GREMLIN Database
ATOE - Short-chain fatty acids transporter
UniProt: P76460 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11671
Length: 440 (437)
Sequences: 589 (396)
Seq/√Len: 18.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_A319_M6.3321.00
35_A46_M5.7411.00
46_M319_M5.3831.00
197_V428_F5.0351.00
282_G292_Y4.8101.00
371_V385_S4.1071.00
140_I407_A3.6521.00
165_P170_E3.5491.00
73_A292_Y3.5031.00
188_I192_V3.3721.00
350_S363_H3.3071.00
156_G159_P3.1530.99
148_L429_S3.1130.99
93_T96_Q2.8810.99
333_F336_V2.7220.98
73_A296_I2.6010.98
393_E396_M2.5450.97
137_P421_Y2.5390.97
80_V119_V2.5140.97
102_T202_T2.4940.97
65_A307_L2.4870.97
363_H370_F2.4870.97
49_M322_H2.4620.96
250_I312_F2.3930.96
99_M103_F2.3700.96
151_G156_G2.2930.95
375_A383_G2.2710.94
363_H367_Q2.2630.94
5_I9_M2.2310.94
29_L246_L2.2080.94
363_H396_M2.1830.93
158_M386_V2.1480.93
166_G170_E2.1190.92
248_L284_L2.0970.92
300_A307_L2.0910.92
85_R126_E2.0430.91
254_G280_I2.0390.90
167_N173_A2.0380.90
251_G284_L2.0370.90
47_V253_L2.0170.90
342_F385_S2.0150.90
185_G189_F1.9600.89
363_H393_E1.8980.87
395_W430_G1.8950.87
276_L280_I1.8940.87
260_M264_E1.8800.86
258_L277_M1.8770.86
91_A100_L1.8760.86
150_W360_G1.8680.86
351_A396_M1.8590.86
19_D241_E1.8590.86
6_S9_M1.8340.85
398_M429_S1.8290.85
292_Y308_V1.8080.84
350_S393_E1.7990.84
306_I310_F1.7940.84
290_M294_R1.7900.83
64_M310_F1.7870.83
134_S139_L1.7840.83
106_S149_T1.7810.83
87_A123_F1.7770.83
54_F314_A1.7760.83
102_T136_Y1.7730.83
108_A119_V1.7630.82
251_G255_I1.7370.82
354_N396_M1.7210.81
29_L249_I1.7150.81
38_L328_L1.6880.80
67_I114_G1.6550.78
86_T90_A1.6520.78
162_A386_V1.6310.77
56_N314_A1.6280.77
162_A167_N1.6200.77
125_R130_R1.6010.76
151_G159_P1.6000.76
350_S396_M1.5980.76
58_L275_N1.5910.75
106_S195_I1.5890.75
391_Y433_F1.5820.75
350_S370_F1.5780.75
431_V435_I1.5760.75
200_F204_M1.5740.75
32_F46_M1.5630.74
39_T328_L1.5630.74
107_V431_V1.5620.74
344_V438_T1.5580.74
281_A414_G1.5510.73
150_W390_A1.5380.73
167_N175_L1.5320.72
102_T145_I1.5240.72
148_L194_L1.5180.72
49_M323_S1.5160.72
61_G275_N1.5130.71
62_M305_G1.5100.71
248_L252_A1.5090.71
344_V434_V1.4860.70
215_I220_L1.4770.70
349_S367_Q1.4660.69
333_F337_A1.4640.69
330_T353_I1.4580.69
174_G324_G1.4550.68
164_T174_G1.4510.68
64_M112_N1.4490.68
137_P394_Q1.4470.68
332_F336_V1.4420.68
285_L309_Q1.4310.67
115_F133_G1.4290.67
44_I256_A1.4230.67
58_L314_A1.4140.66
427_L431_V1.4140.66
167_N324_G1.4110.66
36_L40_P1.4100.66
31_T319_M1.4000.65
48_K52_D1.3990.65
41_Q49_M1.3900.65
394_Q433_F1.3870.65
137_P368_G1.3650.63
116_G147_F1.3640.63
375_A382_L1.3620.63
373_P377_A1.3550.63
23_F356_A1.3430.62
24_A410_I1.3430.62
342_F375_A1.3400.62
103_F196_V1.3400.62
339_K378_L1.3360.62
67_I105_G1.3350.62
176_I275_N1.3300.61
32_F35_A1.3300.61
113_W271_I1.3280.61
35_A49_M1.3170.60
37_W82_S1.3150.60
413_L418_I1.3150.60
82_S86_T1.3150.60
342_F380_A1.3030.60
99_M192_V1.3010.59
78_A82_S1.2950.59
86_T239_R1.2930.59
146_G150_W1.2870.59
337_A342_F1.2860.59
118_V270_T1.2850.58
167_N174_G1.2780.58
46_M49_M1.2760.58
367_Q370_F1.2680.57
215_I219_L1.2680.57
73_A282_G1.2450.56
161_L168_P1.2440.56
330_T355_F1.2440.56
346_T388_A1.2370.56
32_F319_M1.2310.55
71_G114_G1.2270.55
194_L429_S1.2260.55
173_A323_S1.2210.55
93_T245_I1.2170.54
79_P83_L1.2160.54
293_M296_I1.2150.54
57_L314_A1.2140.54
375_A385_S1.2120.54
84_L140_I1.2110.54
55_W275_N1.2060.54
152_G190_I1.2060.54
354_N363_H1.2030.53
367_Q389_I1.2020.53
373_P414_G1.2010.53
118_V330_T1.1970.53
255_I284_L1.1860.52
167_N323_S1.1740.52
327_G331_E1.1720.51
11_R195_I1.1620.51
25_M250_I1.1500.50
373_P376_Q1.1450.50
74_L281_A1.1430.50
162_A173_A1.1430.50
347_F426_L1.1400.49
320_M362_G1.1370.49
344_V348_F1.1370.49
24_A125_R1.1330.49
193_A432_I1.1310.49
32_F43_P1.1300.49
188_I288_T1.1270.49
155_S438_T1.1260.49
7_R14_S1.1170.48
91_A368_G1.1160.48
17_L419_M1.1130.48
398_M425_A1.1120.48
119_V140_I1.1120.48
54_F312_F1.1110.48
127_V133_G1.1090.47
292_Y368_G1.1060.47
166_G427_L1.1020.47
98_V115_F1.1010.47
91_A94_P1.0870.46
169_V323_S1.0840.46
138_L354_N1.0820.46
354_N393_E1.0670.45
247_T283_L1.0650.45
349_S363_H1.0640.45
26_L118_V1.0640.45
16_W236_P1.0620.45
353_I357_V1.0620.45
296_I308_V1.0580.44
348_F352_L1.0570.44
66_L70_T1.0560.44
326_G330_T1.0520.44
69_V303_T1.0500.44
86_T89_S1.0500.44
150_W187_N1.0490.44
166_G171_H1.0480.44
342_F355_F1.0480.44
341_T438_T1.0360.43
33_V37_W1.0330.43
190_I436_G1.0270.42
422_C426_L1.0270.42
167_N171_H1.0110.41
195_I199_P1.0050.41
309_Q417_D1.0010.41
67_I353_I1.0010.41
351_A393_E0.9990.41
11_R15_R0.9990.41
411_A415_V0.9980.41
332_F335_N0.9900.40
178_V182_L0.9870.40
131_V134_S0.9840.40
330_T334_I0.9820.40
300_A308_V0.9800.39
172_I372_I0.9740.39
348_F434_V0.9730.39
317_Q362_G0.9680.39
169_V368_G0.9680.39
350_S353_I0.9620.38
109_C425_A0.9600.38
275_N314_A0.9560.38
245_I366_I0.9480.38
250_I289_P0.9480.38
25_M346_T0.9420.37
142_C202_T0.9420.37
62_M314_A0.9410.37
68_I302_S0.9400.37
103_F199_P0.9350.37
318_L337_A0.9350.37
131_V419_M0.9300.37
151_G360_G0.9240.36
170_E175_L0.9240.36
185_G337_A0.9200.36
370_F393_E0.9190.36
132_P214_S0.9070.35
196_V200_F0.9020.35
6_S10_T0.9000.35
36_L46_M0.9000.35
107_V193_A0.8980.35
4_R177_P0.8980.35
34_I328_L0.8970.35
7_R82_S0.8960.35
6_S118_V0.8950.35
286_H295_A0.8950.35
391_Y394_Q0.8890.34
104_F120_G0.8870.34
257_Y276_L0.8870.34
142_C344_V0.8840.34
121_A404_A0.8800.34
100_L103_F0.8790.34
317_Q342_F0.8770.33
293_M308_V0.8700.33
290_M293_M0.8690.33
395_W419_M0.8650.33
127_V134_S0.8630.33
64_M114_G0.8620.33
22_I192_V0.8620.33
117_L398_M0.8600.33
23_F355_F0.8570.32
165_P323_S0.8550.32
193_A428_F0.8550.32
68_I120_G0.8500.32
15_R253_L0.8500.32
174_G389_I0.8490.32
310_F342_F0.8470.32
187_N390_A0.8460.32
145_I202_T0.8450.32
135_D214_S0.8450.32
182_L189_F0.8430.32
99_M249_I0.8430.32
243_S285_L0.8420.32
101_V243_S0.8420.32
363_H389_I0.8390.31
23_F262_F0.8390.31
144_Y362_G0.8340.31
244_R287_K0.8310.31
159_P393_E0.8310.31
28_T50_W0.8300.31
315_G421_Y0.8300.31
73_A293_M0.8280.31
55_W154_F0.8270.31
117_L136_Y0.8220.30
210_S221_M0.8200.30
73_A414_G0.8200.30
72_H414_G0.8160.30
12_F16_W0.8140.30
19_D309_Q0.8130.30
140_I411_A0.8120.30
271_I415_V0.8080.30
196_V339_K0.8080.30
242_E290_M0.8040.30
11_R82_S0.7980.29
108_A111_I0.7970.29
64_M67_I0.7940.29
54_F276_L0.7940.29
271_I278_F0.7910.29
38_L427_L0.7890.29
16_W432_I0.7880.29
24_A372_I0.7870.29
341_T344_V0.7860.29
105_G283_L0.7850.29
167_N170_E0.7850.29
151_G404_A0.7830.28
34_I201_I0.7820.28
259_A263_S0.7790.28
123_F435_I0.7750.28
115_F312_F0.7750.28
145_I425_A0.7740.28
94_P259_A0.7740.28
136_Y305_G0.7740.28
151_G393_E0.7710.28
21_L356_A0.7710.28
58_L62_M0.7710.28
435_I439_L0.7700.28
351_A363_H0.7690.28
136_Y140_I0.7670.28
64_M405_L0.7670.28
61_G357_V0.7660.28
180_D232_K0.7650.28
193_A436_G0.7650.28
411_A419_M0.7620.27
66_L121_A0.7540.27
115_F147_F0.7540.27
35_A318_L0.7500.27
136_Y147_F0.7500.27
336_V370_F0.7490.27
244_R248_L0.7490.27
207_P278_F0.7430.26
193_A197_V0.7420.26
196_V428_F0.7420.26
187_N391_Y0.7400.26
33_V225_D0.7370.26
215_I218_K0.7370.26
173_A324_G0.7370.26
118_V410_I0.7350.26
22_I423_I0.7350.26
84_L108_A0.7350.26
330_T424_T0.7340.26
192_V268_N0.7330.26
360_G394_Q0.7320.26
25_M289_P0.7290.26
171_H179_G0.7280.26
285_L417_D0.7260.26
350_S354_N0.7250.26
391_Y437_L0.7240.25
5_I427_L0.7230.25
162_A375_A0.7230.25
188_I298_A0.7230.25
72_H298_A0.7230.25
47_V111_I0.7220.25
115_F131_V0.7220.25
347_F396_M0.7200.25
34_I37_W0.7200.25
6_S112_N0.7200.25
148_L394_Q0.7190.25
152_G391_Y0.7180.25
190_I433_F0.7170.25
178_V299_A0.7170.25
20_P416_R0.7160.25
298_A301_R0.7150.25
372_I382_L0.7150.25
152_G194_L0.7140.25
148_L433_F0.7130.25
52_D252_A0.7130.25
56_N308_V0.7110.25
140_I415_V0.7090.25
8_F197_V0.7080.25
15_R265_H0.7070.25
108_A115_F0.7070.25
351_A354_N0.7060.25
26_L301_R0.7060.25
234_A238_E0.7040.25
193_A239_R0.7040.25
4_R175_L0.7040.25
12_F371_V0.7020.24
338_N341_T0.7020.24
92_K193_A0.7020.24
9_M427_L0.7020.24
13_V416_R0.6990.24
145_I365_V0.6970.24
174_G323_S0.6960.24
231_P245_I0.6960.24
239_R435_I0.6950.24
363_H397_N0.6940.24
342_F346_T0.6930.24
54_F290_M0.6910.24
68_I271_I0.6910.24
52_D56_N0.6910.24
118_V260_M0.6900.24
15_R52_D0.6890.24
150_W357_V0.6880.24
429_S433_F0.6860.24
33_V208_K0.6840.24
220_L410_I0.6840.24
174_G375_A0.6820.24
46_M318_L0.6800.23
9_M423_I0.6790.23
51_G395_W0.6750.23
394_Q398_M0.6750.23
135_D368_G0.6740.23
209_P427_L0.6730.23
41_Q324_G0.6720.23
24_A312_F0.6700.23
223_E245_I0.6690.23
309_Q313_Y0.6680.23
101_V110_V0.6670.23
165_P324_G0.6640.23
29_L259_A0.6640.23
45_S86_T0.6640.23
93_T329_I0.6630.23
46_M111_I0.6620.23
393_E426_L0.6610.23
189_F431_V0.6570.22
232_K427_L0.6560.22
80_V399_A0.6550.22
243_S289_P0.6550.22
232_K238_E0.6540.22
52_D171_H0.6530.22
347_F433_F0.6530.22
77_S168_P0.6520.22
269_I277_M0.6520.22
95_V437_L0.6490.22
317_Q365_V0.6480.22
235_P239_R0.6480.22
82_S232_K0.6450.22
103_F223_E0.6430.22
202_T205_M0.6430.22
176_I335_N0.6430.22
16_W44_I0.6410.22
61_G437_L0.6410.22
99_M434_V0.6400.22
111_I418_I0.6400.22
185_G244_R0.6400.22
29_L83_L0.6390.22
107_V189_F0.6380.22
159_P310_F0.6360.22
286_H405_L0.6340.21
138_L393_E0.6340.21
10_T24_A0.6330.21
337_A340_D0.6320.21
198_M428_F0.6310.21
143_A286_H0.6310.21
324_G409_A0.6290.21
248_L427_L0.6280.21
95_V203_R0.6260.21
81_K126_E0.6240.21
175_L210_S0.6240.21
47_V125_R0.6240.21
113_W432_I0.6230.21
15_R236_P0.6220.21
378_L437_L0.6220.21
405_L413_L0.6220.21
368_G398_M0.6210.21
367_Q387_M0.6210.21
349_S389_I0.6200.21
29_L238_E0.6200.21
105_G137_P0.6190.21
270_T353_I0.6180.21
274_V372_I0.6170.21
113_W430_G0.6160.21
56_N432_I0.6140.21
247_T289_P0.6130.21
272_N343_P0.6130.21
375_A380_A0.6130.21
201_I355_F0.6120.21
127_V296_I0.6120.21
216_D220_L0.6110.20
194_L308_V0.6110.20
89_S130_R0.6110.20
182_L275_N0.6110.20
5_I259_A0.6110.20
80_V283_L0.6100.20
70_T278_F0.6100.20
251_G409_A0.6090.20
29_L250_I0.6090.20
320_M355_F0.6090.20
105_G348_F0.6090.20
64_M157_S0.6080.20
30_L238_E0.6070.20
10_T34_I0.6060.20
82_S264_E0.6060.20
168_P171_H0.6010.20
296_I342_F0.6010.20
108_A120_G0.6000.20
25_M246_L0.5990.20
37_W439_L0.5990.20
252_A277_M0.5940.20
87_A193_A0.5940.20
30_L34_I0.5920.20
70_T114_G0.5910.20
282_G438_T0.5910.20
302_S409_A0.5900.20
212_V281_A0.5890.20
105_G415_V0.5890.20
180_D264_E0.5880.20
346_T363_H0.5870.19
201_I320_M0.5860.19
144_Y149_T0.5860.19
354_N408_L0.5850.19
6_S304_A0.5850.19
403_W419_M0.5850.19
59_A314_A0.5840.19
72_H299_A0.5830.19
158_M305_G0.5830.19
212_V235_P0.5830.19
193_A210_S0.5820.19
46_M197_V0.5800.19
338_N409_A0.5800.19
274_V412_G0.5800.19
57_L360_G0.5790.19
188_I427_L0.5780.19
4_R308_V0.5780.19
69_V116_G0.5780.19
82_S107_V0.5770.19
97_G330_T0.5770.19
38_L379_G0.5760.19
280_I386_V0.5740.19
252_A276_L0.5740.19
274_V374_A0.5740.19
395_W429_S0.5740.19
202_T237_S0.5740.19
70_T270_T0.5730.19
33_V232_K0.5720.19
65_A303_T0.5710.19
208_K212_V0.5700.19
192_V196_V0.5690.19
91_A207_P0.5690.19
151_G310_F0.5690.19
54_F164_T0.5680.19
408_L413_L0.5640.19
181_T406_P0.5630.19
404_A411_A0.5630.19
49_M52_D0.5630.19
23_F288_T0.5630.19
391_Y418_I0.5620.19
197_V208_K0.5620.19
102_T198_M0.5610.18
122_M425_A0.5610.18
26_L179_G0.5610.18
253_L338_N0.5610.18
47_V259_A0.5610.18
365_V400_Q0.5600.18
165_P171_H0.5600.18
142_C349_S0.5600.18
84_L415_V0.5590.18
150_W157_S0.5590.18
163_A174_G0.5590.18
62_M307_L0.5580.18
42_T294_R0.5580.18
16_W240_L0.5570.18
68_I113_W0.5570.18
146_G360_G0.5570.18
252_A281_A0.5560.18
333_F371_V0.5560.18
216_D219_L0.5510.18
62_M66_L0.5510.18
221_M231_P0.5500.18
84_L119_V0.5500.18
62_M114_G0.5490.18
183_F380_A0.5490.18
67_I278_F0.5480.18
273_T350_S0.5450.18
304_A355_F0.5450.18
230_L439_L0.5440.18
210_S340_D0.5440.18
22_I258_L0.5430.18
241_E411_A0.5430.18
105_G108_A0.5430.18
251_G329_I0.5420.18
337_A385_S0.5420.18
24_A106_S0.5420.18
23_F290_M0.5400.18
235_P341_T0.5400.18
62_M409_A0.5400.18
386_V419_M0.5380.18
42_T439_L0.5370.18
98_V102_T0.5370.18
162_A174_G0.5370.18
318_L322_H0.5360.18
357_V366_I0.5360.18
302_S310_F0.5350.18
352_L427_L0.5350.18
48_K264_E0.5350.18
170_E246_L0.5340.17
121_A157_S0.5340.17
78_A335_N0.5340.17
26_L33_V0.5330.17
147_F417_D0.5320.17
23_F134_S0.5320.17
165_P175_L0.5320.17
83_L303_T0.5310.17
138_L205_M0.5280.17
350_S397_N0.5280.17
423_I427_L0.5280.17
201_I428_F0.5260.17
108_A422_C0.5260.17
270_T293_M0.5260.17
362_G366_I0.5250.17
124_A146_G0.5240.17
45_S279_M0.5240.17
34_I38_L0.5240.17
146_G284_L0.5230.17
282_G368_G0.5230.17
68_I71_G0.5230.17
399_A413_L0.5220.17
334_I352_L0.5220.17
31_T300_A0.5210.17
110_V156_G0.5210.17
50_W315_G0.5200.17
41_Q46_M0.5200.17
122_M126_E0.5190.17
23_F321_E0.5190.17
222_E231_P0.5190.17
36_L39_T0.5180.17
161_L389_I0.5180.17
140_I275_N0.5180.17
122_M128_A0.5180.17
169_V240_L0.5180.17
82_S233_D0.5170.17
30_L188_I0.5170.17
144_Y403_W0.5160.17
5_I323_S0.5150.17
347_F397_N0.5150.17
30_L99_M0.5150.17
163_A175_L0.5150.17
337_A381_D0.5150.17
300_A305_G0.5130.17
101_V304_A0.5100.17
255_I383_G0.5080.17
21_L49_M0.5080.17
230_L233_D0.5070.17
85_R298_A0.5060.16
150_W415_V0.5060.16
388_A392_G0.5060.16
196_V221_M0.5050.16
9_M424_T0.5050.16
106_S136_Y0.5040.16
106_S372_I0.5030.16
45_S48_K0.5020.16
263_S329_I0.5010.16
256_A259_A0.5010.16
259_A352_L0.5010.16
64_M71_G0.5010.16
189_F435_I0.5010.16
61_G66_L0.5000.16
370_F396_M0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.9068 100 0.783 Contact Map
4r1iA 2 0.95 100 0.827 Contact Map
4f35D 2 0.8705 99.7 0.896 Contact Map
4djkA 2 0.4364 70.7 0.976 Contact Map
3giaA 1 0.4318 44.8 0.98 Contact Map
4eneA 2 0.3886 30.9 0.981 Contact Map
4tphA 2 0.3886 28.4 0.982 Contact Map
2jlnA 1 0.4386 19 0.983 Contact Map
2mmuA 1 0.0977 17.3 0.984 Contact Map
3zuxA 1 0.275 13.5 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0128 seconds.