GREMLIN Database
YEGK - Uncharacterized protein YegK
UniProt: P76395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14054
Length: 253 (212)
Sequences: 9550 (6839)
Seq/√Len: 469.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_L134_V4.7101.00
26_C245_T4.5061.00
42_V249_A3.1481.00
169_L175_T3.0881.00
48_A111_A2.9571.00
126_I134_V2.8081.00
152_E156_M2.8021.00
117_L181_V2.7621.00
133_G148_P2.7361.00
144_L194_N2.6841.00
188_I244_K2.6771.00
147_T156_M2.6491.00
137_D142_L2.3221.00
184_F189_Q2.2621.00
138_L179_H2.1911.00
180_K250_L2.1841.00
45_A112_C2.1821.00
19_D243_D2.1611.00
21_P55_G2.0281.00
116_G127_M2.0261.00
8_A228_K1.9001.00
191_L241_D1.8701.00
117_L183_A1.8601.00
161_T164_D1.8401.00
93_R97_F1.8381.00
89_V114_F1.8351.00
59_M63_N1.8201.00
188_I230_F1.7261.00
224_P228_K1.7021.00
128_Q146_L1.6901.00
61_A112_C1.6451.00
9_S22_C1.6281.00
117_L124_T1.6271.00
233_S238_E1.6131.00
89_V116_G1.6121.00
13_T236_V1.6011.00
60_L64_E1.5821.00
68_Y91_T1.5791.00
207_P211_G1.5651.00
89_V127_M1.5631.00
136_V143_Q1.5371.00
64_E95_R1.5341.00
124_T181_V1.5181.00
228_K232_S1.5141.00
45_A114_F1.4921.00
115_L183_A1.4911.00
236_V240_T1.4861.00
91_T95_R1.4391.00
136_V181_V1.4291.00
42_V247_A1.3871.00
25_A58_A1.3851.00
64_E67_A1.3621.00
154_A158_H1.3501.00
10_T236_V1.3461.00
240_T244_K1.3381.00
8_A231_L1.3301.00
56_E60_L1.3191.00
94_Q98_A1.3171.00
207_P238_E1.3101.00
182_A248_L1.3041.00
48_A51_V1.2921.00
209_F212_L1.2911.00
115_L128_Q1.2761.00
138_L178_A1.2731.00
53_Q107_V1.2721.00
133_G194_N1.2651.00
158_H162_D1.2611.00
117_L126_I1.2591.00
10_T243_D1.2501.00
164_D167_S1.2371.00
25_A55_G1.2301.00
157_T161_T1.2211.00
86_T90_L1.2171.00
27_Q66_M1.2041.00
113_T132_G1.2041.00
235_A240_T1.1941.00
229_Q233_S1.1821.00
232_S237_N1.1791.00
64_E92_I1.1751.00
22_C243_D1.1741.00
43_F65_A1.1641.00
156_M159_F1.1641.00
85_A127_M1.1491.00
209_F213_A1.1441.00
136_V179_H1.1421.00
155_N165_A1.1251.00
227_L230_F1.1171.00
43_F116_G1.1131.00
81_N125_L1.1081.00
169_L172_F1.1071.00
207_P233_S1.1041.00
229_Q232_S1.1031.00
65_A114_F1.0851.00
147_T153_Y1.0781.00
133_G144_L1.0521.00
137_D180_K1.0491.00
68_Y71_Q1.0401.00
188_I246_L1.0391.00
138_L143_Q1.0381.00
39_L120_S1.0351.00
82_D86_T1.0301.00
211_G233_S1.0041.00
43_F62_V0.9931.00
193_L207_P0.9921.00
133_G146_L0.9891.00
69_M88_M0.9881.00
95_R98_A0.9851.00
160_I168_R0.9821.00
192_A233_S0.9811.00
28_M247_A0.9771.00
9_S245_T0.9741.00
182_A246_L0.9731.00
112_C132_G0.9691.00
170_E173_T0.9681.00
84_L88_M0.9671.00
231_L246_L0.9671.00
8_A227_L0.9491.00
233_S237_N0.9441.00
45_A62_V0.9351.00
138_L176_G0.9321.00
137_D209_F0.9301.00
27_Q43_F0.9291.00
207_P210_N0.9191.00
172_F175_T0.9161.00
95_R99_E0.9111.00
153_Y156_M0.9111.00
227_L231_L0.9071.00
44_V245_T0.9071.00
230_F235_A0.9061.00
225_E229_Q0.9041.00
211_G215_A0.9011.00
88_M92_I0.8881.00
215_A226_L0.8841.00
99_E104_E0.8821.00
60_L99_E0.8731.00
208_F212_L0.8721.00
180_K248_L0.8711.00
227_L246_L0.8691.00
136_V178_A0.8531.00
240_T243_D0.8531.00
39_L118_I0.8511.00
26_C247_A0.8481.00
23_Q50_S0.8471.00
195_M210_N0.8451.00
25_A59_M0.8411.00
42_V183_A0.8411.00
53_Q96_L0.8381.00
30_I40_L0.8351.00
155_N158_H0.8351.00
10_T231_L0.8331.00
180_K226_L0.8301.00
54_G58_A0.8221.00
160_I164_D0.8221.00
207_P212_L0.8201.00
136_V145_P0.8161.00
231_L235_A0.8151.00
83_V87_N0.8141.00
27_Q45_A0.8101.00
171_T175_T0.8021.00
87_N91_T0.8011.00
41_S118_I0.7961.00
235_A244_K0.7961.00
107_V110_F0.7941.00
181_V251_W0.7921.00
64_E68_Y0.7901.00
115_L146_L0.7881.00
191_L240_T0.7841.00
25_A62_V0.7841.00
160_I165_A0.7801.00
231_L236_V0.7781.00
138_L141_G0.7771.00
184_F188_I0.7761.00
158_H161_T0.7681.00
227_L248_L0.7631.00
93_R96_L0.7621.00
120_S125_L0.7511.00
128_Q134_V0.7491.00
29_Q66_M0.7491.00
236_V244_K0.7451.00
192_A238_E0.7451.00
228_K231_L0.7451.00
189_Q208_F0.7431.00
161_T165_A0.7411.00
60_L63_N0.7411.00
115_L132_G0.7401.00
215_A229_Q0.7371.00
227_L235_A0.7361.00
128_Q149_M0.7361.00
153_Y157_T0.7351.00
60_L95_R0.7331.00
142_L209_F0.7321.00
91_T94_Q0.7321.00
218_E248_L0.7291.00
104_E107_V0.7281.00
85_A116_G0.7261.00
213_A216_T0.7261.00
182_A212_L0.7251.00
44_V185_T0.7241.00
155_N160_I0.7231.00
90_L94_Q0.7221.00
147_T152_E0.7211.00
60_L96_L0.7161.00
21_P243_D0.7121.00
43_F114_F0.7061.00
80_L83_V0.7021.00
151_G154_A0.7001.00
28_M42_V0.6991.00
57_G112_C0.6931.00
166_V193_L0.6911.00
69_M84_L0.6901.00
171_T174_S0.6891.00
135_V194_N0.6881.00
131_D186_D0.6861.00
19_D49_G0.6801.00
65_A88_M0.6791.00
119_S124_T0.6701.00
56_E59_M0.6691.00
92_I96_L0.6651.00
135_V189_Q0.6631.00
68_Y72_K0.6631.00
235_A239_R0.6591.00
93_R129_I0.6581.00
44_V115_L0.6581.00
137_D179_H0.6571.00
139_G176_G0.6501.00
186_D242_D0.6471.00
142_L195_M0.6441.00
226_L229_Q0.6441.00
225_E228_K0.6411.00
66_M70_S0.6411.00
139_G179_H0.6401.00
151_G170_E0.6381.00
176_G179_H0.6371.00
125_L128_Q0.6371.00
23_Q56_E0.6371.00
119_S181_V0.6361.00
41_S45_A0.6361.00
135_V182_A0.6311.00
182_A208_F0.6311.00
105_L108_R0.6280.99
208_F213_A0.6260.99
45_A51_V0.6220.99
142_L212_L0.6220.99
135_V184_F0.6220.99
224_P230_F0.6210.99
10_T13_T0.6180.99
26_C185_T0.6160.99
41_S116_G0.6130.99
113_T186_D0.6110.99
99_E107_V0.6080.99
51_V55_G0.6060.99
165_A168_R0.6020.99
49_G54_G0.5980.99
10_T244_K0.5960.99
27_Q62_V0.5960.99
182_A188_I0.5940.99
54_G112_C0.5940.99
85_A88_M0.5930.99
151_G159_F0.5920.99
148_P194_N0.5860.99
217_Q225_E0.5860.99
50_S54_G0.5860.99
81_N118_I0.5860.99
208_F211_G0.5830.99
83_V86_T0.5820.99
171_T190_R0.5770.99
154_A159_F0.5760.99
68_Y88_M0.5750.99
137_D213_A0.5740.99
160_I167_S0.5730.99
211_G229_Q0.5700.99
61_A96_L0.5650.99
211_G216_T0.5630.99
236_V243_D0.5620.99
210_N214_A0.5600.99
169_L174_S0.5570.99
137_D212_L0.5530.99
126_I146_L0.5530.99
150_A190_R0.5510.99
162_D166_V0.5510.99
210_N213_A0.5500.99
62_V66_M0.5490.99
215_A225_E0.5470.99
72_K87_N0.5460.99
61_A65_A0.5440.99
48_A54_G0.5420.98
152_E155_N0.5400.98
120_S123_G0.5390.98
64_E91_T0.5380.98
111_A114_F0.5370.98
19_D22_C0.5360.98
23_Q190_R0.5360.98
19_D50_S0.5350.98
97_F100_A0.5350.98
188_I192_A0.5340.98
51_V54_G0.5340.98
119_S249_A0.5330.98
113_T131_D0.5330.98
61_A114_F0.5320.98
77_E80_L0.5320.98
77_E81_N0.5290.98
215_A218_E0.5290.98
41_S66_M0.5220.98
135_V142_L0.5220.98
89_V93_R0.5170.98
235_A238_E0.5140.98
10_T240_T0.5140.98
76_G79_G0.5110.98
41_S62_V0.5110.98
53_Q56_E0.5110.98
195_M209_F0.5110.98
54_G57_G0.5100.98
160_I163_E0.5090.98
63_N67_A0.5080.98
214_A218_E0.5040.98
164_D168_R0.5030.98
98_A103_K0.5020.98
159_F163_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p8eA 1 0.8933 100 0.19 Contact Map
4ra2A 1 0.9249 100 0.199 Contact Map
3qn1B 1 0.913 100 0.206 Contact Map
4oicB 1 0.9091 100 0.208 Contact Map
3kdjB 1 0.8933 100 0.211 Contact Map
4n0gA 1 0.8933 100 0.212 Contact Map
4yzgA 2 0.9091 100 0.213 Contact Map
2i0oA 2 0.8696 100 0.227 Contact Map
2i44A 1 0.9051 100 0.23 Contact Map
2iq1A 1 0.8498 100 0.23 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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