YEGV - ECOLI - GREMLIN Contacts

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YEGV - Uncharacterized sugar kinase YegV

UniProt:	P76419	Sequences: MSGARLHTLLPELTTRQSVMVVGAAVIDVIADAYALPWRGCDIELKQQSVNVGGCALNIAVALKRLGIEAGNALPLGQGVWAEMIRNRMAKEGLISLIDNAEGDNGWCLALVEPDGERTFMSFSGVENQWNRQWLARLTVAPGSLLYFSGYQLASPCGELLVEWLEELQDVTPFIDFGPRIGDIPDALLARIMACRPLVSLNRQEAEIAAERFALSAEITTLGKQWQEKFAAPLIVRLDKEGAWYFSNDASGCIPAFPTQVVDTIGAGDSHAGGVLAGLASGLPLADAVLLGNAVASWVVGHRGGDCAPTREELLLAHKNV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14065
Length:	321 (284)
Sequences:	22389 (16651)
Seq/√Len:	988.1

ECOLI - YEGV YDJH RBSK SQUV YEII PSUK K1PF PFKB KDGK FRLD INGK HLDE
BACSU - IOLC YDJE KDGK K1PF RBSK FRLD
HALSA - Q9HSM7 Q9HMJ3 Q9HP13
SULSO - Q981E2 KDGK Q97W01 Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
68_I	277_A	3.060	1.00
147_Y	174_F	2.975	1.00
18_S	144_S	2.933	1.00
245_Y	289_V	2.509	1.00
71_G	95_I	2.439	1.00
284_P	287_D	2.435	1.00
238_L	244_W	2.406	1.00
278_G	283_L	2.341	1.00
20_M	143_G	2.333	1.00
243_A	271_H	2.321	1.00
63_L	68_I	2.159	1.00
166_E	195_C	2.110	1.00
18_S	69_E	2.110	1.00
65_R	92_E	2.070	1.00
227_Q	246_F	2.049	1.00
174_F	276_L	1.956	1.00
21_V	60_A	1.944	1.00
203_R	238_L	1.915	1.00
270_S	295_V	1.886	1.00
78_Q	101_A	1.864	1.00
278_G	291_L	1.852	1.00
252_G	286_A	1.837	1.00
145_L	172_T	1.822	1.00
220_T	251_S	1.816	1.00
281_S	311_R	1.811	1.00
283_L	287_D	1.791	1.00
200_S	272_A	1.778	1.00
75_P	134_W	1.770	1.00
172_T	197_P	1.765	1.00
197_P	232_A	1.764	1.00
61_V	92_E	1.763	1.00
310_T	313_E	1.750	1.00
243_A	293_N	1.747	1.00
245_Y	252_G	1.738	1.00
267_A	300_V	1.712	1.00
62_A	273_G	1.704	1.00
87_N	91_K	1.698	1.00
168_L	171_V	1.675	1.00
302_H	313_E	1.674	1.00
90_A	96_S	1.662	1.00
145_L	174_F	1.656	1.00
244_W	253_C	1.630	1.00
86_R	90_A	1.626	1.00
296_A	300_V	1.624	1.00
275_V	288_A	1.624	1.00
88_R	91_K	1.621	1.00
223_G	246_F	1.614	1.00
286_A	290_L	1.613	1.00
235_I	275_V	1.589	1.00
238_L	253_C	1.589	1.00
163_E	167_E	1.585	1.00
19_V	63_L	1.582	1.00
274_G	295_V	1.572	1.00
198_L	233_P	1.561	1.00
257_F	294_A	1.556	1.00
247_S	250_A	1.522	1.00
78_Q	83_E	1.521	1.00
75_P	100_N	1.512	1.00
83_E	87_N	1.509	1.00
225_Q	229_K	1.508	1.00
176_D	237_R	1.494	1.00
207_E	213_F	1.492	1.00
63_L	277_A	1.481	1.00
25_A	74_L	1.468	1.00
245_Y	285_L	1.457	1.00
52_V	85_I	1.456	1.00
263_D	304_G	1.455	1.00
254_I	289_V	1.450	1.00
145_L	276_L	1.440	1.00
162_V	191_R	1.434	1.00
50_V	84_M	1.432	1.00
162_V	166_E	1.415	1.00
238_L	241_E	1.412	1.00
86_R	98_I	1.410	1.00
233_P	247_S	1.404	1.00
165_L	173_P	1.404	1.00
177_F	201_L	1.395	1.00
163_E	166_E	1.391	1.00
196_R	199_V	1.380	1.00
172_T	198_L	1.371	1.00
140_V	143_G	1.363	1.00
274_G	291_L	1.361	1.00
225_Q	228_E	1.359	1.00
218_E	221_T	1.350	1.00
82_A	105_N	1.348	1.00
27_I	84_M	1.345	1.00
18_S	71_G	1.343	1.00
86_R	100_N	1.338	1.00
224_K	228_E	1.332	1.00
103_G	129_Q	1.332	1.00
57_L	89_M	1.319	1.00
220_T	224_K	1.319	1.00
78_Q	102_E	1.311	1.00
259_T	301_G	1.307	1.00
32_D	47_Q	1.299	1.00
257_F	290_L	1.283	1.00
69_E	95_I	1.276	1.00
212_R	225_Q	1.275	1.00
29_V	48_Q	1.271	1.00
243_A	289_V	1.271	1.00
275_V	279_L	1.261	1.00
34_Y	46_K	1.245	1.00
254_I	293_N	1.244	1.00
227_Q	248_N	1.243	1.00
172_T	232_A	1.228	1.00
233_P	275_V	1.222	1.00
261_V	300_V	1.212	1.00
34_Y	114_P	1.211	1.00
233_P	279_L	1.210	1.00
277_A	281_S	1.195	1.00
275_V	292_G	1.194	1.00
200_S	237_R	1.191	1.00
141_A	169_Q	1.188	1.00
64_K	94_L	1.188	1.00
274_G	292_G	1.183	1.00
159_E	163_E	1.179	1.00
52_V	88_R	1.179	1.00
237_R	271_H	1.175	1.00
238_L	242_G	1.175	1.00
257_F	293_N	1.169	1.00
287_D	290_L	1.169	1.00
224_K	251_S	1.167	1.00
278_G	288_A	1.166	1.00
259_T	300_V	1.162	1.00
233_P	285_L	1.162	1.00
131_N	134_W	1.160	1.00
224_K	246_F	1.158	1.00
212_R	221_T	1.150	1.00
246_F	251_S	1.147	1.00
66_L	274_G	1.145	1.00
84_M	87_N	1.138	1.00
87_N	90_A	1.135	1.00
88_R	92_E	1.134	1.00
162_V	165_L	1.130	1.00
29_V	50_V	1.130	1.00
206_A	236_V	1.123	1.00
83_E	86_R	1.107	1.00
68_I	280_A	1.103	1.00
221_T	224_K	1.103	1.00
59_I	147_Y	1.101	1.00
63_L	70_A	1.100	1.00
160_L	164_W	1.098	1.00
60_A	70_A	1.092	1.00
119_T	122_S	1.084	1.00
298_W	301_G	1.084	1.00
190_A	229_K	1.078	1.00
298_W	302_H	1.075	1.00
198_L	275_V	1.073	1.00
257_F	297_S	1.072	1.00
232_A	248_N	1.064	1.00
80_V	83_E	1.058	1.00
25_A	85_I	1.054	1.00
203_R	241_E	1.050	1.00
61_V	65_R	1.042	1.00
261_V	264_T	1.035	1.00
148_F	173_P	1.032	1.00
223_G	236_V	1.031	1.00
132_R	163_E	1.027	1.00
233_P	245_Y	1.025	1.00
146_L	171_V	1.023	1.00
62_A	270_S	1.013	1.00
79_G	105_N	1.006	1.00
83_E	100_N	1.005	1.00
275_V	285_L	1.005	1.00
71_G	139_T	1.005	1.00
147_Y	276_L	1.005	1.00
278_G	281_S	1.001	1.00
293_N	296_A	0.996	1.00
198_L	279_L	0.992	1.00
256_A	293_N	0.987	1.00
200_S	275_V	0.986	1.00
77_G	105_N	0.980	1.00
100_N	103_G	0.978	1.00
121_M	124_S	0.977	1.00
206_A	222_L	0.974	1.00
76_L	82_A	0.974	1.00
270_S	299_V	0.974	1.00
63_L	273_G	0.966	1.00
68_I	281_S	0.966	1.00
76_L	86_R	0.965	1.00
29_V	107_W	0.961	1.00
164_W	167_E	0.960	1.00
175_I	196_R	0.959	1.00
288_A	292_G	0.954	1.00
64_K	93_G	0.954	1.00
250_A	286_A	0.953	1.00
120_F	124_S	0.947	1.00
277_A	291_L	0.939	1.00
210_A	222_L	0.937	1.00
21_V	56_A	0.934	1.00
66_L	295_V	0.932	1.00
52_V	84_M	0.932	1.00
202_N	205_E	0.932	1.00
25_A	72_N	0.932	1.00
30_I	51_N	0.918	1.00
45_L	121_M	0.917	1.00
203_R	207_E	0.915	1.00
25_A	57_L	0.915	1.00
143_G	171_V	0.915	1.00
86_R	96_S	0.912	1.00
283_L	291_L	0.910	1.00
32_D	49_S	0.908	1.00
99_D	134_W	0.906	1.00
64_K	69_E	0.904	1.00
261_V	301_G	0.901	1.00
76_L	98_I	0.899	1.00
20_M	73_A	0.898	1.00
84_M	88_R	0.892	1.00
71_G	143_G	0.891	1.00
221_T	225_Q	0.889	1.00
147_Y	272_A	0.889	1.00
290_L	294_A	0.888	1.00
277_A	311_R	0.887	1.00
29_V	81_W	0.885	1.00
242_G	256_A	0.883	1.00
120_F	123_F	0.881	1.00
252_G	289_V	0.878	1.00
270_S	308_A	0.873	1.00
223_G	227_Q	0.873	1.00
75_P	99_D	0.872	1.00
201_L	206_A	0.868	1.00
284_P	288_A	0.866	1.00
176_D	200_S	0.865	1.00
31_A	109_L	0.861	1.00
26_V	106_G	0.856	1.00
241_E	253_C	0.854	1.00
22_V	146_L	0.853	1.00
260_Q	301_G	0.851	1.00
279_L	288_A	0.851	1.00
270_S	274_G	0.849	1.00
57_L	306_D	0.844	1.00
224_K	227_Q	0.842	1.00
140_V	171_V	0.841	1.00
85_I	105_N	0.839	1.00
18_S	142_P	0.835	1.00
146_L	168_L	0.834	1.00
19_V	280_A	0.823	1.00
28_D	53_G	0.817	1.00
174_F	200_S	0.816	1.00
156_P	159_E	0.814	1.00
191_R	194_A	0.811	1.00
176_D	201_L	0.804	1.00
136_A	163_E	0.802	1.00
59_I	272_A	0.797	1.00
223_G	234_L	0.797	1.00
119_T	123_F	0.797	1.00
271_H	293_N	0.796	1.00
262_V	303_R	0.794	1.00
166_E	191_R	0.787	1.00
194_A	230_F	0.784	1.00
254_I	286_A	0.784	1.00
193_M	196_R	0.780	1.00
27_I	81_W	0.776	1.00
118_R	122_S	0.773	1.00
270_S	296_A	0.770	1.00
35_A	41_C	0.766	1.00
274_G	278_G	0.764	1.00
158_G	162_V	0.761	1.00
157_C	161_L	0.760	1.00
148_F	165_L	0.756	1.00
254_I	290_L	0.755	1.00
247_S	285_L	0.750	1.00
227_Q	247_S	0.750	1.00
259_T	297_S	0.749	1.00
157_C	160_L	0.747	1.00
293_N	297_S	0.747	1.00
244_W	251_S	0.746	1.00
60_A	72_N	0.742	1.00
296_A	299_V	0.740	1.00
64_K	70_A	0.733	1.00
100_N	129_Q	0.732	1.00
235_I	245_Y	0.729	1.00
74_L	98_I	0.727	1.00
39_R	117_E	0.727	1.00
266_G	308_A	0.726	1.00
71_G	97_L	0.726	1.00
294_A	298_W	0.725	1.00
139_T	143_G	0.724	1.00
291_L	314_L	0.722	1.00
161_L	164_W	0.719	1.00
133_Q	136_A	0.719	1.00
291_L	311_R	0.713	1.00
20_M	71_G	0.711	1.00
27_I	50_V	0.707	1.00
164_W	168_L	0.707	1.00
66_L	277_A	0.707	1.00
148_F	161_L	0.707	1.00
240_K	258_P	0.705	1.00
145_L	280_A	0.703	1.00
127_E	130_W	0.702	1.00
220_T	253_C	0.697	1.00
32_D	114_P	0.697	1.00
50_V	81_W	0.694	1.00
61_V	306_D	0.694	1.00
271_H	292_G	0.689	1.00
66_L	291_L	0.687	1.00
174_F	198_L	0.681	1.00
20_M	139_T	0.681	1.00
79_G	82_A	0.680	1.00
247_S	252_G	0.679	1.00
66_L	314_L	0.677	1.00
38_W	41_C	0.675	1.00
19_V	145_L	0.675	1.00
242_G	253_C	0.674	1.00
223_G	251_S	0.672	1.00
283_L	288_A	0.669	1.00
206_A	226_W	0.665	1.00
222_L	226_W	0.663	1.00
88_R	306_D	0.661	1.00
220_T	244_W	0.661	1.00
110_A	265_I	0.660	1.00
220_T	246_F	0.657	1.00
75_P	101_A	0.652	1.00
298_W	313_E	0.651	1.00
144_S	171_V	0.647	1.00
49_S	303_R	0.645	1.00
219_I	238_L	0.644	1.00
63_L	276_L	0.643	1.00
271_H	289_V	0.642	1.00
81_W	107_W	0.642	1.00
279_L	282_G	0.642	1.00
53_G	58_N	0.641	1.00
134_W	137_R	0.640	1.00
158_G	161_L	0.638	1.00
78_Q	100_N	0.633	1.00
160_L	163_E	0.632	1.00
60_A	94_L	0.629	1.00
227_Q	230_F	0.628	1.00
243_A	254_I	0.628	1.00
92_E	310_T	0.627	1.00
145_L	198_L	0.624	1.00
32_D	303_R	0.623	1.00
151_Y	154_A	0.622	1.00
190_A	194_A	0.619	1.00
110_A	120_F	0.617	1.00
55_C	178_G	0.615	1.00
199_V	234_L	0.615	1.00
273_G	277_A	0.615	1.00
289_V	293_N	0.614	1.00
298_W	314_L	0.610	1.00
212_R	222_L	0.608	1.00
106_G	127_E	0.606	1.00
174_F	272_A	0.606	1.00
158_G	188_L	0.601	1.00
271_H	296_A	0.601	1.00
35_A	38_W	0.599	1.00
39_R	113_E	0.597	1.00
194_A	229_K	0.597	1.00
219_I	222_L	0.595	1.00
187_A	190_A	0.594	1.00
235_I	271_H	0.594	1.00
19_V	68_I	0.591	1.00
227_Q	231_A	0.590	1.00
162_V	195_C	0.589	1.00
220_T	223_G	0.588	1.00
31_A	48_Q	0.588	1.00
113_E	117_E	0.586	1.00
130_W	134_W	0.583	1.00
57_L	72_N	0.583	1.00
206_A	219_I	0.582	1.00
80_V	84_M	0.582	1.00
160_L	168_L	0.579	1.00
156_P	160_L	0.577	1.00
66_L	273_G	0.576	1.00
31_A	45_L	0.573	1.00
132_R	159_E	0.573	1.00
42_D	55_C	0.572	1.00
118_R	123_F	0.571	1.00
137_R	167_E	0.568	1.00
173_P	196_R	0.568	1.00
159_E	162_V	0.567	1.00
206_A	246_F	0.562	1.00
24_A	178_G	0.561	1.00
285_L	289_V	0.559	1.00
25_A	89_M	0.558	1.00
174_F	279_L	0.557	1.00
176_D	269_D	0.556	1.00
111_L	119_T	0.555	1.00
46_K	114_P	0.554	1.00
179_P	182_G	0.552	1.00
58_N	305_G	0.550	1.00
239_D	264_T	0.545	1.00
144_S	172_T	0.544	1.00
227_Q	234_L	0.543	1.00
29_V	109_L	0.541	1.00
265_I	305_G	0.538	1.00
212_R	218_E	0.537	1.00
287_D	291_L	0.536	1.00
89_M	94_L	0.531	1.00
145_L	279_L	0.530	1.00
161_L	165_L	0.529	1.00
117_E	120_F	0.528	1.00
201_L	237_R	0.528	1.00
83_E	90_A	0.526	1.00
227_Q	249_D	0.524	1.00
59_I	273_G	0.524	1.00
22_V	164_W	0.524	1.00
119_T	124_S	0.523	1.00
57_L	61_V	0.523	1.00
28_D	108_C	0.521	1.00
132_R	160_L	0.520	1.00
139_T	142_P	0.520	1.00
61_V	94_L	0.520	1.00
200_S	235_I	0.519	1.00
21_V	63_L	0.519	1.00
59_I	276_L	0.519	1.00
52_V	306_D	0.518	1.00
240_K	261_V	0.518	1.00
192_I	196_R	0.517	1.00
70_A	94_L	0.515	1.00
219_I	244_W	0.513	1.00
210_A	225_Q	0.512	1.00
294_A	314_L	0.511	1.00
103_G	126_V	0.510	1.00
180_R	208_I	0.510	1.00
69_E	280_A	0.510	1.00
108_C	122_S	0.510	1.00
231_A	234_L	0.509	1.00
59_I	63_L	0.509	1.00
204_Q	208_I	0.504	1.00
235_I	289_V	0.504	1.00
18_S	143_G	0.503	1.00
219_I	223_G	0.503	1.00
78_Q	82_A	0.502	1.00
125_G	129_Q	0.501	1.00
203_R	239_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vm7A	2	0.9221	100	0.223	Contact Map
2rbcA	2	0.9159	100	0.223	Contact Map
3vasA	1	0.9346	100	0.236	Contact Map
3hj6A	2	0.8349	100	0.244	Contact Map
3ljsA	2	0.919	100	0.245	Contact Map
2fv7A	2	0.9221	100	0.246	Contact Map
3pl2A	2	0.9252	100	0.248	Contact Map
3iq0A	2	0.9283	100	0.249	Contact Map
1rkdA	2	0.9252	100	0.25	Contact Map
2v78A	5	0.9159	100	0.254	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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