GREMLIN Database
EUTL - Ethanolamine utilization protein EutL
UniProt: P76541 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14171
Length: 219 (212)
Sequences: 144 (77)
Seq/√Len: 5.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_I125_L6.0380.99
5_D120_Q4.1170.92
78_S81_A3.7610.88
48_T84_V3.4140.82
162_I188_A3.3380.81
75_H81_A3.2110.78
75_H78_S3.1640.77
8_R112_A3.1520.77
13_A156_L2.8170.68
34_I89_G2.6520.63
141_G188_A2.5140.58
40_I103_M2.3170.52
20_V64_V2.3160.52
124_F205_T2.2660.50
20_V25_A2.1660.47
74_A123_A2.1530.46
159_T186_S1.9070.38
7_I73_A1.8130.35
43_D201_C1.8110.35
7_I147_P1.7470.34
71_A77_P1.7310.33
78_S123_A1.7260.33
116_A201_C1.7110.32
116_A122_T1.6590.31
92_N129_V1.6360.30
146_D191_T1.6160.30
48_T201_C1.5940.29
31_P34_I1.5810.29
96_V108_E1.5630.28
48_T58_Q1.5590.28
193_S202_N1.5550.28
181_S186_S1.5530.28
28_L102_A1.5300.27
43_D116_A1.5280.27
15_R210_E1.5050.27
24_F159_T1.5020.27
19_S195_A1.4860.26
9_P101_D1.4780.26
6_L112_A1.4780.26
38_G178_P1.4730.26
62_E134_S1.4580.26
124_F209_L1.4330.25
115_W120_Q1.4190.25
50_I106_H1.4190.25
132_T191_T1.3990.24
23_D104_I1.3920.24
37_L158_A1.3830.24
161_G208_V1.3690.23
11_V159_T1.3690.23
111_A127_H1.3640.23
88_L103_M1.3460.23
131_R144_L1.3430.23
117_N121_D1.3430.23
62_E89_G1.3350.23
8_R110_G1.3340.23
64_V89_G1.3320.22
142_I191_T1.3290.22
110_G208_V1.3220.22
13_A148_M1.3150.22
115_W121_D1.3120.22
125_L160_Y1.3030.22
207_A211_I1.3000.22
9_P111_A1.2830.21
49_Y190_L1.2750.21
35_R188_A1.2670.21
75_H79_P1.2640.21
67_R156_L1.2630.21
13_A178_P1.2510.21
147_P193_S1.2500.21
22_A26_R1.2240.20
79_P122_T1.2220.20
114_Q173_L1.2040.20
14_M103_M1.1960.19
23_D181_S1.1800.19
88_L130_S1.1650.19
30_L64_V1.1620.19
176_Y186_S1.1610.19
132_T137_S1.1520.19
10_S73_A1.1440.18
50_I84_V1.1260.18
26_R38_G1.1240.18
75_H123_A1.1080.18
90_G96_V1.1080.18
20_V30_L1.1040.18
5_D201_C1.1040.18
69_L123_A1.1030.18
62_E138_S1.0970.17
79_P119_A1.0960.17
25_A30_L1.0950.17
106_H110_G1.0860.17
18_A84_V1.0840.17
88_L186_S1.0750.17
44_S73_A1.0750.17
15_R71_A1.0750.17
38_G84_V1.0720.17
125_L174_A1.0710.17
25_A89_G1.0700.17
159_T176_Y1.0660.17
5_D100_L1.0630.17
15_R160_Y1.0600.17
124_F208_V1.0590.17
94_A211_I1.0500.17
95_E131_R1.0500.17
101_D106_H1.0440.16
147_P211_I1.0410.16
118_D213_R1.0380.16
39_L42_A1.0350.16
43_D122_T1.0330.16
88_L92_N1.0310.16
6_L84_V1.0240.16
24_F77_P1.0220.16
126_A156_L1.0220.16
129_V175_T1.0180.16
42_A48_T1.0140.16
16_V22_A1.0130.16
177_V188_A1.0010.16
58_Q89_G0.9910.16
130_S208_V0.9900.16
139_T177_V0.9880.15
79_P115_W0.9800.15
28_L142_I0.9790.15
71_A142_I0.9770.15
122_T198_K0.9750.15
205_T208_V0.9700.15
69_L78_S0.9670.15
78_S124_F0.9660.15
91_P95_E0.9620.15
174_A178_P0.9600.15
33_H172_Q0.9500.15
12_T66_G0.9490.15
85_L152_V0.9450.15
156_L170_D0.9450.15
22_A141_G0.9410.15
88_L125_L0.9410.15
47_V193_S0.9380.15
101_D161_G0.9350.15
161_G188_A0.9180.14
44_S166_L0.9090.14
135_Y139_T0.9060.14
14_M178_P0.9050.14
31_P62_E0.9050.14
29_K110_G0.9010.14
7_I79_P0.9000.14
166_L216_I0.8940.14
81_A124_F0.8930.14
15_R156_L0.8920.14
122_T201_C0.8920.14
90_G131_R0.8890.14
37_L58_Q0.8790.14
47_V107_I0.8650.13
19_S189_F0.8610.13
62_E147_P0.8510.13
43_D161_G0.8410.13
104_I143_T0.8400.13
89_G111_A0.8360.13
38_G88_L0.8300.13
98_A195_A0.8290.13
128_V202_N0.8270.13
9_P42_A0.8260.13
141_G148_M0.8260.13
81_A122_T0.8220.13
5_D116_A0.8210.13
17_I64_V0.8170.13
105_A134_S0.8160.13
11_V48_T0.8160.13
14_M95_E0.8130.13
16_V181_S0.8110.13
13_A38_G0.8110.13
11_V109_N0.8090.13
5_D33_H0.8080.13
81_A123_A0.8020.13
58_Q138_S0.7950.12
79_P147_P0.7910.12
5_D115_W0.7880.12
6_L16_V0.7850.12
78_S122_T0.7830.12
23_D173_L0.7820.12
75_H122_T0.7800.12
125_L175_T0.7800.12
92_N141_G0.7730.12
6_L39_L0.7730.12
6_L38_G0.7690.12
47_V126_A0.7660.12
35_R114_Q0.7640.12
27_E139_T0.7640.12
102_A141_G0.7620.12
74_A208_V0.7530.12
37_L69_L0.7520.12
106_H174_A0.7500.12
10_S84_V0.7410.12
18_A58_Q0.7390.12
73_A106_H0.7350.12
84_V129_V0.7330.12
13_A81_A0.7310.12
170_D186_S0.7230.11
43_D196_A0.7200.11
5_D23_D0.7200.11
173_L198_K0.7150.11
75_H124_F0.7140.11
58_Q84_V0.7130.11
146_D172_Q0.7110.11
44_S84_V0.7090.11
100_L206_D0.7090.11
43_D119_A0.7080.11
43_D48_T0.7080.11
52_A124_F0.7070.11
13_A69_L0.7050.11
25_A64_V0.7050.11
52_A120_Q0.7030.11
132_T142_I0.7030.11
18_A206_D0.7030.11
129_V177_V0.6980.11
77_P80_T0.6890.11
141_G209_L0.6840.11
69_L81_A0.6830.11
162_I185_Y0.6830.11
10_S48_T0.6710.11
6_L148_M0.6600.11
122_T161_G0.6560.11
11_V51_A0.6540.11
6_L31_P0.6520.10
31_P89_G0.6510.10
31_P71_A0.6480.10
79_P121_D0.6460.10
37_L73_A0.6450.10
10_S24_F0.6430.10
44_S48_T0.6370.10
48_T114_Q0.6330.10
134_S216_I0.6330.10
28_L132_T0.6230.10
27_E118_D0.6190.10
22_A31_P0.6190.10
84_V201_C0.6180.10
91_P131_R0.6180.10
6_L102_A0.6180.10
48_T78_S0.6170.10
13_A129_V0.6170.10
14_M138_S0.6140.10
44_S185_Y0.6050.10
60_M111_A0.6010.10
34_I106_H0.5990.10
52_A86_I0.5980.10
10_S44_S0.5940.10
42_A94_A0.5920.10
124_F159_T0.5920.10
20_V211_I0.5910.10
27_E162_I0.5900.10
37_L140_A0.5890.10
84_V112_A0.5880.10
16_V108_E0.5850.10
7_I71_A0.5810.10
20_V74_A0.5790.10
74_A77_P0.5790.10
90_G95_E0.5790.10
24_F128_V0.5780.10
105_A210_E0.5720.10
39_L130_S0.5710.10
8_R125_L0.5700.10
25_A175_T0.5700.10
105_A109_N0.5690.09
77_P162_I0.5690.09
6_L103_M0.5690.09
92_N137_S0.5680.09
161_G206_D0.5640.09
139_T209_L0.5630.09
97_R101_D0.5600.09
8_R27_E0.5600.09
34_I138_S0.5590.09
24_F71_A0.5580.09
107_I159_T0.5560.09
19_S80_T0.5550.09
36_S162_I0.5550.09
124_F176_Y0.5540.09
11_V107_I0.5540.09
60_M92_N0.5520.09
94_A122_T0.5500.09
20_V177_V0.5500.09
60_M134_S0.5490.09
36_S131_R0.5480.09
95_E195_A0.5460.09
42_A84_V0.5450.09
50_I195_A0.5440.09
15_R144_L0.5380.09
80_T95_E0.5360.09
60_M206_D0.5350.09
42_A146_D0.5350.09
18_A76_G0.5350.09
97_R128_V0.5310.09
75_H201_C0.5290.09
79_P120_Q0.5260.09
5_D88_L0.5260.09
56_T65_Y0.5250.09
48_T125_L0.5220.09
100_L124_F0.5220.09
81_A205_T0.5220.09
39_L174_A0.5200.09
7_I119_A0.5180.09
84_V103_M0.5180.09
62_E128_V0.5180.09
113_F158_A0.5180.09
161_G210_E0.5170.09
100_L129_V0.5160.09
20_V40_I0.5150.09
50_I210_E0.5140.09
13_A132_T0.5130.09
43_D75_H0.5120.09
16_V104_I0.5120.09
69_L141_G0.5100.09
22_A66_G0.5080.09
76_G189_F0.5070.09
12_T68_S0.5070.09
33_H108_E0.5060.09
115_W119_A0.5030.09
6_L173_L0.5030.09
15_R161_G0.5020.09
16_V26_R0.5010.09
105_A128_V0.5000.09
16_V23_D0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gfhA 3 0.9772 100 0.579 Contact Map
3u27C 4 0.9954 100 0.579 Contact Map
4tlhA 3 0.9954 100 0.59 Contact Map
4fayA 3 0.9269 100 0.682 Contact Map
3io0A 3 0.9589 100 0.684 Contact Map
3n79A 3 0.7215 99.9 0.785 Contact Map
3nwgA 5 0.726 99.9 0.788 Contact Map
3cgiA 6 0.516 99.7 0.839 Contact Map
4axiA 5 0.4932 99.7 0.842 Contact Map
3i96A 5 0.4977 99.7 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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