GREMLIN Database
THID - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
UniProt: P76422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14068
Length: 266 (248)
Sequences: 6226 (4448)
Seq/√Len: 282.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_Q132_Q3.2481.00
24_L34_G2.8821.00
149_A164_S2.7581.00
88_E128_R2.7421.00
154_T157_E2.7261.00
50_Q66_S2.7011.00
53_Y56_E2.6861.00
30_L222_L2.6101.00
228_N231_D2.5511.00
174_L215_L2.5301.00
222_L227_T2.5251.00
65_D93_R2.3661.00
81_L90_V2.2401.00
143_A175_M2.2151.00
78_I104_L2.1491.00
61_A92_E2.1171.00
41_L59_F2.0911.00
115_P119_P2.0681.00
32_A221_A2.0491.00
196_Q230_A2.0451.00
123_A127_S2.0411.00
6_A32_A1.9771.00
27_F221_A1.9761.00
184_Q199_T1.9741.00
41_L55_I1.9451.00
60_V86_I1.9321.00
222_L225_R1.9201.00
152_A161_Q1.9111.00
27_F34_G1.8911.00
8_T36_S1.8891.00
51_S62_A1.8821.00
12_T21_Q1.8291.00
110_A114_D1.8261.00
27_F32_A1.7811.00
95_Q128_R1.7681.00
54_R82_A1.7281.00
172_A229_W1.7161.00
155_E197_R1.7141.00
61_A89_A1.7111.00
144_A151_H1.6921.00
227_T235_E1.6811.00
93_R96_R1.6371.00
219_L233_V1.6361.00
153_R157_E1.6221.00
64_L93_R1.5921.00
237_K241_S1.5841.00
222_L235_E1.5691.00
6_A27_F1.5481.00
61_A93_R1.5331.00
8_T27_F1.5271.00
94_L102_V1.5231.00
159_L195_E1.5211.00
241_S245_A1.5171.00
65_D69_S1.5101.00
37_V64_L1.4951.00
21_Q36_S1.4891.00
104_L133_V1.4611.00
186_P197_R1.4581.00
5_N74_D1.4561.00
166_L190_F1.4461.00
87_V125_L1.4401.00
185_S237_K1.4391.00
57_P89_A1.4301.00
78_I102_V1.4271.00
172_A191_T1.4241.00
242_S245_A1.4171.00
136_I165_L1.3971.00
162_G175_M1.3961.00
201_P245_A1.3941.00
50_Q69_S1.3771.00
159_L197_R1.3711.00
84_T120_S1.3501.00
101_N134_S1.3451.00
117_L121_A1.3381.00
5_N35_C1.3221.00
144_A152_A1.3211.00
20_I38_I1.3141.00
162_G190_F1.3051.00
147_L165_L1.2981.00
54_R83_E1.2931.00
198_F234_Q1.2751.00
53_Y59_F1.2541.00
5_N71_V1.2491.00
134_S171_G1.2351.00
149_A160_E1.2331.00
37_V60_V1.2151.00
200_A237_K1.2141.00
68_F96_R1.2041.00
196_Q234_Q1.2031.00
124_T128_R1.1951.00
12_T42_V1.1901.00
58_D62_A1.1781.00
115_P122_V1.1751.00
190_F195_E1.1711.00
68_F73_I1.1691.00
164_S167_A1.1671.00
103_V220_A1.1571.00
200_A241_S1.1451.00
5_N72_R1.1421.00
83_E86_I1.1371.00
26_T214_T1.1291.00
91_A128_R1.1281.00
188_W197_R1.1281.00
57_P85_D1.1241.00
55_I59_F1.1131.00
65_D96_R1.1121.00
6_A224_P1.1111.00
227_T231_D1.1091.00
166_L192_R1.1071.00
87_V124_T1.1031.00
223_R229_W1.0971.00
46_T70_D1.0941.00
135_L229_W1.0901.00
92_E128_R1.0861.00
81_L87_V1.0781.00
144_A161_Q1.0771.00
43_A62_A1.0721.00
130_L136_I1.0691.00
186_P199_T1.0671.00
230_A234_Q1.0671.00
158_M188_W1.0641.00
155_E159_L1.0631.00
30_L218_A1.0621.00
126_R146_L1.0501.00
159_L163_R1.0431.00
147_L164_S1.0431.00
89_A92_E1.0431.00
12_T38_I1.0321.00
126_R168_M1.0321.00
163_R167_A1.0231.00
30_L221_A1.0211.00
26_T218_A1.0191.00
88_E124_T1.0171.00
76_T99_I1.0151.00
231_D234_Q1.0141.00
26_T30_L1.0111.00
103_V223_R1.0051.00
160_E164_S1.0021.00
234_Q238_S1.0011.00
172_A189_L0.9971.00
32_A225_R0.9931.00
91_A132_Q0.9911.00
43_A59_F0.9901.00
9_I90_V0.9791.00
184_Q201_P0.9761.00
192_R195_E0.9751.00
35_C73_I0.9711.00
115_P145_A0.9701.00
135_L219_L0.9651.00
59_F62_A0.9621.00
84_T88_E0.9561.00
75_T220_A0.9481.00
109_L145_A0.9451.00
198_F233_V0.9431.00
84_T124_T0.9431.00
51_S59_F0.9411.00
35_C71_V0.9381.00
135_L174_L0.9351.00
68_F99_I0.9331.00
136_I173_V0.9331.00
166_L173_V0.9321.00
47_R254_H0.9311.00
247_A250_L0.9271.00
160_E163_R0.9231.00
40_A80_M0.9201.00
194_G230_A0.9121.00
4_I74_D0.9101.00
126_R148_D0.8941.00
122_V126_R0.8931.00
68_F93_R0.8921.00
85_D88_E0.8921.00
92_E96_R0.8901.00
214_T239_W0.8881.00
219_L236_A0.8871.00
82_A86_I0.8821.00
15_S42_V0.8801.00
157_E160_E0.8771.00
155_E186_P0.8751.00
189_L198_F0.8751.00
166_L170_C0.8691.00
242_S246_Q0.8681.00
134_S229_W0.8681.00
87_V117_L0.8661.00
12_T36_S0.8651.00
208_T244_L0.8631.00
155_E188_W0.8621.00
134_S172_A0.8611.00
207_N251_E0.8571.00
198_F237_K0.8571.00
189_L233_V0.8501.00
203_I241_S0.8491.00
122_V145_A0.8441.00
187_D237_K0.8311.00
5_N73_I0.8271.00
158_M180_L0.8251.00
174_L189_L0.8221.00
30_L225_R0.8211.00
191_T195_E0.8181.00
203_I244_L0.8150.99
218_A239_W0.8080.99
135_L172_A0.8070.99
185_S202_R0.8010.99
14_P42_V0.7840.99
61_A65_D0.7840.99
94_L99_I0.7810.99
62_A66_S0.7800.99
191_T196_Q0.7790.99
32_A224_P0.7780.99
14_P36_S0.7760.99
57_P61_A0.7730.99
149_A157_E0.7730.99
238_S242_S0.7670.99
62_A65_D0.7600.99
164_S168_M0.7600.99
78_I81_L0.7590.99
123_A126_R0.7580.99
191_T194_G0.7570.99
15_S71_V0.7480.99
14_P43_A0.7480.99
156_Q159_L0.7470.99
223_R226_H0.7450.99
223_R232_T0.7390.99
6_A221_A0.7370.99
17_G209_H0.7310.99
35_C67_V0.7300.99
27_F217_A0.7260.99
140_L144_A0.7250.99
98_Q101_N0.7220.99
135_L233_V0.7190.99
140_L180_L0.7160.99
7_L35_C0.7130.99
11_G39_T0.7110.99
77_K217_A0.7100.99
139_N142_E0.7090.99
166_L172_A0.7050.99
130_L170_C0.7030.98
231_D235_E0.7020.98
22_A214_T0.6950.98
227_T232_T0.6900.98
21_Q24_L0.6900.98
27_F220_A0.6900.98
44_Q48_G0.6880.98
141_P179_H0.6880.98
40_A54_R0.6840.98
50_Q62_A0.6830.98
60_V89_A0.6750.98
91_A129_L0.6750.98
175_M188_W0.6740.98
133_V136_I0.6730.98
78_I216_S0.6720.98
57_P60_V0.6700.98
91_A95_Q0.6690.98
152_A158_M0.6630.98
166_L171_G0.6610.98
25_K33_Y0.6600.98
44_Q49_V0.6590.98
12_T20_I0.6560.98
68_F97_Y0.6560.98
10_A23_D0.6530.98
83_E118_S0.6520.98
93_R97_Y0.6510.98
240_L244_L0.6510.98
88_E127_S0.6510.98
5_N252_V0.6500.97
153_R181_D0.6470.97
77_K216_S0.6470.97
39_T86_I0.6450.97
108_M117_L0.6430.97
189_L229_W0.6420.97
76_T102_V0.6410.97
225_R235_E0.6400.97
228_N232_T0.6400.97
89_A93_R0.6370.97
80_M116_L0.6360.97
26_T239_W0.6320.97
113_G116_L0.6320.97
152_A157_E0.6310.97
29_A239_W0.6280.97
13_D19_G0.6280.97
110_A116_L0.6280.97
12_T41_L0.6280.97
78_I94_L0.6260.97
15_S33_Y0.6250.97
76_T94_L0.6180.97
72_R100_Q0.6150.97
92_E95_Q0.6090.96
8_T216_S0.6090.96
168_M171_G0.6080.96
82_A118_S0.6080.96
104_L129_L0.6080.96
6_A220_A0.6070.96
143_A161_Q0.6060.96
65_D97_Y0.6060.96
166_L169_G0.6000.96
237_K240_L0.6000.96
163_R190_F0.5990.96
174_L233_V0.5990.96
235_E238_S0.5950.96
71_V74_D0.5950.96
88_E92_E0.5940.96
56_E59_F0.5930.96
91_A104_L0.5910.96
87_V129_L0.5880.96
87_V121_A0.5860.95
125_L130_L0.5840.95
171_G192_R0.5830.95
247_A251_E0.5810.95
30_L235_E0.5780.95
146_L165_L0.5760.95
9_I64_L0.5750.95
20_I36_S0.5750.95
143_A165_L0.5750.95
8_T34_G0.5710.95
103_V135_L0.5710.95
37_V67_V0.5690.95
51_S58_D0.5670.95
68_F76_T0.5620.94
166_L191_T0.5620.94
46_T255_G0.5600.94
69_S97_Y0.5570.94
226_H232_T0.5550.94
46_T253_G0.5530.94
23_D77_K0.5520.94
44_Q209_H0.5500.94
135_L236_A0.5490.94
105_D138_P0.5480.94
149_A161_Q0.5470.93
141_P144_A0.5470.93
214_T243_A0.5460.93
143_A152_A0.5460.93
7_L37_V0.5440.93
155_E199_T0.5420.93
109_L114_D0.5420.93
163_R166_L0.5420.93
128_R132_Q0.5390.93
140_L152_A0.5390.93
25_K28_S0.5380.93
162_G173_V0.5380.93
109_L115_P0.5320.92
105_D139_N0.5310.92
40_A82_A0.5310.92
159_L190_F0.5310.92
102_V132_Q0.5300.92
233_V236_A0.5300.92
190_F193_E0.5290.92
239_W243_A0.5270.92
104_L125_L0.5250.92
189_L230_A0.5250.92
60_V64_L0.5230.92
128_R131_P0.5230.92
18_A209_H0.5230.92
75_T216_S0.5220.92
156_Q160_E0.5180.91
163_R195_E0.5170.91
44_Q66_S0.5160.91
70_D253_G0.5150.91
138_P142_E0.5140.91
66_S69_S0.5130.91
147_L173_V0.5130.91
111_K211_T0.5100.91
47_R50_Q0.5080.91
236_A240_L0.5050.90
211_T240_L0.5050.90
75_T224_P0.5040.90
140_L158_M0.5040.90
126_R130_L0.5040.90
45_N50_Q0.5030.90
45_N66_S0.5020.90
38_I41_L0.5020.90
13_D23_D0.5010.90
67_V73_I0.5000.90
5_N33_Y0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rm5A 2 0.9549 100 0.326 Contact Map
2i5bA 2 0.9925 100 0.331 Contact Map
1jxhA 2 0.9248 100 0.377 Contact Map
1ub0A 2 0.9248 100 0.382 Contact Map
3h74A 2 0.9774 100 0.384 Contact Map
4yl5A 2 0.8459 100 0.384 Contact Map
2yxtA 3 0.9774 100 0.397 Contact Map
2ddmA 2 0.9662 100 0.407 Contact Map
3mbhA 5 0.9812 100 0.408 Contact Map
3pzsA 2 0.9812 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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