GREMLIN Database
MURQ - N-acetylmuramic acid 6-phosphate etherase
UniProt: P76535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14162
Length: 298 (290)
Sequences: 1850 (1242)
Seq/√Len: 72.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_S252_Q4.0571.00
51_A162_V3.6071.00
155_R177_E3.5911.00
23_T53_D3.4821.00
182_P204_V3.2201.00
30_I195_M3.1611.00
35_K42_E2.9971.00
66_I127_I2.8011.00
58_Q160_R2.7721.00
256_A271_V2.6701.00
276_D279_E2.5561.00
78_I106_I2.5401.00
38_P203_L2.4961.00
88_Y195_M2.4481.00
117_R152_E2.4301.00
68_L150_G2.3811.00
58_Q134_V2.3181.00
129_L135_V2.3101.00
120_G150_G2.3041.00
153_Y156_Q2.2491.00
27_C52_I2.1721.00
35_K39_L2.1601.00
103_E107_Q2.1371.00
52_I211_G2.1291.00
54_V178_F2.1291.00
152_E175_T2.0421.00
151_L161_T2.0401.00
123_D146_Y2.0101.00
21_V29_I2.0001.00
236_V250_A1.9811.00
24_L49_A1.9591.00
55_I208_L1.9491.00
7_I168_P1.9371.00
88_Y189_V1.9041.00
18_I189_V1.8701.00
18_I214_I1.8681.00
153_Y157_L1.8531.00
236_V240_N1.8321.00
59_V216_S1.8151.00
44_V47_D1.7401.00
151_L172_V1.7191.00
27_C45_L1.6951.00
26_M211_G1.6911.00
44_V180_I1.6901.00
170_S173_S1.6821.00
54_V160_R1.6821.00
59_V94_L1.6681.00
65_L95_V1.6651.00
23_T215_K1.6521.00
137_G147_V1.6391.00
218_K226_D1.6300.99
121_V125_K1.6210.99
14_A36_T1.6030.99
24_L28_R1.5960.99
269_V291_I1.5660.99
173_S181_T1.5630.99
60_S288_G1.5610.99
136_V208_L1.5590.99
24_L45_L1.5510.99
263_N266_T1.5270.99
61_G132_Q1.5190.99
124_L153_Y1.5020.99
239_V254_E1.4990.99
255_A259_A1.4920.99
84_C90_V1.4920.99
48_I204_V1.4900.99
184_V197_A1.4740.99
44_V182_P1.4670.99
22_S25_E1.4540.99
53_D215_K1.4530.99
248_C253_A1.4440.99
129_L153_Y1.4330.99
277_A281_K1.4230.99
212_L216_S1.4100.99
116_S119_G1.4100.99
17_E20_R1.4100.99
44_V48_I1.4070.98
15_S29_I1.4060.98
119_G123_D1.3720.98
56_H215_K1.3680.98
59_V212_L1.3630.98
15_S188_V1.3590.98
27_C49_A1.3560.98
270_M277_A1.3520.98
261_E277_A1.3490.98
236_V239_V1.3450.98
138_I164_I1.3400.98
163_G179_A1.3360.98
122_N126_N1.3280.98
12_N15_S1.3050.98
245_A268_I1.3050.98
125_K153_Y1.2940.97
76_L205_L1.2930.97
68_L120_G1.2840.97
68_L98_L1.2790.97
20_R292_R1.2790.97
16_A221_G1.2740.97
33_E36_T1.2680.97
84_C95_V1.2670.97
163_G176_A1.2600.97
160_R178_F1.2600.97
11_S221_G1.2550.97
68_L135_V1.2450.97
254_E258_I1.2440.97
65_L136_V1.2390.97
155_R175_T1.2220.96
66_I96_V1.2180.96
49_A53_D1.1750.95
93_G96_V1.1730.95
32_D35_K1.1700.95
110_V113_A1.1560.95
122_N125_K1.1500.95
242_V268_I1.1390.95
166_C197_A1.1320.94
82_S106_I1.1310.94
68_L124_L1.1300.94
166_C200_A1.1220.94
223_L245_A1.1220.94
92_P108_H1.1150.94
55_I212_L1.1090.94
19_D292_R1.1080.94
121_V156_Q1.1050.94
143_R171_A1.1000.93
38_P41_V1.0980.93
266_T277_A1.0980.93
96_V127_I1.0970.93
163_G173_S1.0970.93
121_V149_A1.0820.93
51_A208_L1.0780.93
104_Y110_V1.0620.92
51_A55_I1.0580.92
48_I180_I1.0570.92
283_R287_H1.0540.92
263_N281_K1.0480.92
258_I262_R1.0440.92
242_V257_L1.0360.91
223_L244_N1.0300.91
31_N38_P1.0280.91
227_V241_I1.0240.91
29_I188_V1.0210.91
260_C270_M1.0170.90
129_L157_L1.0110.90
118_E122_N1.0050.90
56_H211_G1.0030.90
77_G97_G0.9990.90
7_I167_N0.9960.90
12_N33_E0.9950.90
27_C211_G0.9920.89
51_A180_I0.9880.89
163_G172_V0.9850.89
51_A178_F0.9850.89
82_S85_P0.9800.89
82_S107_Q0.9790.89
243_K250_A0.9780.89
14_A32_D0.9700.88
90_V94_L0.9670.88
229_A238_Q0.9650.88
198_G201_Q0.9540.87
139_A144_T0.9520.87
44_V204_V0.9470.87
129_L159_C0.9470.87
23_T26_M0.9460.87
39_L42_E0.9430.87
28_R32_D0.9380.87
120_G149_A0.9320.86
248_C271_V0.9300.86
28_R45_L0.9300.86
31_N34_D0.9300.86
279_E282_K0.9280.86
165_S181_T0.9270.86
26_M214_I0.9260.86
84_C226_D0.9240.86
52_I208_L0.9150.85
6_M143_R0.9120.85
54_V58_Q0.9090.85
273_K295_L0.9080.85
238_Q264_C0.9080.85
7_I183_I0.9060.85
75_R111_E0.9040.84
32_D42_E0.9000.84
56_H212_L0.8980.84
139_A230_T0.8930.84
24_L46_P0.8930.84
23_T27_C0.8870.83
164_I204_V0.8870.83
45_L207_M0.8860.83
171_A174_T0.8860.83
151_L176_A0.8830.83
11_S190_T0.8790.83
239_V250_A0.8770.83
55_I134_V0.8750.82
11_S223_L0.8730.82
104_Y108_H0.8720.82
160_R177_E0.8710.82
246_T271_V0.8640.82
124_L129_L0.8630.82
273_K280_A0.8600.81
266_T269_V0.8580.81
25_E28_R0.8570.81
169_G174_T0.8530.81
165_S173_S0.8500.81
17_E29_I0.8480.80
273_K294_V0.8460.80
48_I207_M0.8450.80
282_K286_Q0.8420.80
136_V164_I0.8410.80
226_D263_N0.8370.80
269_V294_V0.8340.79
11_S244_N0.8320.79
11_S15_S0.8320.79
242_V248_C0.8310.79
123_D126_N0.8310.79
116_S122_N0.8290.79
50_A178_F0.8270.79
18_I88_Y0.8220.78
76_L79_L0.8080.77
17_E21_V0.8020.77
281_K285_D0.8010.77
21_V26_M0.8010.77
27_C46_P0.8000.76
99_I106_I0.8000.76
34_D203_L0.7990.76
273_K283_R0.7960.76
11_S16_A0.7950.76
290_F293_Q0.7940.76
248_C256_A0.7920.76
134_V162_V0.7870.75
256_A259_A0.7820.75
226_D265_K0.7760.74
120_G147_V0.7700.74
30_I188_V0.7680.73
55_I65_L0.7660.73
162_V208_L0.7640.73
134_V160_R0.7630.73
250_A253_A0.7630.73
189_V195_M0.7600.73
248_C252_Q0.7590.73
27_C207_M0.7580.72
28_R42_E0.7570.72
31_N37_V0.7540.72
68_L147_V0.7510.72
98_L127_I0.7500.72
7_I184_V0.7500.72
279_E283_R0.7490.72
60_S216_S0.7480.72
266_T275_L0.7470.71
223_L241_I0.7460.71
152_E156_Q0.7460.71
47_D50_A0.7460.71
242_V262_R0.7450.71
252_Q255_A0.7420.71
278_A281_K0.7380.70
162_V180_I0.7380.70
184_V200_A0.7360.70
89_G228_V0.7350.70
17_E292_R0.7350.70
250_A254_E0.7310.70
72_T111_E0.7290.70
59_V209_S0.7260.69
232_E236_V0.7210.69
84_C212_L0.7180.68
269_V275_L0.7160.68
23_T211_G0.7150.68
176_A179_A0.7140.68
275_L279_E0.7140.68
58_Q212_L0.7140.68
147_V172_V0.7120.68
94_L216_S0.7100.68
275_L283_R0.7100.68
171_A175_T0.7090.67
166_C201_Q0.7080.67
266_T281_K0.7020.67
260_C266_T0.6990.66
270_M280_A0.6980.66
167_N184_V0.6950.66
14_A33_E0.6940.66
189_V210_T0.6930.66
23_T49_A0.6910.65
184_V193_S0.6890.65
252_Q271_V0.6880.65
78_I82_S0.6870.65
15_S222_N0.6870.65
30_I38_P0.6850.65
37_V203_L0.6840.65
154_A159_C0.6820.64
261_E281_K0.6820.64
55_I162_V0.6810.64
31_N45_L0.6810.64
18_I26_M0.6760.64
278_A282_K0.6740.63
221_G245_A0.6740.63
252_Q256_A0.6720.63
8_T291_I0.6720.63
136_V162_V0.6700.63
199_T203_L0.6690.63
266_T280_A0.6680.63
82_S97_G0.6620.62
109_A230_T0.6600.62
124_L150_G0.6590.62
82_S99_I0.6570.62
166_C193_S0.6570.62
190_T244_N0.6560.61
17_E221_G0.6550.61
160_R212_L0.6520.61
241_I264_C0.6500.61
41_V200_A0.6470.60
235_H238_Q0.6440.60
59_V134_V0.6440.60
26_M215_K0.6430.60
77_G138_I0.6420.60
54_V57_A0.6400.60
229_A242_V0.6310.58
269_V283_R0.6300.58
66_I98_L0.6290.58
77_G82_S0.6290.58
257_L262_R0.6280.58
6_M167_N0.6270.58
60_S290_F0.6260.58
44_V168_P0.6250.58
225_V268_I0.6240.58
65_L84_C0.6230.57
82_S184_V0.6230.57
89_G230_T0.6220.57
45_L48_I0.6220.57
189_V214_I0.6210.57
73_S139_A0.6190.57
148_I163_G0.6180.57
179_A182_P0.6180.57
164_I182_P0.6160.57
66_I94_L0.6150.56
78_I99_I0.6120.56
39_L43_R0.6110.56
84_C136_V0.6110.56
165_S172_V0.6090.56
8_T197_A0.6090.56
59_V138_I0.6030.55
77_G218_K0.6030.55
229_A257_L0.6010.55
30_I211_G0.5980.54
49_A211_G0.5980.54
85_P109_A0.5960.54
38_P42_E0.5960.54
168_P183_I0.5960.54
72_T139_A0.5950.54
61_G131_A0.5890.53
243_K253_A0.5860.53
28_R46_P0.5860.53
26_M188_V0.5860.53
89_G201_Q0.5850.53
151_L163_G0.5820.52
57_A61_G0.5810.52
70_A100_A0.5790.52
173_S179_A0.5790.52
121_V152_E0.5760.52
80_D87_T0.5760.52
236_V243_K0.5750.52
97_G139_A0.5740.51
59_V95_V0.5740.51
164_I201_Q0.5700.51
229_A235_H0.5690.51
14_A17_E0.5660.50
221_G292_R0.5640.50
286_Q293_Q0.5620.50
60_S215_K0.5620.50
65_L216_S0.5620.50
82_S89_G0.5610.50
251_E255_A0.5610.50
59_V65_L0.5590.50
13_T16_A0.5570.49
242_V264_C0.5540.49
63_G132_Q0.5540.49
238_Q257_L0.5540.49
51_A136_V0.5540.49
165_S170_S0.5530.49
52_I273_K0.5510.49
242_V260_C0.5510.49
119_G122_N0.5510.49
68_L116_S0.5510.49
18_I21_V0.5490.48
8_T140_A0.5490.48
269_V280_A0.5490.48
118_E121_V0.5480.48
209_S212_L0.5460.48
291_I294_V0.5440.48
125_K157_L0.5430.48
235_H262_R0.5390.47
138_I209_S0.5380.47
148_I175_T0.5370.47
124_L135_V0.5360.47
225_V265_K0.5360.47
36_T40_A0.5360.47
65_L94_L0.5340.47
188_V253_A0.5330.46
65_L134_V0.5320.46
75_R109_A0.5310.46
188_V197_A0.5310.46
178_F211_G0.5300.46
151_L170_S0.5290.46
185_G196_K0.5280.46
238_Q262_R0.5280.46
139_A190_T0.5260.46
91_K94_L0.5260.46
55_I59_V0.5220.45
37_V184_V0.5220.45
19_D222_N0.5220.45
48_I94_L0.5200.45
269_V273_K0.5190.45
47_D178_F0.5190.45
139_A145_P0.5190.45
107_Q228_V0.5180.45
86_P105_A0.5160.44
39_L251_E0.5160.44
84_C94_L0.5140.44
67_Y80_D0.5140.44
56_H216_S0.5130.44
135_V154_A0.5120.44
19_D223_L0.5120.44
170_S181_T0.5110.44
114_E192_S0.5100.44
87_T233_K0.5090.43
105_A111_E0.5080.43
26_M52_I0.5080.43
72_T78_I0.5070.43
55_I138_I0.5060.43
229_A262_R0.5060.43
165_S179_A0.5050.43
107_Q110_V0.5050.43
106_I109_A0.5050.43
162_V178_F0.5040.43
84_C166_C0.5020.43
117_R149_A0.5020.43
259_A277_A0.5010.42
111_E196_K0.5000.42
75_R196_K0.5000.42
259_A276_D0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nriA 2 0.8322 100 0.388 Contact Map
4s12A 2 0.9899 100 0.414 Contact Map
3w0lB 1 0.953 100 0.428 Contact Map
4bb9A 1 0.9933 100 0.444 Contact Map
1tk9A 4 0.6309 99.9 0.8 Contact Map
3trjA 4 0.6275 99.8 0.813 Contact Map
2xblA 4 0.6443 99.8 0.821 Contact Map
2yvaA 4 0.6376 99.8 0.822 Contact Map
2i2wA 4 0.6342 99.7 0.828 Contact Map
1x92A 4 0.6477 99.7 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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