MDTB - ECOLI - GREMLIN Contacts

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MDTB - Multidrug resistance protein MdtB

UniProt:	P76398	Sequences: MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14057
Length:	1040 (1001)
Sequences:	15845 (10071)
Seq/√Len:	318.3

ECOLI - MDTB MDTC ACRD ACRB CUSA ACRF MDTF
BACSU - SWRC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
952_S	955_E	4.141	1.00
248_E	251_R	4.054	1.00
312_M	315_Q	3.959	1.00
251_R	266_G	3.871	1.00
314_P	317_T	3.861	1.00
721_N	799_E	3.752	1.00
73_T	98_S	3.680	1.00
58_T	98_S	3.444	1.00
528_G	1013_F	3.441	1.00
589_Q	621_A	3.340	1.00
908_A	1002_G	3.278	1.00
428_K	431_A	3.224	1.00
307_D	337_R	3.179	1.00
252_Q	266_G	3.158	1.00
159_P	162_Q	3.092	1.00
427_E	435_K	3.075	1.00
14_R	18_M	3.061	1.00
530_A	958_Y	3.051	1.00
584_N	587_Q	3.035	1.00
686_A	689_T	2.882	1.00
683_S	686_A	2.838	1.00
198_L	213_V	2.797	1.00
153_V	167_V	2.765	1.00
86_L	102_L	2.747	1.00
751_S	762_V	2.724	1.00
723_D	797_K	2.718	1.00
174_K	312_M	2.707	1.00
178_I	308_S	2.689	1.00
73_T	93_S	2.641	1.00
285_N	604_S	2.635	1.00
283_W	593_A	2.634	1.00
733_S	736_D	2.624	1.00
722_V	727_A	2.614	1.00
310_R	331_D	2.576	1.00
727_A	737_V	2.542	1.00
251_R	271_V	2.531	1.00
69_T	814_P	2.529	1.00
697_K	700_Q	2.529	1.00
697_K	841_T	2.506	1.00
247_A	251_R	2.486	1.00
203_I	208_L	2.479	1.00
348_M	352_A	2.476	1.00
890_H	943_L	2.447	1.00
586_A	590_R	2.445	1.00
87_K	103_Q	2.423	1.00
526_G	962_L	2.398	1.00
695_M	699_Q	2.396	1.00
317_T	325_K	2.388	1.00
381_G	482_I	2.377	1.00
689_T	693_Q	2.374	1.00
199_N	202_A	2.368	1.00
951_M	959_Q	2.366	1.00
304_S	308_S	2.344	1.00
265_L	271_V	2.341	1.00
826_Y	834_A	2.330	1.00
163_V	324_V	2.307	1.00
87_K	105_Q	2.294	1.00
255_I	268_V	2.292	1.00
636_R	639_K	2.274	1.00
723_D	726_S	2.254	1.00
385_V	478_V	2.250	1.00
156_T	325_K	2.238	1.00
775_A	778_D	2.218	1.00
166_M	324_V	2.214	1.00
629_P	632_E	2.206	1.00
690_W	848_I	2.187	1.00
534_N	954_R	2.186	1.00
197_K	272_E	2.185	1.00
599_D	643_R	2.169	1.00
912_A	998_I	2.165	1.00
214_R	764_L	2.155	1.00
721_N	797_K	2.154	1.00
827_S	830_D	2.113	1.00
198_L	210_S	2.079	1.00
719_Y	801_R	2.075	1.00
698_L	835_I	2.064	1.00
598_Q	647_A	2.055	1.00
196_V	217_I	2.053	1.00
695_M	709_S	2.050	1.00
957_I	1020_L	2.048	1.00
778_D	793_S	2.047	1.00
422_Y	427_E	2.042	1.00
192_P	273_Q	2.042	1.00
601_A	635_D	2.038	1.00
572_G	625_I	1.992	1.00
345_F	349_M	1.989	1.00
250_Y	265_L	1.962	1.00
603_Q	628_K	1.957	1.00
701_L	834_A	1.954	1.00
983_M	1001_V	1.949	1.00
422_Y	439_E	1.949	1.00
722_V	737_V	1.948	1.00
156_T	287_E	1.931	1.00
576_A	580_S	1.926	1.00
791_P	794_S	1.925	1.00
308_S	311_Q	1.921	1.00
692_P	695_M	1.916	1.00
635_D	643_R	1.914	1.00
246_S	249_E	1.910	1.00
706_D	821_N	1.910	1.00
66_D	70_S	1.899	1.00
552_L	555_V	1.894	1.00
431_A	435_K	1.883	1.00
596_I	644_L	1.883	1.00
694_L	839_E	1.875	1.00
704_L	707_V	1.873	1.00
837_D	841_T	1.864	1.00
520_R	524_A	1.861	1.00
76_L	80_F	1.859	1.00
836_M	840_K	1.843	1.00
720_V	796_A	1.841	1.00
954_R	1020_L	1.834	1.00
18_M	430_L	1.830	1.00
591_Q	594_D	1.829	1.00
679_L	694_L	1.824	1.00
421_R	425_K	1.824	1.00
946_E	949_Q	1.817	1.00
520_R	523_A	1.816	1.00
283_W	586_A	1.815	1.00
531_K	535_H	1.815	1.00
35_I	39_R	1.813	1.00
68_M	72_V	1.812	1.00
248_E	252_Q	1.806	1.00
690_W	693_Q	1.803	1.00
599_D	647_A	1.798	1.00
946_E	951_M	1.795	1.00
214_R	218_T	1.792	1.00
773_G	776_A	1.787	1.00
535_H	538_L	1.785	1.00
452_I	481_L	1.784	1.00
270_T	767_N	1.784	1.00
732_I	782_L	1.781	1.00
836_M	860_Q	1.773	1.00
595_V	647_A	1.771	1.00
21_V	882_G	1.764	1.00
545_S	549_L	1.759	1.00
76_L	100_I	1.759	1.00
40_A	387_V	1.757	1.00
154_T	327_T	1.752	1.00
14_R	434_L	1.742	1.00
158_M	323_S	1.736	1.00
695_M	707_V	1.735	1.00
525_Y	961_C	1.731	1.00
245_Q	249_E	1.727	1.00
171_V	316_L	1.725	1.00
594_D	598_Q	1.724	1.00
551_V	555_V	1.723	1.00
834_A	837_D	1.718	1.00
691_V	816_T	1.718	1.00
200_A	770_N	1.717	1.00
418_N	439_E	1.716	1.00
719_Y	799_E	1.708	1.00
826_Y	830_D	1.704	1.00
726_S	729_R	1.703	1.00
590_R	594_D	1.701	1.00
374_A	486_V	1.699	1.00
191_R	276_E	1.697	1.00
193_A	763_V	1.697	1.00
536_P	1020_L	1.696	1.00
304_S	307_D	1.694	1.00
704_L	831_A	1.689	1.00
307_D	311_Q	1.689	1.00
80_F	102_L	1.683	1.00
341_D	345_F	1.678	1.00
914_S	998_I	1.675	1.00
209_T	212_T	1.673	1.00
833_Q	836_M	1.672	1.00
526_G	530_A	1.668	1.00
540_L	544_L	1.667	1.00
589_Q	607_S	1.662	1.00
643_R	647_A	1.660	1.00
688_S	692_P	1.658	1.00
203_I	268_V	1.653	1.00
19_R	886_E	1.653	1.00
102_L	117_V	1.634	1.00
310_R	328_V	1.622	1.00
531_K	534_N	1.618	1.00
199_N	270_T	1.600	1.00
673_T	820_F	1.593	1.00
595_V	650_K	1.581	1.00
834_A	838_T	1.580	1.00
252_Q	264_R	1.580	1.00
73_T	91_S	1.577	1.00
642_A	646_T	1.576	1.00
767_N	770_N	1.575	1.00
31_L	380_I	1.572	1.00
732_I	795_I	1.564	1.00
697_K	838_T	1.562	1.00
389_L	478_V	1.557	1.00
85_G	108_L	1.556	1.00
947_R	1019_Y	1.550	1.00
693_Q	696_E	1.549	1.00
703_Q	834_A	1.543	1.00
944_A	948_E	1.537	1.00
215_T	219_G	1.536	1.00
80_F	100_I	1.534	1.00
221_N	751_S	1.534	1.00
208_L	212_T	1.534	1.00
76_L	124_A	1.532	1.00
585_M	621_A	1.530	1.00
528_G	531_K	1.528	1.00
524_A	527_R	1.523	1.00
152_A	284_A	1.521	1.00
37_G	384_A	1.518	1.00
592_V	648_V	1.518	1.00
574_L	589_Q	1.517	1.00
559_K	829_G	1.517	1.00
109_P	112_V	1.513	1.00
310_R	314_P	1.513	1.00
391_F	474_I	1.511	1.00
244_M	250_Y	1.507	1.00
211_E	215_T	1.502	1.00
645_Q	706_D	1.501	1.00
946_E	959_Q	1.492	1.00
570_I	625_I	1.492	1.00
574_L	592_V	1.491	1.00
727_A	732_I	1.488	1.00
419_I	495_C	1.482	1.00
125_T	134_N	1.479	1.00
540_L	1021_L	1.477	1.00
422_Y	425_K	1.474	1.00
421_R	963_L	1.473	1.00
750_I	764_L	1.471	1.00
647_A	650_K	1.470	1.00
594_D	597_L	1.469	1.00
737_V	795_I	1.468	1.00
720_V	798_I	1.467	1.00
839_E	850_T	1.466	1.00
202_A	206_L	1.456	1.00
954_R	958_Y	1.456	1.00
474_I	478_V	1.452	1.00
830_D	833_Q	1.451	1.00
215_T	218_T	1.442	1.00
576_A	588_R	1.440	1.00
89_M	102_L	1.436	1.00
547_L	551_V	1.434	1.00
595_V	599_D	1.434	1.00
686_A	690_W	1.433	1.00
300_A	305_T	1.433	1.00
783_T	789_V	1.426	1.00
198_L	203_I	1.423	1.00
749_L	761_R	1.420	1.00
93_S	98_S	1.419	1.00
217_I	253_L	1.419	1.00
418_N	421_R	1.417	1.00
481_L	485_V	1.416	1.00
580_S	584_N	1.415	1.00
897_T	935_A	1.410	1.00
784_S	788_G	1.408	1.00
181_V	294_V	1.407	1.00
878_Y	891_P	1.402	1.00
58_T	76_L	1.396	1.00
58_T	132_L	1.393	1.00
212_T	215_T	1.391	1.00
587_Q	591_Q	1.388	1.00
108_L	113_A	1.387	1.00
154_T	325_K	1.386	1.00
833_Q	837_D	1.385	1.00
202_A	205_A	1.382	1.00
696_E	700_Q	1.382	1.00
244_M	253_L	1.382	1.00
693_Q	697_K	1.380	1.00
342_D	345_F	1.377	1.00
593_A	597_L	1.372	1.00
548_L	552_L	1.365	1.00
681_A	848_I	1.363	1.00
331_D	334_T	1.361	1.00
574_L	621_A	1.361	1.00
696_E	699_Q	1.361	1.00
596_I	602_V	1.359	1.00
58_T	73_T	1.358	1.00
976_L	1005_I	1.358	1.00
601_A	640_V	1.357	1.00
382_T	479_A	1.353	1.00
264_R	267_D	1.352	1.00
524_A	528_G	1.348	1.00
858_A	861_S	1.346	1.00
254_I	262_P	1.346	1.00
281_G	586_A	1.345	1.00
219_G	728_S	1.343	1.00
427_E	431_A	1.342	1.00
541_S	545_S	1.339	1.00
212_T	783_T	1.338	1.00
238_L	745_F	1.338	1.00
646_T	649_D	1.336	1.00
605_L	623_L	1.336	1.00
549_L	553_L	1.330	1.00
415_V	437_A	1.328	1.00
308_S	312_M	1.328	1.00
72_V	132_L	1.327	1.00
976_L	1001_V	1.324	1.00
352_A	356_M	1.323	1.00
56_V	80_F	1.320	1.00
943_L	948_E	1.320	1.00
25_L	879_I	1.320	1.00
179_S	308_S	1.318	1.00
320_L	326_V	1.317	1.00
628_K	632_E	1.314	1.00
54_I	117_V	1.314	1.00
679_L	687_L	1.314	1.00
570_I	641_I	1.313	1.00
172_A	176_S	1.309	1.00
197_K	270_T	1.309	1.00
590_R	593_A	1.308	1.00
527_R	531_K	1.308	1.00
14_R	438_G	1.306	1.00
355_V	372_G	1.303	1.00
552_L	556_F	1.300	1.00
536_P	1024_R	1.300	1.00
838_T	841_T	1.300	1.00
385_V	389_L	1.300	1.00
597_L	605_L	1.297	1.00
77_E	809_H	1.297	1.00
74_A	809_H	1.295	1.00
45_A	567_N	1.294	1.00
599_D	640_V	1.294	1.00
33_A	384_A	1.290	1.00
153_V	171_V	1.289	1.00
678_T	810_L	1.287	1.00
526_G	959_Q	1.286	1.00
165_D	760_Y	1.284	1.00
602_V	625_I	1.283	1.00
212_T	256_A	1.282	1.00
541_S	548_L	1.281	1.00
30_I	381_G	1.280	1.00
88_Q	811_D	1.279	1.00
85_G	105_Q	1.272	1.00
88_Q	103_Q	1.271	1.00
282_A	291_V	1.270	1.00
601_A	628_K	1.270	1.00
17_I	434_L	1.268	1.00
691_V	709_S	1.265	1.00
704_L	820_F	1.264	1.00
54_I	114_E	1.261	1.00
435_K	438_G	1.259	1.00
68_M	93_S	1.257	1.00
701_L	838_T	1.256	1.00
174_K	319_S	1.255	1.00
166_M	170_R	1.255	1.00
64_S	67_V	1.251	1.00
955_E	959_Q	1.251	1.00
80_F	117_V	1.250	1.00
24_T	888_F	1.249	1.00
609_V	621_A	1.248	1.00
570_I	644_L	1.243	1.00
38_Y	344_Q	1.242	1.00
122_N	125_T	1.241	1.00
311_Q	315_Q	1.240	1.00
249_E	252_Q	1.235	1.00
776_A	779_T	1.232	1.00
947_R	1023_D	1.231	1.00
951_M	955_E	1.230	1.00
603_Q	626_N	1.228	1.00
307_D	310_R	1.225	1.00
312_M	316_L	1.225	1.00
377_L	490_L	1.224	1.00
782_L	795_I	1.222	1.00
588_R	591_Q	1.221	1.00
313_L	326_V	1.220	1.00
58_T	135_P	1.219	1.00
203_I	213_V	1.219	1.00
314_P	318_E	1.216	1.00
942_A	957_I	1.216	1.00
209_T	783_T	1.208	1.00
560_G	915_E	1.208	1.00
411_D	933_K	1.207	1.00
37_G	387_V	1.207	1.00
532_V	1017_V	1.205	1.00
69_T	809_H	1.205	1.00
717_V	803_A	1.203	1.00
735_A	739_N	1.203	1.00
15_L	22_A	1.195	1.00
526_G	958_Y	1.192	1.00
251_R	270_T	1.190	1.00
228_S	235_A	1.190	1.00
158_M	162_Q	1.190	1.00
953_P	957_I	1.189	1.00
527_R	530_A	1.189	1.00
813_F	849_T	1.188	1.00
931_V	1007_S	1.187	1.00
642_A	645_Q	1.187	1.00
422_Y	435_K	1.185	1.00
905_A	924_I	1.185	1.00
857_L	861_S	1.181	1.00
732_I	785_S	1.176	1.00
556_F	910_L	1.174	1.00
157_A	323_S	1.174	1.00
909_L	920_A	1.172	1.00
703_Q	826_Y	1.172	1.00
252_Q	725_D	1.172	1.00
591_Q	651_V	1.171	1.00
914_S	994_R	1.166	1.00
587_Q	590_R	1.164	1.00
311_Q	314_P	1.163	1.00
969_L	973_L	1.160	1.00
680_Q	851_Q	1.159	1.00
254_I	264_R	1.158	1.00
591_Q	595_V	1.156	1.00
206_L	263_I	1.155	1.00
181_V	305_T	1.155	1.00
337_R	341_D	1.154	1.00
692_P	696_E	1.151	1.00
576_A	585_M	1.150	1.00
56_V	102_L	1.150	1.00
680_Q	815_V	1.148	1.00
595_V	598_Q	1.147	1.00
68_M	98_S	1.147	1.00
589_Q	609_V	1.147	1.00
959_Q	962_L	1.147	1.00
175_I	184_V	1.145	1.00
864_G	867_V	1.143	1.00
158_M	324_V	1.143	1.00
17_I	493_M	1.141	1.00
591_Q	653_G	1.139	1.00
544_L	548_L	1.136	1.00
538_L	541_S	1.136	1.00
76_L	121_I	1.134	1.00
752_T	761_R	1.133	1.00
523_A	527_R	1.131	1.00
315_Q	318_E	1.130	1.00
698_L	704_L	1.127	1.00
430_L	434_L	1.126	1.00
31_L	35_I	1.126	1.00
639_K	643_R	1.125	1.00
519_D	523_A	1.125	1.00
120_A	123_A	1.124	1.00
149_M	309_I	1.122	1.00
174_K	316_L	1.121	1.00
701_L	837_D	1.115	1.00
781_R	789_V	1.114	1.00
16_F	23_T	1.114	1.00
694_L	818_I	1.113	1.00
532_V	539_T	1.113	1.00
679_L	690_W	1.111	1.00
980_L	1001_V	1.111	1.00
160_M	190_Q	1.108	1.00
448_T	484_A	1.107	1.00
27_M	490_L	1.101	1.00
87_K	861_S	1.100	1.00
685_D	688_S	1.099	1.00
596_I	623_L	1.098	1.00
700_Q	838_T	1.097	1.00
301_N	304_S	1.097	1.00
226_K	240_A	1.097	1.00
216_A	253_L	1.095	1.00
742_Y	748_R	1.094	1.00
810_L	853_Q	1.094	1.00
80_F	89_M	1.093	1.00
635_D	640_V	1.091	1.00
154_T	287_E	1.090	1.00
449_F	880_V	1.090	1.00
79_Q	124_A	1.089	1.00
382_T	478_V	1.089	1.00
306_A	333_T	1.087	1.00
724_R	734_M	1.084	1.00
516_K	520_R	1.083	1.00
638_Q	642_A	1.081	1.00
779_T	793_S	1.080	1.00
853_Q	857_L	1.080	1.00
681_A	686_A	1.078	1.00
151_L	326_V	1.076	1.00
944_A	949_Q	1.073	1.00
151_L	328_V	1.072	1.00
418_N	941_F	1.065	1.00
391_F	397_T	1.063	1.00
197_K	767_N	1.063	1.00
69_T	807_I	1.060	1.00
90_S	103_Q	1.059	1.00
686_A	848_I	1.059	1.00
743_N	748_R	1.054	1.00
907_L	911_I	1.054	1.00
86_L	89_M	1.053	1.00
22_A	883_I	1.053	1.00
118_Q	122_N	1.049	1.00
595_V	651_V	1.049	1.00
635_D	639_K	1.047	1.00
195_R	765_E	1.046	1.00
699_Q	707_V	1.045	1.00
342_D	993_R	1.045	1.00
153_V	326_V	1.045	1.00
543_A	1014_T	1.044	1.00
373_V	494_M	1.043	1.00
317_T	326_V	1.041	1.00
12_P	16_F	1.040	1.00
184_V	292_M	1.040	1.00
574_L	656_L	1.040	1.00
164_E	189_G	1.040	1.00
495_C	499_L	1.039	1.00
142_N	145_D	1.039	1.00
943_L	947_R	1.038	1.00
60_Y	63_A	1.038	1.00
517_M	520_R	1.038	1.00
822_V	831_A	1.038	1.00
908_A	998_I	1.034	1.00
239_S	717_V	1.034	1.00
690_W	844_L	1.034	1.00
639_K	642_A	1.032	1.00
193_A	276_E	1.032	1.00
676_Q	817_T	1.030	1.00
79_Q	123_A	1.030	1.00
548_L	551_V	1.030	1.00
784_S	787_G	1.029	1.00
211_E	736_D	1.028	1.00
973_L	977_L	1.026	1.00
534_N	537_W	1.025	1.00
643_R	646_T	1.023	1.00
949_Q	959_Q	1.021	1.00
570_I	627_L	1.020	1.00
537_W	1021_L	1.019	1.00
514_S	518_F	1.017	1.00
560_G	917_D	1.017	1.00
553_L	907_L	1.015	1.00
89_M	812_Q	1.015	1.00
522_I	526_G	1.013	1.00
57_V	97_A	1.012	1.00
264_R	725_D	1.009	1.00
431_A	434_L	1.009	1.00
156_T	323_S	1.007	1.00
92_Q	101_T	1.007	1.00
545_S	548_L	1.007	1.00
374_A	491_T	1.006	1.00
108_L	116_E	1.005	1.00
283_W	590_R	1.005	1.00
418_N	422_Y	1.004	1.00
91_S	809_H	1.003	1.00
900_T	1010_L	1.002	1.00
564_V	638_Q	1.002	1.00
677_F	698_L	1.001	1.00
588_R	651_V	1.000	1.00
703_Q	823_P	1.000	1.00
593_A	607_S	0.998	1.00
77_E	91_S	0.997	1.00
265_L	269_A	0.994	1.00
164_E	168_E	0.994	1.00
344_Q	348_M	0.994	1.00
972_T	1008_Q	0.992	1.00
112_V	116_E	0.990	1.00
420_S	424_E	0.989	1.00
765_E	771_T	0.986	1.00
56_V	76_L	0.985	1.00
637_V	641_I	0.985	1.00
941_F	963_L	0.985	1.00
213_V	268_V	0.983	1.00
529_L	533_L	0.983	1.00
542_V	549_L	0.982	1.00
772_P	776_A	0.981	1.00
581_S	584_N	0.980	1.00
447_L	484_A	0.980	1.00
306_A	310_R	0.979	1.00
695_M	818_I	0.978	1.00
140_K	148_I	0.978	1.00
592_V	651_V	0.978	1.00
91_S	100_I	0.977	1.00
893_T	1018_I	0.977	1.00
537_W	541_S	0.976	1.00
593_A	605_L	0.975	1.00
976_L	1004_L	0.975	1.00
172_A	184_V	0.973	1.00
255_I	263_I	0.972	1.00
149_M	310_R	0.971	1.00
250_Y	762_V	0.971	1.00
423_I	429_P	0.971	1.00
965_F	969_L	0.971	1.00
187_S	293_N	0.970	1.00
599_D	644_L	0.969	1.00
31_L	377_L	0.969	1.00
835_I	852_F	0.967	1.00
41_L	383_F	0.967	1.00
532_V	1013_F	0.967	1.00
446_S	880_V	0.966	1.00
373_V	490_L	0.965	1.00
682_T	848_I	0.965	1.00
24_T	28_V	0.965	1.00
572_G	596_I	0.965	1.00
226_K	741_L	0.964	1.00
977_L	980_L	0.963	1.00
592_V	623_L	0.962	1.00
125_T	133_P	0.962	1.00
284_A	289_A	0.961	1.00
18_M	434_L	0.960	1.00
462_G	865_S	0.960	1.00
691_V	695_M	0.960	1.00
958_Y	962_L	0.959	1.00
917_D	920_A	0.958	1.00
434_L	438_G	0.958	1.00
374_A	412_A	0.956	1.00
959_Q	963_L	0.955	1.00
310_R	317_T	0.955	1.00
224_S	738_D	0.954	1.00
453_A	876_A	0.954	1.00
385_V	482_I	0.953	1.00
59_L	97_A	0.951	1.00
441_G	445_I	0.949	1.00
429_P	433_A	0.949	1.00
533_L	1020_L	0.947	1.00
831_A	834_A	0.947	1.00
152_A	289_A	0.944	1.00
178_I	312_M	0.943	1.00
680_Q	849_T	0.943	1.00
832_V	856_T	0.940	1.00
679_L	848_I	0.937	1.00
439_E	944_A	0.937	1.00
867_V	871_V	0.936	1.00
550_S	906_L	0.936	1.00
161_T	275_A	0.936	1.00
363_R	515_E	0.935	1.00
778_D	798_I	0.935	1.00
418_N	440_I	0.934	1.00
341_D	344_Q	0.933	1.00
732_I	737_V	0.929	1.00
517_M	521_I	0.928	1.00
539_T	542_V	0.927	1.00
153_V	163_V	0.927	1.00
208_L	255_I	0.926	1.00
644_L	648_V	0.925	1.00
146_P	153_V	0.925	1.00
685_D	689_T	0.923	1.00
694_L	838_T	0.923	1.00
718_A	774_L	0.923	1.00
710_D	808_N	0.922	1.00
172_A	186_L	0.922	1.00
972_T	976_L	0.921	1.00
155_S	158_M	0.921	1.00
13_S	437_A	0.920	1.00
584_N	653_G	0.919	1.00
235_A	279_W	0.918	1.00
419_I	436_G	0.918	1.00
211_E	739_N	0.917	1.00
885_Y	936_I	0.916	1.00
247_A	273_Q	0.916	1.00
365_I	369_I	0.915	1.00
415_V	444_I	0.913	1.00
250_Y	271_V	0.912	1.00
596_I	625_I	0.912	1.00
736_D	739_N	0.910	1.00
752_T	759_Q	0.910	1.00
521_I	525_Y	0.909	1.00
640_V	643_R	0.909	1.00
549_L	552_L	0.909	1.00
195_R	272_E	0.908	1.00
727_A	795_I	0.907	1.00
284_A	604_S	0.907	1.00
575_Q	655_D	0.907	1.00
583_A	587_Q	0.907	1.00
698_L	707_V	0.906	1.00
749_L	763_V	0.905	1.00
27_M	377_L	0.905	1.00
947_R	953_P	0.904	1.00
183_L	295_Q	0.904	1.00
651_V	654_V	0.902	1.00
386_M	391_F	0.902	1.00
980_L	984_L	0.901	1.00
451_L	933_K	0.901	1.00
199_N	770_N	0.901	1.00
446_S	884_L	0.900	1.00
892_I	896_S	0.900	1.00
518_F	522_I	0.897	1.00
370_I	494_M	0.896	1.00
286_K	593_A	0.895	1.00
676_Q	815_V	0.895	1.00
908_A	912_A	0.895	1.00
570_I	658_L	0.895	1.00
196_V	750_I	0.895	1.00
525_Y	533_L	0.893	1.00
79_Q	127_L	0.892	1.00
1023_D	1026_A	0.892	1.00
777_L	798_I	0.886	1.00
903_V	1006_V	0.885	1.00
377_L	486_V	0.884	1.00
519_D	522_I	0.884	1.00
774_L	778_D	0.883	1.00
310_R	333_T	0.882	1.00
305_T	308_S	0.881	1.00
59_L	133_P	0.881	1.00
718_A	800_Q	0.881	1.00
104_F	117_V	0.880	1.00
574_L	654_V	0.879	1.00
957_I	961_C	0.877	1.00
316_L	320_L	0.877	1.00
162_Q	165_D	0.874	1.00
677_F	694_L	0.874	1.00
536_P	1021_L	0.873	1.00
607_S	623_L	0.873	1.00
720_V	741_L	0.873	1.00
112_V	115_Q	0.872	1.00
871_V	875_V	0.872	1.00
705_S	823_P	0.872	1.00
644_L	658_L	0.871	1.00
941_F	946_E	0.869	1.00
217_I	750_I	0.866	1.00
168_E	172_A	0.866	1.00
807_I	814_P	0.863	1.00
256_A	263_I	0.862	1.00
942_A	960_A	0.862	1.00
219_G	733_S	0.860	1.00
753_I	762_V	0.860	1.00
140_K	153_V	0.859	1.00
426_G	432_A	0.859	1.00
730_L	790_V	0.858	1.00
677_F	850_T	0.856	1.00
704_L	835_I	0.855	1.00
878_Y	888_F	0.854	1.00
546_T	903_V	0.852	1.00
433_A	496_A	0.852	1.00
150_T	293_N	0.852	1.00
679_L	818_I	0.850	1.00
604_S	626_N	0.850	1.00
905_A	999_G	0.848	1.00
942_A	1019_Y	0.848	1.00
467_R	470_R	0.847	1.00
233_S	584_N	0.846	1.00
397_T	471_E	0.845	1.00
149_M	306_A	0.845	1.00
522_I	962_L	0.845	1.00
176_S	183_L	0.844	1.00
441_G	488_L	0.843	1.00
92_Q	806_S	0.843	1.00
81_G	812_Q	0.842	1.00
251_R	269_A	0.841	1.00
175_I	312_M	0.841	1.00
516_K	519_D	0.838	1.00
823_P	826_Y	0.837	1.00
281_G	582_F	0.835	1.00
88_Q	810_L	0.834	1.00
130_S	134_N	0.834	1.00
208_L	213_V	0.833	1.00
811_D	851_Q	0.833	1.00
165_D	169_T	0.833	1.00
196_V	269_A	0.833	1.00
693_Q	843_N	0.832	1.00
155_S	323_S	0.832	1.00
525_Y	529_L	0.832	1.00
82_Q	120_A	0.831	1.00
900_T	1014_T	0.829	1.00
856_T	860_Q	0.829	1.00
592_V	595_V	0.828	1.00
601_A	643_R	0.827	1.00
200_A	766_H	0.827	1.00
953_P	1020_L	0.825	1.00
530_A	954_R	0.824	1.00
214_R	748_R	0.824	1.00
217_I	250_Y	0.824	1.00
55_Q	101_T	0.822	1.00
194_V	753_I	0.822	1.00
687_L	816_T	0.822	1.00
257_Y	262_P	0.822	1.00
291_V	606_T	0.821	1.00
555_V	558_P	0.820	1.00
276_E	761_R	0.819	1.00
105_Q	108_L	0.819	1.00
201_Q	779_T	0.818	1.00
844_L	850_T	0.818	1.00
36_I	40_A	0.816	1.00
349_M	352_A	0.816	1.00
687_L	848_I	0.816	1.00
874_V	895_L	0.816	1.00
214_R	743_N	0.813	1.00
1005_I	1009_V	0.812	1.00
24_T	497_R	0.812	1.00
334_T	337_R	0.811	1.00
572_G	658_L	0.811	1.00
1011_T	1015_T	0.810	1.00
641_I	658_L	0.810	1.00
645_Q	658_L	0.809	1.00
452_I	477_A	0.808	1.00
570_I	637_V	0.808	1.00
675_Y	835_I	0.807	1.00
688_S	816_T	0.806	1.00
707_V	820_F	0.805	1.00
533_L	958_Y	0.804	1.00
15_L	19_R	0.804	1.00
201_Q	204_A	0.802	1.00
210_S	743_N	0.802	1.00
580_S	585_M	0.802	1.00
686_A	847_D	0.802	1.00
198_L	764_L	0.801	1.00
384_A	388_F	0.801	1.00
313_L	317_T	0.801	1.00
204_A	781_R	0.798	1.00
832_V	852_F	0.797	1.00
530_A	955_E	0.796	1.00
627_L	640_V	0.795	1.00
213_V	764_L	0.793	1.00
690_W	694_L	0.792	1.00
530_A	534_N	0.792	1.00
167_V	292_M	0.791	1.00
213_V	265_L	0.791	1.00
219_G	735_A	0.790	1.00
648_V	656_L	0.788	1.00
149_M	328_V	0.787	1.00
747_Q	765_E	0.786	1.00
912_A	1002_G	0.786	1.00
744_A	780_I	0.786	1.00
830_D	834_A	0.785	1.00
540_L	1017_V	0.784	1.00
61_P	133_P	0.783	1.00
186_L	189_G	0.783	1.00
572_G	623_L	0.781	1.00
543_A	547_L	0.781	1.00
832_V	860_Q	0.781	1.00
674_Q	821_N	0.781	1.00
503_S	506_K	0.781	1.00
338_A	341_D	0.780	1.00
743_N	764_L	0.780	1.00
826_Y	831_A	0.780	1.00
21_V	888_F	0.778	1.00
174_K	315_Q	0.778	1.00
533_L	1017_V	0.777	1.00
744_A	766_H	0.777	1.00
340_V	398_L	0.774	1.00
718_A	798_I	0.774	1.00
104_F	113_A	0.773	1.00
213_V	216_A	0.773	1.00
57_V	99_V	0.772	1.00
863_L	867_V	0.772	1.00
1020_L	1024_R	0.771	1.00
440_I	448_T	0.771	1.00
195_R	274_G	0.771	1.00
726_S	794_S	0.768	0.99
211_E	214_R	0.767	0.99
419_I	433_A	0.765	0.99
523_A	526_G	0.764	0.99
425_K	435_K	0.764	0.99
550_S	553_L	0.764	0.99
451_L	480_I	0.763	0.99
178_I	305_T	0.762	0.99
177_Q	312_M	0.762	0.99
213_V	255_I	0.761	0.99
837_D	840_K	0.761	0.99
470_R	474_I	0.761	0.99
60_Y	132_L	0.761	0.99
60_Y	68_M	0.760	0.99
916_L	921_I	0.758	0.99
781_R	791_P	0.757	0.99
679_L	683_S	0.757	0.99
586_A	609_V	0.757	0.99
203_I	206_L	0.757	0.99
111_D	140_K	0.756	0.99
199_N	767_N	0.756	0.99
281_G	609_V	0.756	0.99
950_G	956_A	0.755	0.99
325_K	328_V	0.754	0.99
584_N	588_R	0.754	0.99
175_I	292_M	0.753	0.99
934_N	1007_S	0.752	0.99
364_N	367_A	0.751	0.99
523_A	962_L	0.751	0.99
94_S	97_A	0.751	0.99
703_Q	837_D	0.750	0.99
859_F	863_L	0.750	0.99
250_Y	253_L	0.749	0.99
148_I	306_A	0.749	0.99
547_L	550_S	0.749	0.99
198_L	269_A	0.748	0.99
890_H	1023_D	0.748	0.99
152_A	291_V	0.747	0.99
282_A	289_A	0.747	0.99
53_T	103_Q	0.747	0.99
244_M	753_I	0.745	0.99
147_P	150_T	0.745	0.99
315_Q	319_S	0.745	0.99
73_T	100_I	0.744	0.99
430_L	496_A	0.744	0.99
553_L	910_L	0.743	0.99
554_W	906_L	0.743	0.99
236_V	718_A	0.743	0.99
836_M	852_F	0.743	0.99
254_I	257_Y	0.742	0.99
93_S	100_I	0.742	0.99
532_V	535_H	0.741	0.99
74_A	78_R	0.740	0.99
80_F	121_I	0.740	0.99
740_A	782_L	0.740	0.99
539_T	1014_T	0.739	0.99
588_R	653_G	0.738	0.99
349_M	353_L	0.737	0.99
140_K	146_P	0.737	0.99
1018_I	1022_F	0.737	0.99
602_V	610_G	0.737	0.99
257_Y	260_G	0.736	0.99
557_I	906_L	0.735	0.99
732_I	784_S	0.735	0.99
749_L	752_T	0.735	0.99
303_I	337_R	0.735	0.99
574_L	623_L	0.733	0.99
674_Q	855_S	0.733	0.99
407_F	975_A	0.733	0.99
490_L	494_M	0.733	0.99
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151_L	310_R	0.542	0.95
370_I	499_L	0.542	0.95
423_I	501_Q	0.541	0.95
566_D	633_R	0.540	0.95
873_A	925_I	0.540	0.95
186_L	290_I	0.539	0.95
595_V	648_V	0.538	0.95
947_R	951_M	0.538	0.95
351_I	405_T	0.538	0.95
551_V	554_W	0.538	0.95
296_R	300_A	0.538	0.95
518_F	969_L	0.537	0.95
223_N	243_Q	0.537	0.95
486_V	494_M	0.536	0.95
675_Y	704_L	0.536	0.95
748_R	764_L	0.536	0.95
353_L	977_L	0.536	0.95
851_Q	857_L	0.536	0.95
48_E	298_P	0.536	0.95
273_Q	760_Y	0.536	0.95
20_P	496_A	0.536	0.95
1021_L	1024_R	0.535	0.95
516_K	523_A	0.535	0.95
416_I	436_G	0.535	0.95
448_T	487_S	0.534	0.95
520_R	527_R	0.534	0.95
709_S	818_I	0.534	0.95
83_M	120_A	0.533	0.95
180_G	305_T	0.533	0.95
869_L	872_A	0.533	0.95
423_I	428_K	0.533	0.95
378_S	382_T	0.532	0.94
155_S	324_V	0.532	0.94
437_A	440_I	0.532	0.94
684_L	688_S	0.532	0.94
557_I	916_L	0.531	0.94
158_M	166_M	0.531	0.94
35_I	380_I	0.531	0.94
668_T	671_S	0.531	0.94
413_I	970_M	0.531	0.94
778_D	797_K	0.530	0.94
730_L	784_S	0.528	0.94
964_R	971_T	0.528	0.94
148_I	302_I	0.528	0.94
130_S	133_P	0.528	0.94
683_S	848_I	0.527	0.94
75_P	79_Q	0.527	0.94
100_I	124_A	0.527	0.94
536_P	954_R	0.527	0.94
347_L	351_I	0.527	0.94
61_P	135_P	0.526	0.94
60_Y	131_D	0.526	0.94
903_V	907_L	0.526	0.94
196_V	268_V	0.525	0.94
572_G	592_V	0.525	0.94
48_E	144_A	0.525	0.94
386_M	401_L	0.524	0.94
221_N	244_M	0.524	0.94
693_Q	841_T	0.524	0.94
121_I	137_V	0.523	0.94
990_A	993_R	0.521	0.94
891_P	894_I	0.521	0.94
385_V	474_I	0.521	0.94
682_T	686_A	0.520	0.94
358_I	974_A	0.520	0.94
524_A	535_H	0.520	0.94
83_M	86_L	0.520	0.94
600_P	628_K	0.520	0.94
346_E	933_K	0.520	0.94
738_D	741_L	0.519	0.94
677_F	818_I	0.519	0.94
313_L	328_V	0.519	0.94
142_N	155_S	0.519	0.94
277_N	771_T	0.519	0.94
588_R	654_V	0.519	0.94
222_V	738_D	0.517	0.94
429_P	496_A	0.517	0.94
910_L	913_G	0.516	0.94
23_T	493_M	0.516	0.94
909_L	915_E	0.516	0.94
69_T	93_S	0.516	0.94
351_I	372_G	0.516	0.94
953_P	956_A	0.516	0.94
148_I	296_R	0.516	0.94
462_G	861_S	0.515	0.93
313_L	316_L	0.515	0.93
874_V	928_I	0.515	0.93
730_L	794_S	0.514	0.93
285_N	605_L	0.514	0.93
947_R	952_S	0.514	0.93
933_K	937_M	0.513	0.93
124_A	128_L	0.513	0.93
485_V	489_T	0.513	0.93
894_I	938_M	0.513	0.93
349_M	356_M	0.512	0.93
566_D	630_L	0.512	0.93
694_L	835_I	0.512	0.93
961_C	965_F	0.512	0.93
455_L	476_L	0.512	0.93
701_L	826_Y	0.511	0.93
593_A	596_I	0.511	0.93
529_L	1017_V	0.511	0.93
896_S	1015_T	0.511	0.93
641_I	644_L	0.511	0.93
149_M	294_V	0.510	0.93
114_E	140_K	0.510	0.93
529_L	958_Y	0.510	0.93
84_S	116_E	0.510	0.93
879_I	883_I	0.510	0.93
206_L	268_V	0.510	0.93
220_A	253_L	0.510	0.93
525_Y	532_V	0.509	0.93
167_V	326_V	0.509	0.93
725_D	729_R	0.509	0.93
80_F	83_M	0.508	0.93
770_N	776_A	0.508	0.93
423_I	427_E	0.508	0.93
908_A	1006_V	0.508	0.93
211_E	748_R	0.507	0.93
140_K	149_M	0.507	0.93
411_D	974_A	0.507	0.93
933_K	975_A	0.507	0.93
273_Q	753_I	0.507	0.93
241_N	721_N	0.507	0.93
354_V	368_T	0.507	0.93
217_I	762_V	0.506	0.93
938_M	960_A	0.506	0.93
692_P	709_S	0.506	0.93
426_G	433_A	0.506	0.93
27_M	30_I	0.506	0.93
32_L	36_I	0.505	0.93
486_V	491_T	0.504	0.93
705_S	824_D	0.504	0.93
400_A	475_T	0.504	0.93
187_S	291_V	0.504	0.93
835_I	839_E	0.503	0.93
32_L	875_V	0.503	0.93
175_I	178_I	0.503	0.93
947_R	950_G	0.502	0.93
996_L	1000_M	0.502	0.93
514_S	517_M	0.502	0.93
140_K	147_P	0.502	0.93
703_Q	838_T	0.502	0.93
165_D	758_N	0.501	0.93
580_S	588_R	0.501	0.93
640_V	647_A	0.501	0.93
593_A	609_V	0.500	0.92
602_V	627_L	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.9269	100	0.224	Contact Map
4mt1A	3	0.9558	100	0.287	Contact Map
3ne5A	3	0.9558	100	0.293	Contact Map
3w9iA	3	0.9712	100	0.294	Contact Map
4dx5A	3	0.9798	100	0.308	Contact Map
3aqpA	1	0.676	100	0.727	Contact Map
4r86A	1	0.276	100	0.754	Contact Map
2ew9A	1	0.1423	81.2	0.982	Contact Map
3cq1A	2	0.0933	63.4	0.985	Contact Map
4n8nA	1	0.0962	60.8	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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