GREMLIN Database
YFBK - Uncharacterized protein YfbK
UniProt: P76481 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14095
Length: 575 (469)
Sequences: 815 (574)
Seq/√Len: 26.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_A397_V8.0001.00
304_T340_Q4.5031.00
526_K541_I4.4271.00
189_A195_R4.3621.00
185_E511_S4.1321.00
363_V422_K4.0391.00
546_Q565_E3.8411.00
515_R548_A3.6151.00
229_S232_R3.6151.00
105_Y135_N3.4861.00
526_K538_W3.4641.00
431_N462_D3.4581.00
522_A536_T3.3561.00
507_I544_W3.3191.00
199_K517_R3.3111.00
257_T261_D3.0831.00
186_L198_L3.0021.00
512_E548_A2.9721.00
507_I510_P2.9661.00
254_A268_S2.9541.00
560_F564_I2.9451.00
431_N498_L2.9401.00
289_S325_V2.8981.00
199_K513_D2.8051.00
203_L206_D2.7971.00
153_V524_G2.7811.00
104_R358_N2.7050.99
522_A526_K2.6910.99
125_S437_A2.6810.99
136_V156_I2.6240.99
399_K492_Q2.6140.99
244_V271_G2.5770.99
223_T261_D2.5760.99
187_A514_M2.5700.99
465_R483_W2.5460.99
264_I302_Q2.5390.99
203_L445_H2.4790.99
334_E364_R2.4710.99
188_P196_T2.4520.99
367_D422_K2.4280.99
198_L482_A2.3880.99
541_I564_I2.3030.98
533_L536_T2.2900.98
490_Y493_G2.2860.98
405_I484_L2.2800.98
363_V373_Y2.2680.98
542_K564_I2.2560.98
257_T263_R2.2240.98
103_A135_N2.2170.98
350_F386_L2.1990.98
308_I311_G2.1940.98
236_I240_L2.1260.97
273_H276_E2.0370.96
156_I524_G2.0300.96
352_V376_I2.0290.96
361_M365_I2.0230.96
539_Q568_D2.0110.96
126_L403_A2.0000.96
484_L503_L1.9990.96
358_N361_M1.9910.96
252_N268_S1.9800.95
432_N435_V1.9690.95
196_T505_P1.9420.95
164_W201_D1.9330.95
136_V151_V1.8740.94
247_L253_I1.8730.94
114_K119_N1.8680.94
482_A503_L1.8620.94
248_R271_G1.8570.94
131_G349_T1.8420.93
121_L427_V1.8210.93
126_L486_I1.8170.93
265_A280_A1.8170.93
464_L467_A1.8120.93
330_P360_A1.7930.92
516_F557_R1.7910.92
135_N138_R1.7910.92
198_L405_I1.7550.91
346_T399_K1.7530.91
346_T493_G1.7260.91
244_V281_I1.7140.90
228_I285_D1.6960.90
145_L567_A1.6950.90
241_K278_N1.6840.90
236_I318_A1.6840.90
562_R565_E1.6820.90
536_T541_I1.6720.89
339_K342_E1.6720.89
187_A510_P1.6660.89
135_N139_F1.6610.89
140_L567_A1.6600.89
102_T358_N1.6480.89
110_D530_S1.6430.88
275_A279_A1.6420.88
180_F397_V1.6340.88
542_K565_E1.6270.88
196_T454_L1.6170.88
542_K546_Q1.5890.87
213_P248_R1.5650.86
516_F520_V1.5640.86
239_S244_V1.5550.86
198_L452_L1.5490.85
268_S302_Q1.5410.85
330_P361_M1.5300.85
231_E354_N1.5240.84
411_W505_P1.5160.84
418_I524_G1.5120.84
540_Q543_Q1.4810.83
513_D548_A1.4740.82
101_G148_P1.4570.81
523_Y567_A1.4540.81
223_T284_L1.4360.81
240_L318_A1.4360.81
513_D516_F1.4300.80
379_L566_L1.4250.80
291_N294_A1.4130.79
245_K278_N1.4120.79
293_G297_E1.4060.79
243_L247_L1.3930.78
515_R547_Q1.3930.78
363_V367_D1.3900.78
535_N539_Q1.3770.78
103_A138_R1.3500.76
147_P150_A1.3450.76
131_G359_E1.3440.76
104_R360_A1.3390.76
241_K282_D1.3360.75
220_L299_A1.3320.75
221_I257_T1.3250.75
245_K274_K1.3230.75
223_T257_T1.3220.75
435_V482_A1.3190.74
526_K533_L1.3100.74
232_R236_I1.3050.74
490_Y497_Q1.2940.73
222_D321_G1.2830.72
139_F147_P1.2760.72
164_W203_L1.2710.72
125_S341_R1.2670.71
548_A555_G1.2670.71
533_L541_I1.2570.71
157_V452_L1.2570.71
291_N395_I1.2520.70
552_D555_G1.2430.70
520_V560_F1.2420.70
538_W567_A1.2000.67
257_T265_A1.1760.66
136_V140_L1.1760.66
535_N569_G1.1740.65
239_S352_V1.1710.65
514_M517_R1.1690.65
248_R390_M1.1630.65
537_S540_Q1.1580.64
262_S298_L1.1570.64
221_I240_L1.1410.63
550_G557_R1.1360.63
135_N150_A1.1230.62
122_A450_F1.1230.62
516_F560_F1.1130.61
393_M396_T1.1120.61
257_T289_S1.1080.61
237_Q281_I1.1060.61
242_L383_Q1.0980.60
108_F156_I1.0770.59
232_R352_V1.0750.58
233_L237_Q1.0730.58
519_A545_A1.0730.58
166_I203_L1.0700.58
180_F440_I1.0680.58
462_D485_K1.0640.58
264_I267_P1.0640.58
327_I333_I1.0620.57
236_I352_V1.0600.57
525_Q536_T1.0440.56
113_V525_Q1.0440.56
267_P276_E1.0430.56
548_A554_Q1.0420.56
304_T343_S1.0400.56
286_A299_A1.0400.56
270_S273_H1.0380.56
427_V464_L1.0360.56
221_I255_I1.0250.55
549_K558_A1.0230.55
522_A533_L1.0210.54
372_N393_M1.0150.54
438_G449_L1.0140.54
522_A541_I1.0110.54
123_T404_Q1.0100.54
254_A532_Y1.0050.53
343_S405_I1.0030.53
534_N553_P0.9950.53
433_D437_A0.9840.52
349_T357_Y0.9840.52
288_G321_G0.9810.52
526_K540_Q0.9800.51
510_P514_M0.9800.51
261_D293_G0.9770.51
513_D560_F0.9730.51
546_Q561_I0.9720.51
108_F528_R0.9710.51
404_Q433_D0.9700.51
315_I337_V0.9670.50
186_L531_E0.9670.50
523_Y535_N0.9650.50
525_Q530_S0.9630.50
126_L537_S0.9600.50
120_P386_L0.9570.50
414_E457_Q0.9570.50
556_Y562_R0.9540.49
239_S390_M0.9510.49
430_F433_D0.9490.49
220_L322_D0.9480.49
261_D281_I0.9470.49
239_S526_K0.9460.49
433_D436_D0.9460.49
536_T540_Q0.9460.49
318_A350_F0.9450.49
475_S478_T0.9440.49
103_A150_A0.9430.49
542_K547_Q0.9420.49
178_I497_Q0.9420.49
546_Q553_P0.9410.49
403_A486_I0.9390.48
153_V156_I0.9310.48
276_E568_D0.9300.48
138_R142_Q0.9290.48
182_M501_F0.9230.47
299_A322_D0.9200.47
105_Y271_G0.9190.47
269_I545_A0.9170.47
545_A550_G0.9160.47
558_A562_R0.9150.47
525_Q529_G0.9150.47
237_Q285_D0.9150.47
522_A540_Q0.9090.46
462_D467_A0.9070.46
511_S515_R0.9060.46
374_S386_L0.9040.46
215_S312_I0.9020.46
507_I515_R0.8930.45
240_L255_I0.8880.45
549_K561_I0.8880.45
433_D446_I0.8820.44
399_K493_G0.8770.44
547_Q568_D0.8750.44
151_V156_I0.8750.44
105_Y139_F0.8720.43
562_R566_L0.8710.43
549_K566_L0.8700.43
230_D505_P0.8670.43
145_L328_D0.8650.43
373_Y422_K0.8650.43
212_L312_I0.8650.43
245_K452_L0.8640.43
221_I501_F0.8620.43
307_F313_N0.8610.43
197_L518_A0.8590.42
514_M518_A0.8570.42
300_Y400_D0.8570.42
431_N496_S0.8560.42
103_A139_F0.8530.42
296_L317_L0.8530.42
357_Y361_M0.8530.42
404_Q430_F0.8530.42
187_A452_L0.8500.42
543_Q547_Q0.8470.42
117_A478_T0.8470.42
444_K450_F0.8420.41
542_K549_K0.8410.41
238_S241_K0.8330.41
429_H432_N0.8320.40
290_T321_G0.8280.40
464_L468_P0.8280.40
135_N147_P0.8270.40
539_Q546_Q0.8260.40
226_S320_D0.8260.40
219_F247_L0.8250.40
540_Q548_A0.8220.40
275_A463_K0.8220.40
509_A512_E0.8200.40
548_A557_R0.8200.40
402_K430_F0.8200.40
366_A389_E0.8170.39
431_N485_K0.8170.39
212_L248_R0.8160.39
517_R564_I0.8140.39
488_W499_V0.8130.39
353_G371_G0.8120.39
268_S306_G0.8110.39
193_E196_T0.8080.39
220_L323_F0.8060.39
551_E566_L0.8060.39
332_S335_S0.8060.39
414_E525_Q0.8050.39
192_N198_L0.8040.38
319_T557_R0.8020.38
156_I520_V0.8010.38
292_G322_D0.7990.38
542_K561_I0.7990.38
559_E563_L0.7970.38
118_Q427_V0.7960.38
403_A515_R0.7960.38
116_V134_A0.7910.38
377_D381_E0.7910.38
458_K494_K0.7900.38
463_K466_Y0.7890.37
469_D478_T0.7890.37
200_V514_M0.7890.37
433_D438_G0.7880.37
545_A548_A0.7870.37
146_P567_A0.7860.37
554_Q565_E0.7860.37
566_L569_G0.7830.37
119_N335_S0.7820.37
244_V274_K0.7800.37
391_R503_L0.7790.37
334_E368_V0.7780.37
292_G299_A0.7760.37
312_I395_I0.7760.37
329_D332_S0.7740.36
272_S335_S0.7730.36
217_L266_L0.7730.36
408_N480_E0.7690.36
107_Q331_K0.7670.36
178_I490_Y0.7660.36
350_F385_V0.7650.36
291_N327_I0.7630.36
439_D523_Y0.7620.36
310_G495_E0.7600.35
158_N162_S0.7590.35
251_D353_G0.7580.35
342_E426_R0.7570.35
109_D176_K0.7560.35
436_D439_D0.7550.35
529_G536_T0.7520.35
547_Q569_G0.7520.35
512_E515_R0.7510.35
195_R457_Q0.7490.35
476_D508_N0.7490.35
493_G497_Q0.7480.35
466_Y480_E0.7480.35
154_E160_F0.7440.34
523_Y564_I0.7430.34
298_L301_Q0.7430.34
530_S533_L0.7430.34
292_G356_N0.7430.34
222_D227_M0.7390.34
349_T363_V0.7370.34
118_Q500_E0.7370.34
139_F150_A0.7370.34
130_T362_M0.7370.34
153_V418_I0.7360.34
322_D356_N0.7350.34
480_E485_K0.7350.34
555_G558_A0.7320.34
522_A537_S0.7320.34
346_T492_Q0.7320.34
413_T455_N0.7290.33
253_I259_A0.7270.33
293_G296_L0.7260.33
518_A540_Q0.7260.33
399_K494_K0.7250.33
425_L496_S0.7250.33
424_Q434_N0.7250.33
367_D373_Y0.7240.33
200_V426_R0.7230.33
263_R294_A0.7190.33
346_T370_N0.7180.33
533_L542_K0.7170.33
378_T388_S0.7160.32
264_I298_L0.7160.32
98_A101_G0.7150.32
242_L387_N0.7150.32
216_N311_G0.7120.32
476_D501_F0.7110.32
174_A510_P0.7110.32
512_E529_G0.7110.32
549_K557_R0.7100.32
535_N551_E0.7090.32
249_E543_Q0.7090.32
506_T547_Q0.7090.32
438_G441_G0.7080.32
191_W292_G0.7080.32
236_I255_I0.7060.32
257_T287_E0.7060.32
290_T320_D0.7050.32
113_V453_T0.7040.32
222_D290_T0.7040.32
526_K534_N0.7040.32
275_A562_R0.7040.32
486_I490_Y0.7030.32
165_D181_A0.7030.32
509_A558_A0.7020.32
447_T450_F0.7020.32
512_E550_G0.7020.32
532_Y541_I0.7000.31
251_D317_L0.7000.31
347_L365_I0.7000.31
207_R541_I0.6990.31
267_P335_S0.6990.31
164_W447_T0.6980.31
224_S290_T0.6970.31
226_S290_T0.6960.31
543_Q551_E0.6960.31
297_E537_S0.6950.31
525_Q533_L0.6930.31
240_L364_R0.6920.31
239_S382_A0.6920.31
541_I560_F0.6910.31
279_A485_K0.6910.31
302_Q306_G0.6890.31
295_G299_A0.6870.31
380_S562_R0.6860.31
227_M321_G0.6840.30
538_W553_P0.6830.30
510_P558_A0.6830.30
335_S338_K0.6820.30
218_V376_I0.6810.30
202_I403_A0.6780.30
331_K335_S0.6780.30
188_P302_Q0.6760.30
270_S495_E0.6740.30
155_E158_N0.6730.30
510_P548_A0.6730.30
155_E421_E0.6720.30
104_R364_R0.6720.30
211_E538_W0.6710.30
385_V393_M0.6700.30
194_Q561_I0.6700.30
430_F450_F0.6670.29
292_G323_F0.6670.29
262_S295_G0.6660.29
479_K493_G0.6650.29
432_N439_D0.6650.29
339_K413_T0.6640.29
547_Q550_G0.6640.29
506_T510_P0.6640.29
291_N312_I0.6640.29
490_Y534_N0.6620.29
105_Y150_A0.6620.29
533_L538_W0.6610.29
529_G533_L0.6600.29
123_T152_R0.6600.29
221_I302_Q0.6600.29
549_K553_P0.6580.29
332_S537_S0.6570.29
406_E429_H0.6570.29
230_D543_Q0.6560.29
273_H558_A0.6550.29
224_S321_G0.6550.29
465_R468_P0.6540.29
165_D183_R0.6540.29
404_Q423_R0.6530.29
441_G446_I0.6530.29
462_D498_L0.6510.28
112_P532_Y0.6510.28
221_I236_I0.6510.28
240_L281_I0.6500.28
519_A560_F0.6490.28
392_Q395_I0.6480.28
545_A557_R0.6480.28
414_E465_R0.6480.28
320_D351_G0.6470.28
187_A332_S0.6460.28
506_T543_Q0.6460.28
283_S287_E0.6460.28
187_A567_A0.6450.28
512_E568_D0.6450.28
402_K450_F0.6430.28
184_Y271_G0.6420.28
416_R419_G0.6410.28
547_Q554_Q0.6390.28
389_E392_Q0.6390.28
548_A561_I0.6380.28
378_T554_Q0.6380.28
369_G375_Y0.6360.27
129_D423_R0.6360.27
252_N541_I0.6350.27
239_S376_I0.6350.27
550_G562_R0.6350.27
237_Q380_S0.6350.27
104_R361_M0.6350.27
532_Y539_Q0.6330.27
510_P515_R0.6330.27
515_R538_W0.6320.27
207_R276_E0.6310.27
176_K205_K0.6310.27
417_Q448_L0.6300.27
436_D446_I0.6300.27
234_P318_A0.6300.27
130_T378_T0.6300.27
507_I517_R0.6290.27
254_A267_P0.6290.27
333_I360_A0.6270.27
383_Q418_I0.6270.27
372_N396_T0.6270.27
561_I565_E0.6270.27
518_A554_Q0.6250.27
380_S542_K0.6250.27
245_K305_K0.6240.27
130_T180_F0.6230.27
108_F524_G0.6230.27
230_D546_Q0.6230.27
547_Q551_E0.6230.27
435_V533_L0.6220.27
479_K504_G0.6220.27
182_M484_L0.6200.27
107_Q270_S0.6190.26
470_N473_A0.6190.26
272_S458_K0.6170.26
130_T390_M0.6160.26
123_T430_F0.6160.26
400_D451_E0.6160.26
526_K532_Y0.6150.26
123_T402_K0.6150.26
542_K556_Y0.6150.26
549_K562_R0.6130.26
428_E432_N0.6130.26
327_I397_V0.6120.26
495_E502_P0.6120.26
200_V318_A0.6120.26
205_K490_Y0.6120.26
242_L459_A0.6110.26
507_I543_Q0.6110.26
222_D226_S0.6110.26
552_D556_Y0.6110.26
257_T298_L0.6100.26
112_P569_G0.6100.26
463_K473_A0.6090.26
423_R433_D0.6030.26
273_H512_E0.6020.26
177_P194_Q0.6020.26
462_D465_R0.6020.26
135_N271_G0.6010.25
294_A566_L0.6000.25
123_T433_D0.6000.25
511_S514_M0.5990.25
299_A323_F0.5980.25
206_D566_L0.5980.25
357_Y373_Y0.5980.25
219_F382_A0.5980.25
539_Q543_Q0.5970.25
177_P426_R0.5960.25
121_L483_W0.5950.25
116_V471_K0.5940.25
461_I469_D0.5920.25
296_L304_T0.5910.25
275_A566_L0.5890.25
291_N328_D0.5880.25
199_K395_I0.5870.25
140_L566_L0.5860.25
136_V362_M0.5860.25
132_S449_L0.5850.25
463_K468_P0.5840.24
221_I366_A0.5840.24
229_S535_N0.5840.24
519_A548_A0.5830.24
155_E160_F0.5830.24
512_E547_Q0.5820.24
539_Q547_Q0.5810.24
403_A448_L0.5800.24
133_Y137_R0.5800.24
331_K339_K0.5800.24
245_K380_S0.5790.24
142_Q231_E0.5790.24
103_A355_S0.5780.24
553_P561_I0.5780.24
468_P473_A0.5780.24
477_K558_A0.5780.24
544_W547_Q0.5770.24
215_S393_M0.5740.24
435_V453_T0.5740.24
189_A238_S0.5730.24
338_K368_V0.5730.24
226_S321_G0.5730.24
505_P508_N0.5710.24
151_V154_E0.5710.24
225_G288_G0.5700.24
354_N358_N0.5700.24
453_T459_A0.5700.24
557_R561_I0.5700.24
479_K490_Y0.5700.24
515_R526_K0.5690.24
113_V312_I0.5680.24
159_Y258_Y0.5670.24
510_P531_E0.5670.24
512_E558_A0.5660.24
222_D225_G0.5660.24
495_E506_T0.5660.24
380_S548_A0.5650.23
147_P271_G0.5650.23
93_K96_H0.5650.23
105_Y184_Y0.5650.23
366_A563_L0.5640.23
105_Y138_R0.5630.23
413_T457_Q0.5620.23
361_M530_S0.5620.23
221_I327_I0.5600.23
220_L259_A0.5600.23
467_A470_N0.5590.23
193_E229_S0.5590.23
513_D520_V0.5590.23
518_A544_W0.5580.23
496_S500_E0.5580.23
538_W551_E0.5570.23
471_K475_S0.5560.23
507_I514_M0.5560.23
534_N540_Q0.5550.23
208_K549_K0.5530.23
199_K349_T0.5530.23
380_S383_Q0.5520.23
183_R199_K0.5520.23
146_P151_V0.5520.23
266_L269_I0.5510.23
263_R289_S0.5500.23
488_W491_P0.5490.23
387_N484_L0.5490.23
243_L302_Q0.5480.23
218_V308_I0.5480.23
119_N543_Q0.5470.23
538_W558_A0.5470.23
123_T423_R0.5450.22
506_T531_E0.5450.22
206_D315_I0.5450.22
522_A548_A0.5440.22
229_S262_S0.5430.22
357_Y375_Y0.5420.22
390_M395_I0.5420.22
94_A98_A0.5410.22
509_A568_D0.5410.22
509_A553_P0.5400.22
257_T325_V0.5400.22
327_I367_D0.5400.22
363_V404_Q0.5400.22
441_G450_F0.5390.22
490_Y541_I0.5390.22
436_D442_A0.5380.22
199_K203_L0.5380.22
157_V163_D0.5370.22
117_A538_W0.5360.22
364_R395_I0.5360.22
236_I317_L0.5350.22
176_K568_D0.5340.22
214_A389_E0.5340.22
542_K568_D0.5330.22
486_I500_E0.5320.22
232_R376_I0.5310.22
221_I238_S0.5310.22
206_D510_P0.5300.22
297_E509_A0.5290.22
454_L505_P0.5290.22
420_Y423_R0.5290.22
177_P551_E0.5290.22
163_D183_R0.5280.22
196_T199_K0.5270.21
552_D557_R0.5260.21
129_D160_F0.5250.21
159_Y322_D0.5250.21
540_Q559_E0.5250.21
261_D301_Q0.5240.21
244_V265_A0.5240.21
105_Y147_P0.5230.21
99_N546_Q0.5230.21
116_V120_P0.5210.21
119_N206_D0.5210.21
479_K540_Q0.5210.21
98_A177_P0.5200.21
423_R430_F0.5200.21
452_L475_S0.5200.21
99_N547_Q0.5190.21
286_A322_D0.5180.21
509_A515_R0.5170.21
239_S389_E0.5170.21
526_K559_E0.5170.21
356_N377_D0.5160.21
157_V184_Y0.5160.21
492_Q495_E0.5150.21
196_T203_L0.5150.21
281_I546_Q0.5130.21
435_V536_T0.5120.21
294_A332_S0.5120.21
420_Y430_F0.5110.21
203_L510_P0.5110.21
546_Q558_A0.5110.21
110_D316_L0.5100.21
286_A420_Y0.5100.21
122_A152_R0.5100.21
119_N427_V0.5090.21
182_M422_K0.5090.21
224_S227_M0.5080.21
131_G364_R0.5080.21
544_W562_R0.5080.21
432_N436_D0.5070.20
565_E569_G0.5070.20
349_T368_V0.5070.20
414_E435_V0.5070.20
515_R534_N0.5050.20
332_S500_E0.5050.20
214_A250_Q0.5040.20
347_L407_F0.5040.20
436_D447_T0.5040.20
511_S565_E0.5030.20
115_Q118_Q0.5010.20
212_L449_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fx5A 1 0.6696 100 0.691 Contact Map
4cn9A 1 0.6087 100 0.757 Contact Map
3txaA 1 0.593 100 0.766 Contact Map
2ww8A 1 0.8174 100 0.771 Contact Map
2x31A 2 0.3061 100 0.775 Contact Map
1ijbA 1 0.3391 100 0.776 Contact Map
1q0pA 1 0.2852 100 0.777 Contact Map
1mf7A 1 0.32 100 0.78 Contact Map
4f1jA 1 0.3235 100 0.781 Contact Map
1n3yA 1 0.3113 100 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0133 seconds.