GREMLIN Database
SIXA - Phosphohistidine phosphatase SixA
UniProt: P76502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14126
Length: 161 (138)
Sequences: 10374 (7601)
Seq/√Len: 647.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_C58_Q3.1981.00
2_Q102_S2.6651.00
2_Q135_S2.6221.00
10_D26_N2.5571.00
6_M34_M2.4071.00
6_M63_V2.2871.00
10_D24_T2.2721.00
28_C62_E2.2431.00
2_Q137_T2.1931.00
12_A24_T2.1391.00
32_R62_E2.0391.00
107_S111_L2.0201.00
22_P54_L1.9481.00
4_F45_I1.9401.00
84_D89_S1.9331.00
48_V64_G1.9001.00
58_Q61_E1.8851.00
22_P58_Q1.8511.00
36_N66_C1.8291.00
45_I104_L1.8151.00
4_F102_S1.7701.00
6_M104_L1.7631.00
48_V60_L1.7481.00
46_E101_A1.7111.00
85_V111_L1.6671.00
28_C32_R1.5901.00
29_D32_R1.5871.00
138_L144_G1.5861.00
57_E61_E1.5751.00
107_S112_V1.5591.00
46_E102_S1.5561.00
29_D33_L1.5491.00
31_S59_T1.5041.00
26_N30_E1.4921.00
25_T28_C1.4851.00
84_D91_Y1.4181.00
86_G118_E1.4091.00
18_D52_P1.3901.00
74_E79_L1.3671.00
128_F134_A1.3521.00
75_V78_E1.3411.00
5_I112_V1.3321.00
84_D87_L1.2901.00
83_G87_L1.2851.00
84_D88_V1.2831.00
36_N39_K1.2771.00
112_V128_F1.2461.00
26_N29_D1.2451.00
63_V106_I1.2081.00
45_I102_S1.2031.00
50_V57_E1.1951.00
4_F135_S1.1911.00
32_R66_C1.1881.00
32_R65_D1.1701.00
62_E65_D1.1391.00
86_G90_A1.1331.00
50_V60_L1.1311.00
120_C136_V1.1221.00
47_R101_A1.1201.00
35_A62_E1.1011.00
20_V54_L1.0981.00
25_T29_D1.0971.00
54_L58_Q1.0911.00
84_D93_Q1.0691.00
31_S131_S1.0591.00
11_A130_T1.0561.00
37_W41_Q1.0271.00
33_L36_N1.0221.00
83_G86_G1.0171.00
83_G89_S1.0161.00
47_R103_V1.0161.00
60_L64_G1.0141.00
75_V79_L1.0141.00
116_V134_A1.0021.00
4_F133_I0.9861.00
139_D143_N0.9671.00
49_L98_E0.9631.00
77_P80_T0.9551.00
137_T145_T0.9541.00
76_L79_L0.9531.00
17_S20_V0.9511.00
5_I115_L0.9401.00
61_E65_D0.9391.00
21_R24_T0.9371.00
56_A108_H0.9351.00
39_K66_C0.9321.00
88_V92_L0.9281.00
60_L106_I0.9211.00
129_T132_A0.9191.00
41_Q44_E0.9181.00
10_D30_E0.9151.00
94_A97_N0.9121.00
13_L16_A0.9101.00
11_A24_T0.8891.00
98_E101_A0.8611.00
85_V88_V0.8611.00
4_F41_Q0.8551.00
87_L91_Y0.8541.00
16_A21_R0.8521.00
78_E83_G0.8511.00
58_Q62_E0.8481.00
62_E66_C0.8281.00
51_S108_H0.8271.00
49_L103_V0.8271.00
90_A93_Q0.8261.00
64_G67_L0.8241.00
44_E102_S0.8231.00
87_L90_A0.8221.00
69_L78_E0.8211.00
23_L31_S0.8201.00
50_V56_A0.8061.00
128_F132_A0.8041.00
136_V144_G0.8031.00
89_S93_Q0.8031.00
88_V91_Y0.7841.00
34_M133_I0.7811.00
12_A22_P0.7611.00
74_E78_E0.7611.00
11_A16_A0.7591.00
37_W133_I0.7541.00
30_E130_T0.7541.00
91_Y94_A0.7531.00
113_G117_A0.7491.00
109_L113_G0.7391.00
88_V93_Q0.7351.00
140_E143_N0.7321.00
54_L57_E0.7311.00
116_V120_C0.7311.00
31_S35_A0.7281.00
24_T27_G0.7281.00
51_S56_A0.7221.00
47_R98_E0.7031.00
76_L80_T0.7021.00
35_A66_C0.6951.00
124_T127_M0.6951.00
9_G23_L0.6901.00
27_G31_S0.6871.00
73_A79_L0.6871.00
6_M106_I0.6861.00
16_A130_T0.6861.00
56_A60_L0.6841.00
92_L105_V0.6821.00
48_V104_L0.6701.00
6_M133_I0.6651.00
4_F38_L0.6651.00
116_V136_V0.6611.00
18_D53_F0.6581.00
100_V103_V0.6551.00
90_A94_A0.6521.00
117_A122_G0.6511.00
19_S52_P0.6441.00
45_I67_L0.6371.00
44_E67_L0.6361.00
74_E80_T0.6301.00
73_A78_E0.6301.00
14_D17_S0.6261.00
22_P28_C0.6251.00
88_V105_V0.6191.00
32_R36_N0.6181.00
75_V80_T0.6151.00
49_L92_L0.6021.00
35_A67_L0.6011.00
73_A80_T0.6011.00
120_C123_E0.5981.00
17_S53_F0.5971.00
73_A76_L0.5921.00
139_D145_T0.5901.00
35_A39_K0.5881.00
85_V118_E0.5881.00
87_L92_L0.5871.00
30_E33_L0.5831.00
11_A21_R0.5811.00
14_D21_R0.5791.00
74_E84_D0.5771.00
80_T114_Y0.5771.00
18_D21_R0.5761.00
70_P73_A0.5711.00
83_G91_Y0.5701.00
37_W40_G0.5691.00
10_D130_T0.5671.00
56_A106_I0.5641.00
41_Q45_I0.5621.00
53_F56_A0.5561.00
80_T118_E0.5541.00
49_L88_V0.5531.00
41_Q135_S0.5531.00
97_N100_V0.5511.00
79_L111_L0.5511.00
38_L45_I0.5501.00
12_A21_R0.5491.00
98_E103_V0.5471.00
35_A63_V0.5461.00
5_I105_V0.5421.00
21_R110_P0.5411.00
85_V115_L0.5401.00
89_S92_L0.5330.99
36_N40_G0.5310.99
74_E77_P0.5250.99
32_R35_A0.5240.99
52_P110_P0.5240.99
41_Q67_L0.5240.99
31_S62_E0.5200.99
61_E64_G0.5170.99
94_A98_E0.5150.99
31_S63_V0.5110.99
80_T86_G0.5020.99
120_C126_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r7aA 1 0.9565 100 0.219 Contact Map
1e58A 2 0.9814 100 0.228 Contact Map
1h2eA 1 0.9565 100 0.229 Contact Map
3kkkA 3 0.9193 100 0.237 Contact Map
4embA 2 0.9876 100 0.238 Contact Map
1ujcA 1 0.9503 100 0.239 Contact Map
2yn2A 1 0.9814 100 0.24 Contact Map
2a6pA 2 0.9255 100 0.241 Contact Map
4gpzA 2 0.9689 100 0.241 Contact Map
4ij5A 2 0.9565 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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