GREMLIN Database
EUTK - Ethanolamine utilization protein EutK
UniProt: P76540 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14170
Length: 166 (142)
Sequences: 290 (273)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_L57_L3.7981.00
23_M46_V3.7171.00
11_D41_R2.6990.99
44_L56_A2.5850.99
22_A60_G2.5750.99
10_V34_H2.5160.98
28_N51_A2.4080.98
13_M17_I2.3290.97
5_L75_E2.3170.97
4_A77_G2.1810.96
71_I79_P2.0680.95
59_A63_A1.9530.93
33_S45_V1.8830.91
74_K80_D1.8550.91
19_A56_A1.8520.91
137_P141_A1.8180.90
18_D63_A1.7650.88
23_M33_S1.7550.88
10_V15_A1.7010.86
18_D66_R1.6440.84
23_M79_P1.6320.84
40_G78_R1.6220.83
130_V139_E1.6140.83
57_L80_D1.5810.82
2_I42_L1.5680.81
140_K143_N1.5070.79
22_A26_A1.4860.78
4_A74_K1.4800.77
2_I24_L1.4780.77
135_G139_E1.4650.77
5_L26_A1.4630.76
33_S36_V1.4510.76
113_E131_A1.4370.75
15_A67_T1.4320.75
79_P83_T1.4270.75
13_M23_M1.4260.75
24_L29_V1.4170.74
13_M79_P1.4090.74
123_Q127_A1.4000.73
57_L75_E1.3710.72
7_L74_K1.3590.71
18_D51_A1.3460.70
64_A67_T1.3270.69
15_A38_D1.3170.68
35_E45_V1.3060.68
42_L86_L1.2950.67
108_A112_D1.2760.66
41_R70_V1.2550.65
60_G64_A1.2540.65
19_A33_S1.2480.64
38_D80_D1.2290.63
139_E142_R1.2170.62
139_E143_N1.2150.62
82_D86_L1.2130.62
109_E116_A1.2120.62
55_A62_A1.1930.61
54_R64_A1.1890.60
77_G85_W1.1610.58
10_V64_A1.1580.58
24_L31_L1.1510.58
4_A34_H1.1510.58
14_V68_G1.1460.57
14_V41_R1.1430.57
5_L71_I1.1390.57
33_S80_D1.1210.56
42_L63_A1.1210.56
23_M45_V1.1180.55
61_C73_R1.1070.55
134_F142_R1.0690.52
41_R71_I1.0550.51
23_M70_V1.0430.50
11_D23_M1.0300.49
42_L58_D1.0260.49
64_A68_G1.0250.49
23_M38_D1.0100.48
135_G143_N0.9800.46
23_M77_G0.9740.46
23_M60_G0.9740.46
7_L80_D0.9540.44
11_D70_V0.9470.44
60_G70_V0.9470.44
10_V19_A0.9440.43
83_T86_L0.9400.43
138_L142_R0.9370.43
14_V42_L0.9280.42
113_E121_V0.9240.42
138_L143_N0.9170.42
112_D117_L0.9140.41
41_R74_K0.9030.41
49_D52_A0.8910.40
56_A64_A0.8890.40
134_F140_K0.8870.40
30_R90_F0.8860.40
39_P77_G0.8850.39
127_A130_V0.8850.39
8_L67_T0.8760.39
15_A69_R0.8690.38
36_V42_L0.8660.38
18_D67_T0.8630.38
70_V74_K0.8580.38
34_H41_R0.8540.37
119_T125_M0.8510.37
100_E113_E0.8490.37
133_H140_K0.8460.37
63_A74_K0.8430.37
41_R60_G0.8370.36
44_L116_A0.8350.36
23_M34_H0.8310.36
103_A111_A0.8230.35
101_P105_V0.8220.35
133_H136_W0.8220.35
22_A51_A0.8160.35
123_Q133_H0.8000.34
10_V14_V0.7920.34
4_A41_R0.7870.33
52_A76_I0.7860.33
50_L53_C0.7740.32
2_I46_V0.7730.32
134_F138_L0.7690.32
10_V63_A0.7680.32
111_A129_E0.7670.32
33_S38_D0.7580.31
10_V69_R0.7560.31
34_H39_P0.7540.31
118_L121_V0.7530.31
10_V41_R0.7510.31
17_I139_E0.7500.31
136_W139_E0.7440.31
36_V60_G0.7380.30
111_A125_M0.7370.30
7_L35_E0.7330.30
125_M130_V0.7320.30
2_I45_V0.7300.30
74_K77_G0.7290.30
12_G40_G0.7280.30
3_N33_S0.7220.29
44_L81_D0.7180.29
54_R58_D0.7140.29
99_R116_A0.7010.28
129_E138_L0.6980.28
43_T72_S0.6890.27
59_A76_I0.6890.27
125_M128_G0.6850.27
2_I35_E0.6840.27
97_P109_E0.6770.27
109_E114_L0.6700.26
17_I86_L0.6680.26
16_A52_A0.6630.26
8_L19_A0.6570.26
99_R104_P0.6480.25
2_I10_V0.6460.25
34_H70_V0.6410.25
23_M51_A0.6390.25
130_V135_G0.6330.24
121_V134_F0.6260.24
14_V37_L0.6230.24
105_V117_L0.6230.24
100_E132_A0.6220.24
14_V64_A0.6200.24
32_L45_V0.6160.24
4_A7_L0.6160.24
136_W140_K0.6120.23
39_P67_T0.6100.23
18_D37_L0.6100.23
106_I120_S0.6080.23
47_E64_A0.6070.23
55_A72_S0.6070.23
89_G107_V0.6060.23
19_A23_M0.6020.23
32_L107_V0.5990.23
15_A34_H0.5970.23
92_R123_Q0.5970.23
106_I110_S0.5950.23
19_A63_A0.5920.22
46_V53_C0.5910.22
38_D83_T0.5900.22
106_I128_G0.5890.22
122_R128_G0.5890.22
116_A128_G0.5870.22
55_A71_I0.5850.22
66_R73_R0.5840.22
106_I122_R0.5820.22
107_V122_R0.5740.22
116_A123_Q0.5730.22
49_D56_A0.5720.21
67_T87_V0.5710.21
133_H143_N0.5690.21
43_T68_G0.5660.21
7_L67_T0.5570.21
24_L37_L0.5550.21
20_A86_L0.5540.21
131_A137_P0.5510.21
106_I126_T0.5500.20
45_V52_A0.5500.20
102_D108_A0.5480.20
3_N79_P0.5470.20
135_G138_L0.5350.20
102_D118_L0.5350.20
113_E119_T0.5330.20
47_E70_V0.5310.20
46_V61_C0.5290.20
105_V129_E0.5280.20
136_W142_R0.5270.19
34_H45_V0.5260.19
29_V132_A0.5240.19
16_A49_D0.5210.19
37_L45_V0.5170.19
46_V116_A0.5140.19
24_L51_A0.5130.19
62_A81_D0.5100.19
95_K98_V0.5030.18
14_V52_A0.5000.18
107_V112_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ox8A 5 0.5301 100 0.402 Contact Map
4p7tA 5 0.5241 100 0.413 Contact Map
4qifA 5 0.5542 100 0.413 Contact Map
4ox7A 3 0.5964 100 0.421 Contact Map
3mpyA 5 0.5783 100 0.427 Contact Map
4ox6A 3 0.5964 100 0.429 Contact Map
2ewhA 5 0.5482 100 0.431 Contact Map
4axjA 5 0.5301 100 0.433 Contact Map
3ssqA 6 0.5904 100 0.434 Contact Map
3gv2A 3 0 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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