GREMLIN Database
RHMA - 2-keto-3-deoxy-L-rhamnonate aldolase
UniProt: P76469 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14083
Length: 267 (248)
Sequences: 2339 (1764)
Seq/√Len: 112.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_T160_N3.1911.00
149_L172_G3.1891.00
165_L173_V3.0631.00
102_A106_R2.9101.00
201_T205_R2.8291.00
160_N163_E2.7971.00
150_V170_I2.6341.00
12_R17_E2.6081.00
21_G42_W2.4561.00
162_D205_R2.3931.00
200_E229_W2.2961.00
112_T148_L2.2291.00
100_D156_T2.1901.00
75_P86_V2.1761.00
161_L205_R2.1551.00
103_E106_R2.1491.00
78_G108_V2.1351.00
100_D154_S2.0461.00
108_V148_L2.0461.00
117_Y143_N1.9991.00
155_K159_D1.9251.00
70_Q92_Q1.9091.00
47_G57_L1.9061.00
158_L198_I1.8881.00
96_I108_V1.8711.00
110_S119_E1.8621.00
155_K183_S1.8121.00
203_I231_A1.8011.00
35_A247_L1.7991.00
207_R232_N1.7731.00
189_N192_H1.7551.00
186_Y192_H1.7431.00
113_R143_N1.7401.00
100_D104_Q1.7371.00
32_A64_V1.7021.00
214_G233_F1.6981.00
73_I91_A1.6741.00
101_T104_Q1.6611.00
162_D209_A1.6431.00
152_V157_A1.6401.00
106_R110_S1.6141.00
200_E204_R1.6101.00
33_E128_R1.6081.00
244_S248_D1.5871.00
83_I96_I1.5521.00
162_D165_L1.5271.00
227_L234_V1.5241.00
109_V167_V1.5221.00
224_Q228_A1.5171.00
76_V82_L1.5091.00
104_Q107_Q1.5051.00
166_D209_A1.4991.00
161_L165_L1.4961.00
99_V150_V1.4811.00
186_Y189_N1.4801.00
102_A167_V1.4701.00
103_E107_Q1.4501.00
155_K184_L1.4481.00
36_A67_Y1.4481.00
24_L32_A1.4421.00
48_E121_G1.4411.00
158_L161_L1.4371.00
186_Y194_E1.4311.00
156_T160_N1.4201.00
204_R208_A1.4181.00
72_V93_T1.4111.00
53_T56_D1.4111.00
137_N141_Q1.4041.00
203_I213_A1.4031.00
59_H62_Q1.4021.00
212_A232_N1.3921.00
162_D208_A1.3701.00
141_Q145_S1.3641.00
158_L202_S1.3591.00
159_D201_T1.3571.00
18_V227_L1.3551.00
226_C229_W1.3291.00
86_V94_L1.3271.00
95_L149_L1.3251.00
101_T156_T1.3241.00
128_R132_W1.3231.00
196_Q225_Q1.2980.99
202_S206_I1.2960.99
102_A166_D1.2790.99
22_L35_A1.2740.99
83_I112_T1.2640.99
175_I202_S1.2590.99
113_R117_Y1.2520.99
106_R167_V1.2440.99
107_Q111_A1.2430.99
23_W44_L1.2270.99
10_K14_R1.2250.99
165_L205_R1.2220.99
102_A163_E1.2150.99
77_E81_P1.2150.99
31_M243_Y1.2090.99
113_R146_L1.2080.99
80_K111_A1.1930.99
105_A170_I1.1890.99
12_R19_Q1.1820.99
78_G104_Q1.1780.99
222_M225_Q1.1770.99
100_D157_A1.1740.99
206_I213_A1.1680.99
79_S82_L1.1650.99
156_T159_D1.1630.99
242_L247_L1.1620.99
61_L91_A1.1520.99
71_P92_Q1.1450.99
217_A223_A1.1420.99
52_N60_Q1.1420.99
80_K119_E1.1260.98
98_M154_S1.1190.98
30_Y62_Q1.1160.98
220_P253_M1.1150.98
152_V173_V1.1120.98
40_Y251_L1.0960.98
225_Q229_W1.0920.98
134_R137_N1.0820.98
11_E15_K1.0800.98
194_E197_R1.0770.98
175_I180_L1.0740.98
99_V108_V1.0730.98
157_A160_N1.0580.98
83_I108_V1.0510.98
134_R248_D1.0500.98
36_A64_V1.0380.97
128_R131_R1.0360.97
168_E211_K1.0330.97
54_I85_Q1.0250.97
75_P83_I1.0210.97
174_F216_L1.0190.97
44_L95_L1.0190.97
62_Q65_A1.0150.97
193_P197_R1.0100.97
184_L198_I1.0080.97
162_D201_T1.0040.97
197_R201_T0.9990.97
115_P182_A0.9920.97
58_Y62_Q0.9830.96
112_T146_L0.9790.96
140_A144_D0.9770.96
102_A160_N0.9770.96
206_I209_A0.9720.96
197_R200_E0.9710.96
213_A232_N0.9490.96
20_I227_L0.9450.95
109_V170_I0.9450.95
220_P254_F0.9390.95
109_V169_G0.9380.95
11_E145_S0.9370.95
173_V206_I0.9320.95
16_G232_N0.9310.95
242_L246_A0.9300.95
219_A222_M0.9260.95
24_L64_V0.9200.95
58_Y89_I0.9190.95
57_L86_V0.9180.95
9_F19_Q0.9100.94
40_Y247_L0.8970.94
73_I86_V0.8960.94
29_A59_H0.8960.94
22_L40_Y0.8950.94
215_F231_A0.8920.94
251_L255_K0.8900.94
95_L151_Q0.8890.94
105_A164_I0.8880.94
47_G85_Q0.8870.94
75_P96_I0.8780.93
198_I201_T0.8770.93
158_L184_L0.8730.93
161_L201_T0.8710.93
72_V95_L0.8670.93
245_D248_D0.8630.93
231_A234_V0.8620.93
222_M226_C0.8600.93
206_I211_K0.8590.93
117_Y168_E0.8590.93
165_L209_A0.8570.92
224_Q253_M0.8460.92
57_L73_I0.8440.92
238_V241_M0.8430.92
213_A231_A0.8420.92
8_P12_R0.8410.92
83_I111_A0.8390.92
34_I244_S0.8340.91
9_F147_C0.8320.91
225_Q228_A0.8320.91
40_Y250_R0.8290.91
93_T147_C0.8280.91
161_L202_S0.8260.91
196_Q200_E0.8220.91
243_Y247_L0.8210.91
123_G127_A0.8200.91
19_Q42_W0.8200.91
105_A109_V0.8180.91
249_Q253_M0.8110.90
87_L146_L0.8100.90
18_V232_N0.8060.90
172_G212_A0.8050.90
77_E82_L0.8040.90
138_Y142_V0.8000.90
95_L172_G0.7990.90
220_P224_Q0.7950.89
237_G250_R0.7930.89
205_R208_A0.7930.89
155_K158_L0.7860.89
16_G207_R0.7850.89
246_A249_Q0.7840.89
45_I57_L0.7820.89
105_A167_V0.7790.88
47_G76_V0.7780.88
108_V150_V0.7770.88
200_E225_Q0.7770.88
201_T204_R0.7640.87
45_I64_V0.7630.87
113_R171_D0.7630.87
77_E104_Q0.7580.87
152_V161_L0.7560.87
218_V238_V0.7560.87
61_L73_I0.7510.87
236_V251_L0.7510.87
24_L43_L0.7480.86
11_E14_R0.7470.86
223_A234_V0.7440.86
249_Q252_A0.7410.86
95_L121_G0.7390.86
127_A132_W0.7390.86
10_K171_D0.7380.86
171_D211_K0.7330.85
26_S31_M0.7320.85
155_K194_E0.7300.85
215_F226_C0.7250.85
226_C231_A0.7240.84
72_V147_C0.7200.84
186_Y195_V0.7200.84
82_L86_V0.7140.84
203_I229_W0.7110.83
246_A250_R0.7060.83
76_V81_P0.7060.83
195_V199_I0.7010.83
44_L235_A0.7010.83
23_W174_F0.7010.83
107_Q110_S0.6980.82
96_I112_T0.6960.82
86_V91_A0.6930.82
109_V148_L0.6920.82
96_I99_V0.6910.82
190_A195_V0.6890.81
48_E84_K0.6850.81
115_P187_P0.6840.81
203_I207_R0.6750.80
193_P196_Q0.6740.80
113_R169_G0.6740.80
42_W235_A0.6730.80
150_V173_V0.6730.80
170_I211_K0.6660.79
143_N146_L0.6660.79
98_M121_G0.6640.79
38_S251_L0.6630.79
98_M123_G0.6630.79
84_K121_G0.6570.78
36_A43_L0.6540.78
122_V182_A0.6530.78
83_I94_L0.6490.77
104_Q108_V0.6480.77
8_P11_E0.6450.77
128_R133_G0.6440.77
137_N140_A0.6430.77
141_Q144_D0.6400.76
163_E167_V0.6400.76
41_D255_K0.6400.76
198_I202_S0.6350.76
61_L89_I0.6350.76
103_E163_E0.6330.76
172_G211_K0.6300.75
175_I199_I0.6290.75
174_F235_A0.6280.75
32_A60_Q0.6250.75
36_A63_A0.6220.74
239_D243_Y0.6220.74
122_V181_S0.6200.74
105_A150_V0.6180.74
78_G107_Q0.6170.74
192_H195_V0.6150.74
245_D249_Q0.6130.73
124_A130_A0.6080.73
80_K107_Q0.6080.73
46_D74_R0.6070.73
33_E62_Q0.6040.72
7_N145_S0.6040.72
32_A69_S0.6030.72
45_I60_Q0.6030.72
12_R70_Q0.5990.72
228_A252_A0.5940.71
106_R117_Y0.5940.71
78_G81_P0.5940.71
186_Y198_I0.5930.71
20_I255_K0.5910.71
13_L19_Q0.5900.71
75_P94_L0.5890.70
109_V113_R0.5880.70
113_R148_L0.5870.70
106_R163_E0.5840.70
177_P215_F0.5830.70
55_Q59_H0.5820.70
106_R168_E0.5810.69
181_S195_V0.5770.69
163_E166_D0.5770.69
7_N92_Q0.5770.69
78_G111_A0.5770.69
71_P91_A0.5760.69
92_Q145_S0.5760.69
121_G151_Q0.5750.69
148_L170_I0.5730.68
204_R207_R0.5730.68
175_I214_G0.5720.68
174_F214_G0.5680.68
172_G233_F0.5660.67
181_S189_N0.5650.67
37_T67_Y0.5650.67
65_A92_Q0.5650.67
88_D97_P0.5620.67
94_L148_L0.5620.67
26_S60_Q0.5600.67
48_E151_Q0.5600.67
205_R209_A0.5600.67
77_E80_K0.5600.67
180_L184_L0.5590.66
25_S240_T0.5550.66
84_K98_M0.5530.66
29_A62_Q0.5500.65
236_V254_F0.5500.65
178_A181_S0.5490.65
43_L69_S0.5490.65
93_T149_L0.5460.65
121_G132_W0.5440.64
147_C172_G0.5420.64
165_L206_I0.5410.64
88_D180_L0.5400.64
182_A187_P0.5350.63
33_E36_A0.5350.63
152_V206_I0.5350.63
71_P168_E0.5340.63
28_T55_Q0.5340.63
50_A216_L0.5330.63
62_Q66_P0.5320.63
84_K182_A0.5310.62
161_L173_V0.5310.62
140_A187_P0.5300.62
33_E129_A0.5300.62
47_G73_I0.5300.62
105_A169_G0.5290.62
18_V234_V0.5260.62
31_M34_I0.5260.62
27_T52_N0.5240.61
9_F72_V0.5210.61
84_K138_Y0.5190.61
84_K115_P0.5180.61
152_V158_L0.5150.60
184_L194_E0.5130.60
247_L250_R0.5130.60
24_L35_A0.5130.60
37_T134_R0.5130.60
98_M104_Q0.5110.60
166_D205_R0.5080.59
100_D105_A0.5060.59
64_V69_S0.5050.59
10_K147_C0.5030.58
127_A133_G0.5020.58
24_L31_M0.5010.58
201_T208_A0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v5jA 5 0.985 100 0.291 Contact Map
2vwsA 5 0.9588 100 0.303 Contact Map
1dxeA 5 0.9438 100 0.314 Contact Map
4tv5A 5 0.9139 100 0.319 Contact Map
3qz6A 5 0.9551 100 0.335 Contact Map
4mf4A 5 0.9401 100 0.341 Contact Map
1izcA 5 0.9813 100 0.344 Contact Map
4l80A 5 0.9139 100 0.574 Contact Map
1sgjA 3 0.7678 100 0.6 Contact Map
3qllA 3 0.7154 100 0.616 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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