GREMLIN Database
ATOB - Acetyl-CoA acetyltransferase
UniProt: P76461 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11672
Length: 394 (374)
Sequences: 15194 (8257)
Seq/√Len: 426.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_N262_E3.5231.00
182_H186_K3.4631.00
175_M329_K3.3941.00
264_A268_A3.3101.00
107_A110_I2.9571.00
181_L226_A2.9441.00
36_A39_E2.9101.00
95_V359_L2.8551.00
362_L374_G2.7981.00
182_H185_R2.7341.00
262_E266_L2.7001.00
189_A193_S2.6911.00
176_Q241_T2.6721.00
167_K237_D2.6011.00
264_A267_A2.5991.00
5_V265_A2.5951.00
192_E222_A2.5301.00
300_A304_A2.5281.00
300_A389_V2.4761.00
9_A360_V2.4751.00
102_I259_I2.4551.00
34_I111_V2.3721.00
37_A258_V2.3651.00
10_V40_R2.2151.00
197_T215_S2.1741.00
109_S260_M2.1151.00
313_L340_V2.1021.00
102_I261_E2.0931.00
278_S304_A2.0651.00
366_M371_K2.0611.00
172_T175_M2.0581.00
98_A110_I2.0541.00
191_I220_P2.0421.00
30_G53_M2.0181.00
274_A363_L2.0131.00
275_R391_E2.0101.00
219_F249_G1.9941.00
44_D47_H1.9901.00
7_V260_M1.9641.00
273_L367_Q1.9591.00
32_T203_V1.9451.00
174_E178_E1.9091.00
229_L245_G1.9041.00
3_N275_R1.9041.00
165_V171_I1.9031.00
255_A356_A1.8861.00
278_S300_A1.8731.00
188_A220_P1.8441.00
306_L373_L1.8391.00
260_M265_A1.7561.00
47_H268_A1.7521.00
297_T377_T1.7441.00
191_I200_I1.7411.00
341_N365_A1.7281.00
20_S214_F1.7101.00
197_T216_Q1.7001.00
328_G338_V1.6931.00
298_Q302_Q1.6761.00
108_Q261_E1.6531.00
30_G69_A1.6521.00
159_G236_F1.6491.00
188_A192_E1.6491.00
365_A369_R1.6441.00
37_A41_A1.6431.00
260_M264_A1.6391.00
228_A231_A1.6291.00
328_G335_S1.6261.00
312_D371_K1.6121.00
311_I314_I1.6121.00
306_L311_I1.6121.00
191_I216_Q1.6021.00
311_I389_V1.5971.00
98_A259_I1.5881.00
257_L356_A1.5871.00
308_L314_I1.5681.00
261_E264_A1.5621.00
53_M113_G1.5591.00
195_A341_N1.5541.00
8_S41_A1.5451.00
34_I69_A1.5391.00
32_T201_V1.5331.00
181_L185_R1.5151.00
117_N120_L1.5141.00
306_L389_V1.5141.00
168_E288_L1.5071.00
100_Q106_Q1.5021.00
108_Q264_A1.4901.00
101_A107_A1.4881.00
195_A365_A1.4881.00
198_A367_Q1.4851.00
82_F97_L1.4771.00
36_A201_V1.4761.00
182_H335_S1.4641.00
5_V275_R1.4531.00
313_L365_A1.4511.00
178_E182_H1.4501.00
295_P298_Q1.4451.00
365_A368_A1.4361.00
185_R223_N1.4331.00
21_L214_F1.4251.00
35_K39_E1.4251.00
314_I375_L1.4061.00
36_A40_R1.4001.00
28_D72_K1.3871.00
280_A300_A1.3821.00
372_T391_E1.3741.00
8_S37_A1.3691.00
277_K391_E1.3691.00
33_V256_A1.3671.00
178_E226_A1.3651.00
124_L143_V1.3641.00
33_V254_A1.3531.00
334_D337_K1.3531.00
185_R189_A1.3521.00
175_M178_E1.3511.00
359_L390_I1.3441.00
109_S264_A1.3331.00
301_L308_L1.3261.00
14_I353_A1.3211.00
280_A299_K1.3201.00
96_A388_M1.3101.00
65_P115_M1.2931.00
89_G386_I1.2901.00
299_K302_Q1.2741.00
263_S267_A1.2651.00
311_I373_L1.2481.00
4_C259_I1.2351.00
375_L389_V1.2331.00
363_L367_Q1.2311.00
188_A223_N1.2291.00
111_V258_V1.2141.00
296_A387_A1.2141.00
298_Q330_N1.2111.00
18_N131_S1.2111.00
24_T32_T1.2101.00
95_V257_L1.2061.00
340_V365_A1.2061.00
360_V364_H1.2021.00
89_G380_I1.1991.00
55_N58_Q1.1971.00
195_A368_A1.1961.00
53_M256_A1.1961.00
77_E285_P1.1961.00
49_D107_A1.1901.00
48_V109_S1.1861.00
171_I176_Q1.1821.00
14_I347_L1.1751.00
173_R243_T1.1671.00
5_V262_E1.1581.00
163_E237_D1.1561.00
297_T375_L1.1561.00
31_A72_K1.1541.00
5_V260_M1.1531.00
96_A279_Y1.1511.00
10_V201_V1.1311.00
159_G235_A1.1311.00
98_A112_A1.1241.00
9_A364_H1.1201.00
282_G295_P1.1161.00
199_E361_T1.1131.00
160_I237_D1.1111.00
294_V298_Q1.1061.00
304_A389_V1.1051.00
52_I110_I1.1051.00
284_V291_M1.0991.00
13_A214_F1.0961.00
34_I75_L1.0891.00
312_D337_K1.0881.00
179_L324_F1.0811.00
92_L359_L1.0791.00
171_I325_L1.0771.00
205_V214_F1.0761.00
276_I388_M1.0761.00
362_L376_A1.0691.00
198_A368_A1.0641.00
278_S303_L1.0631.00
93_K97_L1.0601.00
49_D108_Q1.0571.00
106_Q303_L1.0551.00
340_V369_R1.0521.00
312_D366_M1.0501.00
291_M294_V1.0411.00
179_L325_L1.0411.00
278_S389_V1.0361.00
54_G90_S1.0351.00
103_Q106_Q1.0311.00
333_F338_V1.0301.00
47_H264_A1.0281.00
169_Y291_M1.0271.00
307_Q310_D1.0251.00
373_L391_E1.0231.00
164_N168_E1.0221.00
288_L291_M1.0171.00
224_S229_L1.0151.00
32_T36_A1.0151.00
226_A230_G1.0051.00
181_L229_L1.0051.00
198_A364_H1.0021.00
357_R361_T1.0011.00
95_V259_I0.9951.00
38_I75_L0.9921.00
8_S40_R0.9841.00
47_H267_A0.9821.00
308_L311_I0.9791.00
313_L369_R0.9761.00
277_K373_L0.9761.00
33_V36_A0.9721.00
9_A363_L0.9711.00
188_A222_A0.9701.00
311_I375_L0.9631.00
282_G299_K0.9541.00
6_I390_I0.9491.00
232_L245_G0.9491.00
191_I197_T0.9481.00
377_T380_I0.9471.00
168_E287_A0.9451.00
262_E275_R0.9431.00
182_H336_E0.9421.00
15_G218_E0.9371.00
181_L223_N0.9341.00
12_T33_V0.9311.00
100_Q104_A0.9291.00
75_L79_V0.9181.00
255_A353_A0.9161.00
51_V70_L0.9161.00
10_V36_A0.9161.00
273_L363_L0.9151.00
38_I43_I0.9091.00
380_I386_I0.9091.00
7_V270_L0.9081.00
314_I333_F0.9061.00
4_C261_E0.9051.00
163_E167_K0.9031.00
373_L389_V0.9031.00
237_D240_G0.9021.00
99_A276_I0.8891.00
260_M270_L0.8861.00
344_A354_S0.8861.00
12_T32_T0.8811.00
13_A32_T0.8771.00
358_I376_A0.8761.00
187_A220_P0.8761.00
232_L243_T0.8751.00
291_M330_N0.8751.00
380_I384_Q0.8741.00
25_S28_D0.8721.00
225_T228_A0.8711.00
14_I251_N0.8691.00
55_N61_L0.8661.00
31_A35_K0.8651.00
37_A111_V0.8641.00
313_L362_L0.8631.00
52_I94_S0.8571.00
233_R244_A0.8541.00
291_M326_A0.8531.00
177_D246_N0.8531.00
185_R188_A0.8531.00
86_K93_K0.8531.00
371_K374_G0.8521.00
165_V291_M0.8441.00
299_K303_L0.8441.00
3_N103_Q0.8411.00
112_A257_L0.8391.00
12_T29_L0.8381.00
174_E230_G0.8361.00
262_E265_A0.8341.00
359_L388_M0.8301.00
12_T203_V0.8291.00
165_V326_A0.8291.00
166_A322_A0.8281.00
133_Y138_G0.8251.00
255_A360_V0.8251.00
94_S356_A0.8241.00
52_I98_A0.8221.00
363_L390_I0.8181.00
297_T331_L0.8171.00
14_I357_R0.8171.00
4_C103_Q0.8161.00
51_V79_V0.8151.00
52_I82_F0.8111.00
192_E216_Q0.8111.00
234_P237_D0.8111.00
276_I279_Y0.8101.00
33_V37_A0.8091.00
341_N368_A0.8081.00
321_A345_I0.8081.00
193_S368_A0.8051.00
380_I385_G0.8051.00
164_N167_K0.8051.00
169_Y330_N0.8041.00
106_Q279_Y0.8021.00
246_N321_A0.7911.00
297_T387_A0.7901.00
316_A377_T0.7891.00
137_D141_Y0.7891.00
99_A103_Q0.7831.00
284_V295_P0.7831.00
341_N369_R0.7811.00
16_S219_F0.7801.00
47_H109_S0.7791.00
306_L310_D0.7791.00
111_V256_A0.7781.00
49_D299_K0.7761.00
324_F328_G0.7721.00
38_I48_V0.7681.00
191_I222_A0.7641.00
263_S266_L0.7611.00
9_A257_L0.7591.00
328_G333_F0.7571.00
161_T289_M0.7571.00
48_V111_V0.7561.00
271_T367_Q0.7541.00
4_C99_A0.7531.00
294_V330_N0.7521.00
71_L77_E0.7511.00
289_M293_P0.7491.00
284_V292_G0.7481.00
50_E281_S0.7471.00
26_A115_M0.7451.00
175_M325_L0.7441.00
24_T28_D0.7411.00
186_K189_A0.7401.00
224_S228_A0.7391.00
119_S252_D0.7381.00
189_A192_E0.7371.00
92_L388_M0.7361.00
30_G113_G0.7341.00
125_L140_V0.7331.00
174_E226_A0.7321.00
162_A322_A0.7291.00
285_P288_L0.7281.00
37_A256_A0.7271.00
224_S245_G0.7261.00
298_Q331_L0.7251.00
309_A337_K0.7201.00
50_E101_A0.7171.00
297_T316_A0.7171.00
49_D110_I0.7161.00
53_M66_A0.7031.00
150_M155_G0.6991.00
97_L100_Q0.6971.00
101_A106_Q0.6971.00
189_A195_A0.6961.00
10_V33_V0.6931.00
184_Q220_P0.6931.00
187_A191_I0.6911.00
108_Q303_L0.6901.00
130_R134_R0.6891.00
97_L101_A0.6871.00
184_Q219_F0.6841.00
25_S120_L0.6831.00
181_L225_T0.6821.00
181_L228_A0.6821.00
316_A327_V0.6821.00
181_L224_S0.6821.00
55_N65_P0.6791.00
75_L111_V0.6791.00
184_Q188_A0.6741.00
273_L364_H0.6741.00
24_T120_L0.6721.00
4_C102_I0.6721.00
6_I259_I0.6721.00
277_K304_A0.6711.00
378_L381_G0.6691.00
38_I42_K0.6681.00
301_L306_L0.6671.00
138_G142_D0.6631.00
134_R138_G0.6620.99
10_V37_A0.6610.99
86_K281_S0.6610.99
300_A375_L0.6610.99
308_L333_F0.6600.99
96_A386_I0.6590.99
281_S386_I0.6580.99
98_A107_A0.6570.99
171_I175_M0.6560.99
100_Q103_Q0.6540.99
309_A332_G0.6490.99
38_I45_S0.6490.99
35_K45_S0.6490.99
5_V261_E0.6490.99
297_T308_L0.6480.99
34_I73_S0.6480.99
5_V264_A0.6470.99
84_V97_L0.6470.99
41_A258_V0.6460.99
312_D373_L0.6450.99
259_I276_I0.6440.99
379_C382_G0.6410.99
29_L203_V0.6400.99
169_Y288_L0.6390.99
257_L360_V0.6390.99
354_S358_I0.6380.99
92_L376_A0.6370.99
138_G141_Y0.6360.99
187_A346_A0.6360.99
52_I97_L0.6360.99
20_S218_E0.6350.99
6_I363_L0.6340.99
45_S76_A0.6340.99
227_E231_A0.6330.99
53_M69_A0.6320.99
7_V265_A0.6320.99
184_Q345_I0.6320.99
326_A330_N0.6320.99
118_M351_I0.6310.99
50_E86_K0.6300.99
101_A110_I0.6300.99
260_M268_A0.6290.99
18_N119_S0.6280.99
219_F251_N0.6270.99
28_D31_A0.6260.99
184_Q223_N0.6260.99
139_Q142_D0.6250.99
70_L81_G0.6220.99
95_V356_A0.6210.99
314_I377_T0.6200.99
80_C281_S0.6190.99
343_G346_A0.6160.99
35_K74_G0.6160.99
157_H160_I0.6150.99
56_V351_I0.6150.99
379_C383_G0.6140.99
347_L357_R0.6140.99
147_D151_C0.6110.99
162_A242_V0.6100.99
301_L304_A0.6090.99
163_E240_G0.6080.99
121_A143_V0.6080.99
108_Q267_A0.6080.99
109_S268_A0.6080.99
272_P275_R0.6070.99
302_Q307_Q0.6070.99
194_G197_T0.6040.99
48_V75_L0.6030.99
366_M374_G0.6010.99
319_A349_H0.6010.99
138_G143_V0.6010.99
186_K335_S0.6000.99
8_S273_L0.5990.99
64_N384_Q0.5990.99
171_I329_K0.5980.99
370_D373_L0.5980.99
188_A221_K0.5980.99
376_A380_I0.5970.99
38_I41_A0.5970.99
35_K73_S0.5960.99
46_Q78_T0.5960.99
7_V264_A0.5950.99
34_I256_A0.5940.99
160_I164_N0.5930.99
323_Q327_V0.5910.99
187_A347_L0.5900.99
165_V169_Y0.5900.99
34_I38_I0.5880.99
324_F338_V0.5880.99
82_F93_K0.5870.99
5_V268_A0.5840.99
51_V111_V0.5830.99
30_G115_M0.5830.99
34_I51_V0.5810.99
70_L75_L0.5800.99
325_L329_K0.5800.99
269_G272_P0.5800.99
69_A115_M0.5790.99
156_Y160_I0.5790.99
32_T35_K0.5770.99
69_A73_S0.5770.99
366_M390_I0.5750.99
242_V247_A0.5730.99
103_Q279_Y0.5720.99
235_A244_A0.5720.99
328_G334_D0.5710.99
353_A356_A0.5700.99
377_T383_G0.5700.99
24_T117_N0.5680.98
27_I72_K0.5670.98
62_G68_Q0.5670.98
93_K281_S0.5670.98
167_K239_A0.5670.98
277_K306_L0.5660.98
13_A200_I0.5660.98
162_A166_A0.5660.98
195_A369_R0.5650.98
300_A311_I0.5650.98
180_A184_Q0.5640.98
58_Q83_T0.5640.98
199_E364_H0.5630.98
312_D372_T0.5630.98
276_I390_I0.5620.98
43_I258_V0.5610.98
377_T382_G0.5590.98
359_L376_A0.5570.98
113_G256_A0.5550.98
280_A303_L0.5550.98
177_D226_A0.5540.98
95_V112_A0.5530.98
31_A73_S0.5520.98
381_G384_Q0.5500.98
277_K389_V0.5500.98
93_K96_A0.5490.98
27_I61_L0.5490.98
169_Y326_A0.5490.98
136_G139_Q0.5490.98
179_L343_G0.5470.98
377_T381_G0.5460.98
286_P289_M0.5440.98
134_R137_D0.5440.98
92_L386_I0.5420.98
133_Y136_G0.5420.98
223_N228_A0.5410.98
177_D230_G0.5410.98
52_I84_V0.5410.98
67_R71_L0.5410.98
236_F240_G0.5370.98
161_T290_G0.5370.98
60_G124_L0.5370.98
13_A215_S0.5360.98
22_A131_S0.5350.98
310_D373_L0.5340.98
374_G390_I0.5340.98
139_Q143_V0.5340.98
93_K101_A0.5340.98
216_Q220_P0.5340.98
94_S112_A0.5330.98
15_G21_L0.5300.98
49_D79_V0.5280.98
125_L133_Y0.5240.97
367_Q370_D0.5240.97
10_V41_A0.5240.97
379_C385_G0.5240.97
273_L277_K0.5220.97
280_A304_A0.5220.97
196_F347_L0.5200.97
180_A321_A0.5200.97
226_A229_L0.5200.97
156_Y287_A0.5190.97
130_R133_Y0.5180.97
178_E335_S0.5160.97
3_N391_E0.5140.97
319_A323_Q0.5120.97
23_S120_L0.5100.97
316_A324_F0.5100.97
295_P299_K0.5100.97
297_T327_V0.5090.97
180_A229_L0.5070.97
376_A379_C0.5070.97
50_E107_A0.5070.97
158_M319_A0.5070.97
347_L361_T0.5050.97
101_A104_A0.5050.97
165_V322_A0.5050.97
378_L383_G0.5040.97
322_A326_A0.5040.97
356_A360_V0.5030.97
177_D229_L0.5020.97
298_Q332_G0.5010.97
297_T301_L0.5010.97
149_L153_T0.5010.97
166_A171_I0.5000.97
204_N214_F0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ulqA 4 0.9924 100 0.232 Contact Map
2vu1A 4 0.9924 100 0.24 Contact Map
3ss6A 4 0.9924 100 0.242 Contact Map
4n46A 4 0.9949 100 0.244 Contact Map
2wu9A 2 0.9695 100 0.246 Contact Map
4e1lA 4 0.9772 100 0.254 Contact Map
4c2jA 4 0.9873 100 0.255 Contact Map
2ib8A 4 0.9848 100 0.255 Contact Map
1wl4A 4 0.9924 100 0.258 Contact Map
4nzsA 4 0.9924 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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