GREMLIN Database
FADI - 3-ketoacyl-CoA thiolase
UniProt: P76503 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14128
Length: 436 (384)
Sequences: 11795 (6114)
Seq/√Len: 312.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_R212_R3.5501.00
201_Q355_Q3.4291.00
14_R287_E3.2291.00
289_R293_L3.2031.00
47_E50_A3.0531.00
207_H250_L2.7741.00
405_T417_G2.7691.00
13_D288_S2.7321.00
202_Q266_T2.6801.00
118_I121_G2.6661.00
106_V402_I2.6621.00
215_Q219_D2.6611.00
218_S246_G2.6381.00
208_R211_Q2.6221.00
287_E291_K2.6181.00
16_A290_A2.4471.00
289_R292_E2.4201.00
20_G403_T2.3901.00
21_L51_R2.3451.00
326_A432_V2.3421.00
299_G406_L2.3041.00
409_L414_G2.1831.00
41_G64_F2.1831.00
326_A330_A2.1491.00
223_K239_V2.1331.00
243_N274_P2.1151.00
48_L283_I2.0371.00
113_L284_L2.0281.00
217_W244_I2.0251.00
303_S330_A1.9951.00
332_L416_F1.9901.00
193_K262_R1.9881.00
208_R378_D1.9851.00
339_L383_V1.9771.00
45_V122_I1.9731.00
298_L410_R1.9701.00
300_Y434_E1.9301.00
214_A244_I1.9211.00
310_D313_Q1.9101.00
43_M229_A1.9031.00
338_T414_G1.8801.00
214_A218_S1.8541.00
194_T314_D1.8411.00
109_V121_G1.8361.00
323_T420_T1.8321.00
200_E204_A1.8221.00
354_I378_D1.8111.00
58_V293_L1.8101.00
253_Y270_A1.7941.00
303_S326_A1.7931.00
198_T201_Q1.7791.00
45_V80_I1.7791.00
113_L286_T1.7641.00
64_F124_G1.7541.00
280_A399_A1.7371.00
93_Y108_N1.7211.00
230_F237_P1.7051.00
55_P58_V1.6811.00
120_A285_M1.6781.00
31_A238_L1.6781.00
334_M340_I1.6731.00
223_K240_E1.6551.00
285_M290_A1.6411.00
221_K384_L1.6301.00
217_W226_V1.6291.00
14_R300_Y1.6271.00
39_D83_G1.6261.00
18_V285_M1.6181.00
384_L408_E1.6141.00
408_E412_R1.6081.00
282_V399_A1.5971.00
252_D255_K1.5941.00
207_H211_Q1.5921.00
47_E227_M1.5781.00
43_M227_M1.5701.00
332_L432_V1.5671.00
128_S131_V1.5671.00
185_G260_F1.5631.00
337_L432_V1.5591.00
285_M289_R1.5531.00
224_E410_R1.5451.00
41_G80_I1.5421.00
233_P237_P1.5321.00
354_I381_F1.5181.00
332_L337_L1.5151.00
201_Q204_A1.5121.00
217_W240_E1.5111.00
204_A208_R1.5111.00
76_I126_A1.5111.00
339_L408_E1.4971.00
302_R434_E1.4811.00
324_P328_E1.4791.00
337_L340_I1.4761.00
377_D380_K1.4741.00
88_V310_D1.4691.00
211_Q215_Q1.4641.00
19_S52_S1.4611.00
402_I433_L1.4521.00
119_R286_T1.4481.00
107_A431_M1.4461.00
32_F238_L1.4441.00
46_G50_A1.4391.00
119_R289_R1.4311.00
112_S118_I1.4301.00
408_E411_R1.4091.00
135_G168_L1.4061.00
322_S430_A1.4031.00
340_I418_L1.3931.00
233_P236_Q1.3861.00
324_P356_L1.3841.00
286_T289_R1.3811.00
418_L432_V1.3701.00
415_G434_E1.3681.00
48_L52_S1.3641.00
100_A429_A1.3631.00
307_T321_W1.3561.00
109_V284_L1.3401.00
214_A247_N1.3371.00
221_K408_E1.3351.00
47_E51_R1.3301.00
44_V281_A1.3261.00
305_A325_L1.3171.00
42_K83_G1.3121.00
197_I202_Q1.3081.00
323_T418_L1.3001.00
321_W324_P1.2951.00
64_F281_A1.2951.00
337_L416_F1.2891.00
45_V86_M1.2731.00
25_F396_A1.2671.00
13_D286_T1.2571.00
211_Q247_N1.2561.00
106_V282_V1.2551.00
309_I317_L1.2451.00
221_K411_R1.2411.00
317_L320_A1.2401.00
25_F390_Y1.2371.00
339_L412_R1.2331.00
197_I351_L1.2321.00
204_A250_L1.2231.00
100_A423_A1.2191.00
21_L227_M1.2031.00
288_S292_E1.1941.00
107_A304_Y1.1931.00
111_E117_T1.1861.00
19_S48_L1.1801.00
325_L328_E1.1801.00
194_T313_Q1.1781.00
224_E411_R1.1731.00
383_V408_E1.1571.00
195_Y317_L1.1571.00
214_A246_G1.1571.00
66_Q69_Q1.1551.00
49_L86_M1.1541.00
103_F402_I1.1511.00
225_E404_Q1.1491.00
403_T407_H1.1441.00
16_A285_M1.1351.00
60_E118_I1.1261.00
305_A326_A1.1251.00
24_P238_L1.1241.00
302_R416_F1.1201.00
334_M337_L1.1151.00
314_D317_L1.1111.00
58_V289_R1.1111.00
330_A432_V1.1031.00
23_T44_V1.1011.00
333_T336_D1.0971.00
120_A289_R1.0931.00
224_E407_H1.0921.00
59_I120_A1.0901.00
62_L81_V1.0901.00
20_G407_H1.0841.00
301_L431_M1.0811.00
185_G259_A1.0801.00
405_T419_V1.0751.00
400_R404_Q1.0691.00
195_Y356_L1.0651.00
338_T380_K1.0651.00
17_I433_L1.0611.00
298_L406_L1.0601.00
205_L350_T1.0591.00
44_V47_E1.0561.00
208_R379_S1.0521.00
44_V279_A1.0511.00
416_F434_E1.0511.00
337_L418_L1.0501.00
213_A244_I1.0501.00
29_A141_A1.0481.00
383_V412_R1.0401.00
109_V123_A1.0361.00
16_A300_Y1.0351.00
117_T329_R1.0331.00
15_I284_L1.0321.00
104_Q108_N1.0271.00
27_R243_N1.0241.00
25_F276_T1.0231.00
192_A348_A1.0221.00
63_V105_A1.0181.00
26_A242_N1.0151.00
82_L88_V1.0101.00
280_A396_A1.0101.00
320_A356_L1.0101.00
114_M117_T1.0021.00
401_M419_V1.0011.00
384_L411_R0.9961.00
317_L352_A0.9951.00
338_T409_L0.9941.00
191_M317_L0.9931.00
122_I283_I0.9911.00
186_D262_R0.9821.00
191_M352_A0.9771.00
43_M47_E0.9741.00
207_H247_N0.9661.00
324_P357_L0.9651.00
287_E300_Y0.9641.00
60_E119_R0.9641.00
342_M420_T0.9621.00
13_D119_R0.9611.00
376_V381_F0.9591.00
248_S253_Y0.9531.00
189_E262_R0.9501.00
307_T325_L0.9471.00
58_V292_E0.9461.00
18_V295_L0.9441.00
86_M90_T0.9421.00
203_D271_N0.9401.00
339_L405_T0.9381.00
16_A287_E0.9381.00
212_R378_D0.9361.00
402_I431_M0.9351.00
63_V109_V0.9301.00
36_P39_D0.9251.00
296_V410_R0.9221.00
309_I318_G0.9201.00
285_M295_L0.9201.00
166_R169_M0.9201.00
250_L254_A0.9201.00
406_L410_R0.9101.00
63_V121_G0.9051.00
21_L47_E0.9051.00
111_E115_A0.9041.00
72_E131_V0.9031.00
416_F432_V0.9031.00
387_S397_T0.9021.00
106_V284_L0.8981.00
406_L433_L0.8931.00
215_Q221_K0.8901.00
317_L356_L0.8881.00
42_K46_G0.8851.00
347_A388_I0.8841.00
189_E193_K0.8831.00
170_P183_R0.8831.00
303_S432_V0.8811.00
232_P237_P0.8801.00
423_A429_A0.8801.00
15_I114_M0.8771.00
58_V120_A0.8751.00
303_S329_R0.8741.00
35_I43_M0.8731.00
217_W246_G0.8721.00
64_F77_A0.8721.00
123_A282_V0.8691.00
215_Q218_S0.8671.00
176_A181_G0.8671.00
23_T43_M0.8661.00
323_T430_A0.8661.00
256_L270_A0.8661.00
211_Q214_A0.8651.00
45_V62_L0.8591.00
48_L122_I0.8571.00
117_T304_Y0.8501.00
39_D42_K0.8491.00
103_F419_V0.8491.00
107_A429_A0.8471.00
49_L54_I0.8461.00
20_G282_V0.8411.00
309_I321_W0.8401.00
325_L329_R0.8401.00
65_G101_T0.8381.00
310_D314_D0.8381.00
103_F431_M0.8371.00
15_I286_T0.8361.00
105_A399_A0.8331.00
119_R329_R0.8321.00
217_W223_K0.8321.00
219_D411_R0.8321.00
298_L407_H0.8281.00
340_I376_V0.8201.00
95_V108_N0.8191.00
19_S51_R0.8161.00
288_S291_K0.8161.00
110_A301_L0.8151.00
63_V93_Y0.8151.00
207_H252_D0.8091.00
210_H243_N0.8071.00
327_L334_M0.8041.00
306_F429_A0.8021.00
38_V72_E0.7991.00
43_M46_G0.7991.00
35_I131_V0.7971.00
354_I376_V0.7941.00
384_L412_R0.7931.00
350_T354_I0.7911.00
213_A217_W0.7891.00
218_S240_E0.7871.00
187_T315_M0.7871.00
60_E325_L0.7821.00
338_T416_F0.7801.00
61_Q97_R0.7801.00
183_R186_D0.7781.00
35_I128_S0.7771.00
204_A378_D0.7740.99
97_R306_F0.7720.99
201_Q351_L0.7700.99
212_R215_Q0.7690.99
231_I238_L0.7660.99
93_Y104_Q0.7650.99
24_P43_M0.7630.99
46_G85_G0.7580.99
338_T415_G0.7580.99
335_S380_K0.7540.99
170_P176_A0.7530.99
136_V165_L0.7520.99
56_A87_N0.7520.99
106_V123_A0.7520.99
66_Q76_I0.7510.99
195_Y314_D0.7510.99
280_A403_T0.7500.99
134_I139_K0.7480.99
69_Q94_S0.7470.99
37_A126_A0.7450.99
409_L417_G0.7440.99
36_P131_V0.7440.99
23_T229_A0.7430.99
188_A267_V0.7420.99
66_Q72_E0.7410.99
59_I86_M0.7410.99
64_F80_I0.7390.99
61_Q306_F0.7380.99
86_M122_I0.7350.99
57_E89_H0.7350.99
111_E114_M0.7340.99
31_A242_N0.7290.99
14_R114_M0.7250.99
247_N252_D0.7240.99
267_V272_S0.7240.99
46_G56_A0.7210.99
323_T342_M0.7200.99
342_M353_N0.7190.99
15_I110_A0.7190.99
18_V290_A0.7180.99
59_I122_I0.7160.99
326_A418_L0.7150.99
282_V403_T0.7140.99
213_A390_Y0.7140.99
108_N111_E0.7130.99
189_E265_G0.7120.99
335_S358_G0.7120.99
68_V132_L0.7110.99
205_L351_L0.7090.99
332_L336_D0.7070.99
323_T357_L0.7060.99
234_Y237_P0.7050.99
340_I420_T0.7040.99
122_I281_A0.6980.99
75_N427_L0.6980.99
213_A389_A0.6980.99
287_E290_A0.6970.99
160_F169_M0.6960.99
207_H248_S0.6940.99
46_G84_T0.6940.99
195_Y352_A0.6910.99
49_L56_A0.6900.99
210_H244_I0.6880.99
112_S117_T0.6860.99
42_K84_T0.6850.99
402_I419_V0.6840.99
129_S394_F0.6840.99
248_S252_D0.6820.99
108_N112_S0.6810.99
91_D306_F0.6810.99
97_R104_Q0.6810.99
71_P135_G0.6810.99
24_P239_V0.6790.99
81_V92_A0.6780.99
20_G406_L0.6760.99
21_L48_L0.6760.99
220_G223_K0.6750.99
320_A324_P0.6720.99
162_R166_R0.6710.99
189_E267_V0.6710.99
166_R172_P0.6690.99
182_L313_Q0.6680.98
120_A293_L0.6680.98
40_L229_A0.6680.98
352_A356_L0.6680.98
103_F429_A0.6640.98
44_V48_L0.6640.98
207_H249_S0.6630.98
17_I284_L0.6630.98
197_I355_Q0.6600.98
175_V179_S0.6600.98
33_H141_A0.6590.98
81_V86_M0.6580.98
63_V108_N0.6560.98
60_E121_G0.6560.98
109_V118_I0.6550.98
302_R330_A0.6530.98
19_S298_L0.6510.98
78_R82_L0.6510.98
231_I236_Q0.6490.98
25_F400_R0.6480.98
397_T419_V0.6470.98
167_D170_P0.6440.98
67_V98_A0.6430.98
182_L186_D0.6420.98
423_A427_L0.6420.98
221_K412_R0.6420.98
52_S283_I0.6420.98
396_A399_A0.6410.98
302_R332_L0.6400.98
210_H214_A0.6400.98
34_G131_V0.6380.98
182_L190_Q0.6370.98
62_L86_M0.6370.98
49_L59_I0.6370.98
351_L355_Q0.6360.98
358_G377_D0.6360.98
323_T353_N0.6350.98
301_L304_Y0.6330.98
119_R292_E0.6320.98
104_Q107_A0.6320.98
339_L414_G0.6310.98
192_A266_T0.6280.98
160_F170_P0.6280.98
21_L52_S0.6280.98
16_A293_L0.6270.98
225_E407_H0.6250.98
80_I126_A0.6230.98
24_P240_E0.6230.98
29_A130_S0.6230.98
13_D114_M0.6230.98
188_A348_A0.6220.98
206_A253_Y0.6220.98
417_G433_L0.6200.98
35_I39_D0.6200.98
194_T317_L0.6200.98
45_V281_A0.6200.98
134_I138_K0.6190.98
207_H253_Y0.6180.98
164_R167_D0.6170.97
222_L390_Y0.6140.97
67_V394_F0.6120.97
24_P226_V0.6120.97
104_Q112_S0.6110.97
350_T381_F0.6110.97
62_L90_T0.6060.97
342_M350_T0.6060.97
41_G124_G0.6060.97
397_T401_M0.6050.97
336_D416_F0.6040.97
49_L53_E0.6040.97
21_L44_V0.6030.97
200_E250_L0.6020.97
188_A192_A0.6000.97
114_M304_Y0.5990.97
378_D381_F0.5980.97
327_L330_A0.5920.97
205_L386_G0.5920.97
186_D190_Q0.5910.97
26_A32_F0.5890.97
326_A337_L0.5870.97
45_V64_F0.5870.97
262_R265_G0.5860.97
62_L122_I0.5850.97
287_E297_P0.5850.97
161_S167_D0.5840.97
45_V49_L0.5840.97
104_Q306_F0.5840.97
112_S121_G0.5840.97
191_M348_A0.5790.96
249_S252_D0.5790.96
75_N98_A0.5780.96
21_L24_P0.5780.96
23_T40_L0.5760.96
163_L167_D0.5760.96
410_R413_G0.5750.96
357_L376_V0.5750.96
243_N276_T0.5740.96
41_G126_A0.5710.96
240_E246_G0.5710.96
17_I406_L0.5710.96
284_L301_L0.5700.96
334_M376_V0.5690.96
137_S166_R0.5690.96
110_A114_M0.5680.96
48_L281_A0.5680.96
301_L433_L0.5680.96
390_Y404_Q0.5680.96
26_A238_L0.5670.96
231_I234_Y0.5660.96
413_G416_F0.5660.96
61_Q112_S0.5660.96
124_G281_A0.5650.96
165_L169_M0.5620.96
309_I314_D0.5610.96
323_T334_M0.5570.95
189_E260_F0.5570.95
340_I380_K0.5560.95
230_F233_P0.5550.95
342_M354_I0.5530.95
77_A94_S0.5530.95
193_K264_H0.5530.95
49_L52_S0.5530.95
194_T310_D0.5520.95
43_M230_F0.5510.95
240_E244_I0.5510.95
104_Q111_E0.5510.95
54_I283_I0.5500.95
211_Q250_L0.5500.95
302_R432_V0.5490.95
290_A293_L0.5470.95
52_S56_A0.5460.95
228_T239_V0.5460.95
403_T406_L0.5450.95
187_T316_L0.5450.95
15_I113_L0.5430.95
349_Q353_N0.5430.95
80_I84_T0.5420.95
38_V83_G0.5420.95
199_R203_D0.5400.95
324_P358_G0.5390.95
407_H411_R0.5350.94
409_L433_L0.5340.94
35_I229_A0.5330.94
204_A254_A0.5320.94
63_V95_V0.5320.94
204_A211_Q0.5320.94
319_P422_C0.5310.94
32_F35_I0.5310.94
328_E333_T0.5310.94
16_A286_T0.5260.94
202_Q267_V0.5250.94
61_Q104_Q0.5240.94
185_G265_G0.5230.94
51_R407_H0.5210.94
206_A271_N0.5200.93
286_T290_A0.5200.93
190_Q194_T0.5190.93
299_G433_L0.5190.93
15_I18_V0.5180.93
37_A44_V0.5170.93
212_R381_F0.5160.93
214_A217_W0.5150.93
174_A394_F0.5130.93
44_V64_F0.5120.93
320_A353_N0.5110.93
401_M421_A0.5110.93
200_E254_A0.5110.93
139_K163_L0.5100.93
399_A403_T0.5100.93
35_I40_L0.5100.93
419_V433_L0.5080.93
259_A269_A0.5060.93
76_I80_I0.5060.93
290_A297_P0.5060.93
191_M316_L0.5050.92
160_F183_R0.5050.92
37_A131_V0.5020.92
103_F421_A0.5020.92
396_A400_R0.5020.92
28_Q275_L0.5020.92
35_I232_P0.5010.92
66_Q94_S0.5010.92
38_V42_K0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wu9A 2 0.8761 100 0.369 Contact Map
3ss6A 4 0.8991 100 0.388 Contact Map
2vu1A 4 0.8945 100 0.389 Contact Map
1wl4A 4 0.8945 100 0.392 Contact Map
4c2jA 4 0.8968 100 0.398 Contact Map
4o9aA 4 0.8922 100 0.399 Contact Map
4n46A 4 0.8945 100 0.4 Contact Map
2iikA 2 0.8876 100 0.4 Contact Map
4e1lA 4 0.883 100 0.403 Contact Map
2ib8A 4 0.8968 100 0.403 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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