GREMLIN Database
YFEX - Probable deferrochelatase/peroxidase YfeX
UniProt: P76536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14165
Length: 299 (285)
Sequences: 1931 (1185)
Seq/√Len: 70.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_S106_N3.9031.00
22_N124_K3.8111.00
26_E29_A3.7571.00
230_I262_L3.7571.00
21_A114_M3.6231.00
198_T201_A3.6021.00
214_S217_T3.3741.00
59_F291_P3.3191.00
58_A290_A3.3121.00
23_V63_T3.2901.00
65_R72_G3.2741.00
173_V247_Y3.1391.00
206_D209_E3.0231.00
6_S45_E2.9431.00
117_F121_I2.9191.00
75_E254_R2.7821.00
141_F192_E2.6911.00
191_Q199_K2.5141.00
91_Q288_Y2.4981.00
98_I106_N2.3311.00
92_F288_Y2.2991.00
95_L171_V2.2821.00
20_E92_F2.2561.00
77_K256_H2.2051.00
179_N182_Q2.1541.00
66_A69_G2.1361.00
24_K122_E2.0901.00
19_I123_V2.0541.00
171_V249_C2.0511.00
173_V249_C2.0441.00
169_S251_Y1.9901.00
34_S59_F1.9571.00
61_N72_G1.9561.00
175_R283_V1.9541.00
52_H101_L1.9281.00
18_W249_C1.9131.00
139_S276_M1.9051.00
98_I110_A1.8901.00
4_V167_G1.8211.00
111_Q184_N1.8051.00
21_A96_I1.7871.00
75_E170_Y1.7851.00
139_S178_H1.7771.00
30_L63_T1.7741.00
186_M190_D1.7631.00
21_A123_V1.7621.00
62_N66_A1.7221.00
205_I210_R1.7031.00
75_E256_H1.6681.00
255_L287_Y1.6630.99
179_N281_K1.6400.99
127_I239_T1.6350.99
36_T116_A1.6350.99
115_E184_N1.6070.99
61_N65_R1.5950.99
40_K116_A1.5840.99
79_F82_Y1.5700.99
213_T275_A1.5290.99
220_D227_G1.5170.99
239_T243_T1.5030.99
211_P275_A1.5000.99
187_S190_D1.4950.99
16_A247_Y1.4810.99
160_I163_G1.4790.99
21_A121_I1.4680.99
19_I110_A1.4630.99
62_N78_D1.4480.99
83_G267_G1.4340.98
230_I250_A1.4240.98
186_M194_V1.4200.98
97_H251_Y1.4150.98
51_A105_V1.3890.98
77_K259_E1.3730.98
27_V31_R1.3690.98
33_A94_V1.3670.98
177_E243_T1.3650.98
16_A235_L1.3560.98
118_G181_K1.3450.98
130_F138_L1.3230.97
24_K119_D1.3180.97
57_V96_I1.3120.97
95_L251_Y1.3100.97
41_L57_V1.2950.97
99_L235_L1.2880.97
154_R158_A1.2850.97
8_I290_A1.2810.97
234_S246_L1.2550.96
142_V202_N1.2510.96
275_A278_R1.2440.96
42_A46_A1.2300.96
83_G282_P1.2250.96
83_G280_T1.2170.96
112_A203_E1.2160.96
41_L55_A1.2000.95
13_C235_L1.1830.95
82_Y263_L1.1820.95
23_V30_L1.1740.95
193_M211_P1.1660.95
61_N79_F1.1630.95
73_A76_L1.1610.95
17_I110_A1.1570.94
39_D43_T1.1530.94
31_R35_K1.1490.94
58_A95_L1.1440.94
65_R70_G1.1380.94
214_S220_D1.1370.94
160_I253_A1.1370.94
277_L280_T1.1360.94
18_W95_L1.1360.94
160_I166_A1.1350.94
89_T175_R1.1280.94
234_S250_A1.1280.94
220_D223_E1.1080.93
177_E283_V1.1050.93
128_H239_T1.1030.93
17_I106_N1.0980.93
190_D193_M1.0920.93
10_P13_C1.0870.92
213_T218_R1.0820.92
14_R135_E1.0630.92
76_L170_Y1.0560.91
211_P217_T1.0530.91
20_E286_G1.0430.91
197_R232_R1.0290.90
192_E198_T1.0170.90
230_I258_I1.0160.90
213_T217_T1.0140.89
37_F117_F1.0100.89
158_A231_V1.0060.89
78_D91_Q1.0020.89
60_G63_T1.0010.89
193_M205_I0.9960.89
171_V251_Y0.9940.89
103_H128_H0.9910.88
159_V289_F0.9880.88
194_V281_K0.9800.88
8_I169_S0.9790.88
22_N122_E0.9770.88
127_I175_R0.9760.88
198_T205_I0.9710.87
67_L70_G0.9700.87
192_E199_K0.9680.87
163_G166_A0.9680.87
10_P235_L0.9680.87
10_P99_L0.9650.87
64_W72_G0.9640.87
20_E91_Q0.9630.87
141_F199_K0.9600.87
63_T94_V0.9600.87
223_E226_K0.9590.87
212_E217_T0.9510.86
171_V290_A0.9480.86
90_T284_T0.9410.86
216_L219_V0.9400.86
276_M280_T0.9320.85
150_G153_T0.9290.85
115_E181_K0.9190.84
20_E288_Y0.9170.84
33_A116_A0.9050.83
14_R133_V0.9040.83
34_S291_P0.9000.83
86_L89_T0.8990.83
15_A103_H0.8990.83
187_S194_V0.8980.83
33_A117_F0.8930.83
221_L225_G0.8890.82
255_L282_P0.8860.82
176_W266_F0.8860.82
73_A183_L0.8860.82
156_E253_A0.8790.81
102_R105_V0.8790.81
85_G281_K0.8780.81
213_T273_R0.8780.81
51_A101_L0.8760.81
256_H264_S0.8750.81
274_D277_L0.8730.81
14_R101_L0.8720.81
53_L109_V0.8670.81
16_A95_L0.8660.81
13_C99_L0.8640.80
260_Q287_Y0.8540.80
170_Y191_Q0.8500.79
141_F195_I0.8420.79
225_G262_L0.8400.78
210_R216_L0.8380.78
183_L191_Q0.8370.78
246_L250_A0.8360.78
210_R217_T0.8330.78
79_F87_A0.8330.78
142_V145_T0.8320.78
138_L178_H0.8280.77
61_N78_D0.8270.77
59_F94_V0.8270.77
112_A116_A0.8260.77
32_A36_T0.8230.77
32_A35_K0.8180.77
59_F63_T0.8170.77
252_C258_I0.8140.76
232_R248_F0.8110.76
219_V266_F0.8040.75
75_E255_L0.8020.75
12_H131_R0.7980.75
89_T284_T0.7930.74
22_N92_F0.7920.74
182_Q185_R0.7870.74
170_Y255_L0.7840.74
263_L266_F0.7810.73
89_T283_V0.7800.73
76_L255_L0.7750.73
50_D101_L0.7750.73
168_G289_F0.7710.72
189_H193_M0.7700.72
4_V158_A0.7670.72
188_V199_K0.7660.72
80_P263_L0.7640.72
74_E162_D0.7630.71
257_N261_Q0.7630.71
57_V94_V0.7600.71
162_D165_D0.7580.71
7_G56_V0.7570.71
20_E95_L0.7540.71
157_V230_I0.7470.70
138_L180_L0.7420.69
220_D228_L0.7360.69
221_L260_Q0.7330.68
23_V121_I0.7260.68
58_A115_E0.7260.68
30_L155_R0.7230.67
208_D236_P0.7220.67
13_C101_L0.7220.67
144_G248_F0.7210.67
55_A113_A0.7200.67
261_Q265_M0.7170.67
37_F112_A0.7160.67
175_R247_Y0.7120.66
264_S268_D0.7100.66
73_A165_D0.7100.66
156_E229_K0.7090.66
158_A167_G0.7090.66
254_R257_N0.7080.66
28_D31_R0.7070.66
36_T39_D0.7040.65
225_G265_M0.7040.65
219_V263_L0.7030.65
207_G217_T0.7020.65
143_D232_R0.7010.65
112_A115_E0.7010.65
18_W130_F0.6950.64
161_K166_A0.6940.64
97_H249_C0.6940.64
225_G228_L0.6890.64
87_A266_F0.6880.64
227_G257_N0.6870.63
237_Y280_T0.6870.63
108_S111_Q0.6870.63
28_D70_G0.6870.63
153_T156_E0.6840.63
17_I128_H0.6830.63
15_A102_R0.6800.63
194_V275_A0.6780.62
216_L220_D0.6770.62
38_A45_E0.6750.62
139_S214_S0.6750.62
97_H235_L0.6740.62
116_A120_C0.6700.61
264_S267_G0.6700.61
172_F252_C0.6690.61
260_Q263_L0.6680.61
90_T288_Y0.6670.61
190_D240_A0.6670.61
41_L113_A0.6660.61
149_A153_T0.6660.61
19_I96_I0.6660.61
221_L228_L0.6630.61
218_R268_D0.6620.61
118_G121_I0.6610.60
165_D289_F0.6580.60
107_F244_H0.6580.60
79_F285_G0.6550.60
172_F258_I0.6550.60
230_I248_F0.6550.60
13_C54_G0.6530.60
128_H238_G0.6470.59
224_D228_L0.6450.59
204_E265_M0.6450.59
159_V162_D0.6410.58
171_V234_S0.6410.58
18_W247_Y0.6400.58
30_L67_L0.6390.58
18_W171_V0.6390.58
258_I262_L0.6380.58
207_G210_R0.6380.58
76_L191_Q0.6360.57
82_Y262_L0.6350.57
36_T40_K0.6350.57
76_L159_V0.6330.57
178_H280_T0.6290.57
182_Q194_V0.6290.57
172_F250_A0.6290.57
5_Q8_I0.6280.57
50_D155_R0.6260.56
160_I164_V0.6250.56
159_V170_Y0.6230.56
23_V67_L0.6230.56
237_Y276_M0.6230.56
57_V116_A0.6200.56
60_G286_G0.6180.55
190_D194_V0.6170.55
6_S10_P0.6150.55
79_F274_D0.6150.55
92_F124_K0.6140.55
60_G140_G0.6140.55
197_R248_F0.6130.55
98_I148_P0.6110.55
177_E237_Y0.6100.54
76_L289_F0.6070.54
124_K231_V0.6060.54
266_F277_L0.6050.54
65_R68_S0.6040.54
146_E204_E0.6020.53
153_T267_G0.6000.53
35_K38_A0.5990.53
145_T246_L0.5990.53
250_A258_I0.5950.53
246_L280_T0.5950.53
194_V218_R0.5930.52
181_K242_G0.5930.52
148_P156_E0.5930.52
126_E238_G0.5910.52
32_A120_C0.5900.52
39_D42_A0.5900.52
99_L233_Q0.5880.52
194_V211_P0.5870.52
277_L290_A0.5840.51
61_N286_G0.5840.51
230_I261_Q0.5830.51
11_E46_A0.5830.51
204_E210_R0.5820.51
205_I216_L0.5820.51
282_P285_G0.5810.51
131_R142_V0.5800.51
122_E291_P0.5790.51
28_D155_R0.5780.51
12_H133_V0.5770.50
55_A189_H0.5760.50
146_E234_S0.5760.50
188_V279_F0.5750.50
7_G97_H0.5750.50
60_G91_Q0.5740.50
214_S275_A0.5740.50
9_L260_Q0.5720.50
139_S216_L0.5710.50
37_F113_A0.5700.50
114_M118_G0.5700.50
15_A101_L0.5690.49
83_G218_R0.5680.49
57_V291_P0.5670.49
36_T120_C0.5660.49
195_I234_S0.5650.49
64_W73_A0.5650.49
228_L262_L0.5640.49
23_V66_A0.5640.49
149_A155_R0.5630.49
53_L255_L0.5620.49
72_G75_E0.5620.49
172_F263_L0.5610.48
195_I231_V0.5600.48
194_V279_F0.5580.48
195_I280_T0.5570.48
173_V284_T0.5560.48
183_L288_Y0.5550.48
144_G232_R0.5550.48
131_R148_P0.5550.48
194_V205_I0.5530.47
52_H57_V0.5520.47
82_Y266_F0.5520.47
34_S80_P0.5510.47
55_A109_V0.5500.47
252_C280_T0.5480.47
188_V192_E0.5480.47
58_A171_V0.5460.47
57_V121_I0.5460.47
275_A279_F0.5450.47
191_Q279_F0.5450.47
227_G250_A0.5420.46
66_A70_G0.5410.46
26_E94_V0.5410.46
144_G197_R0.5380.46
7_G233_Q0.5370.46
198_T214_S0.5370.46
143_D246_L0.5360.45
237_Y282_P0.5350.45
175_R274_D0.5340.45
133_V234_S0.5340.45
17_I126_E0.5340.45
221_L229_K0.5330.45
7_G13_C0.5330.45
55_A172_F0.5320.45
256_H261_Q0.5320.45
262_L291_P0.5300.45
83_G281_K0.5280.44
40_K112_A0.5260.44
145_T202_N0.5250.44
27_V30_L0.5240.44
16_A131_R0.5220.44
253_A258_I0.5220.44
54_G99_L0.5210.44
60_G130_F0.5200.44
79_F287_Y0.5190.43
159_V169_S0.5180.43
57_V117_F0.5170.43
161_K253_A0.5160.43
45_E54_G0.5150.43
40_K44_F0.5120.43
89_T277_L0.5110.42
262_L267_G0.5090.42
126_E225_G0.5090.42
135_E148_P0.5090.42
19_I156_E0.5070.42
202_N216_L0.5060.42
96_I240_A0.5050.42
31_R65_R0.5040.42
186_M280_T0.5040.42
141_F191_Q0.5030.41
186_M279_F0.5030.41
18_W267_G0.5020.41
147_N291_P0.5020.41
172_F255_L0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iizA 2 0.9967 100 0.134 Contact Map
3qnsA 5 1 100 0.144 Contact Map
4gu7A 2 0.9933 100 0.149 Contact Map
2gvkA 5 0.9799 100 0.16 Contact Map
4grcA 2 0.9699 100 0.194 Contact Map
3o72A 2 0.9833 100 0.196 Contact Map
4gs1A 2 0.9833 100 0.202 Contact Map
4gt2B 2 0.9833 100 0.206 Contact Map
4g2cA 2 0.99 100 0.31 Contact Map
3vxjA 1 0.99 100 0.337 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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