GREMLIN Database
ARNF - Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF
UniProt: P76474 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14094
Length: 128 (115)
Sequences: 620 (458)
Seq/√Len: 42.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_C118_L3.7051.00
23_A50_L3.4621.00
24_A65_Y3.1111.00
82_M85_V2.8391.00
111_C114_S2.7861.00
87_V91_S2.3101.00
88_W109_V2.2291.00
13_A80_L2.2101.00
64_W77_Y2.2011.00
6_G79_L2.1931.00
60_S80_L2.0490.99
79_L84_Y1.9150.99
102_S105_A1.9150.99
16_A60_S1.9070.99
46_D51_L1.8830.99
17_Q21_G1.8350.98
84_Y119_I1.8060.98
12_I64_W1.7990.98
21_G118_L1.7240.98
71_L76_A1.6980.97
20_L54_L1.6630.97
4_M110_A1.5760.96
101_F106_L1.5710.96
67_T76_A1.5330.95
52_L55_L1.5020.95
11_I93_V1.5000.95
9_S13_A1.4540.94
20_L80_L1.3590.91
16_A61_V1.3490.91
17_Q64_W1.2850.89
57_Y60_S1.2780.88
6_G71_L1.2740.88
9_S80_L1.2710.88
8_F63_C1.2500.87
17_Q77_Y1.2470.87
23_A105_A1.2440.87
31_T52_L1.2190.86
16_A57_Y1.2160.86
20_L53_G1.1960.85
56_G75_K1.1840.84
9_S87_V1.1720.83
98_E119_I1.1680.83
4_M89_I1.1520.82
63_C75_K1.1370.81
58_L62_F1.1340.81
81_S84_Y1.1230.81
13_A60_S1.0820.78
21_G78_A1.0580.77
57_Y61_V1.0530.76
57_Y68_L1.0520.76
10_V66_K1.0490.76
9_S67_T1.0430.75
21_G24_A1.0280.74
9_S60_S1.0200.74
68_L119_I1.0030.73
67_T87_V0.9840.71
55_L107_L0.9820.71
13_A84_Y0.9820.71
13_A87_V0.9780.71
73_L83_S0.9750.70
103_L107_L0.9650.70
64_W79_L0.9620.69
17_Q57_Y0.9600.69
75_K79_L0.9510.68
72_A83_S0.9460.68
13_A83_S0.9360.67
75_K105_A0.9360.67
101_F114_S0.9340.67
9_S57_Y0.9250.66
13_A61_V0.9080.65
16_A73_L0.9080.65
10_V18_L0.9060.65
10_V113_M0.8780.62
13_A73_L0.8560.60
93_V107_L0.8520.60
9_S83_S0.8480.60
10_V81_S0.8440.59
21_G77_Y0.8440.59
90_A111_C0.8400.59
32_H58_L0.8380.59
10_V14_S0.8380.59
61_V80_L0.8370.59
50_L117_M0.8350.58
55_L112_I0.8320.58
14_S71_L0.8210.57
13_A91_S0.8170.57
21_G25_S0.8140.56
92_M101_F0.8100.56
16_A81_S0.8090.56
48_R51_L0.8060.56
5_W66_K0.7950.55
5_W69_H0.7940.55
16_A80_L0.7910.54
117_M121_L0.7890.54
62_F86_L0.7880.54
67_T83_S0.7830.53
73_L87_V0.7700.52
50_L62_F0.7630.52
14_S24_A0.7630.52
13_A16_A0.7560.51
8_F59_L0.7540.51
74_S78_A0.7490.50
20_L90_A0.7460.50
7_L66_K0.7310.49
60_S71_L0.7230.48
66_K70_K0.7190.47
78_A97_W0.7160.47
12_I17_Q0.7110.47
79_L109_V0.7020.46
42_A103_L0.7020.46
15_V19_S0.6990.46
84_Y109_V0.6930.45
116_L120_F0.6910.45
13_A81_S0.6790.44
23_A68_L0.6760.43
61_V68_L0.6670.43
86_L97_W0.6660.42
49_I55_L0.6600.42
57_Y64_W0.6580.42
68_L108_G0.6530.41
39_A90_A0.6510.41
57_Y77_Y0.6500.41
23_A53_G0.6490.41
5_W119_I0.6440.40
80_L83_S0.6410.40
54_L71_L0.6410.40
109_V113_M0.6400.40
21_G105_A0.6380.40
69_H105_A0.6350.40
20_L61_V0.6270.39
71_L92_M0.6270.39
47_A119_I0.6270.39
34_W62_F0.6150.38
89_I93_V0.6150.38
23_A57_Y0.6030.37
15_V26_H0.6030.37
101_F116_L0.5960.36
113_M117_M0.5930.36
14_S18_L0.5930.36
12_I77_Y0.5920.36
23_A47_A0.5910.36
12_I80_L0.5870.35
63_C67_T0.5780.35
85_V121_L0.5770.34
48_R110_A0.5760.34
43_F110_A0.5730.34
72_A121_L0.5730.34
11_I97_W0.5730.34
5_W110_A0.5700.34
89_I106_L0.5670.34
50_L118_L0.5670.34
14_S86_L0.5650.33
6_G67_T0.5650.33
51_L98_E0.5640.33
30_M66_K0.5610.33
41_L55_L0.5570.33
61_V91_S0.5560.33
57_Y80_L0.5530.32
63_C83_S0.5490.32
60_S84_Y0.5460.32
88_W116_L0.5440.32
72_A93_V0.5350.31
18_L102_S0.5340.31
116_L121_L0.5300.31
22_F97_W0.5220.30
12_I79_L0.5130.29
9_S20_L0.5110.29
20_L83_S0.5090.29
20_L40_L0.5070.29
45_L103_L0.5010.28
92_M106_L0.5010.28
13_A67_T0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.6016 99.7 0.555 Contact Map
3b5dA 2 0.7891 99.7 0.562 Contact Map
3j01B 1 0.4375 6.6 0.942 Contact Map
3o7qA 1 1 5.1 0.945 Contact Map
2gfpA 2 0.9688 4.4 0.946 Contact Map
4j05A 3 1 3.4 0.949 Contact Map
2cfqA 1 1 3.1 0.95 Contact Map
2mofA 1 0.2578 3.1 0.95 Contact Map
4q65A 1 0.8438 2.9 0.951 Contact Map
4qi1A 3 0.5938 2.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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