GREMLIN Database
RTN - Protein Rtn
UniProt: P76446 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14077
Length: 518 (437)
Sequences: 19284 (15266)
Seq/√Len: 730.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
295_L506_F4.0761.00
287_T492_M3.9061.00
95_T99_V3.6491.00
329_Q369_D3.3721.00
328_T360_H3.2651.00
371_Q409_V3.1721.00
440_R444_N3.1511.00
333_E376_S3.0261.00
498_S501_L2.9281.00
278_Y302_R2.9071.00
281_Y338_D2.8961.00
407_H434_D2.8911.00
385_V435_Y2.7931.00
260_V313_A2.7711.00
286_D289_A2.7011.00
340_A344_K2.5341.00
169_L172_S2.5241.00
483_W487_R2.5171.00
464_K490_N2.4911.00
343_E383_Q2.4801.00
478_P482_R2.4421.00
267_E303_H2.3601.00
111_G183_D2.2351.00
481_A497_I2.2221.00
429_E452_T2.1941.00
330_H334_L2.1671.00
303_H307_G2.1621.00
338_D503_L2.1471.00
414_A435_Y2.1111.00
475_V492_M2.0971.00
457_D465_R2.0831.00
318_A327_L2.0731.00
334_L337_R2.0601.00
299_L331_L1.9861.00
106_C110_T1.9851.00
261_R320_S1.9801.00
270_T274_R1.9691.00
131_D226_L1.9361.00
302_R308_E1.9351.00
115_I233_W1.9311.00
336_A373_L1.9311.00
334_L338_D1.8911.00
477_T480_Q1.8791.00
453_S483_W1.8711.00
275_E334_L1.8681.00
481_A492_M1.8571.00
280_A502_P1.8221.00
278_Y308_E1.8211.00
133_A222_L1.8101.00
232_T235_D1.8091.00
356_I366_F1.8001.00
133_A198_S1.7991.00
284_V491_F1.7931.00
338_D342_L1.7921.00
403_F413_I1.7831.00
373_L377_L1.7551.00
380_H383_Q1.7531.00
279_V331_L1.7431.00
457_D487_R1.7321.00
502_P505_D1.7151.00
351_K412_E1.7151.00
86_R90_S1.7091.00
285_V497_I1.7081.00
339_A379_A1.6951.00
303_H306_A1.6801.00
284_V435_Y1.6721.00
385_V414_A1.6651.00
333_E373_L1.6511.00
435_Y471_V1.6481.00
481_A485_S1.6441.00
333_E377_L1.6331.00
447_G453_S1.6251.00
110_T114_D1.6251.00
138_T221_P1.6171.00
154_P159_S1.6101.00
478_P496_W1.6051.00
412_E434_D1.5891.00
436_L463_A1.5871.00
457_D461_T1.5751.00
144_K152_R1.5671.00
280_A308_E1.5591.00
276_Q303_H1.5581.00
374_L411_V1.5541.00
460_L487_R1.5341.00
247_G256_Y1.5311.00
277_F299_L1.5311.00
481_A496_W1.5281.00
284_V385_V1.5251.00
114_D175_Y1.5241.00
160_G209_D1.5181.00
469_L490_N1.5171.00
342_L503_L1.5141.00
460_L489_V1.5051.00
250_V256_Y1.5031.00
447_G479_E1.4981.00
351_K385_V1.4931.00
469_L491_F1.4871.00
210_M215_T1.4851.00
100_K176_S1.4731.00
495_Y500_P1.4681.00
415_I433_L1.4631.00
293_T491_F1.4461.00
356_I386_L1.4381.00
345_V507_V1.4331.00
279_V330_H1.4311.00
78_Q82_E1.4291.00
284_V294_G1.4251.00
160_G163_A1.4211.00
139_P252_L1.4041.00
429_E445_A1.3981.00
501_L509_W1.3971.00
343_E380_H1.3781.00
131_D194_L1.3771.00
299_L327_L1.3671.00
154_P212_V1.3601.00
163_A166_N1.3371.00
372_K376_S1.3301.00
177_S183_D1.3301.00
435_Y469_L1.3281.00
440_R474_G1.3221.00
447_G483_W1.3181.00
157_K218_A1.3161.00
95_T104_T1.3101.00
92_N96_F1.3091.00
337_R377_L1.2971.00
94_R98_L1.2901.00
116_P233_W1.2841.00
341_E345_V1.2801.00
276_Q301_W1.2751.00
292_V509_W1.2721.00
505_D508_R1.2671.00
79_A82_E1.2671.00
472_A489_V1.2581.00
371_Q405_W1.2571.00
374_L381_H1.2501.00
161_V205_N1.2491.00
400_T404_A1.2471.00
111_G175_Y1.2451.00
114_D173_L1.2441.00
335_I352_F1.2431.00
299_L330_H1.2381.00
325_V363_S1.2291.00
86_R89_F1.2281.00
369_D373_L1.2211.00
246_S249_V1.2201.00
114_D118_N1.2181.00
463_A470_T1.2181.00
260_V306_A1.2181.00
267_E306_A1.2171.00
446_I483_W1.2141.00
270_T276_Q1.2101.00
72_T82_E1.2071.00
306_A313_A1.1981.00
339_A352_F1.1981.00
482_R485_S1.1871.00
400_T430_R1.1811.00
492_M497_I1.1681.00
349_G383_Q1.1681.00
160_G164_A1.1631.00
75_T78_Q1.1551.00
342_L507_V1.1511.00
338_D341_E1.1471.00
186_A197_F1.1441.00
204_V207_L1.1431.00
247_G254_C1.1431.00
286_D291_R1.1401.00
385_V412_E1.1391.00
235_D239_A1.1381.00
135_L220_I1.1341.00
433_L468_M1.1341.00
205_N220_I1.1321.00
287_T481_A1.1301.00
482_R486_E1.1271.00
286_D293_T1.1271.00
284_V353_G1.1261.00
168_N174_F1.1251.00
129_N229_D1.1251.00
498_S509_W1.1231.00
105_F162_F1.1181.00
77_Q80_N1.1171.00
367_K371_Q1.1161.00
446_I456_L1.1121.00
134_I183_D1.1101.00
194_L198_S1.1061.00
371_Q375_T1.1051.00
277_F330_H1.1011.00
139_P142_P1.0981.00
199_S203_N1.0971.00
87_A90_S1.0971.00
99_V110_T1.0951.00
404_A408_S1.0931.00
358_P391_R1.0921.00
137_G161_V1.0921.00
82_E86_R1.0871.00
225_R239_A1.0841.00
353_G385_V1.0831.00
264_P317_F1.0811.00
370_I406_L1.0791.00
198_S224_V1.0751.00
290_L485_S1.0751.00
340_A343_E1.0741.00
304_P307_G1.0741.00
447_G477_T1.0691.00
195_S257_L1.0631.00
154_P160_G1.0621.00
362_H395_K1.0571.00
142_P265_G1.0551.00
478_P481_A1.0541.00
461_T465_R1.0481.00
195_S199_S1.0451.00
224_V257_L1.0411.00
435_Y491_F1.0401.00
333_E337_R1.0361.00
294_G351_K1.0311.00
284_V351_K1.0301.00
501_L505_D1.0291.00
263_R267_E1.0281.00
370_I386_L1.0281.00
339_A343_E1.0231.00
311_P314_F1.0231.00
458_A465_R1.0231.00
340_A377_L1.0191.00
246_S250_V1.0191.00
312_D440_R1.0191.00
278_Y502_P1.0151.00
76_C79_A1.0141.00
268_I318_A1.0091.00
336_A384_I1.0031.00
190_G193_A1.0011.00
78_Q84_T1.0011.00
202_M222_L0.9991.00
164_A209_D0.9961.00
449_E452_T0.9951.00
321_Q325_V0.9941.00
367_K405_W0.9941.00
130_V227_Y0.9911.00
367_K402_L0.9911.00
136_P248_T0.9851.00
92_N95_T0.9841.00
279_V335_I0.9821.00
398_E402_L0.9821.00
134_I244_G0.9801.00
202_M255_Y0.9781.00
227_Y236_V0.9751.00
246_S256_Y0.9721.00
98_L113_M0.9721.00
98_L109_A0.9711.00
85_A88_A0.9641.00
335_I354_I0.9621.00
144_K179_Q0.9611.00
285_V509_W0.9591.00
386_L411_V0.9561.00
405_W408_S0.9561.00
340_A378_P0.9531.00
303_H309_I0.9531.00
483_W486_E0.9511.00
337_R341_E0.9501.00
284_V471_V0.9491.00
503_L507_V0.9471.00
319_E324_I0.9431.00
110_T113_M0.9421.00
286_D490_N0.9401.00
454_P465_R0.9391.00
273_K326_P0.9281.00
326_P329_Q0.9281.00
306_A309_I0.9241.00
265_G269_M0.9211.00
267_E305_V0.9191.00
83_L86_R0.9191.00
75_T82_E0.9181.00
460_L470_T0.9141.00
206_E253_L0.9131.00
288_Q490_N0.9121.00
296_E355_N0.9121.00
332_F373_L0.9091.00
75_T80_N0.9081.00
151_Y154_P0.9081.00
447_G480_Q0.9071.00
112_E234_N0.9071.00
394_L427_Y0.9041.00
270_T273_K0.9021.00
402_L405_W0.9011.00
159_S163_A0.9001.00
338_D507_V0.8991.00
366_F370_I0.8981.00
373_L376_S0.8981.00
315_I324_I0.8971.00
90_S94_R0.8961.00
471_V491_F0.8951.00
210_M213_R0.8931.00
205_N209_D0.8921.00
88_A92_N0.8911.00
275_E330_H0.8881.00
122_P187_L0.8881.00
323_M326_P0.8871.00
71_L75_T0.8871.00
276_Q304_P0.8861.00
110_T173_L0.8851.00
137_G220_I0.8841.00
279_V299_L0.8801.00
119_E187_L0.8801.00
136_P180_E0.8791.00
297_V352_F0.8781.00
101_D109_A0.8761.00
130_V185_V0.8731.00
365_S369_D0.8731.00
275_E333_E0.8701.00
150_W234_N0.8661.00
165_L174_F0.8651.00
168_N172_S0.8641.00
219_G253_L0.8611.00
151_Y214_E0.8611.00
211_P216_K0.8601.00
78_Q81_P0.8591.00
363_S369_D0.8521.00
230_D257_L0.8501.00
144_K153_N0.8491.00
197_F200_R0.8481.00
368_A405_W0.8471.00
76_C80_N0.8471.00
223_T240_F0.8441.00
203_N206_E0.8401.00
133_A186_A0.8381.00
295_L350_V0.8371.00
82_E87_A0.8361.00
72_T75_T0.8351.00
460_L464_K0.8351.00
167_L204_V0.8341.00
235_D238_Y0.8331.00
215_T270_T0.8321.00
89_F92_N0.8311.00
250_V254_C0.8301.00
332_F370_I0.8281.00
119_E130_V0.8261.00
198_S202_M0.8261.00
271_A276_Q0.8241.00
112_E116_P0.8221.00
329_Q373_L0.8211.00
401_Q405_W0.8201.00
351_K383_Q0.8181.00
75_T79_A0.8181.00
271_A277_F0.8171.00
157_K209_D0.8171.00
279_V297_V0.8141.00
444_N480_Q0.8131.00
288_Q485_S0.8121.00
135_L184_G0.8091.00
106_C173_L0.8081.00
98_L110_T0.8081.00
269_M323_M0.8081.00
268_I277_F0.8071.00
77_Q82_E0.8061.00
379_A384_I0.8001.00
325_V360_H0.7991.00
83_L87_A0.7981.00
336_A379_A0.7951.00
329_Q333_E0.7931.00
198_S255_Y0.7901.00
368_A372_K0.7871.00
475_V484_L0.7851.00
369_D372_K0.7851.00
195_S255_Y0.7841.00
464_K470_T0.7831.00
387_E437_K0.7821.00
281_Y295_L0.7811.00
76_C82_E0.7791.00
139_P265_G0.7761.00
115_I185_V0.7751.00
341_E344_K0.7751.00
400_T432_T0.7741.00
167_L200_R0.7731.00
75_T81_P0.7731.00
341_E503_L0.7671.00
318_A324_I0.7671.00
91_M94_R0.7671.00
138_T252_L0.7661.00
461_T464_K0.7651.00
299_L314_F0.7641.00
223_T243_G0.7631.00
364_E398_E0.7631.00
336_A377_L0.7621.00
225_R236_V0.7611.00
73_L77_Q0.7611.00
285_V292_V0.7601.00
143_N152_R0.7601.00
281_Y297_V0.7591.00
429_E455_V0.7571.00
412_E469_L0.7551.00
430_R451_I0.7501.00
404_A432_T0.7501.00
141_V145_P0.7491.00
265_G321_Q0.7481.00
198_S222_L0.7461.00
321_Q324_I0.7441.00
484_L489_V0.7431.00
269_M326_P0.7411.00
417_D473_E0.7411.00
475_V481_A0.7411.00
297_V335_I0.7401.00
149_I241_L0.7391.00
251_G254_C0.7371.00
332_F354_I0.7371.00
162_F174_F0.7361.00
454_P457_D0.7351.00
265_G317_F0.7351.00
110_T175_Y0.7341.00
389_T417_D0.7331.00
89_F93_V0.7311.00
472_A484_L0.7291.00
401_Q404_A0.7291.00
445_A452_T0.7271.00
102_K159_S0.7261.00
241_L245_M0.7251.00
194_L226_L0.7231.00
133_A184_G0.7201.00
111_G115_I0.7201.00
281_Y503_L0.7191.00
93_V96_F0.7181.00
445_A448_T0.7181.00
168_N184_G0.7171.00
136_P245_M0.7171.00
71_L82_E0.7161.00
290_L481_A0.7161.00
225_R240_F0.7141.00
221_P252_L0.7121.00
272_I330_H0.7101.00
453_S457_D0.7091.00
134_I240_F0.7071.00
283_P498_S0.7071.00
74_D78_Q0.7061.00
113_M118_N0.7051.00
72_T76_C0.7051.00
199_S202_M0.7021.00
443_I446_I0.7011.00
140_M158_N0.7001.00
73_L76_C0.6991.00
443_I472_A0.6971.00
418_F459_V0.6971.00
343_E349_G0.6961.00
98_L106_C0.6941.00
147_I214_E0.6931.00
114_D119_E0.6911.00
99_V106_C0.6911.00
495_Y499_R0.6901.00
143_N157_K0.6891.00
87_A91_M0.6871.00
138_T219_G0.6871.00
112_E233_W0.6851.00
179_Q245_M0.6821.00
452_T480_Q0.6811.00
384_I411_V0.6781.00
169_L197_F0.6771.00
139_P320_S0.6771.00
76_C81_P0.6761.00
183_D237_W0.6741.00
324_I359_D0.6741.00
226_L257_L0.6731.00
147_I216_K0.6731.00
302_R307_G0.6731.00
111_G185_V0.6721.00
343_E346_L0.6711.00
450_T453_S0.6691.00
283_P501_L0.6671.00
135_L222_L0.6661.00
116_P121_I0.6661.00
361_L402_L0.6661.00
178_R181_D0.6651.00
354_I384_I0.6641.00
312_D316_N0.6641.00
134_I177_S0.6641.00
398_E401_Q0.6631.00
169_L200_R0.6621.00
161_V165_L0.6611.00
72_T78_Q0.6611.00
181_D241_L0.6611.00
310_P313_A0.6601.00
133_A224_V0.6601.00
151_Y211_P0.6581.00
460_L484_L0.6561.00
374_L377_L0.6561.00
361_L392_D0.6521.00
95_T98_L0.6521.00
196_T200_R0.6511.00
341_E507_V0.6491.00
164_A208_T0.6481.00
506_F509_W0.6481.00
318_A322_K0.6481.00
280_A302_R0.6471.00
140_M152_R0.6471.00
151_Y216_K0.6421.00
128_K188_I0.6421.00
283_P292_V0.6411.00
193_A196_T0.6401.00
140_M144_K0.6401.00
268_I323_M0.6401.00
136_P144_K0.6361.00
161_V209_D0.6361.00
470_T490_N0.6361.00
285_V290_L0.6321.00
347_P350_V0.6321.00
295_L352_F0.6321.00
180_E248_T0.6311.00
368_A371_Q0.6311.00
420_T442_F0.6281.00
476_E495_Y0.6271.00
108_S112_E0.6271.00
141_V245_M0.6271.00
367_K409_V0.6221.00
78_Q83_L0.6221.00
443_I456_L0.6211.00
166_N174_F0.6191.00
438_I489_V0.6151.00
268_I271_A0.6141.00
501_L506_F0.6131.00
453_S487_R0.6131.00
124_L231_W0.6101.00
339_A383_Q0.6101.00
290_L478_P0.6081.00
130_V236_V0.6071.00
73_L80_N0.6071.00
278_Y504_D0.6071.00
189_I194_L0.6041.00
194_L224_V0.6041.00
287_T485_S0.6031.00
342_L506_F0.6031.00
167_L197_F0.6001.00
263_R306_A0.6001.00
228_A239_A0.5991.00
239_A258_M0.5981.00
184_G201_L0.5981.00
268_I327_L0.5971.00
484_L492_M0.5941.00
109_A112_E0.5941.00
72_T84_T0.5931.00
374_L379_A0.5921.00
333_E369_D0.5921.00
506_F510_L0.5921.00
329_Q372_K0.5921.00
370_I411_V0.5911.00
352_F379_A0.5881.00
350_V383_Q0.5881.00
339_A349_G0.5881.00
459_V463_A0.5871.00
128_K187_L0.5861.00
386_L413_I0.5861.00
420_T441_G0.5851.00
102_K153_N0.5851.00
429_E449_E0.5801.00
217_I269_M0.5801.00
80_N84_T0.5791.00
436_L468_M0.5791.00
445_A449_E0.5791.00
412_E435_Y0.5781.00
255_Y258_M0.5771.00
224_V255_Y0.5771.00
71_L78_Q0.5761.00
267_E270_T0.5751.00
415_I427_Y0.5741.00
329_Q363_S0.5741.00
112_E237_W0.5731.00
84_T88_A0.5711.00
263_R305_V0.5701.00
370_I373_L0.5701.00
186_A194_L0.5701.00
358_P392_D0.5691.00
202_M220_I0.5691.00
172_S186_A0.5691.00
71_L74_D0.5671.00
403_F432_T0.5661.00
167_L201_L0.5661.00
231_W235_D0.5651.00
379_A383_Q0.5631.00
355_N437_K0.5621.00
71_L79_A0.5621.00
405_W409_V0.5621.00
172_S197_F0.5621.00
329_Q360_H0.5611.00
389_T473_E0.5601.00
208_T215_T0.5591.00
325_V329_Q0.5581.00
189_I193_A0.5581.00
355_N416_D0.5571.00
147_I151_Y0.5561.00
77_Q81_P0.5551.00
202_M253_L0.5541.00
264_P267_E0.5541.00
339_A384_I0.5541.00
267_E301_W0.5531.00
230_D239_A0.5521.00
280_A500_P0.5501.00
150_W212_V0.5491.00
309_I316_N0.5491.00
221_P247_G0.5481.00
454_P458_A0.5481.00
150_W238_Y0.5471.00
85_A89_F0.5471.00
390_E419_G0.5451.00
90_S93_V0.5441.00
108_S153_N0.5441.00
327_L331_L0.5431.00
192_T195_S0.5421.00
359_D362_H0.5411.00
413_I434_D0.5391.00
79_A83_L0.5391.00
123_A126_I0.5381.00
76_C84_T0.5371.00
114_D185_V0.5371.00
262_M266_R0.5371.00
296_E437_K0.5361.00
277_F301_W0.5361.00
209_D218_A0.5351.00
298_L355_N0.5351.00
164_A204_V0.5321.00
438_I459_V0.5311.00
302_R306_A0.5301.00
427_Y430_R0.5301.00
497_I500_P0.5301.00
260_V264_P0.5291.00
294_G353_G0.5291.00
455_V459_V0.5291.00
75_T83_L0.5281.00
328_T331_L0.5271.00
119_E122_P0.5271.00
202_M206_E0.5261.00
73_L78_Q0.5261.00
394_L399_A0.5251.00
332_F356_I0.5241.00
372_K375_T0.5241.00
254_C258_M0.5241.00
406_L411_V0.5231.00
429_E451_I0.5211.00
75_T84_T0.5201.00
339_A377_L0.5201.00
71_L76_C0.5201.00
296_E416_D0.5191.00
272_I327_L0.5181.00
150_W154_P0.5161.00
72_T80_N0.5161.00
426_I441_G0.5151.00
507_V510_L0.5141.00
427_Y431_F0.5101.00
332_F336_A0.5081.00
462_L466_L0.5051.00
203_N207_L0.5051.00
267_E304_P0.5051.00
120_L227_Y0.5041.00
76_C83_L0.5041.00
123_A227_Y0.5041.00
450_T454_P0.5030.99
149_I152_R0.5030.99
290_L497_I0.5030.99
451_I467_N0.5010.99
340_A379_A0.5010.99
105_F174_F0.5010.99
118_N187_L0.5010.99
479_E482_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rnhA 2 0.7857 100 0.205 Contact Map
4j40A 2 0.473 100 0.217 Contact Map
3pjxA 1 0.7973 100 0.223 Contact Map
3gfzA 2 0.7143 100 0.353 Contact Map
4hjfA 1 0.4961 100 0.396 Contact Map
4kieA 1 0.5019 100 0.468 Contact Map
4hu4A 1 0.473 100 0.469 Contact Map
3sy8A 6 0.7606 100 0.471 Contact Map
4rniA 2 0.4865 100 0.476 Contact Map
2r6oA 2 0.4942 100 0.478 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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