GREMLIN Database
ATOD - Acetate CoA-transferase subunit alpha
UniProt: P76458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11669
Length: 220 (215)
Sequences: 3481 (1807)
Seq/√Len: 123.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_T194_E3.4261.00
120_P139_K3.2441.00
156_A165_L3.1831.00
16_R19_M3.0311.00
135_T140_T2.9391.00
167_Y205_T2.6121.00
165_L187_V2.5981.00
17_D45_R2.5751.00
46_D71_R2.5671.00
158_R191_E2.5621.00
83_E86_R2.4041.00
198_L203_I2.3391.00
137_D145_R2.2861.00
9_Q41_E2.2431.00
71_R94_D2.2261.00
86_R90_S2.2061.00
22_M149_A2.1911.00
133_T140_T2.0881.00
7_T10_D2.0611.00
15_F39_L2.0551.00
38_A41_E2.0031.00
152_A182_A2.0001.00
68_G87_R1.9431.00
72_K94_D1.9291.00
48_T74_I1.9161.00
110_G148_R1.8651.00
159_C189_P1.8471.00
22_M107_I1.7851.00
37_E63_P1.7821.00
14_F212_H1.7661.00
35_L153_L1.7641.00
162_L195_T1.7571.00
148_R183_D1.7501.00
157_H168_Q1.7291.00
159_C187_V1.7171.00
87_R92_E1.7151.00
68_G92_E1.6611.00
126_V129_E1.6601.00
184_I212_H1.6451.00
116_G143_L1.6151.00
40_L69_R1.6011.00
50_I147_L1.5861.00
199_Q202_H1.5841.00
161_T195_T1.5811.00
6_M212_H1.5651.00
19_M151_L1.5251.00
123_V140_T1.5091.00
22_M178_I1.4911.00
64_L69_R1.4871.00
39_L153_L1.4761.00
18_G46_D1.4731.00
158_R166_T1.4611.00
10_D13_G1.4611.00
48_T72_K1.4371.00
58_D66_V1.4271.00
109_C117_F1.4071.00
160_D164_N1.4041.00
118_L134_L1.4021.00
130_G133_T1.3821.00
159_C192_L1.3781.00
23_V153_L1.3451.00
6_M10_D1.3441.00
115_G136_L1.3431.00
179_A185_T1.3191.00
151_L184_I1.3181.00
132_Q137_D1.3131.00
96_V106_Q1.3131.00
128_E133_T1.2811.00
9_Q38_A1.2531.00
12_T38_A1.2521.00
17_D44_V1.2511.00
135_T138_G1.2491.00
20_T50_I1.2410.99
15_F19_M1.2320.99
50_I149_A1.2300.99
158_R193_V1.2260.99
67_N92_E1.2230.99
31_T36_V1.2140.99
40_L66_V1.1800.99
8_L38_A1.1750.99
107_I178_I1.1710.99
38_A42_S1.1700.99
194_E197_E1.1630.99
105_E108_R1.1590.99
72_K96_V1.1550.99
34_R216_S1.1470.99
98_V106_Q1.1450.99
15_F151_L1.1410.99
115_G146_P1.1390.99
48_T71_R1.1320.99
102_T119_T1.1160.99
34_R188_E1.0970.99
23_V36_V1.0940.99
114_L117_F1.0900.99
154_I187_V1.0800.99
12_T15_F1.0800.99
169_L201_D1.0760.99
40_L67_N1.0720.98
16_R151_L1.0670.98
65_I87_R1.0650.98
154_I178_I1.0630.98
49_L70_V1.0590.98
106_Q146_P1.0560.98
156_A189_P1.0450.98
169_L190_D1.0380.98
37_E41_E1.0370.98
40_L63_P1.0160.98
43_G69_R1.0150.98
3_T6_M1.0100.98
186_L214_I1.0060.98
11_A186_L0.9920.97
109_C114_L0.9880.97
192_L215_V0.9870.97
180_L209_V0.9850.97
159_C165_L0.9780.97
157_H190_D0.9760.97
14_F184_I0.9700.97
54_T84_T0.9630.97
165_L189_P0.9610.97
6_M12_T0.9600.97
12_T42_S0.9580.97
187_V205_T0.9580.97
107_I181_A0.9530.97
161_T197_E0.9510.97
54_T73_V0.9440.97
44_V69_R0.9390.96
155_R216_S0.9390.96
22_M147_L0.9370.96
15_F186_L0.9300.96
154_I179_A0.9170.96
191_E215_V0.9160.96
106_Q145_R0.9100.96
66_V83_E0.9040.96
11_A214_I0.9040.96
189_P192_L0.9040.96
19_M150_D0.9030.96
130_G140_T0.8970.95
153_L186_L0.8960.95
172_R204_V0.8930.95
159_C213_I0.8900.95
184_I187_V0.8830.95
166_T202_H0.8780.95
178_I182_A0.8760.95
65_I70_V0.8720.95
158_R168_Q0.8690.95
133_T142_L0.8660.94
83_E87_R0.8620.94
75_A78_I0.8580.94
118_L136_L0.8480.94
17_D46_D0.8470.94
88_M95_V0.8460.94
165_L205_T0.8420.94
17_D43_G0.8400.94
22_M50_I0.8300.93
172_R201_D0.8300.93
34_R217_Q0.8280.93
15_F153_L0.8260.93
77_H80_T0.8260.93
13_G42_S0.8240.93
167_Y176_P0.8220.93
118_L143_L0.8210.93
123_V142_L0.8150.92
24_G175_N0.8090.92
21_I153_L0.8080.92
116_G145_R0.8070.92
107_I149_A0.8030.92
132_Q135_T0.8010.92
110_G147_L0.8000.92
186_L212_H0.7970.92
108_R112_A0.7960.92
105_E117_F0.7840.91
193_V197_E0.7830.91
136_L143_L0.7830.91
115_G141_W0.7800.91
131_K144_E0.7800.91
5_L212_H0.7800.91
116_G134_L0.7780.91
105_E114_L0.7740.90
134_L137_D0.7740.90
128_E142_L0.7680.90
136_L145_R0.7670.90
20_T149_A0.7660.90
185_T211_D0.7630.90
78_I84_T0.7620.90
122_G142_L0.7620.90
152_A178_I0.7520.89
34_R37_E0.7480.89
6_M14_F0.7460.89
116_G146_P0.7400.88
201_D204_V0.7400.88
14_F19_M0.7370.88
149_A182_A0.7370.88
76_S103_L0.7360.88
100_Q104_I0.7330.88
155_R188_E0.7270.87
154_I205_T0.7210.87
169_L199_Q0.7170.87
150_D183_D0.7170.87
51_A61_I0.7140.86
11_A14_F0.7130.86
57_V82_P0.7100.86
45_R69_R0.7060.86
193_V196_G0.6950.85
176_P180_L0.6940.85
166_T198_L0.6930.85
176_P205_T0.6920.85
39_L44_V0.6920.85
111_G180_L0.6900.85
64_L70_V0.6890.84
35_L214_I0.6840.84
56_F59_T0.6770.83
188_E216_S0.6710.83
11_A15_F0.6650.82
11_A42_S0.6640.82
39_L69_R0.6640.82
5_L10_D0.6630.82
166_T203_I0.6620.82
28_G56_F0.6600.82
35_L39_L0.6600.82
33_S59_T0.6590.82
191_E197_E0.6590.82
179_A205_T0.6570.82
4_K213_I0.6520.81
9_Q13_G0.6490.81
57_V62_G0.6490.81
20_T48_T0.6460.81
27_M55_A0.6450.80
15_F44_V0.6420.80
56_F62_G0.6400.80
76_S100_Q0.6390.80
131_K142_L0.6370.80
137_D148_R0.6320.79
54_T80_T0.6320.79
3_T161_T0.6300.79
32_P35_L0.6280.79
12_T35_L0.6270.79
55_A100_Q0.6270.79
50_I107_I0.6230.78
23_V51_A0.6220.78
157_H191_E0.6220.78
29_I171_A0.6210.78
172_R176_P0.6190.78
11_A212_H0.6180.78
177_L180_L0.6170.77
12_T212_H0.6170.77
155_R189_P0.6140.77
7_T11_A0.6140.77
106_Q147_L0.6120.77
167_Y204_V0.6100.77
120_P141_W0.6070.76
157_H166_T0.6060.76
73_V84_T0.6060.76
24_G173_N0.6050.76
112_A180_L0.6050.76
27_M80_T0.6020.76
132_Q143_L0.6000.75
23_V49_L0.5980.75
134_L143_L0.5980.75
128_E140_T0.5960.75
143_L146_P0.5920.74
30_G167_Y0.5910.74
22_M181_A0.5870.74
166_T204_V0.5860.74
169_L189_P0.5850.74
85_G88_M0.5780.73
23_V32_P0.5770.73
166_T199_Q0.5770.73
27_M53_D0.5760.72
14_F186_L0.5740.72
123_V133_T0.5730.72
106_Q144_E0.5680.71
87_R90_S0.5650.71
49_L54_T0.5600.70
24_G32_P0.5590.70
85_G89_I0.5580.70
110_G146_P0.5580.70
59_T63_P0.5560.70
33_S216_S0.5500.69
162_L207_G0.5500.69
67_N90_S0.5490.69
44_V47_L0.5470.69
62_G81_N0.5460.68
39_L64_L0.5450.68
86_R89_I0.5450.68
110_G149_A0.5450.68
53_D61_I0.5430.68
40_L43_G0.5410.68
31_T80_T0.5390.67
16_R44_V0.5350.67
34_R155_R0.5340.67
22_M182_A0.5330.67
62_G80_T0.5330.67
114_L118_L0.5320.66
62_G78_I0.5300.66
50_I74_I0.5290.66
100_Q175_N0.5290.66
105_E112_A0.5270.66
4_K192_L0.5270.66
107_I177_L0.5240.65
158_R202_H0.5240.65
31_T190_D0.5240.65
155_R190_D0.5230.65
74_I96_V0.5230.65
52_N107_I0.5220.65
87_R93_M0.5220.65
127_V142_L0.5210.65
8_L34_R0.5210.65
73_V93_M0.5200.65
123_V128_E0.5190.65
184_I211_D0.5170.64
8_L216_S0.5170.64
58_D62_G0.5090.63
59_T155_R0.5080.63
53_D80_T0.5040.62
52_N100_Q0.5040.62
31_T51_A0.5030.62
192_L213_I0.5030.62
33_S40_L0.5030.62
73_V88_M0.5020.62
152_A177_L0.5020.62
74_I147_L0.5000.62
26_F30_G0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kgbA 2 0.9864 100 0.234 Contact Map
3cdkA 2 1 100 0.234 Contact Map
3rrlA 2 1 100 0.242 Contact Map
1k6dA 2 0.9955 100 0.242 Contact Map
1poiA 3 0.9727 100 0.246 Contact Map
3k6mA 2 0.9955 100 0.246 Contact Map
2ahuA 3 1 100 0.287 Contact Map
2hj0A 2 0.8182 100 0.516 Contact Map
3qliA 2 0.8364 100 0.519 Contact Map
1xr4A 2 0.8136 100 0.524 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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