GREMLIN Database
MLAA - Probable phospholipid-binding lipoprotein MlaA
UniProt: P76506 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14276
Length: 251 (220)
Sequences: 1449 (1064)
Seq/√Len: 71.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_F39_M4.9301.00
131_H135_S3.3991.00
84_M100_F3.2261.00
48_D193_R2.9031.00
157_T218_F2.8211.00
88_F96_G2.7941.00
65_Q68_R2.6201.00
81_P103_F2.6201.00
220_R224_I2.5481.00
226_N231_K2.4041.00
178_W182_V2.3711.00
47_L152_F2.3691.00
33_E37_R2.3411.00
40_Y209_P2.3341.00
63_V67_A2.2931.00
111_M115_I2.2471.00
53_R57_V2.2301.00
70_G73_N2.2171.00
92_D227_G2.1261.00
142_V145_G2.0851.00
91_G139_H1.9931.00
144_Y222_D1.9891.00
134_G160_D1.9881.00
80_E103_F1.8951.00
108_I112_G1.8921.00
132_R135_S1.8921.00
137_L142_V1.8361.00
183_G187_L1.8321.00
86_N136_T1.8001.00
131_H227_G1.7671.00
87_Y99_H1.7471.00
226_N230_L1.7381.00
58_A61_D1.7291.00
44_F209_P1.6531.00
70_G114_F1.6521.00
109_L112_G1.6290.99
92_D131_H1.6140.99
55_V190_I1.6120.99
60_R68_R1.6010.99
42_F47_L1.5960.99
53_R200_D1.5930.99
57_V61_D1.5840.99
160_D221_H1.5540.99
11_G14_L1.5320.99
179_P183_G1.5230.99
83_V87_Y1.5150.99
105_L121_A1.5070.99
163_G167_D1.5040.99
77_N107_T1.5030.99
86_N133_F1.5010.99
76_G127_R1.5010.99
133_F167_D1.4750.99
135_S227_G1.4710.99
132_R221_H1.4620.99
80_E83_V1.4530.99
92_D139_H1.4360.99
72_S191_E1.4330.99
102_R116_D1.4150.98
135_S225_A1.4100.98
60_R198_D1.3910.98
197_L200_D1.3900.98
35_F38_T1.3850.98
32_L146_P1.3660.98
92_D95_Q1.3570.98
66_P70_G1.3430.98
201_G205_Q1.3190.98
43_N149_Q1.3170.98
74_F114_F1.3150.98
83_V99_H1.2980.97
226_N229_E1.2980.97
222_D226_N1.2950.97
200_D203_L1.2930.97
40_Y44_F1.2430.97
135_S139_H1.2390.96
40_Y149_Q1.2210.96
86_N167_D1.2180.96
150_L161_D1.2100.96
105_L109_L1.2000.96
56_A197_L1.1990.96
44_F49_P1.1900.96
87_Y129_E1.1830.95
39_M42_F1.1790.95
35_F148_V1.1710.95
70_G115_I1.1700.95
65_Q69_N1.1680.95
91_G140_Y1.1650.95
156_F160_D1.1620.95
134_G221_H1.1610.95
107_T112_G1.1610.95
150_L156_F1.1550.95
87_Y95_Q1.1470.95
138_G144_Y1.1440.94
137_L166_A1.1370.94
182_V186_T1.1360.94
93_P96_G1.1330.94
80_E99_H1.1310.94
67_A70_G1.1170.94
84_M99_H1.1090.93
34_G39_M1.1090.93
100_F104_F1.1010.93
68_R194_A1.0990.93
131_H225_A1.0950.93
101_T104_F1.0920.93
58_A62_Y1.0880.93
83_V129_E1.0850.93
99_H129_E1.0720.92
135_S228_G1.0690.92
115_I120_M1.0600.92
30_D36_N1.0590.92
84_M103_F1.0490.91
80_E84_M1.0470.91
102_R118_A1.0470.91
201_G204_R1.0420.91
191_E195_Q1.0410.91
84_M96_G1.0360.91
39_M43_N1.0290.91
212_M216_A1.0230.90
19_A22_G1.0130.90
146_P158_L1.0060.90
200_D204_R0.9880.89
98_V123_P0.9880.89
81_P85_V0.9750.88
142_V146_P0.9750.88
117_V120_M0.9700.88
21_S34_G0.9660.88
82_A170_Y0.9610.87
98_V129_E0.9590.87
18_C21_S0.9500.87
133_F137_L0.9450.86
34_G38_T0.9370.86
42_F152_F0.9360.86
162_G165_M0.9210.85
178_W181_S0.9160.85
75_T184_K0.9150.85
95_Q129_E0.9060.84
157_T225_A0.9000.84
85_V170_Y0.8950.83
47_L50_Y0.8940.83
185_W188_E0.8920.83
52_V189_G0.8900.83
105_L108_I0.8900.83
208_D219_Q0.8860.83
211_I214_R0.8810.82
188_E192_T0.8800.82
10_L13_T0.8790.82
215_E219_Q0.8790.82
96_G100_F0.8780.82
222_D225_A0.8760.82
227_G230_L0.8510.80
99_H123_P0.8460.80
83_V130_P0.8430.79
39_M149_Q0.8380.79
138_G225_A0.8370.79
54_P59_W0.8340.79
7_A10_L0.8120.77
71_L114_F0.8100.77
211_I215_E0.8070.76
56_A190_I0.8010.76
133_F166_A0.8010.76
74_F78_L0.7940.75
78_L214_R0.7880.75
143_G146_P0.7840.74
31_P146_P0.7830.74
92_D135_S0.7750.74
12_T15_L0.7700.73
55_V58_A0.7690.73
32_L148_V0.7680.73
71_L74_F0.7660.73
109_L121_A0.7640.72
86_N90_Q0.7630.72
32_L158_L0.7600.72
94_Y97_M0.7600.72
9_A13_T0.7600.72
185_W189_G0.7590.72
152_F189_G0.7580.72
38_T42_F0.7490.71
84_M87_Y0.7470.71
93_P97_M0.7460.71
9_A12_T0.7460.71
156_F161_D0.7390.70
116_D119_G0.7370.70
38_T41_N0.7360.70
16_V21_S0.7320.69
66_P118_A0.7320.69
197_L215_E0.7300.69
14_L17_G0.7300.69
104_F108_I0.7240.68
22_G26_Q0.7240.68
148_V161_D0.7210.68
32_L38_T0.7210.68
209_P213_V0.7150.67
109_L117_V0.7080.67
81_P209_P0.7080.67
202_L205_Q0.7070.67
142_V166_A0.7050.66
132_R160_D0.6990.66
94_Y98_V0.6990.66
9_A14_L0.6920.65
87_Y131_H0.6910.65
149_Q155_S0.6890.65
12_T16_V0.6890.65
50_Y66_P0.6880.64
72_S195_Q0.6870.64
208_D215_E0.6870.64
138_G159_R0.6860.64
48_D196_L0.6850.64
173_L176_L0.6840.64
91_G96_G0.6840.64
103_F107_T0.6810.64
111_M117_V0.6810.64
62_Y170_Y0.6790.63
69_N72_S0.6780.63
13_T16_V0.6750.63
144_Y157_T0.6740.63
131_H228_G0.6720.63
84_M95_Q0.6700.62
28_R218_F0.6690.62
190_I193_R0.6680.62
212_M215_E0.6640.62
202_L208_D0.6580.61
158_L161_D0.6580.61
228_G231_K0.6560.61
32_L35_F0.6550.61
47_L52_V0.6530.60
63_V138_G0.6530.60
186_T189_G0.6520.60
50_Y58_A0.6510.60
53_R197_L0.6510.60
90_Q131_H0.6490.60
189_G192_T0.6480.60
8_L11_G0.6470.60
97_M101_T0.6450.59
206_S209_P0.6440.59
166_A169_F0.6420.59
33_E147_Y0.6400.59
92_D228_G0.6390.59
15_L18_C0.6360.58
183_G186_T0.6350.58
60_R194_A0.6340.58
57_V197_L0.6330.58
134_G225_A0.6300.58
44_F56_A0.6290.58
101_T123_P0.6290.58
88_F91_G0.6280.57
14_L21_S0.6280.57
119_G122_N0.6250.57
192_T196_L0.6240.57
76_G195_Q0.6210.57
30_D214_R0.6200.56
200_D222_D0.6170.56
8_L13_T0.6160.56
30_D33_E0.6120.55
12_T25_Q0.6120.55
173_L184_K0.6090.55
99_H224_I0.6050.55
80_E127_R0.6020.54
58_A63_V0.6000.54
169_F172_V0.5960.54
74_F77_N0.5940.53
163_G166_A0.5910.53
9_A19_A0.5900.53
101_T105_L0.5870.52
58_A178_W0.5860.52
7_A14_L0.5850.52
89_L136_T0.5850.52
180_M183_G0.5830.52
202_L219_Q0.5820.52
216_A219_Q0.5810.52
83_V103_F0.5790.51
16_V24_D0.5790.51
158_L162_G0.5790.51
219_Q223_F0.5780.51
31_P36_N0.5780.51
203_L209_P0.5760.51
63_V68_R0.5760.51
202_L207_S0.5750.51
10_L16_V0.5730.51
138_G145_G0.5710.50
16_V19_A0.5700.50
51_I68_R0.5700.50
147_Y155_S0.5670.50
32_L140_Y0.5670.50
90_Q132_R0.5650.50
47_L153_Y0.5650.50
68_R195_Q0.5640.50
179_P182_V0.5640.50
98_V101_T0.5630.49
203_L206_S0.5610.49
90_Q135_S0.5570.49
56_A60_R0.5560.49
135_S138_G0.5540.48
7_A88_F0.5540.48
71_L187_L0.5530.48
117_V140_Y0.5530.48
18_C22_G0.5520.48
131_H139_H0.5490.48
187_L190_I0.5470.48
111_M120_M0.5460.47
198_D207_S0.5440.47
32_L138_G0.5440.47
70_G101_T0.5430.47
219_Q222_D0.5430.47
166_A170_Y0.5420.47
142_V163_G0.5340.46
159_R221_H0.5330.46
10_L17_G0.5330.46
196_L199_S0.5280.45
41_N152_F0.5270.45
203_L207_S0.5260.45
13_T21_S0.5230.45
74_F184_K0.5220.44
79_E171_P0.5210.44
193_R196_L0.5200.44
111_M114_F0.5190.44
35_F161_D0.5180.44
56_A187_L0.5180.44
81_P172_V0.5170.44
85_V89_L0.5170.44
213_V216_A0.5160.44
42_F90_Q0.5140.44
79_E83_V0.5130.43
15_L22_G0.5100.43
78_L103_F0.5090.43
55_V170_Y0.5080.43
44_F203_L0.5070.43
88_F95_Q0.5050.42
13_T22_G0.5050.42
100_F162_G0.5030.42
206_S215_E0.5030.42
32_L202_L0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.1076 62.5 0.954 Contact Map
4p47A 1 0.8327 13.4 0.968 Contact Map
4p8bA 1 0.8287 10.7 0.969 Contact Map
3nr5A 1 0.239 8.3 0.971 Contact Map
4aqnA 2 0.49 8.2 0.971 Contact Map
4nq8A 2 0.8207 8.1 0.971 Contact Map
4n8yA 1 0.8048 7.5 0.972 Contact Map
3un6A 1 0.7809 7.2 0.972 Contact Map
3sg0A 1 0.7092 7.2 0.972 Contact Map
4nf0A 2 0.7729 6.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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