GREMLIN Database
YEGL - Uncharacterized protein YegL
UniProt: P76396 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14055
Length: 219 (176)
Sequences: 7970 (5066)
Seq/√Len: 381.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_V85_P3.7801.00
49_D81_A3.6511.00
23_I64_G2.9741.00
45_V81_A2.5591.00
21_P62_E2.4991.00
103_A126_I2.4661.00
28_V67_T2.3681.00
184_Q187_E2.2591.00
25_L103_A2.2391.00
26_L44_L2.1991.00
21_P124_P2.1611.00
94_T131_D2.1101.00
24_L44_L2.0621.00
138_W142_A2.0391.00
166_M181_Q2.0091.00
139_Q171_Q1.9781.00
71_V102_K1.8951.00
143_N151_D1.8561.00
25_L126_I1.8411.00
76_P79_S1.8221.00
100_I145_V1.8011.00
138_W141_A1.7931.00
101_T105_D1.7861.00
174_V178_L1.7831.00
37_I41_N1.7011.00
95_P98_A1.6941.00
166_M170_A1.6911.00
31_S94_T1.6871.00
31_S131_D1.6531.00
100_I126_I1.6491.00
104_L152_K1.6481.00
67_T74_E1.6311.00
96_M128_L1.6191.00
104_L145_V1.6161.00
28_V37_I1.5531.00
26_L40_L1.5361.00
125_W157_F1.4801.00
134_P168_T1.4681.00
44_L84_F1.4431.00
48_R63_L1.4421.00
167_K171_Q1.4311.00
108_E152_K1.4281.00
142_A146_F1.4211.00
38_N41_N1.4091.00
158_S173_S1.4011.00
73_V102_K1.3911.00
35_R38_N1.3791.00
158_S169_L1.3761.00
101_T141_A1.3651.00
167_K170_A1.3441.00
126_I156_F1.3351.00
141_A144_K1.3351.00
160_G169_L1.3221.00
133_A165_D1.3201.00
48_R80_A1.3181.00
141_A145_V1.2781.00
46_T189_F1.2681.00
104_L144_K1.2671.00
155_A178_L1.2631.00
24_L47_F1.2581.00
96_M134_P1.2571.00
23_I66_V1.2411.00
23_I103_A1.2361.00
102_K106_M1.2221.00
47_F51_L1.2181.00
139_Q142_A1.2141.00
129_I161_V1.2131.00
48_R84_F1.2041.00
23_I107_V1.2031.00
42_A46_T1.2011.00
146_F174_V1.1981.00
46_T49_D1.1961.00
41_N84_F1.1431.00
66_V99_A1.1381.00
139_Q143_N1.1311.00
78_T82_N1.1261.00
64_G107_V1.1231.00
123_R155_A1.1201.00
94_T132_G1.1151.00
77_F81_A1.0931.00
80_A83_F1.0851.00
93_D135_T1.0831.00
102_K105_D1.0811.00
140_A143_N1.0571.00
49_D77_F1.0511.00
143_N146_F1.0461.00
142_A145_V1.0411.00
100_I172_I1.0291.00
66_V71_V1.0291.00
22_C125_W1.0251.00
50_E193_S1.0201.00
95_P135_T1.0111.00
68_F96_M0.9931.00
104_L141_A0.9841.00
79_S82_N0.9771.00
187_E190_S0.9771.00
97_G141_A0.9711.00
28_V90_A0.9681.00
100_I156_F0.9661.00
144_K151_D0.9621.00
33_N36_P0.9611.00
66_V103_A0.9601.00
30_G92_G0.9591.00
39_E42_A0.9571.00
82_N86_P0.9521.00
97_G136_D0.9451.00
164_A181_Q0.9421.00
101_T144_K0.9351.00
27_D132_G0.9261.00
30_G90_A0.9241.00
28_V88_L0.9051.00
66_V102_K0.8971.00
191_W194_S0.8961.00
50_E196_L0.8941.00
160_G179_P0.8931.00
108_E113_E0.8911.00
20_C125_W0.8851.00
25_L66_V0.8801.00
19_R122_Y0.8691.00
45_V86_P0.8631.00
161_V185_F0.8631.00
170_A174_V0.8501.00
109_E113_E0.8471.00
36_P39_E0.8451.00
71_V99_A0.8441.00
70_P93_D0.8401.00
126_I154_F0.8281.00
24_L127_F0.8251.00
128_L158_S0.8241.00
166_M179_P0.8231.00
64_G106_M0.8211.00
77_F80_A0.8171.00
173_S179_P0.8161.00
39_E186_R0.8131.00
100_I128_L0.8121.00
137_E140_A0.8071.00
51_L61_V0.8061.00
109_E112_R0.7981.00
158_S179_P0.7971.00
46_T50_E0.7951.00
20_C61_V0.7921.00
157_F198_S0.7851.00
24_L63_L0.7831.00
157_F178_L0.7821.00
34_G38_N0.7811.00
170_A176_Q0.7731.00
157_F195_S0.7711.00
105_D108_E0.7671.00
30_G131_D0.7601.00
189_F192_L0.7581.00
160_G181_Q0.7571.00
38_N42_A0.7531.00
175_R178_L0.7521.00
67_T72_H0.7521.00
30_G91_Q0.7511.00
162_Q165_D0.7491.00
104_L154_F0.7481.00
126_I145_V0.7401.00
33_N89_F0.7401.00
36_P89_F0.7391.00
58_L61_V0.7371.00
128_L172_I0.7351.00
145_V154_F0.7341.00
67_T90_A0.7331.00
125_W199_V0.7321.00
79_S83_F0.7311.00
70_P95_P0.7281.00
170_A179_P0.7281.00
107_V126_I0.7271.00
138_W146_F0.7231.00
27_D31_S0.7231.00
67_T88_L0.7191.00
140_A144_K0.7171.00
42_A45_V0.7091.00
165_D168_T0.7091.00
69_G95_P0.7091.00
48_R81_A0.7081.00
32_M36_P0.7071.00
128_L156_F0.7041.00
48_R77_F0.7041.00
45_V49_D0.7011.00
37_I40_L0.6990.99
24_L40_L0.6940.99
41_N45_V0.6890.99
55_P60_R0.6860.99
28_V72_H0.6850.99
98_A102_K0.6810.99
22_C63_L0.6800.99
134_P138_W0.6780.99
71_V98_A0.6780.99
156_F172_I0.6760.99
56_L63_L0.6710.99
137_E141_A0.6690.99
99_A103_A0.6680.99
101_T104_L0.6660.99
70_P92_G0.6610.99
65_I87_I0.6560.99
82_N85_P0.6540.99
98_A101_T0.6540.99
43_G47_F0.6510.99
69_G90_A0.6480.99
71_V95_P0.6430.99
132_G169_L0.6410.99
97_G134_P0.6340.99
29_S94_T0.6320.99
66_V107_V0.6270.99
32_M94_T0.6270.99
141_A146_F0.6250.99
78_T81_A0.6240.99
80_A84_F0.6200.99
72_H90_A0.6110.99
74_E83_F0.6050.99
103_A107_V0.5980.98
188_L192_L0.5970.98
45_V48_R0.5960.98
73_V107_V0.5930.98
28_V69_G0.5900.98
31_S132_G0.5880.98
94_T130_T0.5870.98
20_C123_R0.5810.98
93_D131_D0.5810.98
96_M130_T0.5780.98
159_I188_L0.5750.98
16_P200_S0.5700.98
96_M168_T0.5670.98
190_S194_S0.5670.98
192_L195_S0.5630.98
68_F99_A0.5580.98
110_R113_E0.5530.97
143_N175_R0.5510.97
22_C47_F0.5430.97
39_E185_F0.5430.97
81_A85_P0.5420.97
62_E75_Q0.5420.97
182_G191_W0.5410.97
73_V106_M0.5400.97
130_T158_S0.5370.97
125_W155_A0.5370.97
26_L65_I0.5360.97
40_L129_I0.5360.97
23_I126_I0.5350.97
138_W168_T0.5350.97
43_G188_L0.5330.97
183_L187_E0.5320.97
146_F156_F0.5320.97
32_M40_L0.5310.97
168_T172_I0.5310.97
180_L191_W0.5270.97
160_G164_A0.5250.96
145_V156_F0.5220.96
35_R39_E0.5210.96
41_N87_I0.5150.96
96_M172_I0.5140.96
108_E111_K0.5130.96
127_F159_I0.5130.96
57_A62_E0.5130.96
142_A172_I0.5100.96
124_P154_F0.5080.96
180_L195_S0.5060.96
25_L99_A0.5030.95
103_A145_V0.5030.95
97_G101_T0.5010.95
169_L179_P0.5000.95
134_P142_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4okrA 1 0.8402 100 0.372 Contact Map
4okuA 2 0.8584 100 0.374 Contact Map
4cn9A 1 0.8767 100 0.387 Contact Map
4nehA 1 0.9269 100 0.388 Contact Map
4igiA 1 0.8265 100 0.398 Contact Map
4f1jA 1 0.8174 99.9 0.408 Contact Map
3zqkA 1 0.7854 99.9 0.41 Contact Map
1ijbA 1 0.8539 99.9 0.41 Contact Map
3n2nF 5 0.79 99.9 0.413 Contact Map
4hqoA 1 0.9315 99.9 0.419 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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