GREMLIN Database
YEGS - Lipid kinase YegS
UniProt: P76407 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14367
Length: 299 (280)
Sequences: 6993 (5211)
Seq/√Len: 311.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_A135_F4.1671.00
257_D279_H3.7161.00
255_W279_H3.5861.00
183_R257_D3.4911.00
255_W281_E3.3631.00
128_Q281_E3.3191.00
181_E259_Q3.0901.00
123_A288_R3.0191.00
128_Q283_L2.9621.00
63_A73_V2.8851.00
25_I29_R2.4901.00
125_D219_G2.4881.00
183_R259_Q2.4771.00
220_L252_A2.4641.00
121_A288_R2.4401.00
253_S256_F2.4141.00
42_E45_D2.3971.00
227_T249_I2.3691.00
222_Q252_A2.3641.00
184_G253_S2.3551.00
220_L254_S2.2831.00
78_I126_M2.2741.00
127_A221_L2.2261.00
64_G93_L2.2201.00
259_Q277_N2.1811.00
181_E188_H2.1671.00
139_A280_I2.1121.00
181_E190_Q2.0921.00
126_M286_A1.9801.00
257_D277_N1.9691.00
199_G211_C1.9301.00
230_E247_N1.9031.00
183_R188_H1.8971.00
122_I217_N1.8921.00
108_A111_K1.8661.00
140_T267_N1.8371.00
150_E171_R1.8251.00
283_L286_A1.8031.00
99_F124_I1.7501.00
185_E254_S1.7501.00
8_L58_V1.7221.00
60_T290_R1.7151.00
223_L253_S1.6771.00
128_Q131_K1.6721.00
140_T144_G1.6341.00
70_I90_I1.6251.00
193_A225_I1.6021.00
125_D218_D1.6011.00
121_A290_R1.5761.00
44_G72_E1.5721.00
75_T134_C1.5361.00
26_M30_E1.4921.00
45_D48_R1.4921.00
40_T46_A1.4871.00
146_R171_R1.4741.00
27_L114_K1.4731.00
106_P115_L1.4731.00
123_A285_A1.4721.00
223_L256_F1.4641.00
45_D49_Y1.4631.00
51_E79_Q1.4601.00
128_Q134_C1.4391.00
180_C193_A1.4321.00
105_I112_A1.4211.00
40_T72_E1.4181.00
198_I221_L1.4161.00
179_R192_D1.4111.00
71_N75_T1.3751.00
7_S60_T1.3671.00
8_L38_R1.3631.00
78_I134_C1.3511.00
103_V289_C1.3391.00
225_I251_G1.3371.00
260_A264_I1.3351.00
50_V54_R1.3341.00
40_T45_D1.3301.00
72_E76_A1.3281.00
9_L62_I1.3191.00
184_G187_F1.3061.00
36_H58_V1.2981.00
74_S136_I1.2901.00
71_N271_E1.2861.00
52_E56_F1.2831.00
184_G251_G1.2651.00
6_A59_A1.2621.00
254_S284_P1.2611.00
198_I256_F1.2581.00
11_L39_V1.2541.00
61_V77_L1.2461.00
41_W45_D1.2351.00
127_A280_I1.2171.00
6_A34_T1.2161.00
98_D137_N1.2141.00
48_R52_E1.2101.00
134_C283_L1.2081.00
106_P112_A1.2051.00
141_G258_I1.2041.00
149_T265_T1.2011.00
50_V76_A1.1951.00
183_R186_N1.1911.00
221_L282_I1.1901.00
98_D206_G1.1781.00
102_S202_R1.1721.00
64_G91_L1.1721.00
126_M134_C1.1691.00
230_E233_P1.1681.00
223_L251_G1.1651.00
111_K114_K1.1641.00
48_R51_E1.1591.00
129_V268_L1.1471.00
47_A51_E1.1411.00
23_E110_D1.1381.00
237_S245_N1.1361.00
99_F137_N1.1271.00
50_V53_A1.1261.00
179_R190_Q1.1201.00
62_I89_G1.1161.00
185_E253_S1.1011.00
114_K118_A1.0961.00
46_A50_V1.0951.00
106_P111_K1.0911.00
225_I249_I1.0761.00
31_E114_K1.0761.00
74_S287_L1.0701.00
260_A276_Q1.0671.00
7_S62_I1.0641.00
263_D276_Q1.0631.00
54_R76_A1.0601.00
63_A88_L1.0521.00
91_L109_L1.0501.00
148_T267_N1.0471.00
192_D228_G1.0331.00
167_H170_M1.0281.00
211_C214_A1.0221.00
266_F278_F1.0201.00
11_L37_V1.0191.00
135_F139_A1.0171.00
63_A69_T1.0161.00
98_D207_G1.0151.00
138_M197_G1.0111.00
233_P237_S1.0091.00
198_I280_I1.0061.00
99_F103_V1.0051.00
187_F251_G1.0041.00
27_L113_L1.0031.00
91_L112_A1.0011.00
74_S88_L0.9971.00
129_V139_A0.9921.00
27_L110_D0.9911.00
265_T272_P0.9851.00
129_V280_I0.9831.00
100_A105_I0.9831.00
29_R35_I0.9811.00
224_R250_E0.9791.00
268_L273_L0.9781.00
150_E167_H0.9781.00
101_T203_Q0.9761.00
143_F147_I0.9721.00
109_L113_L0.9671.00
46_A72_E0.9661.00
47_A76_A0.9611.00
237_S242_D0.9581.00
137_N201_G0.9561.00
54_R80_C0.9521.00
62_I116_A0.9491.00
126_M136_I0.9431.00
23_E26_M0.9431.00
222_Q250_E0.9371.00
116_A290_R0.9301.00
218_D222_Q0.9291.00
196_I225_I0.9231.00
144_G204_A0.9161.00
129_V278_F0.9151.00
166_I170_M0.9101.00
26_M29_R0.9101.00
149_T272_P0.9061.00
70_I99_F0.9041.00
144_G267_N0.9021.00
98_D205_G0.8931.00
51_E55_K0.8911.00
6_A36_H0.8871.00
119_G290_R0.8841.00
189_W249_I0.8811.00
8_L36_H0.8791.00
263_D275_G0.8741.00
152_P155_L0.8741.00
198_I223_L0.8691.00
156_K159_L0.8681.00
167_H171_R0.8641.00
185_E255_W0.8631.00
27_L30_E0.8631.00
191_G227_T0.8621.00
186_N255_W0.8611.00
124_I289_C0.8601.00
22_R26_M0.8551.00
60_T116_A0.8521.00
90_I99_F0.8381.00
47_A79_Q0.8341.00
11_L64_G0.8331.00
27_L31_E0.8321.00
89_G116_A0.8321.00
42_E72_E0.8261.00
130_N279_H0.8231.00
47_A75_T0.8201.00
77_L80_C0.8171.00
63_A70_I0.8171.00
138_M199_G0.8131.00
201_G216_I0.8111.00
180_C260_A0.8101.00
125_D200_N0.8091.00
159_L166_I0.8031.00
151_T163_S0.8031.00
150_E170_M0.8021.00
124_I216_I0.7981.00
156_K163_S0.7951.00
99_F136_I0.7911.00
89_G290_R0.7841.00
113_L117_I0.7811.00
70_I289_C0.7791.00
208_Q239_L0.7791.00
38_R52_E0.7760.99
204_A210_L0.7720.99
214_A222_Q0.7700.99
115_L119_G0.7700.99
179_R261_P0.7690.99
105_I115_L0.7640.99
31_E117_I0.7640.99
217_N285_A0.7620.99
65_G69_T0.7580.99
191_G249_I0.7570.99
96_A144_G0.7560.99
111_K115_L0.7550.99
10_I50_V0.7470.99
130_N281_E0.7460.99
51_E76_A0.7450.99
193_A196_I0.7430.99
139_A268_L0.7430.99
96_A164_Y0.7400.99
10_I46_A0.7380.99
153_E156_K0.7380.99
10_I73_V0.7360.99
46_A76_A0.7360.99
80_C85_I0.7340.99
256_F280_I0.7320.99
163_S167_H0.7300.99
208_Q238_T0.7260.99
210_L224_R0.7250.99
42_E48_R0.7250.99
23_E27_L0.7240.99
135_F268_L0.7240.99
13_G40_T0.7230.99
102_S216_I0.7170.99
126_M283_L0.7170.99
137_N267_N0.7110.99
200_N222_Q0.7110.99
236_V240_K0.7090.99
92_P112_A0.7090.99
100_A107_E0.7070.99
71_N134_C0.7070.99
102_S201_G0.7030.99
202_R209_Q0.7030.99
36_H56_F0.7010.99
160_G164_Y0.7010.99
110_D113_L0.6960.99
141_G196_I0.6960.99
140_T197_G0.6880.99
177_P228_G0.6880.99
81_E85_I0.6850.99
44_G47_A0.6850.99
90_I100_A0.6850.99
60_T89_G0.6790.99
126_M287_L0.6750.99
74_S134_C0.6750.99
218_D252_A0.6740.99
197_G204_A0.6720.99
50_V61_V0.6710.99
54_R57_G0.6680.98
98_D138_M0.6670.98
143_F194_L0.6650.98
96_A207_G0.6620.98
175_L194_L0.6600.98
55_K80_C0.6580.98
22_R25_I0.6570.98
44_G48_R0.6560.98
40_T44_G0.6550.98
63_A90_I0.6520.98
11_L20_P0.6510.98
186_N189_W0.6490.98
25_I35_I0.6460.98
95_T137_N0.6460.98
89_G112_A0.6450.98
151_T155_L0.6410.98
184_G256_F0.6390.98
98_D101_T0.6390.98
78_I283_L0.6380.98
77_L88_L0.6380.98
227_T247_N0.6360.98
89_G115_L0.6350.98
170_M173_D0.6320.98
180_C196_I0.6310.98
138_M267_N0.6310.98
141_G266_F0.6300.98
116_A119_G0.6300.98
103_V216_I0.6290.98
110_D114_K0.6260.98
78_I286_A0.6240.98
170_M174_T0.6200.98
169_L173_D0.6190.98
181_E261_P0.6180.97
160_G163_S0.6170.97
139_A266_F0.6150.97
145_T267_N0.6130.97
28_L32_G0.6120.97
98_D102_S0.6080.97
38_R49_Y0.6080.97
9_L35_I0.6080.97
49_Y52_E0.6040.97
28_L33_M0.6030.97
81_E123_A0.6030.97
138_M201_G0.6010.97
233_P245_N0.6000.97
179_R191_G0.5980.97
125_D217_N0.5980.97
199_G222_Q0.5980.97
71_N74_S0.5970.97
112_A117_I0.5970.97
233_P236_V0.5930.97
230_E245_N0.5930.97
231_I243_E0.5930.97
99_F200_N0.5900.97
236_V239_L0.5890.97
155_L159_L0.5890.97
53_A58_V0.5890.97
98_D148_T0.5880.97
61_V73_V0.5860.97
235_L239_L0.5840.96
53_A57_G0.5820.96
137_N148_T0.5820.96
88_L287_L0.5810.96
141_G260_A0.5800.96
162_V165_I0.5800.96
41_W44_G0.5800.96
235_L243_E0.5790.96
122_I215_L0.5760.96
171_R175_L0.5760.96
198_I258_I0.5750.96
10_I38_R0.5740.96
74_S78_I0.5730.96
141_G264_I0.5730.96
152_P156_K0.5720.96
243_E248_I0.5720.96
113_L116_A0.5720.96
40_T76_A0.5710.96
146_R149_T0.5700.96
230_E234_A0.5670.96
98_D144_G0.5660.96
39_V42_E0.5650.96
160_G172_M0.5640.96
46_A73_V0.5640.96
189_W251_G0.5630.96
231_I235_L0.5620.96
54_R85_I0.5620.96
89_G117_I0.5580.95
40_T43_K0.5570.95
33_M117_I0.5570.95
92_P105_I0.5560.95
240_K243_E0.5560.95
183_R255_W0.5560.95
108_A115_L0.5550.95
266_F273_L0.5530.95
187_F279_H0.5500.95
158_A162_V0.5500.95
69_T140_T0.5480.95
229_D247_N0.5470.95
50_V77_L0.5470.95
146_R150_E0.5470.95
69_T73_V0.5470.95
51_E80_C0.5460.95
146_R265_T0.5440.95
132_Q273_L0.5440.95
7_S33_M0.5420.95
80_C86_P0.5420.95
184_G189_W0.5400.95
162_V166_I0.5390.95
7_S35_I0.5390.95
109_L112_A0.5390.95
12_N15_S0.5390.95
210_L238_T0.5370.94
182_I258_I0.5370.94
124_I287_L0.5350.94
98_D267_N0.5320.94
155_L163_S0.5310.94
115_L118_A0.5310.94
114_K117_I0.5310.94
99_F201_G0.5290.94
237_S244_D0.5230.94
15_S18_N0.5230.94
272_P275_G0.5220.94
96_A151_T0.5220.94
139_A258_I0.5200.93
52_E55_K0.5150.93
47_A50_V0.5150.93
12_N68_G0.5140.93
147_I167_H0.5140.93
148_T151_T0.5140.93
195_V199_G0.5130.93
125_D222_Q0.5120.93
264_I276_Q0.5110.93
107_E112_A0.5110.93
124_I136_I0.5100.93
50_V73_V0.5090.93
232_L235_L0.5070.93
144_G207_G0.5070.93
148_T272_P0.5070.93
203_Q207_G0.5060.93
95_T194_L0.5060.93
53_A63_A0.5050.92
108_A112_A0.5040.92
144_G147_I0.5000.92
98_D145_T0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bonA 1 0.9498 100 0.175 Contact Map
4v24A 1 0.9666 100 0.198 Contact Map
4werA 2 0.9197 100 0.218 Contact Map
2qv7A 2 0.9398 100 0.227 Contact Map
3s40A 3 0.9699 100 0.228 Contact Map
1u0tA 4 0.8027 100 0.571 Contact Map
1z0sA 4 0.7525 100 0.579 Contact Map
2an1A 4 0.8227 100 0.584 Contact Map
2i2cA 3 0.8094 100 0.601 Contact Map
1yt5A 4 0.7692 100 0.612 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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