GREMLIN Database
YFBL - Uncharacterized protein YfbL
UniProt: P76482 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14096
Length: 323 (255)
Sequences: 8641 (6339)
Seq/√Len: 397.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_K75_V3.8361.00
73_V76_S3.6151.00
292_Q297_G3.3111.00
71_K83_S3.2151.00
99_D158_Q3.0061.00
74_F161_A2.9971.00
107_L156_G2.9321.00
103_A154_K2.5131.00
63_L163_A2.4961.00
64_N68_E2.4581.00
70_I114_Y2.4171.00
138_V161_A2.3831.00
140_G197_I2.3801.00
102_P156_G2.3281.00
111_G191_M2.2971.00
174_E178_A2.2851.00
143_E146_R2.2411.00
40_Q143_E2.2231.00
111_G162_Y2.1981.00
44_T69_Y2.1681.00
106_P155_T2.0911.00
46_R300_A2.0771.00
61_D65_R2.0721.00
107_L158_Q2.0531.00
44_T73_V2.0111.00
42_E305_Y1.9461.00
72_E76_S1.9441.00
141_L161_A1.9201.00
172_S271_N1.9081.00
67_A96_I1.9041.00
70_I161_A1.9001.00
45_V139_A1.8471.00
99_D156_G1.8371.00
74_F98_A1.8191.00
309_A313_D1.8121.00
299_T302_R1.8021.00
101_G104_D1.8001.00
80_R101_G1.7361.00
68_E72_E1.7221.00
112_A134_N1.7181.00
42_E46_R1.7121.00
110_I141_L1.6551.00
46_R50_Q1.5991.00
97_V160_V1.5831.00
73_V146_R1.5501.00
74_F145_A1.5311.00
68_E71_K1.5261.00
39_E43_K1.5161.00
86_V163_A1.4911.00
63_L114_Y1.4771.00
106_P189_K1.4761.00
133_D165_E1.4711.00
194_L315_V1.4641.00
40_Q146_R1.4571.00
48_L66_S1.4241.00
45_V135_A1.4071.00
71_K81_V1.4021.00
38_P309_A1.3871.00
37_S40_Q1.3851.00
109_I160_V1.3741.00
77_S149_H1.3721.00
129_P299_T1.3561.00
66_S114_Y1.3471.00
49_T300_A1.3471.00
47_Y50_Q1.3441.00
112_A138_V1.3411.00
42_E300_A1.3401.00
112_A141_L1.3391.00
99_D107_L1.3331.00
73_V77_S1.3301.00
72_E75_V1.3271.00
84_Q174_E1.3201.00
79_A100_Y1.3081.00
162_Y172_S1.3021.00
162_Y191_M1.3001.00
69_Y73_V1.2911.00
176_G275_H1.2891.00
67_A114_Y1.2871.00
44_T77_S1.2861.00
71_K96_I1.2841.00
145_A159_L1.2811.00
158_Q175_M1.2691.00
133_D294_H1.2611.00
62_N65_R1.2551.00
38_P306_Q1.2351.00
244_L248_Q1.2331.00
54_P62_N1.2271.00
101_G156_G1.2271.00
141_L159_L1.2231.00
134_N193_A1.2201.00
165_E294_H1.2111.00
166_E294_H1.2001.00
144_L316_I1.1951.00
100_Y159_L1.1921.00
140_G312_V1.1851.00
44_T143_E1.1841.00
36_A312_V1.1771.00
310_Q313_D1.1771.00
47_Y73_V1.1711.00
237_V240_V1.1661.00
160_V175_M1.1651.00
300_A305_Y1.1571.00
292_Q302_R1.1441.00
41_L312_V1.1431.00
74_F142_L1.1291.00
84_Q178_A1.1281.00
100_Y153_P1.1261.00
57_A60_I1.1231.00
132_D290_N1.1201.00
147_L316_I1.1191.00
67_A83_S1.1181.00
82_T99_D1.1181.00
104_D156_G1.1141.00
44_T146_R1.1111.00
153_P157_V1.0921.00
100_Y149_H1.0911.00
114_Y161_A1.0801.00
36_A147_L1.0741.00
49_T131_A1.0661.00
38_P42_E1.0561.00
303_L308_M1.0551.00
241_K245_L1.0531.00
176_G271_N1.0491.00
177_S275_H1.0461.00
79_A98_A1.0451.00
51_T129_P1.0421.00
84_Q179_V1.0411.00
238_R242_A1.0331.00
143_E147_L1.0301.00
173_D271_N1.0291.00
44_T47_Y1.0291.00
117_A128_T1.0281.00
79_A159_L1.0261.00
84_Q95_N1.0231.00
173_D177_S1.0211.00
116_S130_G1.0181.00
116_S128_T1.0141.00
241_K244_L1.0111.00
243_A247_S1.0091.00
110_I319_L1.0061.00
57_A167_P1.0061.00
175_M188_V1.0031.00
269_H281_M1.0021.00
162_Y272_Y1.0021.00
109_I188_V0.9971.00
43_K46_R0.9951.00
65_R68_E0.9941.00
103_A152_V0.9901.00
147_L151_Q0.9841.00
105_G187_P0.9811.00
243_A246_S0.9801.00
44_T142_L0.9781.00
146_R150_Q0.9771.00
44_T139_A0.9641.00
43_K47_Y0.9621.00
51_T69_Y0.9611.00
113_H165_E0.9471.00
47_Y65_R0.9311.00
41_L308_M0.9291.00
238_R241_K0.9251.00
45_V49_T0.9221.00
68_E83_S0.9181.00
164_S170_F0.9121.00
235_N239_Q0.9051.00
110_I159_L0.8871.00
236_A240_V0.8871.00
230_R233_D0.8841.00
155_T189_K0.8841.00
237_V243_A0.8791.00
113_H133_D0.8751.00
30_P34_R0.8721.00
226_A229_G0.8691.00
148_L157_V0.8651.00
233_D236_A0.8651.00
26_V29_L0.8631.00
245_L248_Q0.8621.00
116_S135_A0.8611.00
135_A139_A0.8561.00
273_W279_A0.8551.00
292_Q295_L0.8551.00
79_A145_A0.8401.00
164_S167_P0.8391.00
113_H268_D0.8371.00
83_S96_I0.8351.00
55_R58_D0.8331.00
47_Y51_T0.8331.00
40_Q44_T0.8251.00
39_E42_E0.8221.00
305_Y308_M0.8171.00
73_V142_L0.8051.00
306_Q310_Q0.8051.00
242_A246_S0.8041.00
239_Q242_A0.8031.00
229_G232_Q0.8011.00
61_D64_N0.7991.00
105_G155_T0.7971.00
269_H279_A0.7951.00
96_I161_A0.7921.00
77_S146_R0.7921.00
191_M272_Y0.7871.00
109_I191_M0.7861.00
162_Y175_M0.7851.00
40_Q43_K0.7751.00
191_M279_A0.7701.00
25_W29_L0.7671.00
175_M179_V0.7601.00
29_L33_P0.7591.00
64_N67_A0.7591.00
172_S268_D0.7581.00
234_I237_V0.7551.00
136_S303_L0.7551.00
240_V244_L0.7521.00
244_L247_S0.7511.00
236_A248_Q0.7491.00
148_L153_P0.7471.00
176_G272_Y0.7441.00
67_A71_K0.7381.00
90_G93_Y0.7381.00
114_Y138_V0.7361.00
144_L148_L0.7351.00
58_D63_L0.7341.00
174_E177_S0.7281.00
25_W28_A0.7271.00
236_A243_A0.7251.00
242_A245_L0.7201.00
113_H166_E0.7191.00
74_F159_L0.7161.00
81_V96_I0.7161.00
236_A239_Q0.7151.00
307_K311_V0.7141.00
105_G156_G0.7111.00
41_L139_A0.7071.00
196_M201_D0.7041.00
77_S142_L0.7041.00
106_P187_P0.6981.00
29_L32_T0.6961.00
47_Y69_Y0.6951.00
78_G81_V0.6951.00
25_W31_S0.6941.00
235_N238_R0.6931.00
240_V243_A0.6921.00
168_P172_S0.6911.00
84_Q175_M0.6870.99
270_L274_Q0.6860.99
132_D196_M0.6830.99
128_T296_P0.6820.99
133_D166_E0.6820.99
198_G303_L0.6820.99
111_G172_S0.6820.99
132_D284_D0.6810.99
89_T92_P0.6800.99
63_L70_I0.6790.99
48_L51_T0.6780.99
160_V272_Y0.6760.99
306_Q309_A0.6760.99
243_A248_Q0.6750.99
108_I190_L0.6750.99
46_R305_Y0.6740.99
133_D268_D0.6710.99
225_I228_V0.6690.99
95_N171_R0.6670.99
102_P155_T0.6640.99
80_R99_D0.6620.99
233_D237_V0.6620.99
241_K247_S0.6620.99
102_P153_P0.6570.99
70_I96_I0.6560.99
131_A135_A0.6550.99
239_Q243_A0.6540.99
234_I238_R0.6540.99
113_H294_H0.6530.99
54_P61_D0.6490.99
98_A161_A0.6470.99
175_M272_Y0.6450.99
91_G94_K0.6450.99
25_W32_T0.6440.99
172_S176_G0.6440.99
140_G144_L0.6420.99
266_F270_L0.6410.99
228_V231_I0.6390.99
199_Y292_Q0.6370.99
28_A34_R0.6360.99
116_S129_P0.6350.99
47_Y72_E0.6340.99
28_A32_T0.6340.99
28_A31_S0.6320.99
237_V245_L0.6310.99
55_R116_S0.6290.99
56_S60_I0.6260.99
236_A241_K0.6240.99
108_I189_K0.6240.99
165_E268_D0.6230.99
27_N31_S0.6230.99
232_Q237_V0.6220.99
97_V158_Q0.6210.99
134_N195_E0.6200.99
227_V230_R0.6190.99
173_D274_Q0.6180.99
90_G94_K0.6170.99
70_I138_V0.6170.99
236_A247_S0.6140.99
188_V277_I0.6080.99
293_Y296_P0.6070.99
199_Y290_N0.6060.99
166_E169_F0.6050.99
132_D303_L0.6040.99
33_P317_T0.6040.99
111_G272_Y0.6020.99
110_I144_L0.6020.99
79_A149_H0.5990.99
237_V244_L0.5990.99
167_P170_F0.5980.99
193_A197_I0.5970.99
27_N30_P0.5970.99
175_M181_A0.5960.99
271_N274_Q0.5940.99
169_F271_N0.5930.99
111_G160_V0.5880.98
97_V175_M0.5880.98
172_S272_Y0.5870.98
200_Y204_P0.5870.98
84_Q88_I0.5830.98
144_L315_V0.5780.98
201_D205_G0.5770.98
176_G277_I0.5730.98
103_A153_P0.5720.98
98_A159_L0.5720.98
226_A231_I0.5710.98
55_R127_Y0.5690.98
141_L194_L0.5660.98
67_A163_A0.5660.98
38_P41_L0.5650.98
132_D136_S0.5610.98
69_Y142_L0.5600.98
227_V231_I0.5570.98
104_D107_L0.5570.98
26_V30_P0.5550.98
290_N294_H0.5540.98
191_M197_I0.5540.98
290_N293_Y0.5520.98
75_V81_V0.5510.98
153_P156_G0.5490.98
107_L187_P0.5490.98
58_D167_P0.5490.98
48_L138_V0.5490.98
229_G233_D0.5480.98
165_E293_Y0.5480.98
54_P57_A0.5480.98
225_I229_G0.5470.98
267_S293_Y0.5440.97
56_S59_N0.5420.97
58_D164_S0.5420.97
144_L319_L0.5420.97
107_L189_K0.5410.97
228_V232_Q0.5370.97
76_S146_R0.5360.97
132_D199_Y0.5330.97
110_I315_V0.5300.97
131_A134_N0.5290.97
200_Y307_K0.5280.97
110_I157_V0.5280.97
246_S317_T0.5280.97
54_P58_D0.5280.97
45_V48_L0.5230.97
263_G266_F0.5220.97
308_M312_V0.5200.97
297_G302_R0.5190.97
147_L313_D0.5180.97
201_D206_S0.5180.97
95_N175_M0.5120.96
31_S34_R0.5110.96
190_L204_P0.5100.96
108_I155_T0.5090.96
165_E267_S0.5070.96
33_P36_A0.5070.96
70_I142_L0.5070.96
77_S145_A0.5070.96
148_L316_I0.5030.96
180_H188_V0.5030.96
165_E195_E0.5020.96
284_D311_V0.5010.96
55_R118_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fuuA 1 0.8204 100 0.399 Contact Map
2ek8A 2 0.7895 100 0.404 Contact Map
3tc8A 1 0.8173 100 0.408 Contact Map
2afwA 5 0.8576 100 0.413 Contact Map
3pb6X 1 0.8266 100 0.413 Contact Map
3guxA 1 0.7307 100 0.413 Contact Map
4mhpA 1 0.8545 100 0.416 Contact Map
1tkjA 1 0.7833 100 0.427 Contact Map
4f9uA 1 0.8173 100 0.431 Contact Map
4faiA 1 0.8731 100 0.432 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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