GREMLIN Database
YPEA - Acetyltransferase YpeA
UniProt: P76539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14168
Length: 141 (128)
Sequences: 10051 (8034)
Seq/√Len: 710.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_R49_E3.7471.00
20_R75_H3.0231.00
92_E123_Y3.0051.00
58_V91_L2.4501.00
85_N121_L2.4061.00
48_A83_I2.3371.00
4_R10_D2.2031.00
85_N120_R2.1871.00
46_L90_R2.1381.00
50_V78_F2.0301.00
47_V54_V2.0171.00
89_N121_L2.0121.00
55_V78_F1.9511.00
90_R93_K1.8671.00
94_K98_R1.8051.00
13_E16_T1.8001.00
92_E103_I1.7971.00
105_I118_Y1.7591.00
67_G95_L1.7281.00
94_K97_A1.7261.00
88_L121_L1.6711.00
119_E125_H1.6161.00
78_F81_R1.6081.00
50_V55_V1.5911.00
115_L119_E1.5471.00
60_G91_L1.5351.00
50_V81_R1.5241.00
6_F14_V1.5061.00
116_G119_E1.4641.00
16_T20_R1.4591.00
21_C73_G1.4371.00
62_Y100_C1.4151.00
49_E54_V1.4141.00
44_L94_K1.4101.00
125_H128_V1.4091.00
30_P33_D1.4011.00
79_R113_M1.3761.00
6_F47_V1.3591.00
85_N89_N1.3461.00
53_D77_E1.3171.00
107_V111_N1.2751.00
56_G74_V1.2751.00
90_R94_K1.2681.00
109_E128_V1.2421.00
115_L125_H1.2371.00
69_A88_L1.2341.00
114_V118_Y1.2221.00
15_I19_E1.2081.00
45_F59_M1.2061.00
49_E52_G1.1821.00
53_D75_H1.1761.00
20_R76_P1.1701.00
46_L94_K1.1521.00
13_E54_V1.1461.00
20_R77_E1.1351.00
10_D49_E1.1261.00
88_L118_Y1.1191.00
60_G95_L1.1131.00
66_R104_Q1.0991.00
12_E31_E1.0951.00
112_D116_G1.0931.00
82_G85_N1.0841.00
18_W57_T1.0541.00
95_L103_I1.0351.00
22_D25_R1.0281.00
88_L117_M1.0251.00
50_V53_D1.0221.00
17_L21_C1.0151.00
93_K97_A1.0061.00
44_L98_R1.0041.00
58_V87_L0.9861.00
16_T75_H0.9831.00
75_H78_F0.9801.00
35_E39_N0.9741.00
67_G100_C0.9701.00
74_V83_I0.9671.00
3_I46_L0.9661.00
112_D115_L0.9561.00
17_L54_V0.9551.00
68_S104_Q0.9481.00
72_L118_Y0.9321.00
14_V57_T0.9311.00
111_N114_V0.9221.00
31_E35_E0.9191.00
22_D26_P0.9031.00
34_I38_M0.8961.00
59_M70_Y0.8581.00
32_M36_R0.8551.00
89_N93_K0.8551.00
11_F15_I0.8521.00
53_D78_F0.8391.00
56_G87_L0.8391.00
3_I90_R0.8231.00
92_E121_L0.8181.00
117_M121_L0.8171.00
8_Q35_E0.8161.00
13_E53_D0.8111.00
105_I114_V0.8071.00
17_L75_H0.8061.00
60_G94_K0.8061.00
72_L88_L0.8041.00
8_Q39_N0.7991.00
61_G70_Y0.7981.00
6_F11_F0.7871.00
107_V114_V0.7851.00
12_E16_T0.7761.00
104_Q126_A0.7731.00
58_V69_A0.7691.00
107_V115_L0.7691.00
95_L100_C0.7681.00
21_C79_R0.7671.00
66_R102_K0.7671.00
55_V83_I0.7481.00
45_F49_E0.7441.00
33_D36_R0.7351.00
62_Y98_R0.7331.00
33_D37_K0.7291.00
92_E96_I0.7211.00
72_L105_I0.7081.00
80_G113_M0.7051.00
6_F45_F0.7001.00
34_I37_K0.6951.00
16_T53_D0.6901.00
69_A105_I0.6891.00
36_R40_H0.6831.00
5_V46_L0.6821.00
93_K96_I0.6731.00
44_L60_G0.6701.00
25_R28_N0.6691.00
113_M116_G0.6691.00
103_I123_Y0.6681.00
56_G83_I0.6661.00
69_A123_Y0.6561.00
48_A56_G0.6551.00
84_A117_M0.6501.00
32_M35_E0.6431.00
30_P34_I0.6381.00
7_R10_D0.6321.00
68_S106_N0.6291.00
57_T73_G0.6281.00
83_I86_A0.6231.00
86_A89_N0.6231.00
63_D66_R0.6221.00
24_L28_N0.6211.00
63_D68_S0.6191.00
114_V117_M0.6141.00
18_W34_I0.6101.00
33_D38_M0.6101.00
62_Y67_G0.5991.00
5_V44_L0.5951.00
13_E17_L0.5931.00
37_K40_H0.5931.00
4_R7_R0.5931.00
23_L26_P0.5911.00
105_I123_Y0.5901.00
3_I86_A0.5891.00
17_L73_G0.5881.00
18_W73_G0.5841.00
30_P38_M0.5841.00
8_Q11_F0.5831.00
72_L114_V0.5801.00
22_D73_G0.5791.00
22_D28_N0.5781.00
18_W71_Y0.5771.00
4_R47_V0.5741.00
48_A55_V0.5711.00
71_Y108_P0.5641.00
78_F83_I0.5561.00
74_V84_A0.5561.00
24_L76_P0.5521.00
89_N92_E0.5511.00
24_L27_W0.5511.00
107_V118_Y0.5511.00
15_I31_E0.5491.00
13_E75_H0.5481.00
23_L28_N0.5441.00
21_C76_P0.5371.00
80_G120_R0.5331.00
5_V94_K0.5291.00
37_K59_M0.5291.00
102_K126_A0.5241.00
14_V18_W0.5221.00
59_M71_Y0.5201.00
72_L87_L0.5201.00
48_A87_L0.5181.00
84_A118_Y0.5161.00
16_T19_E0.5141.00
29_D37_K0.5121.00
116_G120_R0.5121.00
12_E15_I0.5100.99
111_N117_M0.5050.99
57_T111_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s3zA 2 0.9574 99.9 0.277 Contact Map
4qusA 5 1 99.9 0.281 Contact Map
3fynA 2 0.9433 99.8 0.296 Contact Map
3fixA 2 0.9574 99.8 0.32 Contact Map
3dr6A 2 1 99.8 0.321 Contact Map
2j8mA 2 1 99.8 0.322 Contact Map
4evyA 2 0.9574 99.8 0.324 Contact Map
3zj0A 1 0.9645 99.8 0.325 Contact Map
1p0hA 1 0.9433 99.8 0.326 Contact Map
4kvxA 1 0.9362 99.8 0.328 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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