MDTC - ECOLI - GREMLIN Contacts

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MDTC - Multidrug resistance protein MdtC

UniProt:	P76399	Sequences: MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14058
Length:	1025 (998)
Sequences:	15840 (10118)
Seq/√Len:	320.3

ECOLI - MDTC MDTB ACRB ACRD CUSA ACRF MDTF
BACSU - SWRC SECDF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
938_T	941_E	4.174	1.00
239_A	242_Q	4.103	1.00
303_K	306_E	3.984	1.00
242_Q	257_G	3.908	1.00
305_P	308_Q	3.887	1.00
64_A	89_T	3.757	1.00
707_V	785_Q	3.702	1.00
49_A	89_T	3.535	1.00
518_S	999_Y	3.454	1.00
894_A	988_G	3.363	1.00
579_L	607_G	3.360	1.00
298_D	328_R	3.216	1.00
419_K	422_Q	3.197	1.00
243_P	257_G	3.140	1.00
520_K	944_F	3.113	1.00
150_S	153_E	3.083	1.00
5_A	9_Y	3.082	1.00
574_A	577_G	3.053	1.00
418_M	426_Q	3.038	1.00
144_L	158_A	2.868	1.00
669_D	672_A	2.843	1.00
672_A	675_E	2.828	1.00
189_L	204_V	2.826	1.00
709_D	783_K	2.811	1.00
77_V	93_L	2.791	1.00
737_S	748_V	2.788	1.00
169_I	299_S	2.730	1.00
276_N	594_N	2.716	1.00
165_T	303_K	2.716	1.00
708_Y	713_M	2.711	1.00
64_A	84_S	2.699	1.00
274_M	583_M	2.681	1.00
683_K	827_Q	2.636	1.00
713_M	723_A	2.628	1.00
719_D	722_A	2.618	1.00
301_R	322_D	2.583	1.00
60_A	800_A	2.572	1.00
194_L	199_V	2.562	1.00
242_Q	262_V	2.551	1.00
683_K	686_T	2.549	1.00
339_I	343_A	2.514	1.00
238_A	242_Q	2.486	1.00
876_H	929_L	2.478	1.00
78_S	94_Q	2.473	1.00
622_T	625_Q	2.465	1.00
256_L	262_V	2.448	1.00
576_R	580_Q	2.433	1.00
308_Q	316_D	2.406	1.00
154_L	315_I	2.398	1.00
675_E	679_K	2.389	1.00
190_N	193_A	2.385	1.00
372_G	473_I	2.379	1.00
516_G	948_L	2.376	1.00
681_R	685_A	2.363	1.00
246_I	259_V	2.346	1.00
78_S	96_D	2.329	1.00
937_L	945_Q	2.316	1.00
812_K	820_A	2.294	1.00
295_Q	299_S	2.267	1.00
709_D	712_T	2.251	1.00
157_F	315_I	2.249	1.00
376_A	469_V	2.226	1.00
147_D	316_D	2.221	1.00
676_W	834_V	2.217	1.00
524_N	940_Q	2.207	1.00
761_S	764_E	2.189	1.00
684_L	821_I	2.183	1.00
898_F	984_I	2.173	1.00
188_G	263_T	2.157	1.00
205_R	750_M	2.151	1.00
187_V	208_V	2.146	1.00
813_S	816_D	2.125	1.00
707_V	783_K	2.120	1.00
413_H	418_M	2.111	1.00
189_L	201_L	2.104	1.00
589_D	629_R	2.080	1.00
591_A	621_E	2.066	1.00
183_P	264_D	2.061	1.00
931_A	937_L	2.057	1.00
681_R	695_S	2.048	1.00
588_D	633_K	2.047	1.00
943_I	1006_L	2.042	1.00
241_Y	256_L	2.038	1.00
705_N	787_A	2.020	1.00
764_E	779_S	2.013	1.00
562_G	611_I	2.013	1.00
932_Q	1005_Y	2.011	1.00
413_H	430_E	2.008	1.00
708_Y	723_A	2.007	1.00
931_A	934_H	2.004	1.00
680_I	825_M	1.998	1.00
336_Q	340_I	1.986	1.00
422_Q	426_Q	1.955	1.00
687_L	820_A	1.955	1.00
566_A	570_I	1.945	1.00
969_V	987_V	1.943	1.00
147_D	278_K	1.940	1.00
690_L	693_V	1.939	1.00
510_A	513_Q	1.933	1.00
777_P	780_Y	1.929	1.00
692_D	807_N	1.924	1.00
237_T	240_E	1.921	1.00
593_D	614_K	1.919	1.00
706_L	782_A	1.890	1.00
299_S	302_A	1.889	1.00
67_L	71_L	1.887	1.00
57_E	61_S	1.885	1.00
678_P	681_R	1.882	1.00
586_I	630_L	1.881	1.00
621_E	629_R	1.876	1.00
412_R	416_A	1.850	1.00
515_Y	947_C	1.841	1.00
9_Y	421_L	1.840	1.00
665_L	680_I	1.827	1.00
274_M	576_R	1.826	1.00
67_L	91_I	1.821	1.00
542_W	545_I	1.820	1.00
59_M	63_V	1.819	1.00
510_A	514_G	1.818	1.00
931_A	945_Q	1.816	1.00
822_D	846_Q	1.812	1.00
521_W	525_H	1.811	1.00
239_A	243_P	1.805	1.00
718_I	768_V	1.804	1.00
525_H	528_L	1.800	1.00
443_V	472_G	1.799	1.00
940_Q	1006_L	1.798	1.00
535_G	539_L	1.794	1.00
261_T	753_D	1.790	1.00
12_V	868_G	1.790	1.00
759_D	762_A	1.789	1.00
581_D	584_K	1.786	1.00
676_W	679_K	1.783	1.00
26_I	30_R	1.775	1.00
589_D	633_K	1.772	1.00
205_R	209_S	1.772	1.00
162_L	307_L	1.768	1.00
409_N	430_E	1.764	1.00
681_R	693_V	1.737	1.00
690_L	817_A	1.737	1.00
365_S	477_V	1.737	1.00
585_I	633_K	1.736	1.00
191_P	756_Y	1.727	1.00
31_M	378_Y	1.716	1.00
526_T	1006_L	1.712	1.00
677_E	802_S	1.710	1.00
149_Y	314_A	1.708	1.00
145_T	318_Q	1.706	1.00
5_A	425_L	1.705	1.00
71_L	93_L	1.703	1.00
516_G	520_K	1.702	1.00
236_K	240_E	1.696	1.00
900_A	984_I	1.694	1.00
184_A	749_V	1.693	1.00
194_L	259_V	1.687	1.00
820_A	823_R	1.686	1.00
712_T	715_R	1.685	1.00
705_N	785_Q	1.683	1.00
295_Q	298_D	1.682	1.00
584_K	588_D	1.671	1.00
580_Q	584_K	1.668	1.00
659_A	806_F	1.668	1.00
298_D	302_A	1.667	1.00
521_W	524_N	1.666	1.00
541_I	545_I	1.665	1.00
10_R	872_E	1.664	1.00
200_S	203_D	1.652	1.00
93_L	108_V	1.647	1.00
674_R	678_P	1.645	1.00
629_R	633_K	1.644	1.00
332_E	336_Q	1.636	1.00
579_L	597_G	1.629	1.00
530_G	534_L	1.628	1.00
819_A	822_D	1.625	1.00
585_I	636_K	1.621	1.00
929_L	933_R	1.605	1.00
301_R	319_I	1.605	1.00
116_Q	126_R	1.602	1.00
190_N	261_T	1.599	1.00
64_A	82_S	1.599	1.00
930_E	934_H	1.592	1.00
560_L	611_I	1.589	1.00
824_A	827_Q	1.581	1.00
71_L	91_I	1.581	1.00
22_T	371_I	1.581	1.00
753_D	756_Y	1.569	1.00
820_A	824_A	1.567	1.00
182_L	267_Q	1.566	1.00
143_T	275_T	1.566	1.00
718_I	781_F	1.565	1.00
67_L	115_A	1.564	1.00
243_P	255_R	1.561	1.00
199_V	203_D	1.555	1.00
76_G	99_R	1.555	1.00
679_K	682_K	1.551	1.00
628_D	632_V	1.548	1.00
380_C	469_V	1.548	1.00
382_F	465_V	1.542	1.00
518_S	521_W	1.538	1.00
689_E	820_A	1.536	1.00
575_M	607_G	1.534	1.00
28_G	375_A	1.533	1.00
564_I	579_L	1.527	1.00
713_M	718_I	1.527	1.00
683_K	824_A	1.524	1.00
212_N	737_S	1.521	1.00
564_I	582_F	1.516	1.00
100_D	103_G	1.516	1.00
206_T	210_N	1.513	1.00
633_K	636_K	1.510	1.00
301_R	305_P	1.510	1.00
584_K	587_R	1.508	1.00
549_K	815_S	1.505	1.00
631_R	692_D	1.503	1.00
412_R	949_L	1.502	1.00
202_D	206_T	1.498	1.00
812_K	816_D	1.494	1.00
769_I	775_A	1.492	1.00
472_G	476_L	1.492	1.00
235_L	241_Y	1.488	1.00
723_A	781_F	1.487	1.00
410_I	486_C	1.484	1.00
582_F	634_L	1.475	1.00
682_K	686_T	1.473	1.00
409_N	412_R	1.471	1.00
465_V	469_V	1.468	1.00
189_L	194_L	1.468	1.00
208_V	244_L	1.466	1.00
514_G	517_K	1.464	1.00
413_H	416_A	1.463	1.00
822_D	826_T	1.461	1.00
84_S	89_T	1.460	1.00
706_L	784_W	1.457	1.00
736_I	750_M	1.449	1.00
291_A	296_T	1.444	1.00
586_I	592_V	1.440	1.00
566_A	578_K	1.439	1.00
80_M	93_L	1.437	1.00
530_G	1007_F	1.437	1.00
883_T	921_A	1.431	1.00
735_Q	747_K	1.431	1.00
193_A	197_Q	1.429	1.00
816_D	819_A	1.429	1.00
542_W	546_S	1.428	1.00
672_A	676_W	1.427	1.00
570_I	574_A	1.426	1.00
585_I	589_D	1.424	1.00
49_A	123_M	1.424	1.00
864_Y	877_P	1.421	1.00
172_V	285_I	1.420	1.00
206_T	209_S	1.420	1.00
940_Q	944_F	1.413	1.00
235_L	244_L	1.408	1.00
203_D	206_T	1.407	1.00
203_D	769_I	1.393	1.00
49_A	67_L	1.388	1.00
819_A	823_R	1.386	1.00
373_T	470_A	1.385	1.00
679_K	683_K	1.382	1.00
333_E	336_Q	1.380	1.00
193_A	196_N	1.377	1.00
49_A	64_A	1.376	1.00
682_K	685_A	1.375	1.00
844_V	847_E	1.374	1.00
514_G	518_S	1.369	1.00
537_I	541_I	1.366	1.00
577_G	581_D	1.365	1.00
99_R	104_A	1.364	1.00
932_Q	1009_D	1.359	1.00
591_A	626_I	1.359	1.00
229_I	731_F	1.357	1.00
770_N	774_K	1.354	1.00
322_D	325_P	1.351	1.00
299_S	303_K	1.350	1.00
599_T	607_G	1.347	1.00
580_Q	583_M	1.345	1.00
665_L	673_L	1.344	1.00
255_R	258_D	1.342	1.00
163_A	167_S	1.342	1.00
47_V	71_L	1.340	1.00
538_A	542_W	1.340	1.00
962_L	991_V	1.339	1.00
583_M	587_R	1.338	1.00
210_N	714_A	1.338	1.00
36_P	557_T	1.335	1.00
145_T	316_D	1.335	1.00
45_I	108_V	1.335	1.00
564_I	607_G	1.329	1.00
272_A	576_R	1.329	1.00
526_T	1010_R	1.324	1.00
170_D	299_S	1.324	1.00
343_A	347_L	1.321	1.00
16_L	865_I	1.321	1.00
406_V	428_T	1.316	1.00
560_L	627_I	1.315	1.00
79_E	797_G	1.310	1.00
68_E	795_H	1.310	1.00
144_L	162_L	1.307	1.00
539_L	543_L	1.305	1.00
63_V	123_M	1.305	1.00
962_L	987_V	1.304	1.00
249_N	252_G	1.303	1.00
768_V	781_F	1.300	1.00
24_C	375_A	1.298	1.00
311_I	317_L	1.296	1.00
21_I	372_G	1.296	1.00
376_A	380_C	1.296	1.00
531_V	535_G	1.291	1.00
690_L	806_F	1.291	1.00
677_E	695_S	1.291	1.00
346_I	363_A	1.289	1.00
516_G	945_Q	1.287	1.00
203_D	247_H	1.285	1.00
59_M	84_S	1.280	1.00
65_T	795_H	1.279	1.00
941_E	945_Q	1.279	1.00
587_R	595_V	1.277	1.00
55_S	58_T	1.275	1.00
200_S	769_I	1.275	1.00
402_D	919_K	1.274	1.00
531_V	538_A	1.273	1.00
589_D	626_I	1.273	1.00
273_G	282_L	1.272	1.00
79_E	94_Q	1.272	1.00
595_V	609_M	1.270	1.00
592_V	611_I	1.270	1.00
71_L	108_V	1.268	1.00
156_D	746_Y	1.266	1.00
188_G	261_T	1.266	1.00
76_G	96_D	1.262	1.00
664_T	796_Q	1.262	1.00
823_R	827_Q	1.259	1.00
667_S	834_V	1.259	1.00
5_A	429_R	1.257	1.00
240_E	243_P	1.257	1.00
368_V	481_L	1.255	1.00
165_T	310_T	1.255	1.00
937_L	941_E	1.254	1.00
762_A	765_K	1.253	1.00
426_Q	429_R	1.252	1.00
29_F	335_E	1.252	1.00
194_L	204_V	1.251	1.00
157_F	161_Q	1.248	1.00
15_I	874_Y	1.248	1.00
8_I	425_L	1.248	1.00
932_Q	939_P	1.245	1.00
113_N	116_Q	1.245	1.00
45_I	105_A	1.242	1.00
825_M	836_G	1.240	1.00
550_T	901_P	1.237	1.00
245_I	253_A	1.236	1.00
591_A	614_K	1.235	1.00
522_V	1003_V	1.228	1.00
516_G	944_F	1.223	1.00
687_L	824_A	1.222	1.00
28_G	378_Y	1.219	1.00
560_L	630_L	1.218	1.00
593_D	612_T	1.218	1.00
242_Q	261_T	1.216	1.00
928_A	943_I	1.215	1.00
304_L	317_L	1.214	1.00
302_A	306_E	1.211	1.00
298_D	301_R	1.211	1.00
60_A	795_H	1.211	1.00
689_E	812_K	1.206	1.00
917_V	993_S	1.204	1.00
6_L	13_A	1.204	1.00
305_P	309_E	1.203	1.00
49_A	127_P	1.201	1.00
303_K	307_L	1.201	1.00
581_D	585_I	1.198	1.00
683_K	828_L	1.196	1.00
149_Y	153_E	1.193	1.00
413_H	426_Q	1.191	1.00
628_D	631_R	1.185	1.00
703_E	789_A	1.185	1.00
895_L	906_A	1.184	1.00
517_K	520_K	1.184	1.00
891_A	910_I	1.181	1.00
939_P	943_I	1.179	1.00
219_A	226_R	1.179	1.00
513_Q	517_K	1.176	1.00
666_L	837_S	1.173	1.00
172_V	296_T	1.167	1.00
59_M	89_T	1.165	1.00
718_I	771_N	1.163	1.00
566_A	575_M	1.162	1.00
578_K	581_D	1.161	1.00
843_Q	847_E	1.161	1.00
71_L	80_M	1.160	1.00
666_L	801_A	1.160	1.00
47_V	93_L	1.158	1.00
149_Y	315_I	1.158	1.00
585_I	588_D	1.157	1.00
721_Q	725_S	1.154	1.00
243_P	711_D	1.152	1.00
799_S	835_R	1.151	1.00
166_I	175_V	1.151	1.00
546_S	896_E	1.150	1.00
900_A	980_Q	1.150	1.00
955_M	959_L	1.146	1.00
8_I	484_M	1.146	1.00
517_K	521_W	1.146	1.00
945_Q	948_L	1.145	1.00
579_L	599_T	1.143	1.00
67_L	112_I	1.143	1.00
245_I	255_R	1.142	1.00
515_Y	519_L	1.141	1.00
197_Q	254_V	1.139	1.00
966_L	987_V	1.136	1.00
302_A	305_P	1.133	1.00
738_T	747_K	1.132	1.00
621_E	626_I	1.131	1.00
680_I	804_I	1.131	1.00
678_P	682_K	1.126	1.00
70_S	115_A	1.122	1.00
217_Q	231_T	1.122	1.00
111_A	114_A	1.121	1.00
140_M	300_I	1.120	1.00
684_L	690_L	1.117	1.00
418_M	422_Q	1.117	1.00
839_A	843_Q	1.115	1.00
687_L	823_R	1.115	1.00
581_D	637_E	1.115	1.00
850_N	853_V	1.114	1.00
665_L	676_W	1.112	1.00
439_S	475_L	1.112	1.00
165_T	307_L	1.112	1.00
60_A	793_V	1.110	1.00
207_A	244_L	1.109	1.00
142_L	317_L	1.108	1.00
577_G	580_Q	1.108	1.00
328_R	332_E	1.107	1.00
440_L	866_V	1.107	1.00
409_N	927_F	1.105	1.00
306_E	309_E	1.104	1.00
18_S	481_L	1.102	1.00
929_L	932_Q	1.102	1.00
78_S	847_E	1.101	1.00
142_L	319_I	1.097	1.00
729_N	734_R	1.097	1.00
373_T	469_V	1.095	1.00
796_Q	839_A	1.094	1.00
728_N	734_R	1.093	1.00
585_I	637_E	1.090	1.00
538_A	541_I	1.089	1.00
22_T	26_I	1.088	1.00
625_Q	629_R	1.087	1.00
297_V	324_S	1.086	1.00
767_F	775_A	1.085	1.00
421_L	425_L	1.085	1.00
292_N	295_Q	1.085	1.00
13_A	869_I	1.083	1.00
77_V	80_M	1.081	1.00
382_F	388_S	1.077	1.00
519_L	523_L	1.075	1.00
927_F	931_A	1.071	1.00
333_E	979_R	1.067	1.00
823_R	826_T	1.067	1.00
151_Q	181_S	1.067	1.00
7_F	14_T	1.067	1.00
808_L	817_A	1.065	1.00
710_R	720_V	1.064	1.00
528_L	531_V	1.064	1.00
144_L	317_L	1.062	1.00
935_G	945_Q	1.062	1.00
550_T	903_S	1.062	1.00
51_L	54_A	1.061	1.00
624_Q	628_D	1.060	1.00
3_F	7_F	1.060	1.00
364_V	485_M	1.058	1.00
671_A	674_R	1.058	1.00
535_G	538_A	1.057	1.00
109_Q	113_N	1.056	1.00
175_V	283_L	1.055	1.00
581_D	639_G	1.054	1.00
527_R	1007_F	1.051	1.00
959_L	963_F	1.050	1.00
672_A	834_V	1.050	1.00
81_T	94_Q	1.050	1.00
155_Y	180_S	1.047	1.00
145_T	278_K	1.047	1.00
486_C	490_L	1.045	1.00
202_D	722_A	1.041	1.00
186_R	751_E	1.041	1.00
893_L	897_L	1.040	1.00
409_N	413_H	1.039	1.00
770_N	773_G	1.039	1.00
184_A	267_Q	1.037	1.00
128_T	131_K	1.036	1.00
308_Q	317_L	1.036	1.00
930_E	933_R	1.036	1.00
534_L	538_A	1.036	1.00
70_S	114_A	1.034	1.00
80_M	798_L	1.033	1.00
894_A	984_I	1.032	1.00
188_G	753_D	1.032	1.00
667_S	672_A	1.029	1.00
509_V	513_Q	1.029	1.00
230_Q	703_E	1.027	1.00
522_V	529_V	1.026	1.00
83_S	92_I	1.024	1.00
685_A	693_V	1.024	1.00
564_I	642_L	1.023	1.00
583_M	597_G	1.023	1.00
204_V	259_V	1.021	1.00
765_K	779_S	1.020	1.00
422_Q	425_L	1.020	1.00
524_N	527_R	1.019	1.00
676_W	830_V	1.018	1.00
621_E	625_Q	1.018	1.00
632_V	635_A	1.017	1.00
48_S	88_S	1.016	1.00
68_E	82_S	1.016	1.00
256_L	260_A	1.014	1.00
255_R	711_D	1.012	1.00
821_I	838_F	1.010	1.00
82_S	795_H	1.008	1.00
629_R	632_V	1.006	1.00
522_V	999_Y	1.006	1.00
662_Q	803_T	1.005	1.00
99_R	107_D	1.004	1.00
751_E	757_T	1.002	1.00
365_S	482_T	1.001	1.00
562_G	586_I	1.001	1.00
586_I	609_M	1.001	1.00
630_L	634_L	1.000	1.00
625_Q	628_D	0.998	1.00
668_D	834_V	0.998	1.00
411_A	415_E	0.995	1.00
438_M	475_L	0.995	1.00
143_T	280_A	0.994	1.00
103_G	107_D	0.994	1.00
217_Q	727_L	0.993	1.00
437_S	866_V	0.992	1.00
274_M	580_Q	0.991	1.00
560_L	613_L	0.989	1.00
927_F	949_L	0.985	1.00
432_G	436_L	0.985	1.00
47_V	67_L	0.985	1.00
82_S	91_I	0.983	1.00
680_I	824_A	0.982	1.00
962_L	990_L	0.982	1.00
376_A	473_I	0.982	1.00
817_A	820_A	0.981	1.00
414_L	420_P	0.980	1.00
50_S	88_S	0.980	1.00
543_L	893_L	0.979	1.00
554_E	624_Q	0.979	1.00
963_F	966_L	0.979	1.00
155_Y	159_S	0.979	1.00
147_D	314_A	0.978	1.00
246_I	254_V	0.978	1.00
365_S	403_A	0.977	1.00
934_H	937_L	0.976	1.00
582_F	609_M	0.975	1.00
631_R	635_A	0.975	1.00
958_T	994_Q	0.974	1.00
663_Y	684_L	0.974	1.00
945_Q	949_L	0.973	1.00
589_D	630_L	0.972	1.00
15_I	19_V	0.971	1.00
32_L	374_F	0.969	1.00
951_F	955_M	0.969	1.00
163_A	175_V	0.968	1.00
686_T	824_A	0.968	1.00
116_Q	124_P	0.968	1.00
144_L	154_L	0.966	1.00
215_K	724_N	0.966	1.00
681_R	804_I	0.965	1.00
364_V	481_L	0.965	1.00
22_T	368_V	0.965	1.00
879_T	1004_V	0.965	1.00
275_T	280_A	0.964	1.00
677_E	681_R	0.964	1.00
187_V	736_I	0.964	1.00
335_E	339_I	0.963	1.00
571_S	574_A	0.963	1.00
578_K	637_E	0.963	1.00
533_L	1000_T	0.958	1.00
818_S	842_A	0.958	1.00
601_G	604_V	0.955	1.00
453_G	851_S	0.955	1.00
297_V	301_R	0.953	1.00
903_S	906_A	0.953	1.00
523_L	1006_L	0.953	1.00
718_I	723_A	0.951	1.00
140_M	301_R	0.950	1.00
241_Y	748_V	0.950	1.00
430_E	930_E	0.948	1.00
944_F	948_L	0.945	1.00
583_M	595_V	0.945	1.00
704_M	760_I	0.941	1.00
444_A	862_T	0.939	1.00
886_S	996_L	0.938	1.00
409_N	431_V	0.938	1.00
527_R	531_V	0.935	1.00
871_Y	922_I	0.935	1.00
241_Y	262_V	0.934	1.00
735_Q	749_V	0.934	1.00
178_G	284_M	0.934	1.00
275_T	594_N	0.934	1.00
425_L	429_R	0.933	1.00
665_L	834_V	0.933	1.00
442_L	919_K	0.932	1.00
958_T	962_L	0.932	1.00
666_L	835_R	0.932	1.00
722_A	725_S	0.929	1.00
679_K	828_L	0.929	1.00
226_R	270_R	0.927	1.00
301_R	308_Q	0.927	1.00
9_Y	425_L	0.926	1.00
199_V	246_I	0.926	1.00
507_M	510_A	0.926	1.00
406_V	435_V	0.925	1.00
169_I	303_K	0.924	1.00
532_V	539_L	0.924	1.00
619_R	622_T	0.923	1.00
696_D	794_N	0.921	1.00
623_A	627_I	0.918	1.00
573_Q	577_G	0.917	1.00
437_S	870_L	0.917	1.00
758_Q	762_A	0.915	1.00
208_V	736_I	0.914	1.00
966_L	970_L	0.913	1.00
238_A	264_D	0.912	1.00
277_A	583_M	0.911	1.00
356_G	360_I	0.911	1.00
152_G	266_V	0.911	1.00
420_P	424_A	0.911	1.00
354_R	505_G	0.910	1.00
163_A	177_V	0.909	1.00
763_L	784_W	0.909	1.00
4_F	428_T	0.908	1.00
540_N	892_L	0.907	1.00
764_E	784_W	0.906	1.00
713_M	781_F	0.905	1.00
582_F	637_E	0.905	1.00
186_R	263_T	0.904	1.00
671_A	675_E	0.904	1.00
878_L	882_S	0.902	1.00
307_L	311_I	0.902	1.00
586_I	611_I	0.901	1.00
410_I	427_G	0.901	1.00
332_E	335_E	0.900	1.00
574_A	639_G	0.900	1.00
361_I	485_M	0.899	1.00
894_A	898_F	0.899	1.00
512_Q	516_G	0.898	1.00
424_A	487_G	0.897	1.00
684_L	693_V	0.897	1.00
18_S	368_V	0.896	1.00
190_N	756_Y	0.895	1.00
853_V	857_I	0.894	1.00
95_F	108_V	0.893	1.00
140_M	297_V	0.891	1.00
377_M	382_F	0.889	1.00
1009_D	1012_R	0.889	1.00
148_T	314_A	0.889	1.00
529_V	532_V	0.888	1.00
202_D	725_S	0.888	1.00
50_S	124_P	0.885	1.00
706_L	727_L	0.884	1.00
301_R	324_S	0.884	1.00
663_Y	680_I	0.883	1.00
368_V	477_V	0.883	1.00
793_V	800_A	0.882	1.00
523_L	944_F	0.882	1.00
626_I	629_R	0.881	1.00
943_I	947_C	0.881	1.00
296_T	299_S	0.880	1.00
174_D	286_R	0.880	1.00
565_Q	641_N	0.880	1.00
146_S	149_Y	0.879	1.00
70_S	118_L	0.878	1.00
520_K	941_E	0.878	1.00
662_Q	801_A	0.878	1.00
928_A	1005_Y	0.877	1.00
539_L	542_W	0.877	1.00
690_L	821_I	0.874	1.00
857_I	861_A	0.873	1.00
704_M	786_P	0.870	1.00
103_G	106_R	0.869	1.00
72_G	798_L	0.869	1.00
889_V	992_M	0.867	1.00
388_S	462_E	0.866	1.00
739_I	748_V	0.864	1.00
242_Q	260_A	0.864	1.00
631_R	644_L	0.862	1.00
591_A	629_R	0.862	1.00
506_R	510_A	0.861	1.00
432_G	479_L	0.859	1.00
597_G	609_M	0.855	1.00
663_Y	836_G	0.855	1.00
891_A	985_T	0.854	1.00
738_T	745_Q	0.854	1.00
526_T	1007_F	0.854	1.00
509_V	512_Q	0.851	1.00
73_R	111_A	0.849	1.00
582_F	585_I	0.849	1.00
166_I	303_K	0.848	1.00
153_E	156_D	0.848	1.00
208_V	241_Y	0.847	1.00
133_N	136_D	0.846	1.00
928_A	946_A	0.843	1.00
864_Y	874_Y	0.843	1.00
187_V	260_A	0.842	1.00
204_V	750_M	0.840	1.00
760_I	764_E	0.840	1.00
167_S	174_D	0.840	1.00
458_R	461_R	0.839	1.00
591_A	620_S	0.839	1.00
199_V	204_V	0.839	1.00
191_P	752_V	0.837	1.00
210_N	719_D	0.837	1.00
121_S	126_R	0.836	1.00
512_Q	948_L	0.836	1.00
156_D	160_T	0.835	1.00
665_L	804_I	0.833	1.00
562_G	644_L	0.833	1.00
304_L	308_Q	0.832	1.00
443_V	468_S	0.830	1.00
272_A	572_F	0.829	1.00
131_K	139_I	0.829	1.00
224_T	574_A	0.826	1.00
886_S	1000_T	0.826	1.00
141_I	284_M	0.826	1.00
340_I	343_A	0.826	1.00
564_I	640_A	0.825	1.00
159_S	163_A	0.823	1.00
417_G	423_A	0.822	1.00
46_I	92_I	0.822	1.00
536_T	889_V	0.821	1.00
576_R	599_T	0.821	1.00
248_Y	253_A	0.818	1.00
6_L	10_R	0.818	1.00
189_L	750_M	0.818	1.00
247_H	254_V	0.817	1.00
201_L	729_N	0.817	1.00
630_L	644_L	0.817	1.00
15_I	488_W	0.817	1.00
997_T	1001_T	0.817	1.00
818_S	838_F	0.815	1.00
83_S	792_S	0.815	1.00
205_R	729_N	0.814	1.00
96_D	99_R	0.812	1.00
79_E	796_Q	0.812	1.00
716_L	776_I	0.812	1.00
520_K	940_Q	0.811	1.00
52_P	124_P	0.808	1.00
507_M	511_L	0.807	1.00
673_L	802_S	0.805	1.00
730_A	766_M	0.804	1.00
673_L	834_V	0.804	1.00
137_A	144_L	0.804	1.00
991_V	995_L	0.804	1.00
540_N	543_L	0.803	1.00
824_A	828_L	0.803	1.00
158_A	283_L	0.802	1.00
416_A	426_Q	0.802	1.00
27_L	31_M	0.801	1.00
523_L	1003_V	0.801	1.00
204_V	256_L	0.800	1.00
797_G	837_S	0.799	1.00
325_P	328_R	0.799	1.00
672_A	833_T	0.799	1.00
194_L	197_Q	0.798	1.00
733_Q	751_E	0.798	1.00
939_P	1006_L	0.798	1.00
860_I	881_L	0.797	1.00
192_Q	765_K	0.797	1.00
530_G	1003_V	0.797	1.00
674_R	802_S	0.796	1.00
679_K	829_G	0.795	1.00
562_G	609_M	0.795	1.00
660_S	807_N	0.793	1.00
272_A	599_T	0.792	1.00
560_L	623_A	0.792	1.00
570_I	575_M	0.791	1.00
898_F	988_G	0.791	1.00
185_V	739_I	0.791	1.00
48_S	90_R	0.791	1.00
47_V	91_I	0.790	1.00
192_Q	195_F	0.788	1.00
522_V	525_H	0.788	1.00
689_E	823_R	0.788	1.00
128_T	133_N	0.787	1.00
442_L	471_I	0.786	1.00
693_V	806_F	0.785	1.00
64_A	91_I	0.785	1.00
523_L	943_I	0.784	1.00
375_A	379_L	0.784	1.00
195_F	767_F	0.783	1.00
816_D	820_A	0.783	1.00
594_N	612_T	0.783	1.00
267_Q	747_K	0.782	1.00
146_S	314_A	0.782	1.00
931_A	935_G	0.781	1.00
177_V	180_S	0.780	1.00
831_P	834_V	0.779	1.00
842_A	846_Q	0.778	1.00
204_V	207_A	0.778	1.00
51_L	59_M	0.777	1.00
830_V	836_G	0.775	1.00
818_S	846_Q	0.775	1.00
812_K	817_A	0.774	1.00
560_L	644_L	0.773	1.00
241_Y	244_L	0.772	1.00
431_V	439_S	0.771	1.00
264_D	741_Q	0.770	1.00
613_L	626_I	0.770	1.00
331_L	389_L	0.770	1.00
849_M	853_V	0.769	1.00
204_V	246_I	0.769	1.00
95_F	104_A	0.768	1.00
729_N	750_M	0.768	1.00
547_I	892_L	0.767	1.00
450_L	468_S	0.766	0.99
520_K	524_N	0.765	0.99
210_N	721_Q	0.765	0.99
544_Y	892_L	0.765	0.99
730_A	752_V	0.764	0.99
12_V	874_Y	0.763	0.99
481_L	485_M	0.763	0.99
355_S	358_A	0.762	0.99
637_E	640_A	0.762	0.99
920_N	993_S	0.762	0.99
534_L	541_I	0.761	0.99
71_L	112_I	0.761	0.99
665_L	669_D	0.761	0.99
461_R	465_V	0.759	0.99
1006_L	1010_R	0.758	0.99
235_L	739_I	0.757	0.99
205_R	734_R	0.756	0.99
494_K	497_E	0.755	0.99
574_A	578_K	0.754	0.99
676_W	680_I	0.753	0.99
902_F	907_L	0.753	0.99
168_Q	303_K	0.753	0.99
227_W	704_M	0.753	0.99
543_L	896_E	0.753	0.99
329_A	332_E	0.753	0.99
189_L	260_A	0.752	0.99
704_M	784_W	0.752	0.99
421_L	487_G	0.752	0.99
712_T	780_Y	0.751	0.99
202_D	205_R	0.751	0.99
508_L	512_Q	0.750	0.99
282_L	596_T	0.750	0.99
767_F	777_P	0.750	0.99
140_M	319_I	0.750	0.99
723_A	778_L	0.749	0.99
545_I	548_P	0.747	0.99
513_Q	948_L	0.747	0.99
51_L	123_M	0.747	0.99
190_N	753_D	0.746	0.99
634_L	642_L	0.746	0.99
903_S	981_P	0.744	0.99
697_Q	802_S	0.744	0.99
728_N	732_G	0.743	0.99
1004_V	1008_F	0.743	0.99
398_F	961_A	0.742	0.99
186_R	265_S	0.741	0.99
325_P	329_A	0.739	0.99
572_F	576_R	0.738	0.99
410_I	424_A	0.738	0.99
924_M	947_C	0.737	0.99
795_H	800_A	0.736	0.99
44_V	94_Q	0.736	0.99
385_N	388_S	0.736	0.99
131_K	144_L	0.734	0.99
85_S	88_S	0.734	0.99
735_Q	738_T	0.734	0.99
540_N	889_V	0.733	0.99
377_M	466_T	0.733	0.99
119_L	123_M	0.732	0.99
822_D	838_F	0.731	0.99
65_T	69_R	0.731	0.99
434_T	930_E	0.731	0.99
726_L	768_V	0.730	0.99
66_P	115_A	0.728	0.99
994_Q	997_T	0.727	0.99
285_I	300_I	0.726	0.99
294_I	328_R	0.726	0.99
166_I	283_L	0.725	0.99
169_I	296_T	0.724	0.99
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562_G	582_F	0.541	0.95
336_Q	339_I	0.540	0.95
950_R	957_T	0.540	0.95
589_D	621_E	0.540	0.95
402_D	960_A	0.540	0.95
349_V	960_A	0.540	0.95
672_A	679_K	0.540	0.95
939_P	942_A	0.538	0.95
578_K	640_A	0.537	0.95
21_I	477_V	0.536	0.95
815_S	845_F	0.536	0.95
808_L	812_K	0.536	0.95
133_N	139_I	0.536	0.95
48_S	130_R	0.536	0.95
158_A	177_V	0.536	0.95
441_S	918_K	0.535	0.95
561_M	645_M	0.535	0.95
337_T	919_K	0.535	0.95
361_I	490_L	0.535	0.95
158_A	317_L	0.534	0.95
26_I	371_I	0.534	0.95
551_F	848_T	0.534	0.95
420_P	423_A	0.534	0.95
924_M	946_A	0.534	0.95
213_V	724_N	0.533	0.95
863_V	914_I	0.533	0.95
137_A	146_S	0.532	0.95
342_V	363_A	0.532	0.95
169_I	300_I	0.531	0.95
668_D	672_A	0.531	0.95
376_A	465_V	0.531	0.95
982_L	986_I	0.531	0.95
722_A	769_I	0.531	0.95
514_G	525_H	0.531	0.95
171_G	296_T	0.530	0.94
149_Y	157_F	0.530	0.94
521_W	532_V	0.530	0.94
939_P	1011_L	0.529	0.94
358_A	411_A	0.529	0.94
585_I	634_L	0.528	0.94
669_D	834_V	0.528	0.94
530_G	1000_T	0.528	0.94
407_L	427_G	0.528	0.94
420_P	487_G	0.528	0.94
74_I	111_A	0.528	0.94
417_G	424_A	0.527	0.94
706_L	778_L	0.527	0.94
919_K	923_M	0.527	0.94
127_P	144_L	0.526	0.94
919_K	961_A	0.526	0.94
527_R	539_L	0.525	0.94
895_L	901_P	0.525	0.94
217_Q	724_N	0.525	0.94
115_A	119_L	0.525	0.94
39_Q	289_P	0.525	0.94
439_S	478_S	0.525	0.94
34_V	331_L	0.523	0.94
159_S	182_L	0.522	0.94
755_R	758_Q	0.522	0.94
214_R	234_E	0.522	0.94
711_D	715_R	0.521	0.94
276_N	318_Q	0.521	0.94
695_S	804_I	0.521	0.94
404_I	956_M	0.521	0.94
121_S	124_P	0.521	0.94
588_D	632_V	0.521	0.94
680_I	821_I	0.521	0.94
769_I	774_K	0.520	0.94
74_I	77_V	0.520	0.94
764_E	783_K	0.520	0.94
1007_F	1010_R	0.520	0.94
976_S	979_R	0.520	0.94
11_P	487_G	0.519	0.94
414_L	418_M	0.519	0.94
895_L	902_F	0.519	0.94
140_M	285_I	0.519	0.94
889_V	893_L	0.519	0.94
75_A	107_D	0.518	0.94
268_D	757_T	0.518	0.94
642_L	645_M	0.518	0.94
896_E	899_N	0.518	0.94
446_F	467_L	0.517	0.94
726_L	769_I	0.517	0.94
338_L	342_V	0.517	0.94
620_S	625_Q	0.517	0.94
778_L	782_A	0.516	0.94
142_L	301_R	0.516	0.94
865_I	869_I	0.516	0.94
304_L	307_L	0.516	0.94
724_N	727_L	0.516	0.94
365_S	369_S	0.515	0.94
438_M	442_L	0.515	0.94
932_Q	938_T	0.515	0.94
66_P	70_S	0.515	0.94
7_F	10_R	0.514	0.94
689_E	816_D	0.514	0.94
127_P	137_A	0.514	0.94
670_L	674_R	0.514	0.94
947_C	951_F	0.514	0.94
166_I	169_I	0.514	0.94
208_V	748_V	0.514	0.94
431_V	961_A	0.514	0.94
337_T	402_D	0.513	0.93
541_I	546_S	0.513	0.93
405_V	964_G	0.513	0.93
435_V	479_L	0.512	0.93
169_I	172_V	0.512	0.93
60_A	84_S	0.512	0.93
131_K	146_S	0.511	0.93
632_V	686_T	0.511	0.93
860_I	914_I	0.511	0.93
760_I	786_P	0.511	0.93
593_D	615_P	0.510	0.93
514_G	521_W	0.510	0.93
105_A	109_Q	0.509	0.93
476_L	480_T	0.509	0.93
590_P	614_K	0.508	0.93
5_A	422_Q	0.507	0.93
151_Q	281_I	0.507	0.93
141_I	321_Q	0.507	0.93
377_M	392_L	0.506	0.93
887_A	1001_T	0.506	0.93
23_L	861_A	0.505	0.93
882_S	1001_T	0.505	0.93
923_M	961_A	0.505	0.93
369_S	373_T	0.505	0.93
443_V	447_L	0.505	0.93
695_S	802_S	0.504	0.93
716_L	780_Y	0.503	0.93
354_R	359_T	0.503	0.93
661_Y	690_L	0.503	0.93
203_D	249_N	0.503	0.93
837_S	843_Q	0.502	0.93
23_L	27_L	0.502	0.93
345_V	359_T	0.502	0.93
66_P	118_L	0.502	0.93
415_E	493_S	0.501	0.93
678_P	695_S	0.501	0.93
71_L	74_I	0.501	0.93
376_A	379_L	0.501	0.93
18_S	480_T	0.500	0.93
583_M	586_I	0.500	0.93
59_M	64_A	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.9366	100	0.201	Contact Map
4mt1A	3	0.9649	100	0.272	Contact Map
3ne5A	3	0.9659	100	0.272	Contact Map
3w9iA	3	0.9805	100	0.279	Contact Map
4dx5A	3	0.9893	100	0.291	Contact Map
3aqpA	1	0.6849	100	0.718	Contact Map
4r86A	1	0.28	100	0.746	Contact Map
2ew9A	1	0.1444	69.8	0.983	Contact Map
4q2lA	1	0.0624	63.4	0.984	Contact Map
4n8nA	1	0.0976	60.2	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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