ATOD - ECOLI - GREMLIN Contacts

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ATOD - Acetate CoA-transferase subunit alpha

UniProt:	P76458	Sequences: MKTKLMTLQDATGFFRDGMTIMVGGFMGIGTPSRLVEALLESGVRDLTLIANDTAFVDTGIGPLIVNGRVRKVIASHIGTNPETGRRMISGEMDVVLVPQGTLIEQIRCGGAGLGGFLTPTGVGTVVEEGKQTLTLDGKTWLLERPLRADLALIRAHRCDTLGNLTYQLSARNFNPLIALAADITLVEPDELVETGELQPDHIVTPGAVIDHIIVSQESK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11669
Length:	220 (215)
Sequences:	3481 (1807)
Seq/√Len:	123.2

ECOLI - ATOD YDIF
BACSU - SCOA YODS
HALSA - Q9HHP2
SULSO - Q97Z52

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
161_T	194_E	3.426	1.00
120_P	139_K	3.244	1.00
156_A	165_L	3.183	1.00
16_R	19_M	3.031	1.00
135_T	140_T	2.939	1.00
167_Y	205_T	2.612	1.00
165_L	187_V	2.598	1.00
17_D	45_R	2.575	1.00
46_D	71_R	2.567	1.00
158_R	191_E	2.562	1.00
83_E	86_R	2.404	1.00
198_L	203_I	2.339	1.00
137_D	145_R	2.286	1.00
9_Q	41_E	2.243	1.00
71_R	94_D	2.226	1.00
86_R	90_S	2.206	1.00
22_M	149_A	2.191	1.00
133_T	140_T	2.088	1.00
7_T	10_D	2.061	1.00
15_F	39_L	2.055	1.00
38_A	41_E	2.003	1.00
152_A	182_A	2.000	1.00
68_G	87_R	1.943	1.00
72_K	94_D	1.929	1.00
48_T	74_I	1.916	1.00
110_G	148_R	1.865	1.00
159_C	189_P	1.847	1.00
22_M	107_I	1.785	1.00
37_E	63_P	1.782	1.00
14_F	212_H	1.766	1.00
35_L	153_L	1.764	1.00
162_L	195_T	1.757	1.00
148_R	183_D	1.750	1.00
157_H	168_Q	1.729	1.00
159_C	187_V	1.717	1.00
87_R	92_E	1.715	1.00
68_G	92_E	1.661	1.00
126_V	129_E	1.660	1.00
184_I	212_H	1.645	1.00
116_G	143_L	1.615	1.00
40_L	69_R	1.601	1.00
50_I	147_L	1.586	1.00
199_Q	202_H	1.584	1.00
161_T	195_T	1.581	1.00
6_M	212_H	1.565	1.00
19_M	151_L	1.525	1.00
123_V	140_T	1.509	1.00
22_M	178_I	1.491	1.00
64_L	69_R	1.487	1.00
39_L	153_L	1.476	1.00
18_G	46_D	1.473	1.00
158_R	166_T	1.461	1.00
10_D	13_G	1.461	1.00
48_T	72_K	1.437	1.00
58_D	66_V	1.427	1.00
109_C	117_F	1.407	1.00
160_D	164_N	1.404	1.00
118_L	134_L	1.402	1.00
130_G	133_T	1.382	1.00
159_C	192_L	1.378	1.00
23_V	153_L	1.345	1.00
6_M	10_D	1.344	1.00
115_G	136_L	1.343	1.00
179_A	185_T	1.319	1.00
151_L	184_I	1.318	1.00
132_Q	137_D	1.313	1.00
96_V	106_Q	1.313	1.00
128_E	133_T	1.281	1.00
9_Q	38_A	1.253	1.00
12_T	38_A	1.252	1.00
17_D	44_V	1.251	1.00
135_T	138_G	1.249	1.00
20_T	50_I	1.241	0.99
15_F	19_M	1.232	0.99
50_I	149_A	1.230	0.99
158_R	193_V	1.226	0.99
67_N	92_E	1.223	0.99
31_T	36_V	1.214	0.99
40_L	66_V	1.180	0.99
8_L	38_A	1.175	0.99
107_I	178_I	1.171	0.99
38_A	42_S	1.170	0.99
194_E	197_E	1.163	0.99
105_E	108_R	1.159	0.99
72_K	96_V	1.155	0.99
34_R	216_S	1.147	0.99
98_V	106_Q	1.145	0.99
15_F	151_L	1.141	0.99
115_G	146_P	1.139	0.99
48_T	71_R	1.132	0.99
102_T	119_T	1.116	0.99
34_R	188_E	1.097	0.99
23_V	36_V	1.094	0.99
114_L	117_F	1.090	0.99
154_I	187_V	1.080	0.99
12_T	15_F	1.080	0.99
169_L	201_D	1.076	0.99
40_L	67_N	1.072	0.98
16_R	151_L	1.067	0.98
65_I	87_R	1.065	0.98
154_I	178_I	1.063	0.98
49_L	70_V	1.059	0.98
106_Q	146_P	1.056	0.98
156_A	189_P	1.045	0.98
169_L	190_D	1.038	0.98
37_E	41_E	1.037	0.98
40_L	63_P	1.016	0.98
43_G	69_R	1.015	0.98
3_T	6_M	1.010	0.98
186_L	214_I	1.006	0.98
11_A	186_L	0.992	0.97
109_C	114_L	0.988	0.97
192_L	215_V	0.987	0.97
180_L	209_V	0.985	0.97
159_C	165_L	0.978	0.97
157_H	190_D	0.976	0.97
14_F	184_I	0.970	0.97
54_T	84_T	0.963	0.97
165_L	189_P	0.961	0.97
6_M	12_T	0.960	0.97
12_T	42_S	0.958	0.97
187_V	205_T	0.958	0.97
107_I	181_A	0.953	0.97
161_T	197_E	0.951	0.97
54_T	73_V	0.944	0.97
44_V	69_R	0.939	0.96
155_R	216_S	0.939	0.96
22_M	147_L	0.937	0.96
15_F	186_L	0.930	0.96
154_I	179_A	0.917	0.96
191_E	215_V	0.916	0.96
106_Q	145_R	0.910	0.96
66_V	83_E	0.904	0.96
11_A	214_I	0.904	0.96
189_P	192_L	0.904	0.96
19_M	150_D	0.903	0.96
130_G	140_T	0.897	0.95
153_L	186_L	0.896	0.95
172_R	204_V	0.893	0.95
159_C	213_I	0.890	0.95
184_I	187_V	0.883	0.95
166_T	202_H	0.878	0.95
178_I	182_A	0.876	0.95
65_I	70_V	0.872	0.95
158_R	168_Q	0.869	0.95
133_T	142_L	0.866	0.94
83_E	87_R	0.862	0.94
75_A	78_I	0.858	0.94
118_L	136_L	0.848	0.94
17_D	46_D	0.847	0.94
88_M	95_V	0.846	0.94
165_L	205_T	0.842	0.94
17_D	43_G	0.840	0.94
22_M	50_I	0.830	0.93
172_R	201_D	0.830	0.93
34_R	217_Q	0.828	0.93
15_F	153_L	0.826	0.93
77_H	80_T	0.826	0.93
13_G	42_S	0.824	0.93
167_Y	176_P	0.822	0.93
118_L	143_L	0.821	0.93
123_V	142_L	0.815	0.92
24_G	175_N	0.809	0.92
21_I	153_L	0.808	0.92
116_G	145_R	0.807	0.92
107_I	149_A	0.803	0.92
132_Q	135_T	0.801	0.92
110_G	147_L	0.800	0.92
186_L	212_H	0.797	0.92
108_R	112_A	0.796	0.92
105_E	117_F	0.784	0.91
193_V	197_E	0.783	0.91
136_L	143_L	0.783	0.91
115_G	141_W	0.780	0.91
131_K	144_E	0.780	0.91
5_L	212_H	0.780	0.91
116_G	134_L	0.778	0.91
105_E	114_L	0.774	0.90
134_L	137_D	0.774	0.90
128_E	142_L	0.768	0.90
136_L	145_R	0.767	0.90
20_T	149_A	0.766	0.90
185_T	211_D	0.763	0.90
78_I	84_T	0.762	0.90
122_G	142_L	0.762	0.90
152_A	178_I	0.752	0.89
34_R	37_E	0.748	0.89
6_M	14_F	0.746	0.89
116_G	146_P	0.740	0.88
201_D	204_V	0.740	0.88
14_F	19_M	0.737	0.88
149_A	182_A	0.737	0.88
76_S	103_L	0.736	0.88
100_Q	104_I	0.733	0.88
155_R	188_E	0.727	0.87
154_I	205_T	0.721	0.87
169_L	199_Q	0.717	0.87
150_D	183_D	0.717	0.87
51_A	61_I	0.714	0.86
11_A	14_F	0.713	0.86
57_V	82_P	0.710	0.86
45_R	69_R	0.706	0.86
193_V	196_G	0.695	0.85
176_P	180_L	0.694	0.85
166_T	198_L	0.693	0.85
176_P	205_T	0.692	0.85
39_L	44_V	0.692	0.85
111_G	180_L	0.690	0.85
64_L	70_V	0.689	0.84
35_L	214_I	0.684	0.84
56_F	59_T	0.677	0.83
188_E	216_S	0.671	0.83
11_A	15_F	0.665	0.82
11_A	42_S	0.664	0.82
39_L	69_R	0.664	0.82
5_L	10_D	0.663	0.82
166_T	203_I	0.662	0.82
28_G	56_F	0.660	0.82
35_L	39_L	0.660	0.82
33_S	59_T	0.659	0.82
191_E	197_E	0.659	0.82
179_A	205_T	0.657	0.82
4_K	213_I	0.652	0.81
9_Q	13_G	0.649	0.81
57_V	62_G	0.649	0.81
20_T	48_T	0.646	0.81
27_M	55_A	0.645	0.80
15_F	44_V	0.642	0.80
56_F	62_G	0.640	0.80
76_S	100_Q	0.639	0.80
131_K	142_L	0.637	0.80
137_D	148_R	0.632	0.79
54_T	80_T	0.632	0.79
3_T	161_T	0.630	0.79
32_P	35_L	0.628	0.79
12_T	35_L	0.627	0.79
55_A	100_Q	0.627	0.79
50_I	107_I	0.623	0.78
23_V	51_A	0.622	0.78
157_H	191_E	0.622	0.78
29_I	171_A	0.621	0.78
172_R	176_P	0.619	0.78
11_A	212_H	0.618	0.78
177_L	180_L	0.617	0.77
12_T	212_H	0.617	0.77
155_R	189_P	0.614	0.77
7_T	11_A	0.614	0.77
106_Q	147_L	0.612	0.77
167_Y	204_V	0.610	0.77
120_P	141_W	0.607	0.76
157_H	166_T	0.606	0.76
73_V	84_T	0.606	0.76
24_G	173_N	0.605	0.76
112_A	180_L	0.605	0.76
27_M	80_T	0.602	0.76
132_Q	143_L	0.600	0.75
23_V	49_L	0.598	0.75
134_L	143_L	0.598	0.75
128_E	140_T	0.596	0.75
143_L	146_P	0.592	0.74
30_G	167_Y	0.591	0.74
22_M	181_A	0.587	0.74
166_T	204_V	0.586	0.74
169_L	189_P	0.585	0.74
85_G	88_M	0.578	0.73
23_V	32_P	0.577	0.73
166_T	199_Q	0.577	0.73
27_M	53_D	0.576	0.72
14_F	186_L	0.574	0.72
123_V	133_T	0.573	0.72
106_Q	144_E	0.568	0.71
87_R	90_S	0.565	0.71
49_L	54_T	0.560	0.70
24_G	32_P	0.559	0.70
85_G	89_I	0.558	0.70
110_G	146_P	0.558	0.70
59_T	63_P	0.556	0.70
33_S	216_S	0.550	0.69
162_L	207_G	0.550	0.69
67_N	90_S	0.549	0.69
44_V	47_L	0.547	0.69
62_G	81_N	0.546	0.68
39_L	64_L	0.545	0.68
86_R	89_I	0.545	0.68
110_G	149_A	0.545	0.68
53_D	61_I	0.543	0.68
40_L	43_G	0.541	0.68
31_T	80_T	0.539	0.67
16_R	44_V	0.535	0.67
34_R	155_R	0.534	0.67
22_M	182_A	0.533	0.67
62_G	80_T	0.533	0.67
114_L	118_L	0.532	0.66
62_G	78_I	0.530	0.66
50_I	74_I	0.529	0.66
100_Q	175_N	0.529	0.66
105_E	112_A	0.527	0.66
4_K	192_L	0.527	0.66
107_I	177_L	0.524	0.65
158_R	202_H	0.524	0.65
31_T	190_D	0.524	0.65
155_R	190_D	0.523	0.65
74_I	96_V	0.523	0.65
52_N	107_I	0.522	0.65
87_R	93_M	0.522	0.65
127_V	142_L	0.521	0.65
8_L	34_R	0.521	0.65
73_V	93_M	0.520	0.65
123_V	128_E	0.519	0.65
184_I	211_D	0.517	0.64
8_L	216_S	0.517	0.64
58_D	62_G	0.509	0.63
59_T	155_R	0.508	0.63
53_D	80_T	0.504	0.62
52_N	100_Q	0.504	0.62
31_T	51_A	0.503	0.62
192_L	213_I	0.503	0.62
33_S	40_L	0.503	0.62
73_V	88_M	0.502	0.62
152_A	177_L	0.502	0.62
74_I	147_L	0.500	0.62
26_F	30_G	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kgbA	2	0.9864	100	0.234	Contact Map
3cdkA	2	1	100	0.234	Contact Map
3rrlA	2	1	100	0.242	Contact Map
1k6dA	2	0.9955	100	0.242	Contact Map
1poiA	3	0.9727	100	0.246	Contact Map
3k6mA	2	0.9955	100	0.246	Contact Map
2ahuA	3	1	100	0.287	Contact Map
2hj0A	2	0.8182	100	0.516	Contact Map
3qliA	2	0.8364	100	0.519	Contact Map
1xr4A	2	0.8136	100	0.524	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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