GREMLIN Database
YEGH - UPF0053 protein YegH
UniProt: P76389 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14051
Length: 527 (423)
Sequences: 1385 (876)
Seq/√Len: 42.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_N110_E4.4491.00
378_F387_A4.1421.00
484_R490_E3.9281.00
106_N109_L3.8241.00
105_L109_L3.6721.00
103_M109_L3.2931.00
103_M110_E3.2181.00
478_L512_V3.1521.00
312_I411_I3.1511.00
491_E500_K3.1161.00
105_L110_E3.0971.00
99_F102_T3.0971.00
102_T109_L3.0111.00
109_L112_K2.9741.00
103_M106_N2.8811.00
340_D346_D2.8721.00
105_L108_R2.8701.00
102_T106_N2.7941.00
319_A323_E2.7411.00
493_Q498_L2.7211.00
102_T110_E2.6861.00
447_T502_L2.6631.00
120_R134_V2.6541.00
500_K515_I2.6281.00
320_P323_E2.6251.00
448_A514_I2.5681.00
102_T105_L2.5081.00
106_N112_K2.4791.00
491_E498_L2.4521.00
104_E110_E2.4401.00
98_L102_T2.4311.00
108_R111_G2.4081.00
302_V387_A2.3541.00
106_N111_G2.3421.00
99_F109_L2.2951.00
498_L515_I2.2731.00
99_F103_M2.2701.00
447_T511_K2.2561.00
103_M112_K2.2491.00
108_R112_K2.2311.00
314_H339_T2.2161.00
109_L114_S2.1681.00
99_F110_E2.1420.99
102_T108_R2.1390.99
103_M108_R2.1200.99
109_L113_D2.1120.99
387_A412_V2.1030.99
105_L113_D2.0850.99
200_L249_T2.0660.99
104_E109_L2.0500.99
101_A108_R2.0380.99
505_E510_Q2.0160.99
111_G114_S2.0040.99
110_E113_D1.9960.99
101_A105_L1.9900.99
339_T347_L1.9890.99
110_E114_S1.9620.99
103_M111_G1.9260.99
104_E108_R1.9040.99
98_L105_L1.8880.99
315_I324_I1.8830.99
104_E112_K1.8560.99
305_I384_L1.8560.99
98_L109_L1.8470.98
124_K127_G1.8270.98
157_M160_A1.8180.98
99_F106_N1.7960.98
106_N113_D1.7870.98
105_L111_G1.7850.98
355_D373_R1.7730.98
474_I512_V1.7510.98
94_G98_L1.7260.98
102_T114_S1.7190.98
477_L494_V1.7070.97
442_A445_S1.6950.97
98_L103_M1.6750.97
101_A110_E1.6670.97
102_T113_D1.6480.97
382_L390_Q1.6400.97
503_Q510_Q1.6280.97
156_V202_A1.6160.96
186_V189_C1.5920.96
108_R113_D1.5810.96
100_K103_M1.5720.96
102_T111_G1.5500.95
218_I221_S1.5440.95
350_V398_F1.5370.95
448_A457_L1.5340.95
128_V131_Q1.5340.95
419_E428_E1.5300.95
159_A202_A1.5290.95
479_M509_V1.5150.95
109_L115_N1.5140.95
99_F105_L1.5060.95
290_M421_I1.5030.95
102_T112_K1.4900.94
99_F104_E1.4760.94
457_L461_V1.4520.94
107_E110_E1.4510.93
106_N114_S1.4510.93
326_Q330_R1.4330.93
105_L112_K1.4270.93
99_F114_S1.4240.93
110_E115_N1.4150.93
345_E407_S1.4000.92
351_V372_I1.3940.92
242_N246_R1.3750.91
338_V372_I1.3680.91
185_I189_C1.3590.91
99_F108_R1.3440.91
101_A109_L1.3430.91
384_L417_V1.3280.90
98_L110_E1.3190.90
457_L514_I1.3170.90
347_L400_F1.3090.89
98_L111_G1.3090.89
478_L501_T1.3050.89
317_L372_I1.3030.89
100_K110_E1.2910.89
104_E229_Q1.2900.89
315_I368_L1.2630.88
502_L513_Q1.2600.87
127_G131_Q1.2520.87
157_M199_S1.2520.87
120_R124_K1.2410.87
340_D369_R1.2380.87
102_T156_V1.2360.86
101_A104_E1.2350.86
422_A425_L1.2160.85
100_K104_E1.2120.85
312_I408_V1.2110.85
398_F411_I1.2090.85
98_L101_A1.2020.85
157_M195_M1.1960.85
463_L497_Y1.1870.84
149_G153_H1.1830.84
415_S428_E1.1810.84
105_L114_S1.1800.84
146_T160_A1.1760.84
160_A163_I1.1740.83
103_M114_S1.1730.83
496_D517_L1.1720.83
478_L499_L1.1620.83
151_V160_A1.1560.82
499_L514_I1.1550.82
163_I198_F1.1550.82
160_A199_S1.1500.82
145_I153_H1.1350.81
95_F98_L1.1340.81
96_F100_K1.1330.81
441_N445_S1.1320.81
142_D212_G1.1250.81
106_N115_N1.1170.80
335_R415_S1.1150.80
101_A106_N1.1100.80
119_Q122_G1.1090.80
98_L108_R1.1080.80
104_E111_G1.0990.79
494_V499_L1.0930.79
403_D406_G1.0930.79
149_G160_A1.0870.78
100_K106_N1.0850.78
141_L144_V1.0830.78
351_V388_L1.0810.78
112_K115_N1.0750.78
99_F112_K1.0730.77
252_A256_L1.0730.77
312_I344_A1.0730.77
149_G152_D1.0610.77
164_A194_L1.0570.76
157_M164_A1.0570.76
160_A164_A1.0540.76
369_R372_I1.0530.76
146_T153_H1.0520.76
441_N503_Q1.0520.76
337_V400_F1.0470.76
120_R127_G1.0470.76
99_F111_G1.0460.76
103_M113_D1.0450.76
157_M165_I1.0400.75
145_I152_D1.0390.75
184_T188_L1.0350.75
123_A224_I1.0330.75
500_K513_Q1.0310.75
148_V161_V1.0250.74
441_N444_G1.0240.74
156_V195_M1.0200.74
105_L115_N1.0200.74
93_G100_K1.0170.74
91_L95_F1.0070.73
447_T513_Q1.0060.73
152_D208_V1.0010.72
103_M107_E0.9940.72
382_L387_A0.9920.72
294_V421_I0.9900.71
348_L372_I0.9900.71
225_E229_Q0.9900.71
497_Y514_I0.9850.71
101_A112_K0.9840.71
319_A496_D0.9830.71
335_R397_H0.9820.71
314_H344_A0.9770.70
498_L517_L0.9730.70
142_D146_T0.9730.70
313_E333_H0.9700.70
405_F450_G0.9700.70
239_L243_Q0.9660.70
108_R114_S0.9640.69
355_D429_V0.9630.69
475_A508_R0.9590.69
208_V223_M0.9580.69
317_L340_D0.9520.68
475_A479_M0.9490.68
415_S427_N0.9470.68
130_T228_N0.9440.68
187_I190_L0.9390.67
426_P430_E0.9370.67
112_K116_N0.9360.67
336_L353_V0.9350.67
160_A195_M0.9340.67
415_S419_E0.9280.66
409_E420_T0.9280.66
448_A460_Y0.9270.66
351_V371_L0.9250.66
445_S513_Q0.9240.66
150_M157_M0.9240.66
116_N119_Q0.9230.66
439_Q447_T0.9230.66
146_T149_G0.9210.66
205_F514_I0.9190.66
152_D207_F0.9160.65
338_V368_L0.9160.65
247_Q250_T0.9110.65
415_S425_L0.9110.65
499_L512_V0.9090.65
118_T121_K0.9080.65
244_T248_R0.9060.65
160_A194_L0.9050.64
141_L212_G0.9050.64
323_E326_Q0.9030.64
158_M161_V0.9030.64
405_F492_V0.9000.64
205_F516_P0.8980.64
389_E392_R0.8970.64
415_S420_T0.8970.64
98_L114_S0.8970.64
419_E430_E0.8960.64
164_A199_S0.8960.64
119_Q123_A0.8930.63
277_H283_F0.8900.63
98_L113_D0.8900.63
380_E409_E0.8860.63
160_A203_E0.8830.63
131_Q153_H0.8810.62
91_L94_G0.8810.62
113_D116_N0.8800.62
334_T514_I0.8780.62
441_N447_T0.8780.62
95_F99_F0.8780.62
141_L155_L0.8760.62
145_I149_G0.8740.62
427_N430_E0.8690.61
400_F411_I0.8680.61
148_V212_G0.8640.61
441_N513_Q0.8630.61
441_N510_Q0.8630.61
110_E116_N0.8600.61
164_A203_E0.8590.60
454_L500_K0.8550.60
144_V148_V0.8550.60
226_A233_F0.8540.60
400_F408_V0.8530.60
103_M115_N0.8520.60
310_H407_S0.8500.60
98_L106_N0.8500.60
342_D371_L0.8490.60
195_M202_A0.8460.59
466_D471_Y0.8410.59
150_M165_I0.8380.58
354_I387_A0.8340.58
355_D395_R0.8340.58
104_E107_E0.8340.58
266_L269_E0.8340.58
228_N232_I0.8330.58
277_H281_Q0.8300.58
144_V230_L0.8270.57
321_E371_L0.8260.57
317_L348_L0.8260.57
482_L492_V0.8240.57
344_A408_V0.8220.57
313_E336_L0.8190.57
248_R251_E0.8190.57
319_A324_I0.8170.57
425_L429_V0.8170.57
445_S500_K0.8160.56
109_L116_N0.8160.56
158_M202_A0.8130.56
107_E111_G0.8090.56
309_R345_E0.8080.56
274_L297_L0.8070.56
415_S422_A0.8070.56
359_Q366_L0.8070.56
454_L457_L0.8040.55
353_V412_V0.8020.55
91_L98_L0.8000.55
379_P404_E0.7980.55
143_S234_N0.7960.55
153_H160_A0.7950.54
120_R135_L0.7940.54
241_A245_L0.7930.54
452_M474_I0.7910.54
325_R478_L0.7910.54
129_V136_D0.7910.54
167_L307_T0.7900.54
335_R352_H0.7860.54
146_T152_D0.7860.54
438_I452_M0.7830.53
493_Q496_D0.7820.53
331_N336_L0.7820.53
270_T277_H0.7820.53
209_I307_T0.7750.53
153_H207_F0.7750.53
129_V196_I0.7740.53
102_T115_N0.7730.52
404_E473_T0.7710.52
270_T273_M0.7700.52
101_A113_D0.7670.52
211_K214_L0.7660.52
177_Q323_E0.7590.51
474_I511_K0.7580.51
384_L420_T0.7570.51
302_V378_F0.7550.51
146_T151_V0.7540.51
438_I513_Q0.7530.51
359_Q371_L0.7500.50
352_H355_D0.7480.50
145_I151_V0.7470.50
431_E490_E0.7450.50
99_F113_D0.7450.50
309_R406_G0.7440.50
128_V224_I0.7440.50
452_M457_L0.7410.49
299_Q449_N0.7410.49
510_Q513_Q0.7400.49
141_L233_F0.7400.49
367_N370_V0.7400.49
369_R381_T0.7360.49
100_K109_L0.7360.49
487_K490_E0.7330.49
352_H429_V0.7330.49
101_A111_G0.7310.48
379_P382_L0.7310.48
131_Q149_G0.7310.48
322_E500_K0.7300.48
324_I327_L0.7280.48
209_I257_L0.7280.48
150_M164_A0.7280.48
492_V499_L0.7260.48
160_A165_I0.7260.48
415_S429_V0.7240.48
357_L388_L0.7230.48
97_L100_K0.7230.48
121_K127_G0.7230.48
203_E212_G0.7230.48
125_F190_L0.7200.47
157_M215_Y0.7190.47
143_S147_A0.7180.47
309_R403_D0.7170.47
378_F401_V0.7150.47
195_M203_E0.7100.46
255_R261_K0.7100.46
145_I207_F0.7090.46
238_F244_T0.7080.46
440_K446_W0.7060.46
419_E427_N0.7060.46
287_E294_V0.7030.46
491_E501_T0.7030.46
398_F408_V0.7020.46
316_D342_D0.6980.45
193_L249_T0.6970.45
150_M233_F0.6960.45
161_V203_E0.6960.45
153_H208_V0.6960.45
181_S185_I0.6950.45
151_V199_S0.6920.45
335_R428_E0.6910.45
291_I358_Q0.6910.45
165_I199_S0.6890.44
386_P390_Q0.6880.44
309_R404_E0.6880.44
228_N231_A0.6880.44
337_V354_I0.6870.44
351_V462_P0.6870.44
496_D516_P0.6860.44
375_P402_V0.6860.44
141_L148_V0.6860.44
297_L385_L0.6850.44
441_N500_K0.6850.44
148_V157_M0.6830.44
156_V163_I0.6830.44
378_F412_V0.6830.44
121_K135_L0.6810.44
335_R430_E0.6810.44
415_S430_E0.6800.44
197_G512_V0.6790.44
403_D412_V0.6790.44
344_A446_W0.6790.44
192_F205_F0.6790.44
347_L512_V0.6780.43
144_V163_I0.6760.43
396_T457_L0.6740.43
129_V132_I0.6730.43
386_P466_D0.6700.43
337_V427_N0.6690.43
306_M421_I0.6690.43
133_V231_A0.6690.43
232_I346_D0.6670.42
128_V446_W0.6670.42
159_A163_I0.6590.42
251_E255_R0.6570.42
345_E380_E0.6560.41
301_T348_L0.6560.41
392_R466_D0.6550.41
99_F115_N0.6540.41
152_D160_A0.6520.41
209_I253_V0.6520.41
300_R304_S0.6470.41
141_L162_V0.6460.41
221_S225_E0.6460.41
129_V520_D0.6450.40
102_T107_E0.6440.40
184_T189_C0.6440.40
151_V163_I0.6410.40
240_S244_T0.6400.40
450_G474_I0.6400.40
198_F506_S0.6390.40
457_L474_I0.6380.40
469_R472_H0.6380.40
350_V375_P0.6370.40
159_A198_F0.6360.40
131_Q220_F0.6350.40
347_L475_A0.6340.39
465_L497_Y0.6340.39
407_S420_T0.6340.39
144_V233_F0.6340.39
345_E475_A0.6330.39
347_L387_A0.6310.39
134_V137_A0.6290.39
347_L377_V0.6290.39
352_H397_H0.6280.39
137_A144_V0.6280.39
194_L203_E0.6270.39
322_E519_K0.6250.39
274_L352_H0.6240.39
287_E418_T0.6240.39
488_P503_Q0.6220.38
101_A107_E0.6200.38
364_E367_N0.6200.38
238_F241_A0.6190.38
171_A213_Y0.6180.38
317_L369_R0.6180.38
164_A195_M0.6150.38
156_V160_A0.6150.38
106_N116_N0.6150.38
485_I504_V0.6140.38
91_L97_L0.6140.38
478_L482_L0.6130.38
121_K124_K0.6130.38
148_V155_L0.6130.38
135_L139_F0.6120.37
205_F222_V0.6110.37
299_Q459_Q0.6100.37
95_F102_T0.6080.37
337_V353_V0.6080.37
108_R116_N0.6060.37
96_F103_M0.6060.37
184_T187_I0.6060.37
241_A269_E0.6050.37
124_K131_Q0.6050.37
397_H415_S0.6030.37
184_T196_I0.6020.37
151_V207_F0.6020.37
290_M294_V0.6020.37
165_I194_L0.6000.36
356_L359_Q0.5990.36
132_I136_D0.5980.36
96_F104_E0.5970.36
415_S472_H0.5960.36
149_G208_V0.5960.36
510_Q515_I0.5960.36
92_F95_F0.5950.36
167_L310_H0.5940.36
170_M250_T0.5930.36
424_N428_E0.5900.36
132_I186_V0.5900.36
296_N459_Q0.5900.36
157_M202_A0.5870.35
95_F167_L0.5870.35
384_L456_D0.5870.35
157_M203_E0.5830.35
144_V212_G0.5830.35
291_I355_D0.5830.35
305_I412_V0.5820.35
196_I297_L0.5790.35
332_Q381_T0.5790.35
461_V499_L0.5770.34
146_T156_V0.5760.34
151_V157_M0.5760.34
278_G288_R0.5760.34
339_T344_A0.5750.34
135_L474_I0.5750.34
142_D250_T0.5740.34
227_L231_A0.5720.34
180_N185_I0.5720.34
111_G116_N0.5710.34
91_L99_F0.5710.34
161_V170_M0.5710.34
338_V412_V0.5700.34
162_V203_E0.5700.34
111_G115_N0.5700.34
455_E466_D0.5690.34
418_T422_A0.5690.34
238_F242_N0.5690.34
99_F107_E0.5690.34
133_V136_D0.5680.34
347_L408_V0.5670.34
100_K107_E0.5670.34
161_V198_F0.5660.33
137_A234_N0.5660.33
438_I448_A0.5650.33
143_S212_G0.5650.33
246_R249_T0.5650.33
152_D206_G0.5640.33
347_L497_Y0.5640.33
139_F178_F0.5630.33
197_G252_A0.5630.33
365_P519_K0.5630.33
134_V138_I0.5610.33
274_L328_L0.5610.33
395_R482_L0.5600.33
255_R512_V0.5600.33
279_N286_Q0.5590.33
318_N392_R0.5590.33
94_G99_F0.5580.33
141_L158_M0.5580.33
275_V465_L0.5560.33
389_E464_P0.5560.33
333_H339_T0.5550.33
172_S192_F0.5550.33
144_V234_N0.5550.33
321_E324_I0.5540.32
415_S424_N0.5530.32
195_M199_S0.5530.32
294_V448_A0.5530.32
337_V401_V0.5530.32
481_Y494_V0.5530.32
411_I508_R0.5530.32
421_I500_K0.5520.32
477_L499_L0.5520.32
233_F508_R0.5520.32
363_G366_L0.5510.32
453_P472_H0.5510.32
299_Q350_V0.5500.32
155_L159_A0.5470.32
269_E273_M0.5470.32
166_S249_T0.5460.32
293_R456_D0.5460.32
164_A215_Y0.5440.32
175_L401_V0.5440.32
493_Q517_L0.5440.32
123_A131_Q0.5430.32
231_A237_R0.5430.32
345_E421_I0.5430.32
175_L372_I0.5420.31
144_V202_A0.5420.31
150_M212_G0.5420.31
168_M176_T0.5410.31
263_D455_E0.5400.31
499_L509_V0.5390.31
449_N511_K0.5390.31
156_V159_A0.5380.31
161_V202_A0.5370.31
264_A350_V0.5360.31
212_G247_Q0.5360.31
312_I415_S0.5350.31
390_Q474_I0.5340.31
354_I485_I0.5330.31
273_M485_I0.5330.31
196_I199_S0.5330.31
120_R123_A0.5330.31
376_L399_A0.5320.31
320_P327_L0.5320.31
291_I388_L0.5310.31
339_T421_I0.5280.30
309_R416_D0.5270.30
360_S454_L0.5260.30
203_E247_Q0.5250.30
391_F399_A0.5250.30
169_L302_V0.5240.30
255_R375_P0.5220.30
158_M162_V0.5220.30
491_E502_L0.5210.30
141_L150_M0.5210.30
161_V164_A0.5200.30
307_T391_F0.5200.30
419_E424_N0.5190.30
133_V158_M0.5170.29
144_V161_V0.5160.29
334_T339_T0.5160.29
153_H156_V0.5160.29
104_E114_S0.5160.29
266_L284_N0.5150.29
175_L213_Y0.5140.29
167_L280_Q0.5140.29
178_F197_G0.5130.29
334_T354_I0.5130.29
104_E116_N0.5130.29
359_Q474_I0.5120.29
318_N342_D0.5110.29
161_V195_M0.5110.29
149_G163_I0.5100.29
142_D156_V0.5090.29
200_L204_G0.5090.29
306_M499_L0.5090.29
252_A255_R0.5080.29
388_L472_H0.5060.29
96_F105_L0.5060.29
171_A189_C0.5060.29
178_F185_I0.5050.29
285_P487_K0.5040.28
156_V203_E0.5020.28
156_V479_M0.5010.28
373_R428_E0.5010.28
155_L164_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.4383 100 0.68 Contact Map
3lhhA 1 0.2372 100 0.855 Contact Map
3ocoA 2 0.2562 99.9 0.864 Contact Map
3ocmA 5 0.2827 99.9 0.864 Contact Map
3oi8A 2 0.296 99.9 0.866 Contact Map
2v8qE 1 0.444 99.9 0.87 Contact Map
3dedA 2 0.1651 99.9 0.873 Contact Map
3lv9A 2 0.2467 99.9 0.873 Contact Map
3kxrA 3 0.3055 99.9 0.874 Contact Map
2pliA 4 0.1594 99.9 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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