MDTA - ECOLI - GREMLIN Contacts

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MDTA - Multidrug resistance protein MdtA

UniProt:	P76397	Sequences: MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPAGGRRGMRSGPLAPVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLIALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTLPESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14056
Length:	415 (332)
Sequences:	19142 (14553)
Seq/√Len:	798.7

ECOLI - MDTA ACRA ACRE MDTE CUSB MACA EMRK EMRA YDHJ YIBH AAEA YIAV YHII MDTN
BACSU - YVRP YKNX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
342_N	348_S	3.271	1.00
100_A	117_E	3.151	1.00
114_L	197_R	2.825	1.00
353_T	366_A	2.790	1.00
66_T	373_R	2.683	1.00
337_F	349_K	2.584	1.00
110_K	203_D	2.557	1.00
350_H	372_D	2.497	1.00
145_R	149_A	2.376	1.00
340_V	350_H	2.367	1.00
83_T	237_V	2.283	1.00
69_E	370_A	2.225	1.00
277_L	295_R	2.190	1.00
326_T	362_V	2.119	1.00
151_Y	160_V	2.113	1.00
70_Q	361_K	2.106	1.00
274_G	294_A	2.100	1.00
323_V	361_K	2.085	1.00
69_E	320_N	2.074	1.00
117_E	197_R	2.043	1.00
152_Q	156_K	2.041	1.00
102_H	117_E	2.041	1.00
110_K	113_D	1.981	1.00
169_Q	173_S	1.961	1.00
93_R	195_W	1.939	1.00
369_S	372_D	1.922	1.00
114_L	199_T	1.901	1.00
253_K	273_E	1.899	1.00
335_G	351_L	1.894	1.00
151_Y	168_Q	1.884	1.00
102_H	114_L	1.882	1.00
70_Q	323_V	1.881	1.00
162_R	166_D	1.878	1.00
152_Q	169_Q	1.862	1.00
238_F	311_A	1.826	1.00
82_I	236_L	1.817	1.00
346_K	387_K	1.807	1.00
355_G	363_V	1.801	1.00
257_P	273_E	1.789	1.00
131_Q	190_Q	1.785	1.00
143_N	147_D	1.781	1.00
270_K	302_A	1.778	1.00
155_A	165_L	1.774	1.00
108_Q	205_R	1.764	1.00
348_S	384_E	1.757	1.00
135_A	138_K	1.747	1.00
353_T	365_R	1.723	1.00
341_L	388_V	1.701	1.00
111_A	203_D	1.691	1.00
172_V	176_E	1.691	1.00
355_G	365_R	1.684	1.00
354_P	362_V	1.679	1.00
75_Y	312_R	1.672	1.00
86_N	230_Q	1.670	1.00
145_R	176_E	1.670	1.00
207_G	229_T	1.670	1.00
180_K	183_E	1.665	1.00
120_P	124_K	1.664	1.00
148_L	152_Q	1.640	1.00
98_L	211_V	1.622	1.00
347_V	375_V	1.621	1.00
257_P	271_L	1.609	1.00
237_V	291_K	1.607	1.00
187_A	190_Q	1.606	1.00
173_S	176_E	1.604	1.00
155_A	162_R	1.597	1.00
235_D	293_K	1.593	1.00
148_L	165_L	1.576	1.00
128_A	131_Q	1.575	1.00
138_K	183_E	1.561	1.00
254_A	294_A	1.558	1.00
141_L	172_V	1.550	1.00
238_F	294_A	1.544	1.00
61_P	389_E	1.524	1.00
67_A	322_V	1.516	1.00
89_T	224_G	1.514	1.00
67_A	371_G	1.496	1.00
82_I	234_I	1.488	1.00
356_I	363_V	1.482	1.00
338_V	352_V	1.481	1.00
145_R	172_V	1.473	1.00
340_V	372_D	1.461	1.00
136_K	178_T	1.460	1.00
64_A	390_V	1.449	1.00
63_Q	377_D	1.449	1.00
127_L	186_V	1.442	1.00
138_K	142_A	1.422	1.00
77_T	312_R	1.410	1.00
64_A	341_L	1.404	1.00
98_L	116_A	1.404	1.00
104_Q	107_Q	1.389	1.00
200_A	228_I	1.388	1.00
134_L	179_I	1.382	1.00
167_A	171_L	1.379	1.00
164_E	167_A	1.375	1.00
239_T	291_K	1.367	1.00
77_T	310_N	1.359	1.00
324_I	374_V	1.355	1.00
71_A	319_Q	1.354	1.00
64_A	373_R	1.349	1.00
260_V	309_V	1.345	1.00
253_K	275_T	1.339	1.00
99_I	119_D	1.331	1.00
236_L	309_V	1.323	1.00
149_A	152_Q	1.319	1.00
96_G	118_I	1.317	1.00
65_A	376_T	1.317	1.00
87_T	227_V	1.314	1.00
124_K	128_A	1.314	1.00
326_T	360_Q	1.311	1.00
165_L	169_Q	1.311	1.00
283_I	290_I	1.307	1.00
134_L	186_V	1.305	1.00
352_V	364_I	1.296	1.00
318_E	363_V	1.296	1.00
134_L	138_K	1.295	1.00
331_M	336_H	1.290	1.00
148_L	172_V	1.278	1.00
183_E	187_A	1.272	1.00
206_V	226_V	1.269	1.00
241_P	244_D	1.268	1.00
115_L	226_V	1.267	1.00
142_A	173_S	1.264	1.00
142_A	145_R	1.256	1.00
148_L	169_Q	1.252	1.00
141_L	145_R	1.247	1.00
71_A	320_N	1.239	1.00
257_P	312_R	1.235	1.00
258_L	296_F	1.232	1.00
233_P	295_R	1.220	1.00
230_Q	233_P	1.211	1.00
332_G	349_K	1.209	1.00
133_Q	136_K	1.208	1.00
136_K	140_T	1.203	1.00
275_T	295_R	1.199	1.00
95_D	219_S	1.197	1.00
218_S	221_D	1.194	1.00
321_A	363_V	1.194	1.00
322_V	370_A	1.192	1.00
188_S	192_Q	1.181	1.00
208_L	227_V	1.163	1.00
257_P	314_L	1.157	1.00
131_Q	135_A	1.149	1.00
103_F	113_D	1.140	1.00
114_L	117_E	1.128	1.00
153_Q	157_T	1.125	1.00
149_A	153_Q	1.119	1.00
341_L	373_R	1.118	1.00
142_A	146_R	1.118	1.00
89_T	227_V	1.115	1.00
163_Q	167_A	1.114	1.00
129_Q	185_S	1.108	1.00
116_A	226_V	1.103	1.00
147_D	151_Y	1.103	1.00
259_V	312_R	1.101	1.00
85_A	233_P	1.093	1.00
245_I	290_I	1.084	1.00
176_E	180_K	1.084	1.00
237_V	293_K	1.083	1.00
124_K	193_L	1.083	1.00
340_V	348_S	1.078	1.00
236_L	311_A	1.078	1.00
123_F	196_S	1.074	1.00
66_T	371_G	1.072	1.00
209_K	212_D	1.072	1.00
127_L	131_Q	1.069	1.00
152_Q	165_L	1.062	1.00
61_P	391_V	1.062	1.00
147_D	167_A	1.055	1.00
358_D	361_K	1.053	1.00
100_A	213_V	1.053	1.00
186_V	190_Q	1.049	1.00
209_K	226_V	1.042	1.00
153_Q	156_K	1.036	1.00
278_S	293_K	1.035	1.00
126_A	129_Q	1.032	1.00
280_D	291_K	1.031	1.00
93_R	97_Q	1.024	1.00
190_Q	194_D	1.023	1.00
260_V	263_W	1.022	1.00
101_L	213_V	1.022	1.00
244_D	247_T	1.020	1.00
326_T	357_Q	1.019	1.00
357_Q	362_V	1.017	1.00
179_I	183_E	1.011	1.00
259_V	271_L	1.009	1.00
169_Q	172_V	1.005	1.00
342_N	350_H	1.003	1.00
342_N	346_K	0.997	1.00
81_T	288_G	0.996	1.00
276_L	294_A	0.991	1.00
82_I	309_V	0.990	1.00
141_L	176_E	0.984	1.00
200_A	203_D	0.983	1.00
235_D	295_R	0.981	1.00
73_P	314_L	0.978	1.00
116_A	198_I	0.977	1.00
98_L	217_I	0.968	1.00
150_R	166_D	0.963	1.00
104_Q	209_K	0.949	1.00
103_F	226_V	0.948	1.00
217_I	225_I	0.946	1.00
236_L	258_L	0.946	1.00
329_L	362_V	0.939	1.00
105_E	208_L	0.936	1.00
332_G	335_G	0.936	1.00
92_S	198_I	0.930	1.00
120_P	196_S	0.927	1.00
60_A	386_A	0.927	1.00
88_V	202_V	0.925	1.00
108_Q	203_D	0.924	1.00
82_I	303_L	0.920	1.00
108_Q	301_D	0.914	1.00
284_D	287_T	0.905	1.00
210_Q	224_G	0.903	1.00
233_P	297_N	0.902	1.00
166_D	169_Q	0.901	1.00
345_N	387_K	0.899	1.00
264_D	269_K	0.897	1.00
158_N	162_R	0.897	1.00
85_A	235_D	0.894	1.00
116_A	209_K	0.886	1.00
339_W	384_E	0.878	1.00
263_W	269_K	0.878	1.00
121_S	191_L	0.878	1.00
171_L	175_T	0.874	1.00
99_I	117_E	0.874	1.00
94_V	123_F	0.872	1.00
324_I	338_V	0.869	1.00
276_L	292_V	0.868	1.00
275_T	297_N	0.867	1.00
116_A	225_I	0.866	1.00
341_L	345_N	0.864	1.00
144_A	175_T	0.864	1.00
137_D	182_D	0.862	1.00
141_L	179_I	0.860	1.00
263_W	272_S	0.858	1.00
128_A	187_A	0.857	1.00
342_N	345_N	0.856	1.00
127_L	190_Q	0.854	1.00
107_Q	113_D	0.850	1.00
140_T	174_E	0.847	1.00
126_A	192_Q	0.844	1.00
259_V	269_K	0.844	1.00
103_F	209_K	0.840	1.00
59_L	387_K	0.839	1.00
129_Q	133_Q	0.838	1.00
95_D	218_S	0.837	1.00
69_E	322_V	0.837	1.00
355_G	362_V	0.836	1.00
74_R	247_T	0.834	1.00
151_Y	164_E	0.833	1.00
375_V	382_L	0.831	1.00
103_F	206_V	0.826	1.00
298_N	301_D	0.825	1.00
202_V	228_I	0.824	1.00
85_A	230_Q	0.823	1.00
62_V	375_V	0.822	1.00
349_K	384_E	0.819	1.00
138_K	179_I	0.819	1.00
234_I	305_P	0.818	1.00
347_V	388_V	0.812	1.00
143_N	170_A	0.812	1.00
147_D	163_Q	0.810	1.00
140_T	178_T	0.809	1.00
137_D	175_T	0.806	1.00
117_E	120_P	0.805	1.00
240_L	292_V	0.805	1.00
140_T	171_L	0.803	1.00
84_A	305_P	0.803	1.00
68_V	370_A	0.802	1.00
332_G	337_F	0.802	1.00
130_A	182_D	0.802	1.00
92_S	217_I	0.801	1.00
75_Y	314_L	0.800	1.00
146_R	149_A	0.796	1.00
126_A	188_S	0.794	1.00
71_A	317_T	0.790	1.00
210_Q	227_V	0.789	1.00
168_Q	171_L	0.786	1.00
350_H	369_S	0.785	1.00
143_N	167_A	0.785	1.00
140_T	143_N	0.785	1.00
341_L	347_V	0.782	1.00
65_A	325_P	0.780	1.00
73_P	317_T	0.776	1.00
86_N	213_V	0.775	1.00
259_V	310_N	0.773	1.00
330_Q	337_F	0.771	1.00
364_I	368_I	0.768	1.00
175_T	178_T	0.768	1.00
171_L	174_E	0.765	1.00
261_E	264_D	0.764	1.00
318_E	321_A	0.764	1.00
329_L	336_H	0.763	1.00
135_A	180_K	0.762	1.00
182_D	185_S	0.762	1.00
272_S	300_D	0.760	1.00
99_I	120_P	0.760	1.00
327_A	377_D	0.759	1.00
120_P	197_R	0.758	1.00
126_A	130_A	0.756	1.00
146_R	166_D	0.756	1.00
204_G	228_I	0.755	1.00
143_N	146_R	0.754	1.00
261_E	310_N	0.754	1.00
189_A	192_Q	0.752	1.00
383_T	386_A	0.749	1.00
314_L	317_T	0.748	1.00
342_N	372_D	0.747	1.00
133_Q	185_S	0.746	1.00
258_L	262_A	0.746	1.00
354_P	364_I	0.744	1.00
86_N	212_D	0.744	1.00
132_G	184_A	0.742	1.00
336_H	354_P	0.740	1.00
131_Q	186_V	0.738	1.00
97_Q	216_Q	0.731	1.00
240_L	248_V	0.730	1.00
279_L	292_V	0.728	1.00
347_V	382_L	0.726	1.00
87_T	229_T	0.724	1.00
140_T	144_A	0.724	1.00
341_L	375_V	0.722	1.00
337_F	351_L	0.720	1.00
350_H	367_G	0.719	1.00
105_E	209_K	0.717	1.00
101_L	116_A	0.713	1.00
373_R	390_V	0.710	1.00
72_V	358_D	0.708	1.00
191_L	194_D	0.707	1.00
108_Q	231_T	0.705	1.00
250_Q	279_L	0.701	1.00
85_A	295_R	0.701	1.00
74_R	316_D	0.700	1.00
93_R	122_Q	0.700	1.00
65_A	68_V	0.697	1.00
191_L	195_W	0.696	1.00
91_R	221_D	0.695	1.00
137_D	140_T	0.693	1.00
76_L	244_D	0.692	1.00
178_T	182_D	0.691	1.00
249_V	252_Q	0.689	1.00
67_A	368_I	0.686	1.00
59_L	389_E	0.683	1.00
238_F	313_M	0.683	1.00
339_W	349_K	0.683	1.00
185_S	189_A	0.683	1.00
80_G	309_V	0.681	1.00
345_N	373_R	0.681	1.00
339_W	347_V	0.680	1.00
339_W	382_L	0.678	1.00
92_S	116_A	0.674	1.00
78_G	238_F	0.671	1.00
175_T	179_I	0.664	1.00
150_R	154_L	0.657	1.00
338_V	374_V	0.657	1.00
98_L	225_I	0.656	1.00
83_T	235_D	0.652	1.00
134_L	183_E	0.651	1.00
355_G	367_G	0.648	1.00
343_S	373_R	0.647	1.00
95_D	216_Q	0.642	1.00
361_K	365_R	0.637	1.00
174_E	178_T	0.636	1.00
65_A	324_I	0.636	1.00
328_A	376_T	0.633	1.00
160_V	165_L	0.632	1.00
258_L	274_G	0.631	1.00
125_V	191_L	0.629	1.00
205_R	231_T	0.628	1.00
160_V	164_E	0.625	1.00
221_D	224_G	0.624	1.00
130_A	189_A	0.622	1.00
99_I	102_H	0.621	1.00
338_V	367_G	0.621	1.00
91_R	224_G	0.619	1.00
324_I	329_L	0.617	1.00
151_Y	154_L	0.616	1.00
324_I	328_A	0.615	1.00
189_A	193_L	0.614	1.00
65_A	361_K	0.613	1.00
64_A	376_T	0.611	1.00
138_K	141_L	0.611	1.00
263_W	270_K	0.609	1.00
76_L	315_V	0.609	1.00
67_A	372_D	0.606	1.00
181_A	185_S	0.605	1.00
133_Q	137_D	0.605	1.00
161_S	164_E	0.605	1.00
109_V	115_L	0.604	1.00
147_D	171_L	0.604	1.00
78_G	244_D	0.603	1.00
260_V	303_L	0.602	1.00
155_A	158_N	0.602	1.00
248_V	276_L	0.602	1.00
232_H	299_Q	0.600	1.00
84_A	229_T	0.599	1.00
57_G	387_K	0.597	1.00
184_A	187_A	0.597	1.00
164_E	168_Q	0.597	1.00
258_L	311_A	0.597	1.00
194_D	199_T	0.596	1.00
68_V	361_K	0.593	1.00
232_H	301_D	0.593	1.00
78_G	313_M	0.592	1.00
211_V	217_I	0.592	1.00
78_G	240_L	0.590	1.00
345_N	390_V	0.588	1.00
152_Q	155_A	0.587	1.00
130_A	133_Q	0.585	1.00
162_R	169_Q	0.584	1.00
277_L	293_K	0.584	1.00
170_A	174_E	0.579	1.00
90_V	201_P	0.579	1.00
63_Q	391_V	0.578	1.00
325_P	328_A	0.578	1.00
131_Q	138_K	0.576	1.00
234_I	298_N	0.576	1.00
236_L	296_F	0.575	1.00
86_N	202_V	0.574	1.00
66_T	69_E	0.574	1.00
140_T	175_T	0.574	1.00
155_A	160_V	0.572	1.00
122_Q	192_Q	0.569	1.00
146_R	170_A	0.569	1.00
274_G	296_F	0.568	1.00
331_M	334_E	0.568	1.00
89_T	215_N	0.567	1.00
235_D	277_L	0.566	1.00
322_V	367_G	0.565	1.00
234_I	296_F	0.565	1.00
382_L	388_V	0.563	1.00
147_D	168_Q	0.557	1.00
72_V	323_V	0.557	1.00
329_L	352_V	0.557	1.00
304_F	307_Q	0.557	1.00
253_K	314_L	0.557	1.00
72_V	363_V	0.557	1.00
340_V	374_V	0.556	1.00
330_Q	339_W	0.556	1.00
144_A	171_L	0.555	1.00
182_D	186_V	0.554	1.00
239_T	284_D	0.554	1.00
162_R	165_L	0.554	1.00
253_K	257_P	0.553	1.00
270_K	300_D	0.553	1.00
127_L	193_L	0.552	1.00
72_V	356_I	0.551	1.00
74_R	356_I	0.551	1.00
254_A	258_L	0.550	1.00
251_A	275_T	0.549	1.00
185_S	188_S	0.548	1.00
211_V	215_N	0.548	1.00
88_V	228_I	0.544	1.00
90_V	226_V	0.544	1.00
242_E	308_F	0.541	1.00
90_V	202_V	0.540	1.00
134_L	141_L	0.538	1.00
147_D	150_R	0.538	1.00
262_A	307_Q	0.536	1.00
74_R	315_V	0.535	1.00
198_I	225_I	0.534	1.00
283_I	288_G	0.532	1.00
123_F	127_L	0.529	1.00
80_G	236_L	0.529	1.00
123_F	192_Q	0.529	1.00
82_I	296_F	0.528	1.00
323_V	363_V	0.528	1.00
229_T	281_N	0.527	1.00
151_Y	155_A	0.527	1.00
102_H	113_D	0.527	1.00
92_S	225_I	0.520	1.00
224_G	227_V	0.520	1.00
101_L	209_K	0.518	1.00
120_P	193_L	0.518	1.00
154_L	158_N	0.518	1.00
111_A	201_P	0.516	1.00
92_S	118_I	0.515	1.00
65_A	69_E	0.511	1.00
103_F	107_Q	0.511	1.00
178_T	181_A	0.510	1.00
148_L	151_Y	0.510	1.00
192_Q	195_W	0.510	1.00
264_D	270_K	0.509	1.00
78_G	311_A	0.508	1.00
347_V	387_K	0.508	1.00
76_L	313_M	0.507	1.00
139_A	143_N	0.506	1.00
138_K	190_Q	0.505	1.00
341_L	344_E	0.505	1.00
338_V	372_D	0.505	1.00
154_L	161_S	0.503	1.00
229_T	305_P	0.502	1.00
170_A	177_G	0.501	1.00
137_D	141_L	0.501	1.00
112_G	199_T	0.501	1.00
269_K	272_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lnnA	6	0.7928	100	0.286	Contact Map
1vf7A	5	0.5446	100	0.295	Contact Map
4dk0A	5	0.7325	100	0.311	Contact Map
3ne5B	3	0.7735	100	0.316	Contact Map
4l8jA	2	0.7566	100	0.329	Contact Map
3fppA	3	0.5976	100	0.335	Contact Map
4kkuA	1	0.6386	100	0.379	Contact Map
2f1mA	2	0.5614	100	0.443	Contact Map
4tkoB	1	0.5614	100	0.519	Contact Map
2k32A	1	0.2771	99.9	0.726	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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