YEGS - ECOLI - GREMLIN Contacts

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YEGS - Lipid kinase YegS

UniProt:	P76407	Sequences: MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKFGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGDAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGSVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHDITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14367
Length:	299 (280)
Sequences:	6993 (5211)
Seq/√Len:	311.4

ECOLI - YEGS
BACSU - BMRU DAGK YTLR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
127_A	135_F	4.167	1.00
257_D	279_H	3.716	1.00
255_W	279_H	3.586	1.00
183_R	257_D	3.491	1.00
255_W	281_E	3.363	1.00
128_Q	281_E	3.319	1.00
181_E	259_Q	3.090	1.00
123_A	288_R	3.019	1.00
128_Q	283_L	2.962	1.00
63_A	73_V	2.885	1.00
25_I	29_R	2.490	1.00
125_D	219_G	2.488	1.00
183_R	259_Q	2.477	1.00
220_L	252_A	2.464	1.00
121_A	288_R	2.440	1.00
253_S	256_F	2.414	1.00
42_E	45_D	2.397	1.00
227_T	249_I	2.369	1.00
222_Q	252_A	2.364	1.00
184_G	253_S	2.355	1.00
220_L	254_S	2.283	1.00
78_I	126_M	2.274	1.00
127_A	221_L	2.226	1.00
64_G	93_L	2.220	1.00
259_Q	277_N	2.181	1.00
181_E	188_H	2.167	1.00
139_A	280_I	2.112	1.00
181_E	190_Q	2.092	1.00
126_M	286_A	1.980	1.00
257_D	277_N	1.969	1.00
199_G	211_C	1.930	1.00
230_E	247_N	1.903	1.00
183_R	188_H	1.897	1.00
122_I	217_N	1.892	1.00
108_A	111_K	1.866	1.00
140_T	267_N	1.837	1.00
150_E	171_R	1.825	1.00
283_L	286_A	1.803	1.00
99_F	124_I	1.750	1.00
185_E	254_S	1.750	1.00
8_L	58_V	1.722	1.00
60_T	290_R	1.715	1.00
223_L	253_S	1.677	1.00
128_Q	131_K	1.672	1.00
140_T	144_G	1.634	1.00
70_I	90_I	1.625	1.00
193_A	225_I	1.602	1.00
125_D	218_D	1.601	1.00
121_A	290_R	1.576	1.00
44_G	72_E	1.572	1.00
75_T	134_C	1.536	1.00
26_M	30_E	1.492	1.00
45_D	48_R	1.492	1.00
40_T	46_A	1.487	1.00
146_R	171_R	1.474	1.00
27_L	114_K	1.473	1.00
106_P	115_L	1.473	1.00
123_A	285_A	1.472	1.00
223_L	256_F	1.464	1.00
45_D	49_Y	1.463	1.00
51_E	79_Q	1.460	1.00
128_Q	134_C	1.439	1.00
180_C	193_A	1.432	1.00
105_I	112_A	1.421	1.00
40_T	72_E	1.418	1.00
198_I	221_L	1.416	1.00
179_R	192_D	1.411	1.00
71_N	75_T	1.375	1.00
7_S	60_T	1.367	1.00
8_L	38_R	1.363	1.00
78_I	134_C	1.351	1.00
103_V	289_C	1.339	1.00
225_I	251_G	1.337	1.00
260_A	264_I	1.335	1.00
50_V	54_R	1.334	1.00
40_T	45_D	1.330	1.00
72_E	76_A	1.328	1.00
9_L	62_I	1.319	1.00
184_G	187_F	1.306	1.00
36_H	58_V	1.298	1.00
74_S	136_I	1.290	1.00
71_N	271_E	1.286	1.00
52_E	56_F	1.283	1.00
184_G	251_G	1.265	1.00
6_A	59_A	1.262	1.00
254_S	284_P	1.261	1.00
198_I	256_F	1.258	1.00
11_L	39_V	1.254	1.00
61_V	77_L	1.246	1.00
41_W	45_D	1.235	1.00
127_A	280_I	1.217	1.00
6_A	34_T	1.216	1.00
98_D	137_N	1.214	1.00
48_R	52_E	1.210	1.00
134_C	283_L	1.208	1.00
106_P	112_A	1.205	1.00
141_G	258_I	1.204	1.00
149_T	265_T	1.201	1.00
50_V	76_A	1.195	1.00
183_R	186_N	1.191	1.00
221_L	282_I	1.190	1.00
98_D	206_G	1.178	1.00
102_S	202_R	1.172	1.00
64_G	91_L	1.172	1.00
126_M	134_C	1.169	1.00
230_E	233_P	1.168	1.00
223_L	251_G	1.165	1.00
111_K	114_K	1.164	1.00
48_R	51_E	1.159	1.00
129_V	268_L	1.147	1.00
47_A	51_E	1.141	1.00
23_E	110_D	1.138	1.00
237_S	245_N	1.136	1.00
99_F	137_N	1.127	1.00
50_V	53_A	1.126	1.00
179_R	190_Q	1.120	1.00
62_I	89_G	1.116	1.00
185_E	253_S	1.101	1.00
114_K	118_A	1.096	1.00
46_A	50_V	1.095	1.00
106_P	111_K	1.091	1.00
225_I	249_I	1.076	1.00
31_E	114_K	1.076	1.00
74_S	287_L	1.070	1.00
260_A	276_Q	1.067	1.00
7_S	62_I	1.064	1.00
263_D	276_Q	1.063	1.00
54_R	76_A	1.060	1.00
63_A	88_L	1.052	1.00
91_L	109_L	1.050	1.00
148_T	267_N	1.047	1.00
192_D	228_G	1.033	1.00
167_H	170_M	1.028	1.00
211_C	214_A	1.022	1.00
266_F	278_F	1.020	1.00
11_L	37_V	1.019	1.00
135_F	139_A	1.017	1.00
63_A	69_T	1.016	1.00
98_D	207_G	1.015	1.00
138_M	197_G	1.011	1.00
233_P	237_S	1.009	1.00
198_I	280_I	1.006	1.00
99_F	103_V	1.005	1.00
187_F	251_G	1.004	1.00
27_L	113_L	1.003	1.00
91_L	112_A	1.001	1.00
74_S	88_L	0.997	1.00
129_V	139_A	0.992	1.00
27_L	110_D	0.991	1.00
265_T	272_P	0.985	1.00
129_V	280_I	0.983	1.00
100_A	105_I	0.983	1.00
29_R	35_I	0.981	1.00
224_R	250_E	0.979	1.00
268_L	273_L	0.978	1.00
150_E	167_H	0.978	1.00
101_T	203_Q	0.976	1.00
143_F	147_I	0.972	1.00
109_L	113_L	0.967	1.00
46_A	72_E	0.966	1.00
47_A	76_A	0.961	1.00
237_S	242_D	0.958	1.00
137_N	201_G	0.956	1.00
54_R	80_C	0.952	1.00
62_I	116_A	0.949	1.00
126_M	136_I	0.943	1.00
23_E	26_M	0.943	1.00
222_Q	250_E	0.937	1.00
116_A	290_R	0.930	1.00
218_D	222_Q	0.929	1.00
196_I	225_I	0.923	1.00
144_G	204_A	0.916	1.00
129_V	278_F	0.915	1.00
166_I	170_M	0.910	1.00
26_M	29_R	0.910	1.00
149_T	272_P	0.906	1.00
70_I	99_F	0.904	1.00
144_G	267_N	0.902	1.00
98_D	205_G	0.893	1.00
51_E	55_K	0.891	1.00
6_A	36_H	0.887	1.00
119_G	290_R	0.884	1.00
189_W	249_I	0.881	1.00
8_L	36_H	0.879	1.00
263_D	275_G	0.874	1.00
152_P	155_L	0.874	1.00
198_I	223_L	0.869	1.00
156_K	159_L	0.868	1.00
167_H	171_R	0.864	1.00
185_E	255_W	0.863	1.00
27_L	30_E	0.863	1.00
191_G	227_T	0.862	1.00
186_N	255_W	0.861	1.00
124_I	289_C	0.860	1.00
22_R	26_M	0.855	1.00
60_T	116_A	0.852	1.00
90_I	99_F	0.838	1.00
47_A	79_Q	0.834	1.00
11_L	64_G	0.833	1.00
27_L	31_E	0.832	1.00
89_G	116_A	0.832	1.00
42_E	72_E	0.826	1.00
130_N	279_H	0.823	1.00
47_A	75_T	0.820	1.00
77_L	80_C	0.817	1.00
63_A	70_I	0.817	1.00
138_M	199_G	0.813	1.00
201_G	216_I	0.811	1.00
180_C	260_A	0.810	1.00
125_D	200_N	0.809	1.00
159_L	166_I	0.803	1.00
151_T	163_S	0.803	1.00
150_E	170_M	0.802	1.00
124_I	216_I	0.798	1.00
156_K	163_S	0.795	1.00
99_F	136_I	0.791	1.00
89_G	290_R	0.784	1.00
113_L	117_I	0.781	1.00
70_I	289_C	0.779	1.00
208_Q	239_L	0.779	1.00
38_R	52_E	0.776	0.99
204_A	210_L	0.772	0.99
214_A	222_Q	0.770	0.99
115_L	119_G	0.770	0.99
179_R	261_P	0.769	0.99
105_I	115_L	0.764	0.99
31_E	117_I	0.764	0.99
217_N	285_A	0.762	0.99
65_G	69_T	0.758	0.99
191_G	249_I	0.757	0.99
96_A	144_G	0.756	0.99
111_K	115_L	0.755	0.99
10_I	50_V	0.747	0.99
130_N	281_E	0.746	0.99
51_E	76_A	0.745	0.99
193_A	196_I	0.743	0.99
139_A	268_L	0.743	0.99
96_A	164_Y	0.740	0.99
10_I	46_A	0.738	0.99
153_E	156_K	0.738	0.99
10_I	73_V	0.736	0.99
46_A	76_A	0.736	0.99
80_C	85_I	0.734	0.99
256_F	280_I	0.732	0.99
163_S	167_H	0.730	0.99
208_Q	238_T	0.726	0.99
210_L	224_R	0.725	0.99
42_E	48_R	0.725	0.99
23_E	27_L	0.724	0.99
135_F	268_L	0.724	0.99
13_G	40_T	0.723	0.99
102_S	216_I	0.717	0.99
126_M	283_L	0.717	0.99
137_N	267_N	0.711	0.99
200_N	222_Q	0.711	0.99
236_V	240_K	0.709	0.99
92_P	112_A	0.709	0.99
100_A	107_E	0.707	0.99
71_N	134_C	0.707	0.99
102_S	201_G	0.703	0.99
202_R	209_Q	0.703	0.99
36_H	56_F	0.701	0.99
160_G	164_Y	0.701	0.99
110_D	113_L	0.696	0.99
141_G	196_I	0.696	0.99
140_T	197_G	0.688	0.99
177_P	228_G	0.688	0.99
81_E	85_I	0.685	0.99
44_G	47_A	0.685	0.99
90_I	100_A	0.685	0.99
60_T	89_G	0.679	0.99
126_M	287_L	0.675	0.99
74_S	134_C	0.675	0.99
218_D	252_A	0.674	0.99
197_G	204_A	0.672	0.99
50_V	61_V	0.671	0.99
54_R	57_G	0.668	0.98
98_D	138_M	0.667	0.98
143_F	194_L	0.665	0.98
96_A	207_G	0.662	0.98
175_L	194_L	0.660	0.98
55_K	80_C	0.658	0.98
22_R	25_I	0.657	0.98
44_G	48_R	0.656	0.98
40_T	44_G	0.655	0.98
63_A	90_I	0.652	0.98
11_L	20_P	0.651	0.98
186_N	189_W	0.649	0.98
25_I	35_I	0.646	0.98
95_T	137_N	0.646	0.98
89_G	112_A	0.645	0.98
151_T	155_L	0.641	0.98
184_G	256_F	0.639	0.98
98_D	101_T	0.639	0.98
78_I	283_L	0.638	0.98
77_L	88_L	0.638	0.98
227_T	247_N	0.636	0.98
89_G	115_L	0.635	0.98
170_M	173_D	0.632	0.98
180_C	196_I	0.631	0.98
138_M	267_N	0.631	0.98
141_G	266_F	0.630	0.98
116_A	119_G	0.630	0.98
103_V	216_I	0.629	0.98
110_D	114_K	0.626	0.98
78_I	286_A	0.624	0.98
170_M	174_T	0.620	0.98
169_L	173_D	0.619	0.98
181_E	261_P	0.618	0.97
160_G	163_S	0.617	0.97
139_A	266_F	0.615	0.97
145_T	267_N	0.613	0.97
28_L	32_G	0.612	0.97
98_D	102_S	0.608	0.97
38_R	49_Y	0.608	0.97
9_L	35_I	0.608	0.97
49_Y	52_E	0.604	0.97
28_L	33_M	0.603	0.97
81_E	123_A	0.603	0.97
138_M	201_G	0.601	0.97
233_P	245_N	0.600	0.97
179_R	191_G	0.598	0.97
125_D	217_N	0.598	0.97
199_G	222_Q	0.598	0.97
71_N	74_S	0.597	0.97
112_A	117_I	0.597	0.97
233_P	236_V	0.593	0.97
230_E	245_N	0.593	0.97
231_I	243_E	0.593	0.97
99_F	200_N	0.590	0.97
236_V	239_L	0.589	0.97
155_L	159_L	0.589	0.97
53_A	58_V	0.589	0.97
98_D	148_T	0.588	0.97
61_V	73_V	0.586	0.97
235_L	239_L	0.584	0.96
53_A	57_G	0.582	0.96
137_N	148_T	0.582	0.96
88_L	287_L	0.581	0.96
141_G	260_A	0.580	0.96
162_V	165_I	0.580	0.96
41_W	44_G	0.580	0.96
235_L	243_E	0.579	0.96
122_I	215_L	0.576	0.96
171_R	175_L	0.576	0.96
198_I	258_I	0.575	0.96
10_I	38_R	0.574	0.96
74_S	78_I	0.573	0.96
141_G	264_I	0.573	0.96
152_P	156_K	0.572	0.96
243_E	248_I	0.572	0.96
113_L	116_A	0.572	0.96
40_T	76_A	0.571	0.96
146_R	149_T	0.570	0.96
230_E	234_A	0.567	0.96
98_D	144_G	0.566	0.96
39_V	42_E	0.565	0.96
160_G	172_M	0.564	0.96
46_A	73_V	0.564	0.96
189_W	251_G	0.563	0.96
231_I	235_L	0.562	0.96
54_R	85_I	0.562	0.96
89_G	117_I	0.558	0.95
40_T	43_K	0.557	0.95
33_M	117_I	0.557	0.95
92_P	105_I	0.556	0.95
240_K	243_E	0.556	0.95
183_R	255_W	0.556	0.95
108_A	115_L	0.555	0.95
266_F	273_L	0.553	0.95
187_F	279_H	0.550	0.95
158_A	162_V	0.550	0.95
69_T	140_T	0.548	0.95
229_D	247_N	0.547	0.95
50_V	77_L	0.547	0.95
146_R	150_E	0.547	0.95
69_T	73_V	0.547	0.95
51_E	80_C	0.546	0.95
146_R	265_T	0.544	0.95
132_Q	273_L	0.544	0.95
7_S	33_M	0.542	0.95
80_C	86_P	0.542	0.95
184_G	189_W	0.540	0.95
162_V	166_I	0.539	0.95
7_S	35_I	0.539	0.95
109_L	112_A	0.539	0.95
12_N	15_S	0.539	0.95
210_L	238_T	0.537	0.94
182_I	258_I	0.537	0.94
124_I	287_L	0.535	0.94
98_D	267_N	0.532	0.94
155_L	163_S	0.531	0.94
115_L	118_A	0.531	0.94
114_K	117_I	0.531	0.94
99_F	201_G	0.529	0.94
237_S	244_D	0.523	0.94
15_S	18_N	0.523	0.94
272_P	275_G	0.522	0.94
96_A	151_T	0.522	0.94
139_A	258_I	0.520	0.93
52_E	55_K	0.515	0.93
47_A	50_V	0.515	0.93
12_N	68_G	0.514	0.93
147_I	167_H	0.514	0.93
148_T	151_T	0.514	0.93
195_V	199_G	0.513	0.93
125_D	222_Q	0.512	0.93
264_I	276_Q	0.511	0.93
107_E	112_A	0.511	0.93
124_I	136_I	0.510	0.93
50_V	73_V	0.509	0.93
232_L	235_L	0.507	0.93
144_G	207_G	0.507	0.93
148_T	272_P	0.507	0.93
203_Q	207_G	0.506	0.93
95_T	194_L	0.506	0.93
53_A	63_A	0.505	0.92
108_A	112_A	0.504	0.92
144_G	147_I	0.500	0.92
98_D	145_T	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bonA	1	0.9498	100	0.175	Contact Map
4v24A	1	0.9666	100	0.198	Contact Map
4werA	2	0.9197	100	0.218	Contact Map
2qv7A	2	0.9398	100	0.227	Contact Map
3s40A	3	0.9699	100	0.228	Contact Map
1u0tA	4	0.8027	100	0.571	Contact Map
1z0sA	4	0.7525	100	0.579	Contact Map
2an1A	4	0.8227	100	0.584	Contact Map
2i2cA	3	0.8094	100	0.601	Contact Map
1yt5A	4	0.7692	100	0.612	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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