GREMLIN Database
THIM - Hydroxyethylthiazole kinase
UniProt: P76423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14069
Length: 262 (248)
Sequences: 1874 (1460)
Seq/√Len: 92.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_A211_C3.6951.00
184_I218_L2.9801.00
83_R115_E2.7161.00
193_M232_G2.5821.00
59_Q107_D2.5721.00
79_A112_F2.5111.00
46_A209_A2.4711.00
188_G230_Q2.4421.00
188_G229_K2.4391.00
33_V198_G2.4121.00
68_L208_A2.4111.00
33_V37_T2.4091.00
242_P254_W2.3901.00
125_R204_S2.3851.00
49_A60_F2.3621.00
88_Q92_S2.3381.00
216_D219_E2.3271.00
171_T225_C2.3101.00
123_A207_V2.3011.00
116_L121_P2.2881.00
40_T202_A2.2391.00
40_T253_L2.2191.00
86_V119_F2.2131.00
44_L206_V2.1901.00
190_D236_V2.0661.00
196_V199_T2.0431.00
122_A217_T1.9931.00
31_D34_Q1.9901.00
27_C41_L1.9541.00
47_S145_D1.9381.00
234_R252_A1.8991.00
248_H251_D1.8961.00
55_E76_Q1.8911.00
210_C227_W1.8631.00
188_G233_E1.8611.00
27_C205_A1.8071.00
169_V221_V1.7901.00
41_L205_A1.7681.00
107_D111_H1.7391.00
157_A170_V1.7291.00
129_S141_G1.7211.00
179_D182_R1.6701.00
157_A178_T1.6701.00
161_A179_D1.6411.00
25_V212_A1.6151.00
176_Y185_G1.6031.00
68_L204_S1.5741.00
126_G131_I1.5731.00
60_F106_L1.5701.00
37_T205_A1.5561.00
184_I222_A1.5521.00
252_A255_Q1.5251.00
52_I78_R1.5241.00
34_Q52_I1.5211.00
174_M187_H1.5191.00
41_L209_A1.5171.00
88_Q91_S1.5121.00
71_V113_C1.4941.00
36_F246_V1.4691.00
206_V228_M1.4431.00
244_S247_P1.4340.99
123_A221_V1.4320.99
186_I222_A1.4310.99
161_A178_T1.4130.99
238_R248_H1.4110.99
28_M67_L1.3950.99
54_T80_Q1.3920.99
161_A180_G1.3910.99
174_M185_G1.3720.99
17_L21_H1.3550.99
36_F202_A1.3520.99
52_I75_T1.3350.99
14_A210_C1.3320.99
113_C134_L1.3130.99
98_L113_C1.3120.99
230_Q233_E1.3090.99
131_I168_V1.3090.99
22_S195_K1.2940.99
49_A102_A1.2760.99
27_C68_L1.2740.99
158_Q183_I1.2560.99
71_V98_L1.2550.99
177_V186_I1.2310.98
61_A92_S1.2240.98
182_R216_D1.2230.98
169_V207_V1.2230.98
159_T163_E1.2210.98
228_M249_F1.2140.98
90_K121_P1.2130.98
65_S212_A1.2000.98
169_V225_C1.1920.98
96_W119_F1.1920.98
16_H258_Q1.1860.98
16_H20_Q1.1740.98
69_I86_V1.1700.98
90_K120_K1.1550.98
21_H65_S1.1450.97
207_V224_A1.1440.97
154_I158_Q1.1430.97
18_F213_L1.1350.97
31_D52_I1.1280.97
42_L197_V1.1150.97
25_V66_A1.1120.97
243_G250_L1.1080.97
213_L220_N1.1050.97
74_L112_F1.1030.97
90_K119_F1.0950.97
96_W121_P1.0910.97
111_H115_E1.0810.96
34_Q78_R1.0770.96
53_E108_Y1.0660.96
173_E191_P1.0630.96
58_S88_Q1.0600.96
211_C217_T1.0600.96
193_M199_T1.0350.95
66_A208_A1.0300.95
228_M232_G1.0290.95
65_S94_T1.0260.95
203_L224_A1.0240.95
238_R252_A1.0200.95
160_L168_V1.0190.95
61_A88_Q1.0180.95
125_R194_T1.0120.95
167_I221_V1.0110.95
79_A108_Y1.0100.95
75_T78_R1.0040.94
59_Q62_A1.0020.94
244_S248_H1.0020.94
54_T84_A1.0010.94
229_K232_G0.9980.94
39_N42_L0.9950.94
83_R119_F0.9910.94
15_L210_C0.9880.94
206_V249_F0.9860.94
51_V56_E0.9810.94
51_V60_F0.9660.93
162_R181_H0.9650.93
160_L164_T0.9600.93
26_H51_V0.9570.93
35_T197_V0.9560.93
217_T221_V0.9540.93
203_L225_C0.9520.93
244_S251_D0.9500.93
121_P124_I0.9370.92
245_F249_F0.9280.92
124_I134_L0.9170.91
124_I166_A0.9160.91
186_I229_K0.9080.91
227_W256_L0.9060.91
117_L121_P0.9060.91
86_V96_W0.9050.91
178_T183_I0.9020.91
129_S132_M0.8920.90
246_V250_L0.8910.90
86_V90_K0.8890.90
194_T232_G0.8860.90
83_R87_E0.8850.90
14_A223_S0.8790.90
25_V208_A0.8790.90
83_R86_V0.8740.89
177_V225_C0.8740.89
155_P159_T0.8730.89
31_D78_R0.8730.89
137_I159_T0.8720.89
239_S248_H0.8670.89
135_A160_L0.8660.89
54_T77_P0.8640.89
182_R218_L0.8630.89
199_T232_G0.8620.89
17_L20_Q0.8580.88
49_A106_L0.8570.88
241_G255_Q0.8520.88
71_V74_L0.8450.88
120_K165_G0.8450.88
202_A249_F0.8420.87
179_D218_L0.8420.87
214_P220_N0.8400.87
108_Y112_F0.8310.87
32_V73_T0.8280.87
195_K254_W0.8270.86
199_T249_F0.8270.86
140_G147_T0.8270.86
190_D229_K0.8260.86
12_A258_Q0.8250.86
58_S84_A0.8250.86
191_P194_T0.8240.86
192_L254_W0.8240.86
204_S207_V0.8190.86
62_A88_Q0.8190.86
98_L121_P0.8180.86
74_L79_A0.8160.86
64_A94_T0.8110.85
62_A92_S0.8090.85
86_V116_L0.8050.85
128_A146_T0.8040.85
55_E108_Y0.8040.85
98_L116_L0.8030.85
176_Y183_I0.7980.84
207_V221_V0.7900.84
103_V113_C0.7820.83
61_A94_T0.7810.83
69_I96_W0.7800.83
34_Q37_T0.7800.83
132_M153_A0.7790.83
80_Q84_A0.7790.83
190_D194_T0.7770.83
206_V253_L0.7710.82
14_A214_P0.7690.82
243_G247_P0.7660.82
154_I185_G0.7650.82
18_F223_S0.7640.82
97_T208_A0.7640.82
43_A243_G0.7600.81
37_T68_L0.7580.81
57_A61_A0.7570.81
60_F102_A0.7570.81
218_L222_A0.7520.81
35_T39_N0.7510.81
31_D75_T0.7460.80
226_H230_Q0.7450.80
61_A67_L0.7430.80
26_H81_A0.7420.80
38_A50_M0.7410.80
203_L228_M0.7400.80
192_L242_P0.7390.80
90_K96_W0.7360.79
154_I176_Y0.7360.79
110_R113_C0.7350.79
51_V81_A0.7340.79
231_A253_L0.7330.79
157_A176_Y0.7260.78
194_T199_T0.7230.78
35_T246_V0.7190.78
122_A166_A0.7140.77
89_A94_T0.7140.77
234_R237_A0.7110.77
37_T41_L0.7090.77
18_F209_A0.7080.77
186_I226_H0.7080.77
111_H118_S0.7030.76
158_Q162_R0.7010.76
123_A167_I0.7010.76
167_I217_T0.6990.76
37_T198_G0.6960.75
190_D193_M0.6890.75
67_L96_W0.6840.74
202_A250_L0.6830.74
248_H252_A0.6830.74
134_L164_T0.6820.74
178_T218_L0.6810.74
12_A15_L0.6790.74
110_R141_G0.6740.73
110_R114_H0.6740.73
39_N197_V0.6730.73
196_V235_A0.6730.73
154_I178_T0.6720.73
37_T202_A0.6710.73
32_V100_P0.6690.73
231_A256_L0.6690.73
202_A228_M0.6660.72
194_T229_K0.6660.72
240_E248_H0.6620.72
32_V47_S0.6600.72
49_A64_A0.6570.71
129_S139_N0.6560.71
202_A253_L0.6520.71
164_T168_V0.6510.70
110_R133_A0.6500.70
41_L46_A0.6490.70
26_H57_A0.6490.70
67_L85_A0.6480.70
26_H49_A0.6460.70
40_T206_V0.6440.70
57_A88_Q0.6410.69
60_F64_A0.6400.69
51_V78_R0.6400.69
61_A85_A0.6350.69
150_A176_Y0.6300.68
36_F250_L0.6300.68
159_T162_R0.6280.68
18_F210_C0.6240.67
25_V76_Q0.6240.67
221_V224_A0.6230.67
67_L89_A0.6230.67
132_M156_A0.6150.66
214_P219_E0.6120.66
87_E91_S0.6080.65
28_M52_I0.6070.65
87_E119_F0.6070.65
226_H229_K0.6070.65
24_L143_G0.6040.65
225_C229_K0.6010.64
33_V202_A0.5990.64
27_C203_L0.5980.64
128_A153_A0.5980.64
60_F105_A0.5970.64
29_T144_V0.5950.64
28_M85_A0.5930.63
111_H114_H0.5920.63
214_P223_S0.5910.63
15_L258_Q0.5890.63
41_L125_R0.5870.63
100_P125_R0.5870.63
26_H61_A0.5840.62
148_D152_N0.5830.62
44_L253_L0.5810.62
26_H60_F0.5780.61
33_V36_F0.5770.61
188_G234_R0.5770.61
13_H17_L0.5740.61
104_G110_R0.5720.61
43_A197_V0.5710.60
116_L119_F0.5670.60
178_T181_H0.5660.60
102_A144_V0.5660.60
77_P80_Q0.5650.60
144_V201_C0.5650.60
61_A89_A0.5630.59
136_G139_N0.5630.59
58_S87_E0.5620.59
153_A156_A0.5610.59
27_C48_P0.5590.59
180_G183_I0.5570.59
150_A154_I0.5550.58
198_G202_A0.5540.58
81_A84_A0.5520.58
170_V178_T0.5500.58
63_I141_G0.5500.58
27_C204_S0.5490.57
204_S208_A0.5480.57
83_R116_L0.5460.57
192_L236_V0.5450.57
42_L201_C0.5450.57
54_T81_A0.5450.57
56_E109_R0.5440.57
144_V197_V0.5430.57
51_V102_A0.5410.56
69_I121_P0.5400.56
54_T76_Q0.5390.56
33_V68_L0.5370.56
27_C208_A0.5370.56
29_T42_L0.5360.56
97_T211_C0.5350.56
14_A219_E0.5350.56
128_A170_V0.5320.55
188_G226_H0.5300.55
210_C220_N0.5300.55
40_T44_L0.5280.55
210_C224_A0.5270.54
71_V89_A0.5260.54
129_S147_T0.5260.54
161_A168_V0.5240.54
162_R218_L0.5240.54
247_P254_W0.5230.54
114_H118_S0.5210.54
83_R112_F0.5210.54
29_T201_C0.5210.54
43_A201_C0.5200.53
124_I164_T0.5190.53
15_L18_F0.5180.53
87_E187_H0.5180.53
43_A250_L0.5140.53
230_Q237_A0.5080.52
84_A87_E0.5080.52
243_G249_F0.5080.52
197_V201_C0.5060.52
152_N155_P0.5050.51
13_H16_H0.5050.51
101_V144_V0.5030.51
193_M249_F0.5010.51
139_N149_A0.5010.51
241_G254_W0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dzvA 3 0.9504 100 0.401 Contact Map
1ekqA 3 0.9275 100 0.426 Contact Map
3nl6A 4 0.9466 100 0.536 Contact Map
3hpdA 3 0.9313 100 0.56 Contact Map
3bgkA 3 0.9122 99.9 0.729 Contact Map
2r3bA 3 0.9122 99.9 0.73 Contact Map
3k5wA 4 0.855 99.9 0.751 Contact Map
3rpzA 3 0.9008 99.9 0.757 Contact Map
3rssA 4 0.9008 99.9 0.766 Contact Map
2yxtA 3 0.8931 99.8 0.793 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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