GREMLIN Database
ATOA - Acetate CoA-transferase subunit beta
UniProt: P76459 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11670
Length: 216 (203)
Sequences: 3106 (1441)
Seq/√Len: 101.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_D108_N4.1541.00
193_A197_A3.3721.00
143_A147_S3.3261.00
174_F203_F3.2461.00
80_D83_M3.1591.00
166_M175_R3.1571.00
152_R200_E3.0381.00
177_I180_K2.8371.00
186_I195_V2.6241.00
175_R184_T2.6131.00
186_I192_L2.6031.00
177_I182_W2.5711.00
150_I181_M2.4251.00
171_L198_K2.4001.00
183_L205_V2.3921.00
72_V76_A2.3421.00
10_R185_E2.3191.00
105_E152_R2.2981.00
176_F181_M2.2751.00
192_L205_V2.2721.00
194_T198_K2.2701.00
49_F72_V2.1691.00
16_R19_D2.1321.00
11_V138_A2.0111.00
72_V78_M1.9201.00
105_E202_R1.9091.00
182_W206_A1.8951.00
55_V68_Q1.8561.00
11_V97_V1.8291.00
191_D194_T1.8231.00
7_I138_A1.8011.00
171_L190_C1.7811.00
167_L176_F1.7781.00
11_V168_V1.7651.00
106_E153_R1.7611.00
194_T197_A1.7221.00
196_R203_F1.7151.00
192_L196_R1.7111.00
44_Q88_I1.6961.00
19_D95_A1.6851.00
182_W204_E1.6821.00
154_C158_L1.6491.00
183_L192_L1.6401.00
187_A190_C1.6401.00
89_R127_D1.6311.00
5_Q34_Y1.6191.00
31_V97_V1.5961.00
141_H199_T1.5901.00
184_T206_A1.5841.00
180_K204_E1.5731.00
15_L31_V1.4781.00
196_R202_R1.4701.00
94_D133_R1.4361.00
166_M184_T1.4351.00
100_G139_M1.4231.00
102_Q155_T1.4141.00
150_I167_L1.4051.00
134_K164_V1.3951.00
14_E166_M1.3330.99
179_G204_E1.3310.99
148_A200_E1.3190.99
14_E168_V1.2960.99
49_F52_L1.2560.99
167_L181_M1.2390.99
95_A136_I1.2340.99
15_L21_V1.2270.99
199_T203_F1.2180.99
45_S49_F1.2070.99
172_A195_V1.2060.99
100_G109_L1.1910.99
153_R156_M1.1860.98
136_I168_V1.1850.98
147_S150_I1.1780.98
175_R182_W1.1740.98
50_L79_F1.1600.98
4_K30_M1.1440.98
152_R202_R1.1400.98
186_I190_C1.1310.98
173_V185_E1.1220.98
64_N68_Q1.1130.98
142_C198_K1.1130.98
27_L138_A1.1070.98
193_A196_R1.1020.98
134_K166_M1.0970.97
4_K27_L1.0680.97
151_L155_T1.0630.97
152_R201_A1.0600.97
138_A168_V1.0570.97
4_K140_E1.0530.97
142_C170_E1.0530.97
102_Q156_M1.0240.96
95_A134_K1.0210.96
183_L195_V1.0170.96
6_R9_R1.0090.96
32_A35_L1.0060.96
146_G157_P1.0030.96
174_F196_R1.0000.96
102_Q151_L0.9880.95
153_R157_P0.9820.95
129_V160_A0.9820.95
97_V138_A0.9810.95
176_F180_K0.9780.95
17_D40_H0.9770.95
87_L93_I0.9720.95
150_I153_R0.9670.95
8_A31_V0.9570.94
136_I166_M0.9470.94
146_G156_M0.9380.94
35_L43_L0.9250.93
146_G153_R0.9170.93
54_P73_L0.9050.93
181_M201_A0.9040.93
171_L194_T0.9040.93
102_Q148_A0.8990.92
148_A156_M0.8980.92
177_I204_E0.8950.92
146_G154_C0.8890.92
53_G71_G0.8850.92
28_P99_G0.8830.92
106_E162_H0.8790.91
183_L203_F0.8790.91
32_A55_V0.8740.91
17_D39_I0.8720.91
25_I47_N0.8710.91
190_C194_T0.8700.91
146_G150_I0.8500.90
147_S155_T0.8490.90
100_G103_V0.8400.89
10_R173_V0.8380.89
20_I87_L0.8330.89
15_L97_V0.8290.89
56_T71_G0.8270.89
101_L115_P0.8220.88
6_R188_D0.8220.88
53_G56_T0.8160.88
190_C195_V0.8130.88
141_H171_L0.8110.88
59_H62_L0.8090.88
179_G206_A0.8060.87
174_F205_V0.8020.87
147_S154_C0.7990.87
14_E134_K0.7910.86
11_V31_V0.7880.86
103_V109_L0.7810.86
15_L41_I0.7790.86
105_E201_A0.7770.85
28_P47_N0.7770.85
181_M203_F0.7750.85
150_I154_C0.7750.85
151_L154_C0.7720.85
27_L30_M0.7630.84
179_G182_W0.7590.84
63_V66_G0.7580.84
69_P120_P0.7580.84
148_A153_R0.7520.84
113_V119_V0.7460.83
192_L203_F0.7450.83
112_W115_P0.7380.82
9_R34_Y0.7360.82
5_Q9_R0.7340.82
102_Q143_A0.7300.82
152_R155_T0.7300.82
9_R13_Q0.7300.82
160_A163_A0.7290.82
164_V175_R0.7280.82
25_I99_G0.7210.81
36_P39_I0.7190.81
134_K165_H0.7120.80
196_R204_E0.7120.80
27_L140_E0.7100.80
129_V163_A0.7080.80
177_I206_A0.7070.80
15_L95_A0.7050.79
10_R14_E0.7010.79
97_V168_V0.6910.78
49_F78_M0.6910.78
145_D148_A0.6890.78
171_L187_A0.6870.78
79_F84_S0.6850.78
196_R205_V0.6850.78
167_L174_F0.6840.77
192_L195_V0.6830.77
25_I67_G0.6790.77
148_A157_P0.6770.77
114_V117_K0.6750.76
60_P69_P0.6740.76
150_I157_P0.6730.76
62_L65_A0.6730.76
20_I50_L0.6720.76
171_L195_V0.6720.76
60_P64_N0.6700.76
143_A148_A0.6690.76
158_L161_Q0.6680.76
91_G98_L0.6670.76
46_E85_F0.6670.76
55_V69_P0.6590.75
11_V136_I0.6570.75
104_D153_R0.6560.74
14_E136_I0.6540.74
55_V71_G0.6540.74
150_I156_M0.6520.74
6_R187_A0.6470.73
5_Q30_M0.6470.73
174_F181_M0.6470.73
171_L199_T0.6460.73
122_M126_M0.6410.73
10_R13_Q0.6390.72
68_Q130_T0.6390.72
187_A195_V0.6310.72
7_I11_V0.6250.71
25_I29_T0.6250.71
193_A202_R0.6230.71
147_S157_P0.6210.70
52_L72_V0.6150.70
21_V41_I0.6110.69
103_V181_M0.6100.69
45_S84_S0.6040.68
147_S153_R0.6020.68
58_A62_L0.5990.68
58_A69_P0.5980.67
70_C78_M0.5920.67
59_H70_C0.5910.67
114_V156_M0.5910.67
186_I189_G0.5870.66
17_D38_G0.5870.66
12_A91_G0.5850.66
172_A203_F0.5840.66
121_G168_V0.5830.66
14_E173_V0.5820.65
142_C148_A0.5800.65
147_S156_M0.5770.65
111_N115_P0.5760.65
6_R170_E0.5760.65
109_L137_I0.5740.64
49_F75_G0.5710.64
186_I191_D0.5710.64
55_V120_P0.5710.64
122_M129_V0.5690.64
13_Q16_R0.5670.63
101_L114_V0.5660.63
8_A34_Y0.5650.63
202_R205_V0.5640.63
195_V198_K0.5640.63
19_D134_K0.5610.63
67_G71_G0.5590.62
109_L129_V0.5570.62
154_C157_P0.5570.62
8_A27_L0.5560.62
146_G155_T0.5560.62
26_G46_E0.5540.62
20_I42_T0.5530.61
17_D36_P0.5520.61
146_G151_L0.5490.61
121_G136_I0.5480.61
148_A201_A0.5480.61
95_A130_T0.5470.61
35_L39_I0.5470.61
55_V73_L0.5460.61
172_A186_I0.5450.60
114_V118_M0.5450.60
172_A184_T0.5450.60
11_V130_T0.5430.60
49_F70_C0.5420.60
8_A30_M0.5400.60
25_I81_S0.5400.60
64_N70_C0.5400.60
58_A72_V0.5400.60
115_P121_G0.5400.60
90_G131_G0.5390.60
183_L196_R0.5370.59
58_A113_V0.5370.59
5_Q38_G0.5370.59
31_V35_L0.5350.59
122_M156_M0.5330.59
109_L164_V0.5330.59
190_C198_K0.5300.58
7_I170_E0.5300.58
130_T160_A0.5290.58
93_I98_L0.5280.58
108_N162_H0.5280.58
109_L122_M0.5260.58
29_T66_G0.5250.58
28_P138_A0.5230.57
50_L77_A0.5220.57
146_G152_R0.5210.57
118_M122_M0.5210.57
118_M156_M0.5190.57
13_Q196_R0.5170.56
159_T162_H0.5160.56
155_T178_D0.5160.56
88_I93_I0.5160.56
49_F76_A0.5150.56
202_R206_A0.5140.56
127_D131_G0.5130.56
126_M131_G0.5110.56
182_W205_V0.5080.55
16_R39_I0.5080.55
102_Q152_R0.5070.55
35_L41_I0.5060.55
7_I92_H0.5030.54
29_T102_Q0.5020.54
63_V69_P0.5010.54
75_G78_M0.5010.54
35_L119_V0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1poiB 1 0.963 100 0.3 Contact Map
3k6mA 2 0.9954 100 0.32 Contact Map
4kgbA 2 0.9722 100 0.328 Contact Map
2ahuA 3 0.9306 100 0.34 Contact Map
1xr4A 2 0.9815 100 0.444 Contact Map
2hj0A 2 0.9769 100 0.465 Contact Map
3gk7A 2 0.9769 100 0.506 Contact Map
3rrlB 1 0.9444 100 0.508 Contact Map
3d3uA 1 0.8843 100 0.519 Contact Map
2oasA 3 0.9676 100 0.523 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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