GREMLIN Database
YEGV - Uncharacterized sugar kinase YegV
UniProt: P76419 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14065
Length: 321 (284)
Sequences: 22389 (16651)
Seq/√Len: 988.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_I277_A3.0601.00
147_Y174_F2.9751.00
18_S144_S2.9331.00
245_Y289_V2.5091.00
71_G95_I2.4391.00
284_P287_D2.4351.00
238_L244_W2.4061.00
278_G283_L2.3411.00
20_M143_G2.3331.00
243_A271_H2.3211.00
63_L68_I2.1591.00
166_E195_C2.1101.00
18_S69_E2.1101.00
65_R92_E2.0701.00
227_Q246_F2.0491.00
174_F276_L1.9561.00
21_V60_A1.9441.00
203_R238_L1.9151.00
270_S295_V1.8861.00
78_Q101_A1.8641.00
278_G291_L1.8521.00
252_G286_A1.8371.00
145_L172_T1.8221.00
220_T251_S1.8161.00
281_S311_R1.8111.00
283_L287_D1.7911.00
200_S272_A1.7781.00
75_P134_W1.7701.00
172_T197_P1.7651.00
197_P232_A1.7641.00
61_V92_E1.7631.00
310_T313_E1.7501.00
243_A293_N1.7471.00
245_Y252_G1.7381.00
267_A300_V1.7121.00
62_A273_G1.7041.00
87_N91_K1.6981.00
168_L171_V1.6751.00
302_H313_E1.6741.00
90_A96_S1.6621.00
145_L174_F1.6561.00
244_W253_C1.6301.00
86_R90_A1.6261.00
296_A300_V1.6241.00
275_V288_A1.6241.00
88_R91_K1.6211.00
223_G246_F1.6141.00
286_A290_L1.6131.00
235_I275_V1.5891.00
238_L253_C1.5891.00
163_E167_E1.5851.00
19_V63_L1.5821.00
274_G295_V1.5721.00
198_L233_P1.5611.00
257_F294_A1.5561.00
247_S250_A1.5221.00
78_Q83_E1.5211.00
75_P100_N1.5121.00
83_E87_N1.5091.00
225_Q229_K1.5081.00
176_D237_R1.4941.00
207_E213_F1.4921.00
63_L277_A1.4811.00
25_A74_L1.4681.00
245_Y285_L1.4571.00
52_V85_I1.4561.00
263_D304_G1.4551.00
254_I289_V1.4501.00
145_L276_L1.4401.00
162_V191_R1.4341.00
50_V84_M1.4321.00
162_V166_E1.4151.00
238_L241_E1.4121.00
86_R98_I1.4101.00
233_P247_S1.4041.00
165_L173_P1.4041.00
177_F201_L1.3951.00
163_E166_E1.3911.00
196_R199_V1.3801.00
172_T198_L1.3711.00
140_V143_G1.3631.00
274_G291_L1.3611.00
225_Q228_E1.3591.00
218_E221_T1.3501.00
82_A105_N1.3481.00
27_I84_M1.3451.00
18_S71_G1.3431.00
86_R100_N1.3381.00
224_K228_E1.3321.00
103_G129_Q1.3321.00
57_L89_M1.3191.00
220_T224_K1.3191.00
78_Q102_E1.3111.00
259_T301_G1.3071.00
32_D47_Q1.2991.00
257_F290_L1.2831.00
69_E95_I1.2761.00
212_R225_Q1.2751.00
29_V48_Q1.2711.00
243_A289_V1.2711.00
275_V279_L1.2611.00
34_Y46_K1.2451.00
254_I293_N1.2441.00
227_Q248_N1.2431.00
172_T232_A1.2281.00
233_P275_V1.2221.00
261_V300_V1.2121.00
34_Y114_P1.2111.00
233_P279_L1.2101.00
277_A281_S1.1951.00
275_V292_G1.1941.00
200_S237_R1.1911.00
141_A169_Q1.1881.00
64_K94_L1.1881.00
274_G292_G1.1831.00
159_E163_E1.1791.00
52_V88_R1.1791.00
237_R271_H1.1751.00
238_L242_G1.1751.00
257_F293_N1.1691.00
287_D290_L1.1691.00
224_K251_S1.1671.00
278_G288_A1.1661.00
259_T300_V1.1621.00
233_P285_L1.1621.00
131_N134_W1.1601.00
224_K246_F1.1581.00
212_R221_T1.1501.00
246_F251_S1.1471.00
66_L274_G1.1451.00
84_M87_N1.1381.00
87_N90_A1.1351.00
88_R92_E1.1341.00
162_V165_L1.1301.00
29_V50_V1.1301.00
206_A236_V1.1231.00
83_E86_R1.1071.00
68_I280_A1.1031.00
221_T224_K1.1031.00
59_I147_Y1.1011.00
63_L70_A1.1001.00
160_L164_W1.0981.00
60_A70_A1.0921.00
119_T122_S1.0841.00
298_W301_G1.0841.00
190_A229_K1.0781.00
298_W302_H1.0751.00
198_L275_V1.0731.00
257_F297_S1.0721.00
232_A248_N1.0641.00
80_V83_E1.0581.00
25_A85_I1.0541.00
203_R241_E1.0501.00
61_V65_R1.0421.00
261_V264_T1.0351.00
148_F173_P1.0321.00
223_G236_V1.0311.00
132_R163_E1.0271.00
233_P245_Y1.0251.00
146_L171_V1.0231.00
62_A270_S1.0131.00
79_G105_N1.0061.00
83_E100_N1.0051.00
275_V285_L1.0051.00
71_G139_T1.0051.00
147_Y276_L1.0051.00
278_G281_S1.0011.00
293_N296_A0.9961.00
198_L279_L0.9921.00
256_A293_N0.9871.00
200_S275_V0.9861.00
77_G105_N0.9801.00
100_N103_G0.9781.00
121_M124_S0.9771.00
206_A222_L0.9741.00
76_L82_A0.9741.00
270_S299_V0.9741.00
63_L273_G0.9661.00
68_I281_S0.9661.00
76_L86_R0.9651.00
29_V107_W0.9611.00
164_W167_E0.9601.00
175_I196_R0.9591.00
288_A292_G0.9541.00
64_K93_G0.9541.00
250_A286_A0.9531.00
120_F124_S0.9471.00
277_A291_L0.9391.00
210_A222_L0.9371.00
21_V56_A0.9341.00
66_L295_V0.9321.00
52_V84_M0.9321.00
202_N205_E0.9321.00
25_A72_N0.9321.00
30_I51_N0.9181.00
45_L121_M0.9171.00
203_R207_E0.9151.00
25_A57_L0.9151.00
143_G171_V0.9151.00
86_R96_S0.9121.00
283_L291_L0.9101.00
32_D49_S0.9081.00
99_D134_W0.9061.00
64_K69_E0.9041.00
261_V301_G0.9011.00
76_L98_I0.8991.00
20_M73_A0.8981.00
84_M88_R0.8921.00
71_G143_G0.8911.00
221_T225_Q0.8891.00
147_Y272_A0.8891.00
290_L294_A0.8881.00
277_A311_R0.8871.00
29_V81_W0.8851.00
242_G256_A0.8831.00
120_F123_F0.8811.00
252_G289_V0.8781.00
270_S308_A0.8731.00
223_G227_Q0.8731.00
75_P99_D0.8721.00
201_L206_A0.8681.00
284_P288_A0.8661.00
176_D200_S0.8651.00
31_A109_L0.8611.00
26_V106_G0.8561.00
241_E253_C0.8541.00
22_V146_L0.8531.00
260_Q301_G0.8511.00
279_L288_A0.8511.00
270_S274_G0.8491.00
57_L306_D0.8441.00
224_K227_Q0.8421.00
140_V171_V0.8411.00
85_I105_N0.8391.00
18_S142_P0.8351.00
146_L168_L0.8341.00
19_V280_A0.8231.00
28_D53_G0.8171.00
174_F200_S0.8161.00
156_P159_E0.8141.00
191_R194_A0.8111.00
176_D201_L0.8041.00
136_A163_E0.8021.00
59_I272_A0.7971.00
223_G234_L0.7971.00
119_T123_F0.7971.00
271_H293_N0.7961.00
262_V303_R0.7941.00
166_E191_R0.7871.00
194_A230_F0.7841.00
254_I286_A0.7841.00
193_M196_R0.7801.00
27_I81_W0.7761.00
118_R122_S0.7731.00
270_S296_A0.7701.00
35_A41_C0.7661.00
274_G278_G0.7641.00
158_G162_V0.7611.00
157_C161_L0.7601.00
148_F165_L0.7561.00
254_I290_L0.7551.00
247_S285_L0.7501.00
227_Q247_S0.7501.00
259_T297_S0.7491.00
157_C160_L0.7471.00
293_N297_S0.7471.00
244_W251_S0.7461.00
60_A72_N0.7421.00
296_A299_V0.7401.00
64_K70_A0.7331.00
100_N129_Q0.7321.00
235_I245_Y0.7291.00
74_L98_I0.7271.00
39_R117_E0.7271.00
266_G308_A0.7261.00
71_G97_L0.7261.00
294_A298_W0.7251.00
139_T143_G0.7241.00
291_L314_L0.7221.00
161_L164_W0.7191.00
133_Q136_A0.7191.00
291_L311_R0.7131.00
20_M71_G0.7111.00
27_I50_V0.7071.00
164_W168_L0.7071.00
66_L277_A0.7071.00
148_F161_L0.7071.00
240_K258_P0.7051.00
145_L280_A0.7031.00
127_E130_W0.7021.00
220_T253_C0.6971.00
32_D114_P0.6971.00
50_V81_W0.6941.00
61_V306_D0.6941.00
271_H292_G0.6891.00
66_L291_L0.6871.00
174_F198_L0.6811.00
20_M139_T0.6811.00
79_G82_A0.6801.00
247_S252_G0.6791.00
66_L314_L0.6771.00
38_W41_C0.6751.00
19_V145_L0.6751.00
242_G253_C0.6741.00
223_G251_S0.6721.00
283_L288_A0.6691.00
206_A226_W0.6651.00
222_L226_W0.6631.00
88_R306_D0.6611.00
220_T244_W0.6611.00
110_A265_I0.6601.00
220_T246_F0.6571.00
75_P101_A0.6521.00
298_W313_E0.6511.00
144_S171_V0.6471.00
49_S303_R0.6451.00
219_I238_L0.6441.00
63_L276_L0.6431.00
271_H289_V0.6421.00
81_W107_W0.6421.00
279_L282_G0.6421.00
53_G58_N0.6411.00
134_W137_R0.6401.00
158_G161_L0.6381.00
78_Q100_N0.6331.00
160_L163_E0.6321.00
60_A94_L0.6291.00
227_Q230_F0.6281.00
243_A254_I0.6281.00
92_E310_T0.6271.00
145_L198_L0.6241.00
32_D303_R0.6231.00
151_Y154_A0.6221.00
190_A194_A0.6191.00
110_A120_F0.6171.00
55_C178_G0.6151.00
199_V234_L0.6151.00
273_G277_A0.6151.00
289_V293_N0.6141.00
298_W314_L0.6101.00
212_R222_L0.6081.00
106_G127_E0.6061.00
174_F272_A0.6061.00
158_G188_L0.6011.00
271_H296_A0.6011.00
35_A38_W0.5991.00
39_R113_E0.5971.00
194_A229_K0.5971.00
219_I222_L0.5951.00
187_A190_A0.5941.00
235_I271_H0.5941.00
19_V68_I0.5911.00
227_Q231_A0.5901.00
162_V195_C0.5891.00
220_T223_G0.5881.00
31_A48_Q0.5881.00
113_E117_E0.5861.00
130_W134_W0.5831.00
57_L72_N0.5831.00
206_A219_I0.5821.00
80_V84_M0.5821.00
160_L168_L0.5791.00
156_P160_L0.5771.00
66_L273_G0.5761.00
31_A45_L0.5731.00
132_R159_E0.5731.00
42_D55_C0.5721.00
118_R123_F0.5711.00
137_R167_E0.5681.00
173_P196_R0.5681.00
159_E162_V0.5671.00
206_A246_F0.5621.00
24_A178_G0.5611.00
285_L289_V0.5591.00
25_A89_M0.5581.00
174_F279_L0.5571.00
176_D269_D0.5561.00
111_L119_T0.5551.00
46_K114_P0.5541.00
179_P182_G0.5521.00
58_N305_G0.5501.00
239_D264_T0.5451.00
144_S172_T0.5441.00
227_Q234_L0.5431.00
29_V109_L0.5411.00
265_I305_G0.5381.00
212_R218_E0.5371.00
287_D291_L0.5361.00
89_M94_L0.5311.00
145_L279_L0.5301.00
161_L165_L0.5291.00
117_E120_F0.5281.00
201_L237_R0.5281.00
83_E90_A0.5261.00
227_Q249_D0.5241.00
59_I273_G0.5241.00
22_V164_W0.5241.00
119_T124_S0.5231.00
57_L61_V0.5231.00
28_D108_C0.5211.00
132_R160_L0.5201.00
139_T142_P0.5201.00
61_V94_L0.5201.00
200_S235_I0.5191.00
21_V63_L0.5191.00
59_I276_L0.5191.00
52_V306_D0.5181.00
240_K261_V0.5181.00
192_I196_R0.5171.00
70_A94_L0.5151.00
219_I244_W0.5131.00
210_A225_Q0.5121.00
294_A314_L0.5111.00
103_G126_V0.5101.00
180_R208_I0.5101.00
69_E280_A0.5101.00
108_C122_S0.5101.00
231_A234_L0.5091.00
59_I63_L0.5091.00
204_Q208_I0.5041.00
235_I289_V0.5041.00
18_S143_G0.5031.00
219_I223_G0.5031.00
78_Q82_A0.5021.00
125_G129_Q0.5011.00
203_R239_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vm7A 2 0.9221 100 0.223 Contact Map
2rbcA 2 0.9159 100 0.223 Contact Map
3vasA 1 0.9346 100 0.236 Contact Map
3hj6A 2 0.8349 100 0.244 Contact Map
3ljsA 2 0.919 100 0.245 Contact Map
2fv7A 2 0.9221 100 0.246 Contact Map
3pl2A 2 0.9252 100 0.248 Contact Map
3iq0A 2 0.9283 100 0.249 Contact Map
1rkdA 2 0.9252 100 0.25 Contact Map
2v78A 5 0.9159 100 0.254 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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