YFBL - ECOLI - GREMLIN Contacts

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YFBL - Uncharacterized protein YfbL

UniProt:	P76482	Sequences: MKKIIFAFIILFVFLLPMIIFYQPWVNALPSTPRHASPEQLEKTVRYLTQTVHPRSADNIDNLNRSAEYIKEVFVSSGARVTSQDVPITGGPYKNIVADYGPADGPLIIIGAHYDSASSYENDQLTYTPGADDNASGVAGLLELARLLHQQVPKTGVQLVAYASEEPPFFRSDEMGSAVHAASLERPVKLMIALEMIGYYDSAPGSQNYPYPAMSWLYPDRGDFIAVVGRIQDINAVRQVKAALLSSQDLSVYSMNTPGFIPGIDFSDHLNYWQHDIPAIMITDTAFYRNKQYHLPGDTADRLNYQKMAQVVDGVITLLYNSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14096
Length:	323 (255)
Sequences:	8641 (6339)
Seq/√Len:	397.0

ECOLI - YFBL IAP
BACSU - BSAP
HALSA - Q9HRR8 Q9HNP7
SULSO - Q7LXL7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_K	75_V	3.836	1.00
73_V	76_S	3.615	1.00
292_Q	297_G	3.311	1.00
71_K	83_S	3.215	1.00
99_D	158_Q	3.006	1.00
74_F	161_A	2.997	1.00
107_L	156_G	2.932	1.00
103_A	154_K	2.513	1.00
63_L	163_A	2.496	1.00
64_N	68_E	2.458	1.00
70_I	114_Y	2.417	1.00
138_V	161_A	2.383	1.00
140_G	197_I	2.380	1.00
102_P	156_G	2.328	1.00
111_G	191_M	2.297	1.00
174_E	178_A	2.285	1.00
143_E	146_R	2.241	1.00
40_Q	143_E	2.223	1.00
111_G	162_Y	2.198	1.00
44_T	69_Y	2.168	1.00
106_P	155_T	2.091	1.00
46_R	300_A	2.077	1.00
61_D	65_R	2.072	1.00
107_L	158_Q	2.053	1.00
44_T	73_V	2.011	1.00
42_E	305_Y	1.946	1.00
72_E	76_S	1.944	1.00
141_L	161_A	1.920	1.00
172_S	271_N	1.908	1.00
67_A	96_I	1.904	1.00
70_I	161_A	1.900	1.00
45_V	139_A	1.847	1.00
99_D	156_G	1.837	1.00
74_F	98_A	1.819	1.00
309_A	313_D	1.812	1.00
299_T	302_R	1.802	1.00
101_G	104_D	1.800	1.00
80_R	101_G	1.736	1.00
68_E	72_E	1.722	1.00
112_A	134_N	1.718	1.00
42_E	46_R	1.712	1.00
110_I	141_L	1.655	1.00
46_R	50_Q	1.599	1.00
97_V	160_V	1.583	1.00
73_V	146_R	1.550	1.00
74_F	145_A	1.531	1.00
68_E	71_K	1.526	1.00
39_E	43_K	1.516	1.00
86_V	163_A	1.491	1.00
63_L	114_Y	1.477	1.00
106_P	189_K	1.476	1.00
133_D	165_E	1.471	1.00
194_L	315_V	1.464	1.00
40_Q	146_R	1.457	1.00
48_L	66_S	1.424	1.00
45_V	135_A	1.407	1.00
71_K	81_V	1.402	1.00
38_P	309_A	1.387	1.00
37_S	40_Q	1.385	1.00
109_I	160_V	1.374	1.00
77_S	149_H	1.372	1.00
129_P	299_T	1.356	1.00
66_S	114_Y	1.347	1.00
49_T	300_A	1.347	1.00
47_Y	50_Q	1.344	1.00
112_A	138_V	1.341	1.00
42_E	300_A	1.340	1.00
112_A	141_L	1.339	1.00
99_D	107_L	1.333	1.00
73_V	77_S	1.330	1.00
72_E	75_V	1.327	1.00
84_Q	174_E	1.320	1.00
79_A	100_Y	1.308	1.00
162_Y	172_S	1.302	1.00
162_Y	191_M	1.300	1.00
69_Y	73_V	1.291	1.00
176_G	275_H	1.289	1.00
67_A	114_Y	1.287	1.00
44_T	77_S	1.286	1.00
71_K	96_I	1.284	1.00
145_A	159_L	1.281	1.00
158_Q	175_M	1.269	1.00
133_D	294_H	1.261	1.00
62_N	65_R	1.255	1.00
38_P	306_Q	1.235	1.00
244_L	248_Q	1.233	1.00
54_P	62_N	1.227	1.00
101_G	156_G	1.227	1.00
141_L	159_L	1.223	1.00
134_N	193_A	1.220	1.00
165_E	294_H	1.211	1.00
166_E	294_H	1.200	1.00
144_L	316_I	1.195	1.00
100_Y	159_L	1.192	1.00
140_G	312_V	1.185	1.00
44_T	143_E	1.184	1.00
36_A	312_V	1.177	1.00
310_Q	313_D	1.177	1.00
47_Y	73_V	1.171	1.00
237_V	240_V	1.166	1.00
160_V	175_M	1.165	1.00
300_A	305_Y	1.157	1.00
292_Q	302_R	1.144	1.00
41_L	312_V	1.143	1.00
74_F	142_L	1.129	1.00
84_Q	178_A	1.128	1.00
100_Y	153_P	1.126	1.00
57_A	60_I	1.123	1.00
132_D	290_N	1.120	1.00
147_L	316_I	1.119	1.00
67_A	83_S	1.118	1.00
82_T	99_D	1.118	1.00
104_D	156_G	1.114	1.00
44_T	146_R	1.111	1.00
153_P	157_V	1.092	1.00
100_Y	149_H	1.091	1.00
114_Y	161_A	1.080	1.00
36_A	147_L	1.074	1.00
49_T	131_A	1.066	1.00
38_P	42_E	1.056	1.00
303_L	308_M	1.055	1.00
241_K	245_L	1.053	1.00
176_G	271_N	1.049	1.00
177_S	275_H	1.046	1.00
79_A	98_A	1.045	1.00
51_T	129_P	1.042	1.00
84_Q	179_V	1.041	1.00
238_R	242_A	1.033	1.00
143_E	147_L	1.030	1.00
173_D	271_N	1.029	1.00
44_T	47_Y	1.029	1.00
117_A	128_T	1.028	1.00
79_A	159_L	1.026	1.00
84_Q	95_N	1.023	1.00
173_D	177_S	1.021	1.00
116_S	130_G	1.018	1.00
116_S	128_T	1.014	1.00
241_K	244_L	1.011	1.00
243_A	247_S	1.009	1.00
110_I	319_L	1.006	1.00
57_A	167_P	1.006	1.00
175_M	188_V	1.003	1.00
269_H	281_M	1.002	1.00
162_Y	272_Y	1.002	1.00
109_I	188_V	0.997	1.00
43_K	46_R	0.995	1.00
65_R	68_E	0.994	1.00
103_A	152_V	0.990	1.00
147_L	151_Q	0.984	1.00
105_G	187_P	0.981	1.00
243_A	246_S	0.980	1.00
44_T	142_L	0.978	1.00
146_R	150_Q	0.977	1.00
44_T	139_A	0.964	1.00
43_K	47_Y	0.962	1.00
51_T	69_Y	0.961	1.00
113_H	165_E	0.947	1.00
47_Y	65_R	0.931	1.00
41_L	308_M	0.929	1.00
238_R	241_K	0.925	1.00
45_V	49_T	0.922	1.00
68_E	83_S	0.918	1.00
164_S	170_F	0.912	1.00
235_N	239_Q	0.905	1.00
110_I	159_L	0.887	1.00
236_A	240_V	0.887	1.00
230_R	233_D	0.884	1.00
155_T	189_K	0.884	1.00
237_V	243_A	0.879	1.00
113_H	133_D	0.875	1.00
30_P	34_R	0.872	1.00
226_A	229_G	0.869	1.00
148_L	157_V	0.865	1.00
233_D	236_A	0.865	1.00
26_V	29_L	0.863	1.00
245_L	248_Q	0.862	1.00
116_S	135_A	0.861	1.00
135_A	139_A	0.856	1.00
273_W	279_A	0.855	1.00
292_Q	295_L	0.855	1.00
79_A	145_A	0.840	1.00
164_S	167_P	0.839	1.00
113_H	268_D	0.837	1.00
83_S	96_I	0.835	1.00
55_R	58_D	0.833	1.00
47_Y	51_T	0.833	1.00
40_Q	44_T	0.825	1.00
39_E	42_E	0.822	1.00
305_Y	308_M	0.817	1.00
73_V	142_L	0.805	1.00
306_Q	310_Q	0.805	1.00
242_A	246_S	0.804	1.00
239_Q	242_A	0.803	1.00
229_G	232_Q	0.801	1.00
61_D	64_N	0.799	1.00
105_G	155_T	0.797	1.00
269_H	279_A	0.795	1.00
96_I	161_A	0.792	1.00
77_S	146_R	0.792	1.00
191_M	272_Y	0.787	1.00
109_I	191_M	0.786	1.00
162_Y	175_M	0.785	1.00
40_Q	43_K	0.775	1.00
191_M	279_A	0.770	1.00
25_W	29_L	0.767	1.00
175_M	179_V	0.760	1.00
29_L	33_P	0.759	1.00
64_N	67_A	0.759	1.00
172_S	268_D	0.758	1.00
234_I	237_V	0.755	1.00
136_S	303_L	0.755	1.00
240_V	244_L	0.752	1.00
244_L	247_S	0.751	1.00
236_A	248_Q	0.749	1.00
148_L	153_P	0.747	1.00
176_G	272_Y	0.744	1.00
67_A	71_K	0.738	1.00
90_G	93_Y	0.738	1.00
114_Y	138_V	0.736	1.00
144_L	148_L	0.735	1.00
58_D	63_L	0.734	1.00
174_E	177_S	0.728	1.00
25_W	28_A	0.727	1.00
236_A	243_A	0.725	1.00
242_A	245_L	0.720	1.00
113_H	166_E	0.719	1.00
74_F	159_L	0.716	1.00
81_V	96_I	0.716	1.00
236_A	239_Q	0.715	1.00
307_K	311_V	0.714	1.00
105_G	156_G	0.711	1.00
41_L	139_A	0.707	1.00
196_M	201_D	0.704	1.00
77_S	142_L	0.704	1.00
106_P	187_P	0.698	1.00
29_L	32_T	0.696	1.00
47_Y	69_Y	0.695	1.00
78_G	81_V	0.695	1.00
25_W	31_S	0.694	1.00
235_N	238_R	0.693	1.00
240_V	243_A	0.692	1.00
168_P	172_S	0.691	1.00
84_Q	175_M	0.687	0.99
270_L	274_Q	0.686	0.99
132_D	196_M	0.683	0.99
128_T	296_P	0.682	0.99
133_D	166_E	0.682	0.99
198_G	303_L	0.682	0.99
111_G	172_S	0.682	0.99
132_D	284_D	0.681	0.99
89_T	92_P	0.680	0.99
63_L	70_I	0.679	0.99
48_L	51_T	0.678	0.99
160_V	272_Y	0.676	0.99
306_Q	309_A	0.676	0.99
243_A	248_Q	0.675	0.99
108_I	190_L	0.675	0.99
46_R	305_Y	0.674	0.99
133_D	268_D	0.671	0.99
225_I	228_V	0.669	0.99
95_N	171_R	0.667	0.99
102_P	155_T	0.664	0.99
80_R	99_D	0.662	0.99
233_D	237_V	0.662	0.99
241_K	247_S	0.662	0.99
102_P	153_P	0.657	0.99
70_I	96_I	0.656	0.99
131_A	135_A	0.655	0.99
239_Q	243_A	0.654	0.99
234_I	238_R	0.654	0.99
113_H	294_H	0.653	0.99
54_P	61_D	0.649	0.99
98_A	161_A	0.647	0.99
175_M	272_Y	0.645	0.99
91_G	94_K	0.645	0.99
25_W	32_T	0.644	0.99
172_S	176_G	0.644	0.99
140_G	144_L	0.642	0.99
266_F	270_L	0.641	0.99
228_V	231_I	0.639	0.99
199_Y	292_Q	0.637	0.99
28_A	34_R	0.636	0.99
116_S	129_P	0.635	0.99
47_Y	72_E	0.634	0.99
28_A	32_T	0.634	0.99
28_A	31_S	0.632	0.99
237_V	245_L	0.631	0.99
55_R	116_S	0.629	0.99
56_S	60_I	0.626	0.99
236_A	241_K	0.624	0.99
108_I	189_K	0.624	0.99
165_E	268_D	0.623	0.99
27_N	31_S	0.623	0.99
232_Q	237_V	0.622	0.99
97_V	158_Q	0.621	0.99
134_N	195_E	0.620	0.99
227_V	230_R	0.619	0.99
173_D	274_Q	0.618	0.99
90_G	94_K	0.617	0.99
70_I	138_V	0.617	0.99
236_A	247_S	0.614	0.99
188_V	277_I	0.608	0.99
293_Y	296_P	0.607	0.99
199_Y	290_N	0.606	0.99
166_E	169_F	0.605	0.99
132_D	303_L	0.604	0.99
33_P	317_T	0.604	0.99
111_G	272_Y	0.602	0.99
110_I	144_L	0.602	0.99
79_A	149_H	0.599	0.99
237_V	244_L	0.599	0.99
167_P	170_F	0.598	0.99
193_A	197_I	0.597	0.99
27_N	30_P	0.597	0.99
175_M	181_A	0.596	0.99
271_N	274_Q	0.594	0.99
169_F	271_N	0.593	0.99
111_G	160_V	0.588	0.98
97_V	175_M	0.588	0.98
172_S	272_Y	0.587	0.98
200_Y	204_P	0.587	0.98
84_Q	88_I	0.583	0.98
144_L	315_V	0.578	0.98
201_D	205_G	0.577	0.98
176_G	277_I	0.573	0.98
103_A	153_P	0.572	0.98
98_A	159_L	0.572	0.98
226_A	231_I	0.571	0.98
55_R	127_Y	0.569	0.98
141_L	194_L	0.566	0.98
67_A	163_A	0.566	0.98
38_P	41_L	0.565	0.98
132_D	136_S	0.561	0.98
69_Y	142_L	0.560	0.98
227_V	231_I	0.557	0.98
104_D	107_L	0.557	0.98
26_V	30_P	0.555	0.98
290_N	294_H	0.554	0.98
191_M	197_I	0.554	0.98
290_N	293_Y	0.552	0.98
75_V	81_V	0.551	0.98
153_P	156_G	0.549	0.98
107_L	187_P	0.549	0.98
58_D	167_P	0.549	0.98
48_L	138_V	0.549	0.98
229_G	233_D	0.548	0.98
165_E	293_Y	0.548	0.98
54_P	57_A	0.548	0.98
225_I	229_G	0.547	0.98
267_S	293_Y	0.544	0.97
56_S	59_N	0.542	0.97
58_D	164_S	0.542	0.97
144_L	319_L	0.542	0.97
107_L	189_K	0.541	0.97
228_V	232_Q	0.537	0.97
76_S	146_R	0.536	0.97
132_D	199_Y	0.533	0.97
110_I	315_V	0.530	0.97
131_A	134_N	0.529	0.97
200_Y	307_K	0.528	0.97
110_I	157_V	0.528	0.97
246_S	317_T	0.528	0.97
54_P	58_D	0.528	0.97
45_V	48_L	0.523	0.97
263_G	266_F	0.522	0.97
308_M	312_V	0.520	0.97
297_G	302_R	0.519	0.97
147_L	313_D	0.518	0.97
201_D	206_S	0.518	0.97
95_N	175_M	0.512	0.96
31_S	34_R	0.511	0.96
190_L	204_P	0.510	0.96
108_I	155_T	0.509	0.96
165_E	267_S	0.507	0.96
33_P	36_A	0.507	0.96
70_I	142_L	0.507	0.96
77_S	145_A	0.507	0.96
148_L	316_I	0.503	0.96
180_H	188_V	0.503	0.96
165_E	195_E	0.502	0.96
284_D	311_V	0.501	0.96
55_R	118_S	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fuuA	1	0.8204	100	0.399	Contact Map
2ek8A	2	0.7895	100	0.404	Contact Map
3tc8A	1	0.8173	100	0.408	Contact Map
2afwA	5	0.8576	100	0.413	Contact Map
3pb6X	1	0.8266	100	0.413	Contact Map
3guxA	1	0.7307	100	0.413	Contact Map
4mhpA	1	0.8545	100	0.416	Contact Map
1tkjA	1	0.7833	100	0.427	Contact Map
4f9uA	1	0.8173	100	0.431	Contact Map
4faiA	1	0.8731	100	0.432	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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