251_C301_V0.8571.00
123_S126_K0.8551.00
68_E72_R0.8501.00
333_G336_T0.8501.00
167_Q171_L0.8471.00
344_E372_A0.8441.00
240_L283_Q0.8431.00
231_I315_A0.8411.00
116_R177_E0.8381.00
116_R119_G0.8361.00
67_K70_R0.8351.00
284_A287_L0.8321.00
149_T186_E0.8321.00
148_I153_V0.8311.00
345_S383_D0.8311.00
58_I72_R0.8291.00
179_F183_V0.8261.00
123_S127_Q0.8241.00
253_W288_L0.8221.00
339_S343_N0.8221.00
43_W66_L0.8221.00
279_P377_R0.8201.00
292_F296_G0.8191.00
339_S365_R0.8181.00
183_V191_N0.8181.00
79_L82_N0.8161.00
130_S133_E0.8151.00
75_E82_N0.8141.00
246_A250_L0.8111.00
151_R186_E0.8101.00
71_R81_A0.8071.00
348_Y352_W0.8051.00
209_A215_E0.8011.00
235_I334_W0.7991.00
362_K366_G0.7981.00
176_G193_V0.7981.00
103_A111_D0.7961.00
103_A187_L0.7961.00
352_W376_Q0.7941.00
339_S369_N0.7941.00
338_F357_L0.7931.00
136_V175_I0.7921.00
74_T78_S0.7911.00
191_N194_A0.7911.00
359_H365_R0.7861.00
154_L157_L0.7831.00
71_R78_S0.7771.00
318_K322_R0.7761.00
362_K365_R0.7751.00
186_E195_D0.7681.00
375_K378_R0.7671.00
286_E289_Q0.7651.00
222_A323_I0.7641.00
155_A159_K0.7581.00
111_D187_L0.7581.00
69_A73_A0.7561.00
112_W116_R0.7531.00
112_W177_E0.7521.00
139_V155_A0.7501.00
357_L365_R0.7481.00
104_G144_S0.7471.00
38_N41_K0.7421.00
42_Y60_V0.7391.00
279_P378_R0.7391.00
282_R385_A0.7341.00
339_S364_I0.7331.00
145_I182_A0.7321.00
356_Q381_M0.7311.00
382_Q385_A0.7301.00
336_T367_V0.7301.00
47_Y54_F0.7271.00
304_G309_K0.7271.00
329_A333_G0.7261.00
208_N330_T0.7261.00
182_A188_V0.7231.00
223_L232_Q0.7221.00
219_F235_I0.7211.00
243_L247_E0.7201.00
314_S318_K0.7191.00
109_A137_Y0.7161.00
120_W124_Y0.7141.00
157_L168_A0.7121.00
344_E375_K0.7121.00
375_K379_A0.7111.00
108_V187_L0.7101.00
211_I215_E0.7071.00
339_S354_E0.7071.00
107_K110_E0.7071.00
343_N350_P0.7051.00
258_L280_L0.7051.00
292_F295_S0.7031.00
111_D185_T0.6951.00
258_L261_A0.6941.00
161_E165_P0.6861.00
343_N351_D0.6841.00
319_A323_I0.6841.00
110_E133_E0.6831.00
380_M383_D0.6831.00
112_W181_F0.6801.00
237_L288_L0.6801.00
379_A382_Q0.6801.00
70_R73_A0.6751.00
134_K138_P0.6751.00
64_I68_E0.6741.00
361_P365_R0.6711.00
317_L328_I0.6711.00
245_T313_A0.6701.00
136_V141_G0.6681.00
137_Y141_G0.6671.00
256_I288_L0.6671.00
158_Q185_T0.6641.00
115_T158_Q0.6631.00
343_N372_A0.6631.00
243_L251_C0.6621.00
36_H44_R0.6611.00
188_V192_P0.6601.00
215_E326_K0.6581.00
85_N88_E0.6581.00
252_R267_A0.6571.00
244_R332_H0.6551.00
218_A221_K0.6541.00
172_R196_L0.6531.00
103_A146_V0.6521.00
210_W340_T0.6521.00
156_L160_K0.6511.00
45_F73_A0.6511.00
127_Q170_K0.6491.00
139_V156_L0.6481.00
114_A117_V0.6461.00
237_L241_T0.6461.00
134_K171_L0.6441.00
183_V194_A0.6431.00
45_F76_S0.6431.00
349_S376_Q0.6411.00
150_A154_L0.6411.00
216_I337_T0.6411.00
140_L152_D0.6401.00
263_I280_L0.6401.00
354_E357_L0.6381.00
150_A195_D0.6381.00
351_D366_G0.6371.00
266_P275_P0.6331.00
178_I181_F0.6321.00
107_K111_D0.6311.00
154_L184_I0.6311.00
229_V232_Q0.6301.00
340_T371_A0.6291.00
345_S348_Y0.6291.00
350_P354_E0.6261.00
116_R128_V0.6241.00
140_L148_I0.6241.00
158_Q161_E0.6231.00
111_D155_A0.6231.00
80_I85_N0.6191.00
239_I337_T0.6181.00
132_L136_V0.6171.00
169_R173_R0.6161.00
256_I263_I0.6141.00
143_R148_I0.6121.00
179_F191_N0.6121.00
44_R55_L0.6071.00
111_D181_F0.6061.00
354_E361_P0.6061.00
351_D365_R0.6061.00
344_E371_A0.6051.00
184_I194_A0.6031.00
243_L263_I0.6001.00
131_A171_L0.5991.00
83_G86_P0.5961.00
264_T275_P0.5951.00
214_S218_A0.5951.00
242_A357_L0.5951.00
213_I345_S0.5931.00
332_H357_L0.5931.00
36_H40_S0.5921.00
241_T278_V0.5901.00
57_A60_V0.5891.00
343_N365_R0.5881.00
180_K183_V0.5841.00
177_E181_F0.5831.00
349_S380_M0.5831.00
287_L290_D0.5791.00
342_L356_Q0.5791.00
56_Q76_S0.5771.00
220_Y240_L0.5741.00
290_D293_T0.5731.00
343_N371_A0.5721.00
175_I193_V0.5711.00
128_V131_A0.5701.00
111_D114_A0.5681.00
315_A319_A0.5671.00
156_L159_K0.5661.00
243_L278_V0.5661.00
180_K184_I0.5651.00
247_E270_M0.5651.00
106_K132_L0.5641.00
132_L178_I0.5631.00
250_L270_M0.5631.00
213_I344_E0.5601.00
262_T378_R0.5571.00
241_T281_S0.5561.00
61_Y72_R0.5541.00
300_F303_P0.5541.00
257_N264_T0.5541.00
45_F77_R0.5531.00
279_P381_M0.5531.00
350_P366_G0.5501.00
159_K162_R0.5491.00
239_I341_A0.5471.00
321_E328_I0.5461.00
359_H363_G0.5461.00
204_R273_R0.5451.00
249_R313_A0.5441.00
132_L174_R0.5431.00
229_V233_T0.5421.00
79_L83_G0.5401.00
339_S359_H0.5401.00
45_F58_I0.5401.00
316_I331_G0.5381.00
230_Q291_Q0.5341.00
272_A358_A0.5341.00
300_F310_P0.5331.00
157_L199_A0.5311.00
286_E290_D0.5311.00
270_M358_A0.5301.00
373_Y377_R0.5291.00
257_N261_A0.5281.00
214_S217_P0.5251.00
241_T284_A0.5251.00
250_L269_V0.5241.00
220_Y224_E0.5241.00
348_Y353_I0.5241.00
350_P362_K0.5221.00
124_Y127_Q0.5151.00
36_H42_Y0.5141.00
232_Q287_L0.5141.00
49_L54_F0.5141.00
209_A326_K0.5131.00
220_Y232_Q0.5121.00
230_Q233_T0.5111.00
45_F80_I0.5111.00
180_K195_D0.5111.00
103_A144_S0.5101.00
209_A333_G0.5081.00
161_E168_A0.5071.00
173_R177_E0.5071.00
381_M384_Y0.5061.00
265_L270_M0.5061.00
258_L263_I0.5051.00
60_V65_T0.5051.00
229_V290_D0.5041.00
64_I72_R0.5041.00
222_A225_R0.5031.00
316_I319_A0.5021.00
58_I64_I0.5011.00
176_G191_N0.5001.00
105_F140_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.8308 100 0.346 Contact Map
2a3vA 3 0.6741 100 0.395 Contact Map
1a0pA 1 0.6294 100 0.398 Contact Map
1z19A 3 0.6667 100 0.403 Contact Map
1xo0A 3 0.6866 100 0.446 Contact Map
4a8eA 2 0.6368 100 0.447 Contact Map
3nkhA 2 0.4552 100 0.543 Contact Map
1aihA 2 0.4179 100 0.607 Contact Map
1ae9A 4 0.393 100 0.608 Contact Map
4e0gA 2 0.6493 99.9 0.635 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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