GREMLIN Database
MDTA - Multidrug resistance protein MdtA
UniProt: P76397 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14056
Length: 415 (332)
Sequences: 19142 (14553)
Seq/√Len: 798.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
342_N348_S3.2711.00
100_A117_E3.1511.00
114_L197_R2.8251.00
353_T366_A2.7901.00
66_T373_R2.6831.00
337_F349_K2.5841.00
110_K203_D2.5571.00
350_H372_D2.4971.00
145_R149_A2.3761.00
340_V350_H2.3671.00
83_T237_V2.2831.00
69_E370_A2.2251.00
277_L295_R2.1901.00
326_T362_V2.1191.00
151_Y160_V2.1131.00
70_Q361_K2.1061.00
274_G294_A2.1001.00
323_V361_K2.0851.00
69_E320_N2.0741.00
117_E197_R2.0431.00
152_Q156_K2.0411.00
102_H117_E2.0411.00
110_K113_D1.9811.00
169_Q173_S1.9611.00
93_R195_W1.9391.00
369_S372_D1.9221.00
114_L199_T1.9011.00
253_K273_E1.8991.00
335_G351_L1.8941.00
151_Y168_Q1.8841.00
102_H114_L1.8821.00
70_Q323_V1.8811.00
162_R166_D1.8781.00
152_Q169_Q1.8621.00
238_F311_A1.8261.00
82_I236_L1.8171.00
346_K387_K1.8071.00
355_G363_V1.8011.00
257_P273_E1.7891.00
131_Q190_Q1.7851.00
143_N147_D1.7811.00
270_K302_A1.7781.00
155_A165_L1.7741.00
108_Q205_R1.7641.00
348_S384_E1.7571.00
135_A138_K1.7471.00
353_T365_R1.7231.00
341_L388_V1.7011.00
111_A203_D1.6911.00
172_V176_E1.6911.00
355_G365_R1.6841.00
354_P362_V1.6791.00
75_Y312_R1.6721.00
86_N230_Q1.6701.00
145_R176_E1.6701.00
207_G229_T1.6701.00
180_K183_E1.6651.00
120_P124_K1.6641.00
148_L152_Q1.6401.00
98_L211_V1.6221.00
347_V375_V1.6211.00
257_P271_L1.6091.00
237_V291_K1.6071.00
187_A190_Q1.6061.00
173_S176_E1.6041.00
155_A162_R1.5971.00
235_D293_K1.5931.00
148_L165_L1.5761.00
128_A131_Q1.5751.00
138_K183_E1.5611.00
254_A294_A1.5581.00
141_L172_V1.5501.00
238_F294_A1.5441.00
61_P389_E1.5241.00
67_A322_V1.5161.00
89_T224_G1.5141.00
67_A371_G1.4961.00
82_I234_I1.4881.00
356_I363_V1.4821.00
338_V352_V1.4811.00
145_R172_V1.4731.00
340_V372_D1.4611.00
136_K178_T1.4601.00
64_A390_V1.4491.00
63_Q377_D1.4491.00
127_L186_V1.4421.00
138_K142_A1.4221.00
77_T312_R1.4101.00
64_A341_L1.4041.00
98_L116_A1.4041.00
104_Q107_Q1.3891.00
200_A228_I1.3881.00
134_L179_I1.3821.00
167_A171_L1.3791.00
164_E167_A1.3751.00
239_T291_K1.3671.00
77_T310_N1.3591.00
324_I374_V1.3551.00
71_A319_Q1.3541.00
64_A373_R1.3491.00
260_V309_V1.3451.00
253_K275_T1.3391.00
99_I119_D1.3311.00
236_L309_V1.3231.00
149_A152_Q1.3191.00
96_G118_I1.3171.00
65_A376_T1.3171.00
87_T227_V1.3141.00
124_K128_A1.3141.00
326_T360_Q1.3111.00
165_L169_Q1.3111.00
283_I290_I1.3071.00
134_L186_V1.3051.00
352_V364_I1.2961.00
318_E363_V1.2961.00
134_L138_K1.2951.00
331_M336_H1.2901.00
148_L172_V1.2781.00
183_E187_A1.2721.00
206_V226_V1.2691.00
241_P244_D1.2681.00
115_L226_V1.2671.00
142_A173_S1.2641.00
142_A145_R1.2561.00
148_L169_Q1.2521.00
141_L145_R1.2471.00
71_A320_N1.2391.00
257_P312_R1.2351.00
258_L296_F1.2321.00
233_P295_R1.2201.00
230_Q233_P1.2111.00
332_G349_K1.2091.00
133_Q136_K1.2081.00
136_K140_T1.2031.00
275_T295_R1.1991.00
95_D219_S1.1971.00
218_S221_D1.1941.00
321_A363_V1.1941.00
322_V370_A1.1921.00
188_S192_Q1.1811.00
208_L227_V1.1631.00
257_P314_L1.1571.00
131_Q135_A1.1491.00
103_F113_D1.1401.00
114_L117_E1.1281.00
153_Q157_T1.1251.00
149_A153_Q1.1191.00
341_L373_R1.1181.00
142_A146_R1.1181.00
89_T227_V1.1151.00
163_Q167_A1.1141.00
129_Q185_S1.1081.00
116_A226_V1.1031.00
147_D151_Y1.1031.00
259_V312_R1.1011.00
85_A233_P1.0931.00
245_I290_I1.0841.00
176_E180_K1.0841.00
237_V293_K1.0831.00
124_K193_L1.0831.00
340_V348_S1.0781.00
236_L311_A1.0781.00
123_F196_S1.0741.00
66_T371_G1.0721.00
209_K212_D1.0721.00
127_L131_Q1.0691.00
152_Q165_L1.0621.00
61_P391_V1.0621.00
147_D167_A1.0551.00
358_D361_K1.0531.00
100_A213_V1.0531.00
186_V190_Q1.0491.00
209_K226_V1.0421.00
153_Q156_K1.0361.00
278_S293_K1.0351.00
126_A129_Q1.0321.00
280_D291_K1.0311.00
93_R97_Q1.0241.00
190_Q194_D1.0231.00
260_V263_W1.0221.00
101_L213_V1.0221.00
244_D247_T1.0201.00
326_T357_Q1.0191.00
357_Q362_V1.0171.00
179_I183_E1.0111.00
259_V271_L1.0091.00
169_Q172_V1.0051.00
342_N350_H1.0031.00
342_N346_K0.9971.00
81_T288_G0.9961.00
276_L294_A0.9911.00
82_I309_V0.9901.00
141_L176_E0.9841.00
200_A203_D0.9831.00
235_D295_R0.9811.00
73_P314_L0.9781.00
116_A198_I0.9771.00
98_L217_I0.9681.00
150_R166_D0.9631.00
104_Q209_K0.9491.00
103_F226_V0.9481.00
217_I225_I0.9461.00
236_L258_L0.9461.00
329_L362_V0.9391.00
105_E208_L0.9361.00
332_G335_G0.9361.00
92_S198_I0.9301.00
120_P196_S0.9271.00
60_A386_A0.9271.00
88_V202_V0.9251.00
108_Q203_D0.9241.00
82_I303_L0.9201.00
108_Q301_D0.9141.00
284_D287_T0.9051.00
210_Q224_G0.9031.00
233_P297_N0.9021.00
166_D169_Q0.9011.00
345_N387_K0.8991.00
264_D269_K0.8971.00
158_N162_R0.8971.00
85_A235_D0.8941.00
116_A209_K0.8861.00
339_W384_E0.8781.00
263_W269_K0.8781.00
121_S191_L0.8781.00
171_L175_T0.8741.00
99_I117_E0.8741.00
94_V123_F0.8721.00
324_I338_V0.8691.00
276_L292_V0.8681.00
275_T297_N0.8671.00
116_A225_I0.8661.00
341_L345_N0.8641.00
144_A175_T0.8641.00
137_D182_D0.8621.00
141_L179_I0.8601.00
263_W272_S0.8581.00
128_A187_A0.8571.00
342_N345_N0.8561.00
127_L190_Q0.8541.00
107_Q113_D0.8501.00
140_T174_E0.8471.00
126_A192_Q0.8441.00
259_V269_K0.8441.00
103_F209_K0.8401.00
59_L387_K0.8391.00
129_Q133_Q0.8381.00
95_D218_S0.8371.00
69_E322_V0.8371.00
355_G362_V0.8361.00
74_R247_T0.8341.00
151_Y164_E0.8331.00
375_V382_L0.8311.00
103_F206_V0.8261.00
298_N301_D0.8251.00
202_V228_I0.8241.00
85_A230_Q0.8231.00
62_V375_V0.8221.00
349_K384_E0.8191.00
138_K179_I0.8191.00
234_I305_P0.8181.00
347_V388_V0.8121.00
143_N170_A0.8121.00
147_D163_Q0.8101.00
140_T178_T0.8091.00
137_D175_T0.8061.00
117_E120_P0.8051.00
240_L292_V0.8051.00
140_T171_L0.8031.00
84_A305_P0.8031.00
68_V370_A0.8021.00
332_G337_F0.8021.00
130_A182_D0.8021.00
92_S217_I0.8011.00
75_Y314_L0.8001.00
146_R149_A0.7961.00
126_A188_S0.7941.00
71_A317_T0.7901.00
210_Q227_V0.7891.00
168_Q171_L0.7861.00
350_H369_S0.7851.00
143_N167_A0.7851.00
140_T143_N0.7851.00
341_L347_V0.7821.00
65_A325_P0.7801.00
73_P317_T0.7761.00
86_N213_V0.7751.00
259_V310_N0.7731.00
330_Q337_F0.7711.00
364_I368_I0.7681.00
175_T178_T0.7681.00
171_L174_E0.7651.00
261_E264_D0.7641.00
318_E321_A0.7641.00
329_L336_H0.7631.00
135_A180_K0.7621.00
182_D185_S0.7621.00
272_S300_D0.7601.00
99_I120_P0.7601.00
327_A377_D0.7591.00
120_P197_R0.7581.00
126_A130_A0.7561.00
146_R166_D0.7561.00
204_G228_I0.7551.00
143_N146_R0.7541.00
261_E310_N0.7541.00
189_A192_Q0.7521.00
383_T386_A0.7491.00
314_L317_T0.7481.00
342_N372_D0.7471.00
133_Q185_S0.7461.00
258_L262_A0.7461.00
354_P364_I0.7441.00
86_N212_D0.7441.00
132_G184_A0.7421.00
336_H354_P0.7401.00
131_Q186_V0.7381.00
97_Q216_Q0.7311.00
240_L248_V0.7301.00
279_L292_V0.7281.00
347_V382_L0.7261.00
87_T229_T0.7241.00
140_T144_A0.7241.00
341_L375_V0.7221.00
337_F351_L0.7201.00
350_H367_G0.7191.00
105_E209_K0.7171.00
101_L116_A0.7131.00
373_R390_V0.7101.00
72_V358_D0.7081.00
191_L194_D0.7071.00
108_Q231_T0.7051.00
250_Q279_L0.7011.00
85_A295_R0.7011.00
74_R316_D0.7001.00
93_R122_Q0.7001.00
65_A68_V0.6971.00
191_L195_W0.6961.00
91_R221_D0.6951.00
137_D140_T0.6931.00
76_L244_D0.6921.00
178_T182_D0.6911.00
249_V252_Q0.6891.00
67_A368_I0.6861.00
59_L389_E0.6831.00
238_F313_M0.6831.00
339_W349_K0.6831.00
185_S189_A0.6831.00
80_G309_V0.6811.00
345_N373_R0.6811.00
339_W347_V0.6801.00
339_W382_L0.6781.00
92_S116_A0.6741.00
78_G238_F0.6711.00
175_T179_I0.6641.00
150_R154_L0.6571.00
338_V374_V0.6571.00
98_L225_I0.6561.00
83_T235_D0.6521.00
134_L183_E0.6511.00
355_G367_G0.6481.00
343_S373_R0.6471.00
95_D216_Q0.6421.00
361_K365_R0.6371.00
174_E178_T0.6361.00
65_A324_I0.6361.00
328_A376_T0.6331.00
160_V165_L0.6321.00
258_L274_G0.6311.00
125_V191_L0.6291.00
205_R231_T0.6281.00
160_V164_E0.6251.00
221_D224_G0.6241.00
130_A189_A0.6221.00
99_I102_H0.6211.00
338_V367_G0.6211.00
91_R224_G0.6191.00
324_I329_L0.6171.00
151_Y154_L0.6161.00
324_I328_A0.6151.00
189_A193_L0.6141.00
65_A361_K0.6131.00
64_A376_T0.6111.00
138_K141_L0.6111.00
263_W270_K0.6091.00
76_L315_V0.6091.00
67_A372_D0.6061.00
181_A185_S0.6051.00
133_Q137_D0.6051.00
161_S164_E0.6051.00
109_V115_L0.6041.00
147_D171_L0.6041.00
78_G244_D0.6031.00
260_V303_L0.6021.00
155_A158_N0.6021.00
248_V276_L0.6021.00
232_H299_Q0.6001.00
84_A229_T0.5991.00
57_G387_K0.5971.00
184_A187_A0.5971.00
164_E168_Q0.5971.00
258_L311_A0.5971.00
194_D199_T0.5961.00
68_V361_K0.5931.00
232_H301_D0.5931.00
78_G313_M0.5921.00
211_V217_I0.5921.00
78_G240_L0.5901.00
345_N390_V0.5881.00
152_Q155_A0.5871.00
130_A133_Q0.5851.00
162_R169_Q0.5841.00
277_L293_K0.5841.00
170_A174_E0.5791.00
90_V201_P0.5791.00
63_Q391_V0.5781.00
325_P328_A0.5781.00
131_Q138_K0.5761.00
234_I298_N0.5761.00
236_L296_F0.5751.00
86_N202_V0.5741.00
66_T69_E0.5741.00
140_T175_T0.5741.00
155_A160_V0.5721.00
122_Q192_Q0.5691.00
146_R170_A0.5691.00
274_G296_F0.5681.00
331_M334_E0.5681.00
89_T215_N0.5671.00
235_D277_L0.5661.00
322_V367_G0.5651.00
234_I296_F0.5651.00
382_L388_V0.5631.00
147_D168_Q0.5571.00
72_V323_V0.5571.00
329_L352_V0.5571.00
304_F307_Q0.5571.00
253_K314_L0.5571.00
72_V363_V0.5571.00
340_V374_V0.5561.00
330_Q339_W0.5561.00
144_A171_L0.5551.00
182_D186_V0.5541.00
239_T284_D0.5541.00
162_R165_L0.5541.00
253_K257_P0.5531.00
270_K300_D0.5531.00
127_L193_L0.5521.00
72_V356_I0.5511.00
74_R356_I0.5511.00
254_A258_L0.5501.00
251_A275_T0.5491.00
185_S188_S0.5481.00
211_V215_N0.5481.00
88_V228_I0.5441.00
90_V226_V0.5441.00
242_E308_F0.5411.00
90_V202_V0.5401.00
134_L141_L0.5381.00
147_D150_R0.5381.00
262_A307_Q0.5361.00
74_R315_V0.5351.00
198_I225_I0.5341.00
283_I288_G0.5321.00
123_F127_L0.5291.00
80_G236_L0.5291.00
123_F192_Q0.5291.00
82_I296_F0.5281.00
323_V363_V0.5281.00
229_T281_N0.5271.00
151_Y155_A0.5271.00
102_H113_D0.5271.00
92_S225_I0.5201.00
224_G227_V0.5201.00
101_L209_K0.5181.00
120_P193_L0.5181.00
154_L158_N0.5181.00
111_A201_P0.5161.00
92_S118_I0.5151.00
65_A69_E0.5111.00
103_F107_Q0.5111.00
178_T181_A0.5101.00
148_L151_Y0.5101.00
192_Q195_W0.5101.00
264_D270_K0.5091.00
78_G311_A0.5081.00
347_V387_K0.5081.00
76_L313_M0.5071.00
139_A143_N0.5061.00
138_K190_Q0.5051.00
341_L344_E0.5051.00
338_V372_D0.5051.00
154_L161_S0.5031.00
229_T305_P0.5021.00
170_A177_G0.5011.00
137_D141_L0.5011.00
112_G199_T0.5011.00
269_K272_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lnnA 6 0.7928 100 0.286 Contact Map
1vf7A 5 0.5446 100 0.295 Contact Map
4dk0A 5 0.7325 100 0.311 Contact Map
3ne5B 3 0.7735 100 0.316 Contact Map
4l8jA 2 0.7566 100 0.329 Contact Map
3fppA 3 0.5976 100 0.335 Contact Map
4kkuA 1 0.6386 100 0.379 Contact Map
2f1mA 2 0.5614 100 0.443 Contact Map
4tkoB 1 0.5614 100 0.519 Contact Map
2k32A 1 0.2771 99.9 0.726 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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