GREMLIN Database
5DNU - 5'-deoxynucleotidase YfbR
UniProt: P76491 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14102
Length: 199 (165)
Sequences: 2113 (1496)
Seq/√Len: 116.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_L115_I4.0981.00
102_Q117_A3.3721.00
74_L103_K3.0161.00
29_N32_E2.6111.00
10_L70_A2.5051.00
37_V65_A2.3861.00
117_A121_D2.2561.00
172_S175_M2.2441.00
98_K121_D2.1921.00
36_Q147_E2.1521.00
59_E63_L2.0471.00
58_A62_A2.0401.00
95_A99_I1.9951.00
157_L161_T1.8941.00
41_A65_A1.8861.00
71_S101_Q1.8751.00
13_L30_V1.8701.00
40_V136_A1.8251.00
67_Y116_F1.7921.00
10_L39_M1.7661.00
54_G128_E1.7501.00
37_V136_A1.7341.00
61_I129_E1.7331.00
114_D118_P1.7291.00
57_N129_E1.7221.00
171_R176_D1.7111.00
98_K102_Q1.5841.00
36_Q140_C1.5681.00
88_Q91_Q1.5621.00
125_Y134_K1.5501.00
86_N89_I1.5151.00
11_S36_Q1.5071.00
21_L148_E1.5041.00
42_H63_L1.4821.00
6_F108_V1.4661.00
68_H72_E1.4651.00
17_N27_T1.4521.00
60_R64_L1.4281.00
59_E62_A1.4201.00
122_E127_D1.4101.00
100_A104_L1.3971.00
131_S171_R1.3851.00
7_F40_V1.3651.00
161_T165_A1.3511.00
41_A136_A1.3501.00
9_H74_L1.3421.00
35_L66_M1.3311.00
110_E114_D1.3291.00
94_K98_K1.3291.00
158_L161_T1.3251.00
57_N60_R1.3221.00
60_R129_E1.3191.00
173_Q178_F1.3151.00
160_K164_E1.3141.00
74_L104_L1.3021.00
55_N128_E1.2830.99
45_A61_I1.2810.99
34_S37_V1.2760.99
123_H133_V1.2720.99
7_F43_A1.2700.99
165_A168_E1.2640.99
19_W156_F1.2610.99
110_E113_R1.2580.99
33_H68_H1.2510.99
118_P121_D1.2500.99
69_D72_E1.2350.99
92_E96_I1.2200.99
173_Q176_D1.2180.99
21_L144_K1.1960.99
9_H12_R1.1920.99
41_A61_I1.1920.99
40_V140_C1.1830.99
45_A58_A1.1760.99
140_C144_K1.1610.99
67_Y119_L1.1460.99
33_H72_E1.1340.99
92_E95_A1.1250.99
125_Y130_K1.1210.99
145_C153_N1.1140.99
44_L61_I1.0980.98
21_L25_V1.0930.98
97_E100_A1.0900.98
90_A93_Y1.0740.98
20_P148_E1.0680.98
175_M178_F1.0530.98
65_A133_V1.0460.98
128_E132_L1.0420.98
16_I30_V1.0340.98
64_L130_K1.0300.98
33_H69_D1.0250.98
150_A153_N1.0200.97
101_Q105_V1.0160.97
68_H97_E1.0120.97
119_L130_K1.0040.97
73_V104_L0.9980.97
35_L39_M0.9960.97
138_A166_T0.9760.97
144_K148_E0.9660.96
167_L170_R0.9620.96
156_F159_A0.9490.96
149_L160_K0.9460.96
174_E178_F0.9420.96
152_G156_F0.9330.96
40_V139_L0.9320.96
68_H137_D0.9310.96
114_D117_A0.9280.96
26_R32_E0.9260.95
172_S176_D0.9250.95
171_R175_M0.9170.95
89_I92_E0.9090.95
38_A66_M0.9050.95
56_V61_I0.8960.95
41_A58_A0.8950.95
145_C148_E0.8920.94
5_H10_L0.8850.94
123_H127_D0.8770.94
19_W79_P0.8740.94
171_R178_F0.8740.94
100_A103_K0.8740.94
13_L34_S0.8690.94
33_H137_D0.8610.93
64_L122_E0.8600.93
39_M66_M0.8500.93
14_K28_E0.8330.92
64_L129_E0.8220.92
45_A132_L0.8170.91
33_H97_E0.8120.91
170_R173_Q0.8110.91
93_Y134_K0.8070.91
102_Q121_D0.8070.91
71_S97_E0.8060.91
64_L67_Y0.8040.91
156_F167_L0.8030.91
21_L27_T0.8000.91
69_D137_D0.7930.90
72_E137_D0.7860.90
42_H62_A0.7830.90
122_E126_S0.7750.89
29_N140_C0.7750.89
56_V132_L0.7750.89
171_R174_E0.7700.89
165_A169_A0.7690.89
31_S35_L0.7670.89
111_E177_Y0.7650.89
135_Q172_S0.7610.88
14_K31_S0.7530.88
91_Q94_K0.7460.87
105_V117_A0.7420.87
81_P141_A0.7350.86
61_I133_V0.7350.86
86_N96_I0.7330.86
78_L93_Y0.7320.86
106_D113_R0.7290.86
41_A62_A0.7240.86
164_E168_E0.7130.85
113_R116_F0.7050.84
116_F156_F0.7050.84
89_I93_Y0.7030.84
148_E151_A0.7020.84
102_Q114_D0.6970.83
39_M67_Y0.6940.83
100_A105_V0.6880.83
11_S147_E0.6860.82
163_L166_T0.6860.82
61_I64_L0.6840.82
12_R15_L0.6830.82
44_L136_A0.6820.82
28_E72_E0.6820.82
60_R118_P0.6790.82
17_N20_P0.6740.81
69_D97_E0.6680.81
63_L67_Y0.6670.81
146_L150_A0.6640.80
29_N116_F0.6630.80
30_V34_S0.6570.80
169_A172_S0.6530.79
128_E131_S0.6520.79
72_E97_E0.6500.79
10_L66_M0.6450.78
23_R70_A0.6380.78
6_F100_A0.6350.77
162_R165_A0.6320.77
61_I65_A0.6310.77
67_Y108_V0.6310.77
23_R144_K0.6270.76
103_K107_M0.6250.76
113_R117_A0.6150.75
19_W22_M0.6130.75
34_S38_A0.6130.75
16_I29_N0.6100.75
127_D130_K0.6090.74
30_V72_E0.6020.74
174_E177_Y0.6010.73
64_L127_D0.5980.73
123_H130_K0.5940.73
105_V113_R0.5920.72
114_D126_S0.5920.72
93_Y96_I0.5920.72
101_Q104_L0.5800.71
42_H67_Y0.5770.70
134_K138_A0.5770.70
80_T96_I0.5750.70
157_L168_E0.5750.70
72_E76_G0.5730.70
161_T164_E0.5720.70
31_S36_Q0.5650.69
145_C150_A0.5640.69
98_K101_Q0.5630.69
34_S69_D0.5620.68
164_E167_L0.5610.68
79_P86_N0.5520.67
55_N114_D0.5520.67
78_L96_I0.5460.66
113_R118_P0.5450.66
74_L107_M0.5440.66
28_E33_H0.5440.66
79_P134_K0.5430.66
30_V69_D0.5400.65
20_P143_L0.5400.65
159_A162_R0.5390.65
62_A65_A0.5380.65
69_D76_G0.5360.65
32_E140_C0.5340.65
91_Q95_A0.5330.64
114_D131_S0.5310.64
15_L22_M0.5280.64
21_L156_F0.5240.63
33_H76_G0.5220.63
163_L167_L0.5200.62
44_L132_L0.5200.62
148_E152_G0.5190.62
162_R166_T0.5190.62
15_L29_N0.5180.62
75_T81_P0.5180.62
148_E153_N0.5180.62
74_L100_A0.5140.62
122_E130_K0.5140.62
120_I124_A0.5140.62
97_E137_D0.5120.61
166_T169_A0.5120.61
75_T80_T0.5110.61
96_I115_I0.5090.61
145_C156_F0.5090.61
22_M25_V0.5070.61
53_G56_V0.5070.61
6_F10_L0.5010.60
63_L142_Y0.5010.60
110_E165_A0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2paqA 5 0.8894 100 0.23 Contact Map
3mzoA 5 0.9849 100 0.249 Contact Map
3kh1A 2 0.9095 100 0.314 Contact Map
4l1jA 2 0.9095 100 0.323 Contact Map
1xx7A 5 0.8492 100 0.329 Contact Map
1ynbA 5 0.809 100 0.366 Contact Map
2cqzA 5 0.8442 100 0.398 Contact Map
2gz4A 2 0.8744 99.9 0.471 Contact Map
2qgsA 2 0.8794 97.5 0.839 Contact Map
3b57A 2 0.794 97.3 0.844 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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