GREMLIN Database
YEGQ - Uncharacterized protease YegQ
UniProt: P76403 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14060
Length: 453 (420)
Sequences: 402 (169)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_V78_F7.9061.00
17_R54_E5.9951.00
272_I304_V5.9841.00
65_V339_L4.7240.99
276_E280_K4.6840.99
8_S302_A3.7950.97
391_L400_F3.6040.95
364_G377_V3.3600.93
75_L124_W3.3490.93
243_E249_G3.3020.93
49_Q53_N3.1630.91
131_Q158_D3.0750.90
407_N411_E3.0490.89
20_F55_A3.0360.89
150_E277_R2.9900.88
368_G376_A2.7480.83
336_E340_R2.6810.82
127_V159_M2.6700.81
112_P136_T2.6250.80
244_E247_R2.6000.79
156_V284_H2.5480.78
382_K415_I2.5320.78
68_I96_S2.4470.75
69_A96_S2.4280.74
14_K365_E2.4270.74
127_V138_V2.3570.72
243_E251_Y2.3210.71
65_V171_M2.3080.70
405_M425_L2.2950.70
121_A126_T2.2940.70
233_G236_T2.2430.68
307_K319_D2.2390.68
12_T15_N2.2360.68
228_P233_G2.1780.66
15_N38_V2.1650.65
362_F365_E2.1610.65
273_A323_L2.1560.65
124_W155_Q2.1140.63
336_E343_T2.0860.62
8_S15_N2.0710.62
72_N124_W2.0680.62
306_R310_D2.0650.61
150_E154_N2.0610.61
339_L346_D2.0330.60
15_N18_Y1.9930.59
16_M20_F1.9680.58
69_A122_V1.9600.57
230_L233_G1.9500.57
16_M62_F1.9440.57
7_L10_A1.8980.55
389_L402_L1.8780.54
5_E9_P1.8780.54
330_A373_D1.8770.54
121_A138_V1.8390.52
14_K295_F1.7730.49
87_E368_G1.7650.49
42_E46_E1.7490.48
64_V85_V1.7380.48
183_I254_A1.6980.46
12_T413_M1.6520.44
38_V65_V1.6510.44
202_N243_E1.6420.44
138_V171_M1.6350.44
351_E362_F1.6290.44
18_Y362_F1.6250.43
50_L54_E1.6240.43
5_E10_A1.5940.42
150_E280_K1.5900.42
171_M339_L1.5880.42
320_T323_L1.5760.41
18_Y295_F1.5700.41
108_F185_K1.5570.41
232_I236_T1.5490.40
7_L11_G1.5430.40
95_M100_L1.5190.39
192_T344_H1.5180.39
6_L9_P1.5160.39
65_V358_D1.5150.39
8_S288_I1.5110.39
21_A360_Q1.4870.38
295_F362_F1.4830.38
89_G132_Q1.4790.38
4_P313_A1.4720.37
31_Q66_V1.4690.37
379_V383_F1.4680.37
21_A58_L1.4620.37
200_E245_A1.4570.37
31_Q78_F1.4560.37
203_V243_E1.4560.37
240_F254_A1.4540.37
311_D316_K1.4540.37
107_H171_M1.4420.36
378_A419_D1.4410.36
324_E345_D1.4380.36
205_E238_K1.4330.36
31_Q86_V1.4310.36
16_M54_E1.4160.35
236_T240_F1.4110.35
70_P113_I1.4050.35
376_A424_W1.4000.34
388_S399_N1.3960.34
106_E132_Q1.3860.34
131_Q159_M1.3790.34
82_L105_R1.3740.34
229_T233_G1.3680.33
16_M55_A1.3340.32
65_V295_F1.3240.32
15_N47_N1.3190.31
283_V339_L1.3110.31
413_M421_Y1.3080.31
228_P231_G1.3050.31
183_I284_H1.2980.31
415_I421_Y1.2920.31
17_R50_L1.2880.30
45_H82_L1.2790.30
72_N151_E1.2510.29
151_E155_Q1.2500.29
5_E11_G1.2430.29
233_G237_D1.2400.29
6_L10_A1.2390.29
3_K228_P1.2250.28
300_R303_Q1.2220.28
12_T42_E1.2220.28
66_V253_T1.2170.28
18_Y22_Y1.2150.28
16_M88_M1.2130.28
31_Q85_V1.2080.28
203_V254_A1.2020.27
281_M340_R1.2020.27
75_L272_I1.2010.27
78_F86_V1.2000.27
8_S14_K1.1990.27
75_L108_F1.1940.27
214_I239_V1.1920.27
42_E339_L1.1890.27
15_N295_F1.1880.27
273_A336_E1.1880.27
368_G374_L1.1720.26
213_N216_H1.1650.26
202_N389_L1.1640.26
184_N311_D1.1630.26
72_N188_P1.1540.26
6_L11_G1.1530.26
234_A237_D1.1530.26
340_R343_T1.1490.26
233_G344_H1.1460.26
128_K131_Q1.1460.26
13_L51_G1.1460.26
38_V295_F1.1320.25
54_E208_E1.1260.25
82_L251_Y1.1180.25
236_T255_F1.1180.25
154_N277_R1.1170.25
408_A422_T1.1160.25
18_Y393_T1.1150.25
328_G359_R1.1110.25
8_S38_V1.1110.25
273_A343_T1.1070.24
336_E344_H1.1070.24
14_K18_Y1.1030.24
45_H68_I1.0970.24
132_Q384_S1.0940.24
79_I83_K1.0920.24
273_A281_M1.0840.24
279_T407_N1.0770.24
76_K151_E1.0660.23
171_M252_M1.0640.23
65_V346_D1.0530.23
304_V325_T1.0530.23
18_Y360_Q1.0530.23
65_V185_K1.0500.23
228_P236_T1.0410.22
75_L80_R1.0400.22
73_A77_T1.0350.22
204_Q241_M1.0340.22
96_S344_H1.0330.22
216_H378_A1.0300.22
110_E361_Q1.0270.22
79_I108_F1.0260.22
53_N371_K1.0250.22
22_Y133_M1.0240.22
216_H392_M1.0230.22
75_L107_H1.0200.22
169_L342_H1.0190.22
204_Q405_M1.0190.22
82_L365_E1.0180.22
349_N355_S1.0120.22
69_A121_A1.0110.22
18_Y21_A1.0100.22
77_T81_D1.0090.22
159_M284_H1.0060.21
133_M154_N1.0050.21
50_L138_V1.0040.21
352_Y357_S1.0030.21
367_T378_A1.0020.21
12_T417_P1.0010.21
242_I429_Q1.0010.21
324_E351_E1.0000.21
63_Y284_H0.9980.21
375_A427_V0.9870.21
255_F376_A0.9860.21
402_L425_L0.9760.21
95_M113_I0.9740.21
200_E323_L0.9720.21
369_E374_L0.9640.20
72_N267_K0.9630.20
63_Y242_I0.9630.20
13_L54_E0.9620.20
95_M353_G0.9590.20
8_S18_Y0.9480.20
254_A284_H0.9460.20
243_E247_R0.9430.20
112_P251_Y0.9410.20
12_T65_V0.9360.20
167_G191_G0.9360.20
167_G290_G0.9360.20
191_G290_G0.9360.20
32_P98_P0.9350.20
60_K72_N0.9320.19
65_V108_F0.9320.19
283_V346_D0.9290.19
124_W188_P0.9290.19
46_E89_G0.9260.19
257_D262_Y0.9250.19
237_D255_F0.9240.19
280_K422_T0.9200.19
232_I240_F0.9180.19
371_K402_L0.9160.19
69_A126_T0.9160.19
274_H336_E0.9140.19
320_T324_E0.9140.19
295_F365_E0.9120.19
108_F171_M0.9080.19
82_L192_T0.9050.19
44_N63_Y0.9030.19
244_E296_Y0.9020.19
135_L188_P0.9010.19
57_A229_T0.8990.19
385_V414_P0.8990.19
192_T345_D0.8980.19
369_E377_V0.8960.19
325_T331_H0.8940.18
283_V399_N0.8930.18
154_N284_H0.8910.18
78_F377_V0.8870.18
80_R132_Q0.8840.18
14_K38_V0.8830.18
228_P344_H0.8820.18
373_D413_M0.8820.18
126_T339_L0.8800.18
51_G296_Y0.8800.18
183_I203_V0.8780.18
183_I192_T0.8720.18
108_F298_C0.8710.18
63_Y133_M0.8700.18
15_N358_D0.8700.18
106_E128_K0.8660.18
82_L89_G0.8630.18
215_V283_V0.8620.18
96_S108_F0.8600.18
55_A62_F0.8590.18
69_A229_T0.8580.18
89_G307_K0.8550.18
239_V255_F0.8550.18
128_K207_K0.8540.17
18_Y365_E0.8460.17
325_T328_G0.8450.17
244_E251_Y0.8450.17
183_I236_T0.8430.17
44_N361_Q0.8420.17
51_G311_D0.8420.17
288_I301_T0.8420.17
374_L378_A0.8390.17
38_V428_P0.8360.17
236_T254_A0.8300.17
369_E399_N0.8300.17
42_E54_E0.8290.17
65_V298_C0.8280.17
96_S232_I0.8260.17
266_S309_I0.8240.17
255_F344_H0.8220.17
54_E57_A0.8220.17
124_W171_M0.8220.17
251_Y255_F0.8220.17
136_T188_P0.8220.17
48_L319_D0.8200.17
95_M101_I0.8200.17
171_M358_D0.8200.17
209_D238_K0.8180.17
233_G240_F0.8170.17
108_F339_L0.8150.17
150_E276_E0.8130.17
83_K401_T0.8120.17
138_V377_V0.8110.16
121_A133_M0.8110.16
156_V159_M0.8080.16
230_L236_T0.8070.16
230_L235_P0.8050.16
264_M401_T0.8030.16
32_P379_V0.8020.16
82_L417_P0.8020.16
45_H352_Y0.8010.16
279_T313_A0.7970.16
32_P262_Y0.7940.16
89_G111_M0.7930.16
32_P257_D0.7910.16
211_V325_T0.7910.16
65_V417_P0.7910.16
408_A424_W0.7900.16
246_Q344_H0.7890.16
152_I333_G0.7870.16
75_L131_Q0.7860.16
185_K339_L0.7860.16
367_T419_D0.7860.16
281_M336_E0.7840.16
149_I339_L0.7830.16
103_L111_M0.7820.16
171_M392_M0.7790.16
331_H405_M0.7780.16
22_Y360_Q0.7770.16
373_D402_L0.7770.16
66_V86_V0.7760.16
53_N77_T0.7740.16
135_L159_M0.7730.16
105_R251_Y0.7690.16
23_G167_G0.7690.16
23_G191_G0.7690.16
23_G290_G0.7690.16
232_I235_P0.7680.16
4_P279_T0.7650.15
196_A324_E0.7650.15
3_K229_T0.7620.15
3_K313_A0.7610.15
78_F419_D0.7600.15
153_R284_H0.7590.15
115_L135_L0.7590.15
366_F395_Q0.7590.15
150_E211_V0.7590.15
196_A252_M0.7590.15
409_K412_A0.7560.15
378_A422_T0.7520.15
236_T344_H0.7490.15
343_T347_Y0.7480.15
156_V254_A0.7470.15
128_K285_S0.7450.15
158_D284_H0.7430.15
52_I56_H0.7430.15
117_V141_S0.7420.15
33_R341_R0.7420.15
45_H135_L0.7400.15
328_G358_D0.7400.15
377_V402_L0.7400.15
377_V425_L0.7390.15
21_A393_T0.7370.15
216_H377_V0.7350.15
53_N57_A0.7340.15
323_L343_T0.7330.15
14_K362_F0.7320.15
203_V235_P0.7300.15
247_R251_Y0.7300.15
214_I367_T0.7290.15
61_K264_M0.7290.15
124_W132_Q0.7290.15
54_E58_L0.7270.15
216_H249_G0.7260.15
231_G345_D0.7240.15
215_V243_E0.7240.15
82_L427_V0.7230.15
340_R344_H0.7230.15
42_E302_A0.7200.15
16_M226_V0.7190.14
3_K354_Y0.7160.14
22_Y393_T0.7130.14
379_V382_K0.7130.14
200_E362_F0.7100.14
340_R347_Y0.7090.14
369_E373_D0.7070.14
188_P302_A0.7060.14
408_A413_M0.7060.14
74_K141_S0.7060.14
204_Q239_V0.7060.14
63_Y135_L0.7050.14
131_Q407_N0.7040.14
357_S388_S0.7040.14
22_Y391_L0.7030.14
378_A411_E0.7030.14
8_S393_T0.7020.14
267_K298_C0.7020.14
245_A414_P0.7020.14
409_K424_W0.7000.14
61_K267_K0.6990.14
203_V240_F0.6990.14
90_P120_N0.6980.14
196_A245_A0.6970.14
110_E283_V0.6940.14
3_K395_Q0.6930.14
20_F428_P0.6920.14
123_N137_R0.6910.14
123_N172_A0.6910.14
63_Y236_T0.6900.14
138_V155_Q0.6900.14
200_E211_V0.6880.14
382_K417_P0.6880.14
57_A408_A0.6880.14
154_N158_D0.6870.14
35_S152_I0.6850.14
47_N50_L0.6840.14
20_F54_E0.6840.14
136_T367_T0.6820.14
203_V215_V0.6820.14
242_I254_A0.6810.14
227_E231_G0.6770.14
207_K280_K0.6770.14
47_N88_M0.6750.14
382_K389_L0.6740.14
61_K375_A0.6740.14
231_G325_T0.6710.14
60_K188_P0.6710.14
183_I331_H0.6700.14
73_A245_A0.6700.14
200_E351_E0.6660.13
358_D424_W0.6660.13
80_R113_I0.6650.13
233_G255_F0.6650.13
288_I365_E0.6640.13
165_V311_D0.6630.13
117_V139_I0.6630.13
123_N160_E0.6610.13
75_L339_L0.6600.13
147_E279_T0.6600.13
202_N209_D0.6560.13
211_V214_I0.6550.13
320_T410_G0.6550.13
149_I405_M0.6530.13
231_G236_T0.6530.13
379_V389_L0.6520.13
128_K208_E0.6520.13
311_D318_F0.6490.13
252_M313_A0.6490.13
366_F428_P0.6480.13
260_G265_N0.6460.13
108_F417_P0.6460.13
204_Q251_Y0.6460.13
98_P129_F0.6440.13
121_A159_M0.6430.13
245_A371_K0.6420.13
71_H199_W0.6410.13
357_S374_L0.6400.13
13_L17_R0.6400.13
352_Y356_V0.6380.13
231_G407_N0.6370.13
169_L181_G0.6370.13
137_R160_E0.6370.13
87_E328_G0.6370.13
147_E153_R0.6340.13
51_G396_G0.6330.13
283_V388_S0.6300.13
80_R83_K0.6300.13
113_I388_S0.6280.13
18_Y391_L0.6280.13
53_N235_P0.6280.13
206_G241_M0.6260.13
244_E263_I0.6250.13
15_N65_V0.6240.13
95_M104_V0.6230.13
62_F295_F0.6220.13
354_Y357_S0.6210.13
96_S229_T0.6210.13
183_I233_G0.6200.13
96_S358_D0.6190.13
98_P130_W0.6190.13
389_L400_F0.6190.13
17_R208_E0.6170.13
405_M413_M0.6160.12
126_T132_Q0.6160.12
231_G235_P0.6160.12
188_P361_Q0.6150.12
18_Y48_L0.6140.12
228_P235_P0.6130.12
367_T414_P0.6120.12
61_K159_M0.6120.12
66_V108_F0.6110.12
126_T368_G0.6110.12
274_H288_I0.6090.12
210_D404_H0.6080.12
190_Q257_D0.6070.12
273_A391_L0.6070.12
103_L301_T0.6060.12
231_G240_F0.6050.12
63_Y336_E0.6040.12
36_L308_A0.6030.12
150_E401_T0.5990.12
383_F423_V0.5990.12
276_E358_D0.5980.12
48_L209_D0.5980.12
274_H277_R0.5970.12
55_A58_L0.5970.12
121_A127_V0.5950.12
205_E209_D0.5940.12
4_P248_P0.5930.12
211_V351_E0.5930.12
247_R250_E0.5930.12
367_T377_V0.5920.12
74_K187_D0.5910.12
135_L138_V0.5890.12
55_A380_K0.5880.12
262_Y333_G0.5870.12
38_V111_M0.5850.12
243_E394_P0.5840.12
108_F183_I0.5830.12
276_E428_P0.5830.12
23_G30_G0.5830.12
141_S182_Y0.5810.12
401_T429_Q0.5800.12
117_V187_D0.5800.12
69_A285_S0.5800.12
79_I86_V0.5780.12
16_M124_W0.5770.12
229_T388_S0.5760.12
321_S388_S0.5750.12
45_H64_V0.5750.12
356_V427_V0.5730.12
79_I366_F0.5730.12
229_T345_D0.5730.12
152_I256_E0.5730.12
384_S415_I0.5710.12
74_K117_V0.5700.12
53_N406_E0.5700.12
242_I362_F0.5700.12
89_G414_P0.5680.12
80_R107_H0.5680.12
185_K344_H0.5670.12
88_M321_S0.5670.12
3_K276_E0.5660.12
45_H133_M0.5650.12
78_F108_F0.5640.12
126_T414_P0.5630.12
369_E389_L0.5620.12
24_A28_Y0.5620.12
33_R271_A0.5620.12
178_L263_I0.5620.12
215_V323_L0.5610.12
343_T351_E0.5590.11
276_E321_S0.5590.11
31_Q72_N0.5580.11
391_L399_N0.5570.11
82_L246_Q0.5570.11
83_K87_E0.5570.11
241_M244_E0.5550.11
367_T376_A0.5550.11
374_L424_W0.5550.11
294_S335_T0.5540.11
104_V113_I0.5540.11
138_V328_G0.5520.11
331_H382_K0.5500.11
65_V357_S0.5480.11
18_Y65_V0.5470.11
38_V42_E0.5470.11
134_G167_G0.5470.11
134_G290_G0.5470.11
134_G191_G0.5470.11
415_I419_D0.5460.11
209_D214_I0.5460.11
53_N376_A0.5440.11
124_W138_V0.5430.11
214_I412_A0.5430.11
324_E343_T0.5410.11
96_S233_G0.5410.11
85_V110_E0.5400.11
42_E47_N0.5400.11
18_Y38_V0.5400.11
331_H352_Y0.5400.11
141_S179_L0.5390.11
366_F371_K0.5380.11
102_M302_A0.5360.11
205_E414_P0.5350.11
361_Q365_E0.5340.11
15_N362_F0.5340.11
376_A414_P0.5330.11
202_N284_H0.5330.11
60_K302_A0.5330.11
61_K136_T0.5320.11
63_Y285_S0.5320.11
126_T358_D0.5320.11
85_V89_G0.5310.11
234_A323_L0.5310.11
171_M183_I0.5300.11
8_S60_K0.5300.11
188_P192_T0.5300.11
124_W227_E0.5290.11
271_A292_T0.5290.11
133_M336_E0.5290.11
368_G371_K0.5290.11
354_Y382_K0.5280.11
75_L122_V0.5280.11
17_R376_A0.5270.11
401_T413_M0.5260.11
257_D265_N0.5250.11
251_Y263_I0.5250.11
328_G385_V0.5220.11
272_I307_K0.5210.11
328_G391_L0.5210.11
366_F378_A0.5210.11
22_Y365_E0.5190.11
331_H392_M0.5180.11
211_V304_V0.5150.11
43_F168_A0.5150.11
276_E279_T0.5150.11
260_G333_G0.5140.11
65_V374_L0.5130.11
225_N228_P0.5120.11
244_E249_G0.5110.11
104_V244_E0.5090.11
16_M239_V0.5080.11
320_T408_A0.5080.11
101_I334_Y0.5070.11
106_E153_R0.5060.11
244_E253_T0.5060.11
340_R392_M0.5060.11
195_N292_T0.5060.11
75_L110_E0.5050.11
311_D386_G0.5050.11
395_Q414_P0.5040.11
307_K325_T0.5040.11
8_S250_E0.5020.11
378_A402_L0.5020.11
74_K190_Q0.5020.11
68_I121_A0.5010.11
360_Q391_L0.5010.11
204_Q378_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he6A 1 0.1921 99.7 0.917 Contact Map
2bdqA 2 0.3885 97.5 0.963 Contact Map
1h5yA 1 0.4172 96.1 0.969 Contact Map
3f4wA 2 0.3113 95.5 0.971 Contact Map
3tsmA 2 0.2958 94.8 0.972 Contact Map
3qjaA 1 0.3267 94.6 0.972 Contact Map
3q58A 2 0.3024 94.4 0.973 Contact Map
1q6oA 3 0.3046 93.9 0.973 Contact Map
3igsA 1 0.3024 93.8 0.973 Contact Map
3jr2A 3 0.298 93.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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