GREMLIN Database
ACOCT - Acetyl-CoA:oxalate CoA-transferase
UniProt: P76518 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13284
Length: 381 (369)
Sequences: 10374 (7063)
Seq/√Len: 367.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_R72_E3.6521.00
112_S115_T3.5821.00
301_Q305_V3.2251.00
189_Y192_E3.1351.00
28_T98_A3.1341.00
126_A184_I2.9661.00
92_K119_I2.8961.00
126_A180_L2.8641.00
340_E343_G2.7661.00
80_N83_D2.7641.00
88_I119_I2.7411.00
244_T303_A2.5461.00
107_E112_S2.5301.00
301_Q306_W2.5291.00
116_L123_L2.5151.00
84_K88_I2.5071.00
302_A305_V2.4761.00
190_G198_A2.4361.00
14_L37_R2.4271.00
245_Q302_A2.4261.00
113_W117_Q2.4171.00
76_L87_F2.4041.00
301_Q309_R2.3281.00
89_N92_K2.2701.00
369_D372_G2.2661.00
297_T300_T2.2141.00
85_S89_N2.1941.00
243_N299_K2.1661.00
96_V184_I2.1201.00
340_E345_M2.0971.00
371_H374_Q2.0551.00
18_M87_F2.0311.00
14_L93_Q1.9711.00
292_Q296_R1.9711.00
286_N289_I1.9571.00
372_G376_R1.9541.00
115_T118_E1.9201.00
293_Y296_R1.8631.00
268_L297_T1.8611.00
72_E374_Q1.8591.00
172_A208_T1.8371.00
16_I91_L1.8001.00
140_A311_H1.7711.00
133_H201_D1.7681.00
322_S325_E1.7661.00
182_S185_V1.7641.00
190_G194_S1.7631.00
117_Q196_R1.7531.00
77_D80_N1.7511.00
106_M111_F1.7471.00
34_M186_S1.7421.00
240_D291_K1.7321.00
8_G11_E1.7221.00
304_E308_A1.7051.00
137_L140_A1.6821.00
72_E378_E1.6791.00
276_R289_I1.6701.00
190_G355_G1.6661.00
268_L271_L1.6641.00
16_I94_A1.6601.00
137_L329_L1.6581.00
91_L116_L1.6561.00
367_T370_Q1.6551.00
97_L123_L1.6521.00
159_Y162_A1.6501.00
127_S199_H1.6141.00
32_C70_G1.6121.00
279_S282_L1.6011.00
13_L188_L1.5921.00
81_D84_K1.5841.00
265_A309_R1.5651.00
74_V375_I1.5591.00
76_L83_D1.5491.00
17_D28_T1.5471.00
190_G196_R1.5391.00
113_W125_Y1.5391.00
308_A312_E1.5371.00
264_Q269_T1.5341.00
268_L293_Y1.5031.00
282_L285_Q1.4821.00
149_A250_T1.4731.00
294_I298_L1.4711.00
205_F332_T1.4631.00
303_A325_E1.4591.00
91_L120_N1.4521.00
198_A354_S1.4501.00
206_D335_R1.4471.00
151_S208_T1.4401.00
364_G370_Q1.4381.00
328_K333_Q1.4351.00
74_V372_G1.4341.00
243_N295_E1.4301.00
297_T306_W1.4161.00
244_T249_I1.4151.00
183_G351_I1.4101.00
305_V309_R1.4091.00
264_Q272_V1.4081.00
175_C211_F1.4071.00
373_E377_Q1.4001.00
88_I115_T1.3831.00
33_N69_H1.3771.00
289_I292_Q1.3681.00
122_R191_R1.3661.00
261_A264_Q1.3641.00
196_R355_G1.3581.00
243_N248_P1.3561.00
260_S273_N1.3531.00
271_L293_Y1.3451.00
366_A371_H1.3451.00
76_L86_I1.3401.00
303_A319_P1.3291.00
13_L189_Y1.3231.00
158_G228_R1.3171.00
137_L150_M1.3051.00
298_L306_W1.2991.00
113_W199_H1.2991.00
99_E127_S1.2981.00
278_S282_L1.2931.00
262_L266_L1.2921.00
338_L345_M1.2921.00
265_A313_V1.2841.00
260_S264_Q1.2781.00
242_F291_K1.2691.00
128_S180_L1.2661.00
324_A328_K1.2601.00
124_I191_R1.2551.00
15_V96_V1.2511.00
331_Q334_A1.2501.00
105_T108_K1.2491.00
88_I111_F1.2421.00
256_D260_S1.2401.00
259_F263_C1.2381.00
189_Y193_K1.2341.00
266_L297_T1.2111.00
203_A206_D1.1811.00
198_A356_C1.1781.00
209_L332_T1.1781.00
307_L317_V1.1751.00
82_H85_S1.1721.00
179_Y210_S1.1661.00
86_I89_N1.1641.00
183_G200_V1.1521.00
257_K261_A1.1521.00
70_G362_M1.1451.00
243_N298_L1.1391.00
18_M97_L1.1371.00
253_C262_L1.1291.00
185_V189_Y1.1271.00
305_V308_A1.1261.00
116_L125_Y1.1161.00
225_S324_A1.1131.00
188_L192_E1.1091.00
44_P75_V1.1081.00
73_S366_A1.1061.00
106_M125_Y1.1031.00
27_G181_F1.1021.00
78_L109_L1.0981.00
209_L326_A1.0921.00
91_L119_I1.0861.00
9_P353_I1.0761.00
144_D148_Q1.0721.00
86_I376_R1.0671.00
136_P334_A1.0661.00
70_G363_P1.0661.00
249_I298_L1.0621.00
95_D191_R1.0611.00
79_K109_L1.0571.00
75_V372_G1.0561.00
83_D86_I1.0491.00
249_I306_W1.0421.00
321_L329_L1.0421.00
150_M329_L1.0381.00
247_K303_A1.0381.00
307_L319_P1.0311.00
14_L39_I1.0311.00
10_F185_V1.0291.00
136_P331_Q1.0281.00
142_A204_M1.0261.00
277_F286_N1.0221.00
262_L294_I1.0171.00
187_A198_A1.0161.00
330_P334_A1.0091.00
264_Q313_V1.0071.00
12_G189_Y1.0061.00
296_R300_T1.0051.00
27_G180_L1.0021.00
148_Q172_A1.0011.00
83_D376_R1.0011.00
198_A355_G0.9991.00
304_E307_L0.9991.00
16_I87_F0.9961.00
309_R312_E0.9961.00
341_A346_M0.9941.00
96_V124_I0.9931.00
113_W197_G0.9871.00
84_K111_F0.9861.00
88_I92_K0.9861.00
142_A147_I0.9841.00
18_M106_M0.9831.00
310_I317_V0.9751.00
212_L323_V0.9741.00
74_V86_I0.9721.00
30_L182_S0.9701.00
134_T138_K0.9671.00
289_I293_Y0.9671.00
14_L94_A0.9641.00
225_S322_S0.9641.00
131_F150_M0.9631.00
194_S355_G0.9621.00
304_E319_P0.9601.00
99_E106_M0.9571.00
333_Q345_M0.9561.00
87_F111_F0.9561.00
276_R286_N0.9521.00
92_K120_N0.9501.00
243_N247_K0.9471.00
164_P248_P0.9461.00
363_P371_H0.9451.00
81_D85_S0.9441.00
239_F252_C0.9431.00
181_F185_V0.9321.00
41_V74_V0.9251.00
19_T24_G0.9251.00
219_Y324_A0.9231.00
87_F91_L0.9221.00
191_R194_S0.9211.00
161_D228_R0.9191.00
295_E299_K0.9161.00
232_R287_Q0.9131.00
87_F97_L0.9131.00
277_F289_I0.9111.00
122_R192_E0.9061.00
190_G356_C0.9021.00
321_L325_E0.9021.00
179_Y207_A0.9021.00
188_L191_R0.9001.00
260_S272_V0.9001.00
308_A311_H0.8971.00
125_Y199_H0.8961.00
41_V87_F0.8921.00
309_R313_V0.8911.00
374_Q378_E0.8901.00
339_I348_G0.8891.00
8_G362_M0.8881.00
85_S88_I0.8871.00
93_Q378_E0.8851.00
96_V188_L0.8761.00
280_N284_V0.8731.00
101_F105_T0.8721.00
133_H199_H0.8711.00
21_V143_Y0.8691.00
29_Q33_N0.8681.00
261_A265_A0.8681.00
303_A307_L0.8641.00
157_T168_G0.8631.00
130_G142_A0.8621.00
134_T334_A0.8601.00
32_C38_V0.8601.00
293_Y297_T0.8581.00
145_T252_C0.8581.00
42_E51_R0.8571.00
349_N358_D0.8571.00
206_D337_M0.8551.00
29_Q69_H0.8551.00
149_A318_A0.8541.00
182_S189_Y0.8521.00
37_R374_Q0.8491.00
259_F283_R0.8431.00
97_L116_L0.8371.00
249_I307_L0.8351.00
26_F30_L0.8311.00
31_L184_I0.8291.00
261_A313_V0.8281.00
241_V250_T0.8271.00
88_I120_N0.8271.00
34_M182_S0.8261.00
249_I303_A0.8231.00
97_L106_M0.8231.00
219_Y225_S0.8201.00
295_E298_L0.8201.00
107_E114_E0.8201.00
68_N71_K0.8181.00
84_K110_G0.8181.00
74_V376_R0.8141.00
64_Y68_N0.8131.00
307_L311_H0.8121.00
19_T28_T0.8081.00
23_N128_S0.8051.00
129_S132_G0.8041.00
39_I375_I0.8011.00
115_T119_I0.7991.00
27_G98_A0.7971.00
366_A370_Q0.7941.00
329_L332_T0.7921.00
145_T250_T0.7901.00
358_D361_V0.7881.00
41_V76_L0.7871.00
159_Y163_P0.7851.00
124_I187_A0.7831.00
250_T318_A0.7831.00
245_Q305_V0.7831.00
332_T337_M0.7791.00
37_R378_E0.7781.00
88_I91_L0.7771.00
348_G352_K0.7731.00
114_E117_Q0.7731.00
159_Y165_V0.7731.00
150_M321_L0.7721.00
155_M322_S0.7681.00
112_S125_Y0.7671.00
302_A306_W0.7671.00
45_G75_V0.7631.00
147_I172_A0.7591.00
267_E309_R0.7591.00
331_Q335_R0.7591.00
249_I317_V0.7561.00
337_M352_K0.7561.00
311_H317_V0.7491.00
290_L294_I0.7491.00
75_V368_L0.7481.00
182_S186_S0.7471.00
14_L72_E0.7461.00
84_K109_L0.7451.00
105_T109_L0.7441.00
97_L125_Y0.7441.00
156_E212_L0.7431.00
89_N93_Q0.7391.00
126_A200_V0.7381.00
102_R105_T0.7371.00
277_F293_Y0.7351.00
22_L67_I0.7351.00
135_G331_Q0.7321.00
277_F290_L0.7271.00
40_K48_D0.7271.00
336_N352_K0.7271.00
198_A353_I0.7261.00
275_P278_S0.7261.00
201_D335_R0.7231.00
9_P356_C0.7221.00
99_E133_H0.7211.00
266_L294_I0.7191.00
216_L327_I0.7191.00
104_G107_E0.7140.99
291_K295_E0.7130.99
124_I189_Y0.7120.99
73_S369_D0.7120.99
292_Q295_E0.7080.99
296_R299_K0.7070.99
39_I94_A0.7070.99
237_A284_V0.7070.99
332_T338_L0.7060.99
104_G139_D0.7060.99
107_E127_S0.7050.99
354_S357_A0.7050.99
219_Y223_G0.7030.99
319_P325_E0.7020.99
245_Q300_T0.7020.99
281_I285_Q0.7010.99
178_V182_S0.6990.99
119_I122_R0.6970.99
146_I318_A0.6960.99
75_V369_D0.6920.99
288_A292_Q0.6920.99
149_A154_M0.6910.99
47_G368_L0.6900.99
209_L337_M0.6890.99
190_G193_K0.6880.99
75_V86_I0.6860.99
255_N258_L0.6860.99
202_I207_A0.6860.99
269_T272_V0.6860.99
216_L220_I0.6840.99
240_D295_E0.6840.99
241_V320_L0.6820.99
327_I338_L0.6810.99
134_T352_K0.6800.99
175_C178_V0.6780.99
113_W123_L0.6780.99
10_F13_L0.6770.99
159_Y240_D0.6770.99
83_D87_F0.6770.99
16_I97_L0.6730.99
76_L376_R0.6710.99
25_P173_D0.6690.99
85_S119_I0.6660.99
91_L111_F0.6650.99
102_R141_P0.6650.99
251_I298_L0.6610.99
153_I167_V0.6600.99
258_L316_P0.6590.99
30_L181_F0.6590.99
16_I93_Q0.6570.99
65_S365_A0.6570.99
114_E118_E0.6560.99
300_T306_W0.6560.99
153_I212_L0.6560.99
122_R194_S0.6550.99
232_R240_D0.6540.99
137_L331_Q0.6540.99
263_C269_T0.6530.99
26_F210_S0.6500.99
284_V287_Q0.6500.99
232_R291_K0.6490.99
20_H49_D0.6480.99
237_A291_K0.6470.99
122_R196_R0.6460.99
72_E363_P0.6440.99
175_C207_A0.6410.99
326_A332_T0.6410.99
172_A176_G0.6390.99
244_T306_W0.6380.99
150_M318_A0.6360.99
134_T335_R0.6350.99
163_P228_R0.6350.99
129_S201_D0.6340.99
150_M319_P0.6340.99
107_E199_H0.6330.99
17_D24_G0.6330.99
73_S368_L0.6310.99
9_P34_M0.6310.99
16_I90_M0.6290.99
70_G361_V0.6290.99
26_F174_L0.6290.99
282_L286_N0.6270.99
17_D71_K0.6240.99
132_G201_D0.6230.99
156_E323_V0.6230.99
13_L96_V0.6200.99
265_A315_V0.6190.99
180_L202_I0.6180.99
22_L170_S0.6180.99
145_T239_F0.6170.99
120_N123_L0.6170.99
83_D372_G0.6160.99
372_G375_I0.6140.98
33_N70_G0.6130.98
187_A200_V0.6120.98
114_E199_H0.6110.98
40_K47_G0.6110.98
17_D20_H0.6110.98
24_G98_A0.6090.98
251_I262_L0.6080.98
153_I208_T0.6080.98
31_L181_F0.6070.98
336_N339_I0.6070.98
220_I345_M0.6060.98
176_G207_A0.6060.98
78_L87_F0.6010.98
274_D277_F0.6010.98
88_I110_G0.6010.98
8_G356_C0.5980.98
60_Q65_S0.5960.98
251_I317_V0.5960.98
261_A314_G0.5950.98
99_E104_G0.5950.98
12_G193_K0.5940.98
246_D303_A0.5940.98
34_M353_I0.5930.98
96_V191_R0.5910.98
245_Q299_K0.5880.98
91_L94_A0.5860.98
99_E125_Y0.5840.98
186_S353_I0.5840.98
73_S370_Q0.5810.98
244_T298_L0.5800.98
205_F331_Q0.5790.98
28_T71_K0.5770.98
374_Q377_Q0.5770.98
353_I356_C0.5760.98
91_L97_L0.5760.98
28_T38_V0.5760.98
43_P75_V0.5750.98
141_P314_G0.5720.98
60_Q367_T0.5720.98
339_I346_M0.5680.98
107_E133_H0.5670.97
341_A361_V0.5670.97
353_I357_A0.5660.97
177_G181_F0.5650.97
180_L184_I0.5650.97
218_A235_Y0.5640.97
96_V185_V0.5630.97
103_P129_S0.5630.97
26_F177_G0.5600.97
21_V49_D0.5590.97
176_G204_M0.5590.97
113_W127_S0.5580.97
283_R286_N0.5570.97
18_M78_L0.5570.97
104_G108_K0.5560.97
337_M348_G0.5550.97
265_A312_E0.5530.97
56_Y59_G0.5500.97
264_Q273_N0.5480.97
237_A290_L0.5470.97
47_G51_R0.5460.97
353_I358_D0.5460.97
163_P243_N0.5450.97
39_I93_Q0.5450.97
237_A287_Q0.5450.97
12_G37_R0.5450.97
143_Y316_P0.5440.97
266_L269_T0.5440.97
246_D302_A0.5400.97
181_F186_S0.5390.97
363_P370_Q0.5390.97
112_S118_E0.5380.97
67_I174_L0.5370.97
27_G177_G0.5370.97
13_L191_R0.5350.96
132_G135_G0.5350.96
174_L213_E0.5340.96
167_V171_L0.5330.96
11_E193_K0.5330.96
151_S205_F0.5320.96
146_I316_P0.5320.96
43_P49_D0.5320.96
186_S189_Y0.5320.96
139_D311_H0.5310.96
39_I90_M0.5280.96
23_N176_G0.5280.96
117_Q125_Y0.5280.96
330_P333_Q0.5280.96
107_E115_T0.5270.96
342_G364_G0.5250.96
246_D304_E0.5250.96
82_H86_I0.5250.96
372_G377_Q0.5240.96
172_A204_M0.5240.96
200_V353_I0.5240.96
363_P374_Q0.5240.96
24_G128_S0.5210.96
294_I297_T0.5200.96
128_S176_G0.5190.96
157_T165_V0.5190.96
104_G112_S0.5180.96
143_Y255_N0.5170.96
339_I361_V0.5170.96
270_E293_Y0.5170.96
135_G138_K0.5150.96
42_E47_G0.5150.96
73_S371_H0.5150.96
325_E328_K0.5140.96
127_S133_H0.5130.95
48_D51_R0.5120.95
262_L310_I0.5120.95
306_W309_R0.5100.95
124_I188_L0.5070.95
216_L347_P0.5050.95
268_L296_R0.5040.95
42_E73_S0.5020.95
176_G202_I0.5020.95
75_V376_R0.5010.95
27_G128_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hl6A 2 0.9843 100 0.01 Contact Map
1q7eA 2 0.9633 100 0.02 Contact Map
4ed9A 2 0.979 100 0.021 Contact Map
3ubmA 2 0.979 100 0.028 Contact Map
2vjqA 2 0.979 100 0.029 Contact Map
1xk7A 2 0.9764 100 0.036 Contact Map
2yimA 2 0.9213 100 0.081 Contact Map
2g04A 2 0.9134 100 0.108 Contact Map
1vl6A 4 0.5407 87.3 0.956 Contact Map
3l07A 2 0.3543 82 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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