GREMLIN Database
UDG - UDP-glucose 6-dehydrogenase
UniProt: P76373 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13407
Length: 388 (375)
Sequences: 8292 (4951)
Seq/√Len: 255.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_A191_T4.8541.00
32_P36_A4.5691.00
335_Y372_L4.1601.00
291_I364_I3.3531.00
2_K24_E3.2501.00
298_V331_E3.2031.00
309_G370_E3.1761.00
298_V333_I3.0741.00
37_M42_I3.0181.00
66_D69_E2.9821.00
292_L328_K2.9671.00
137_I171_A2.8051.00
291_I362_V2.7421.00
300_G360_A2.5831.00
188_T227_Q2.5611.00
163_R166_R2.5111.00
285_D324_R2.4831.00
301_I322_M2.4311.00
4_T74_A2.4241.00
189_D192_E2.3601.00
129_K136_I2.3531.00
219_E290_A2.3521.00
21_Q56_S2.3331.00
102_K134_E2.2961.00
39_N63_A2.2941.00
36_A40_D2.2531.00
321_I366_N2.2491.00
271_N278_D2.2431.00
305_I339_M2.1601.00
108_N111_A2.1481.00
150_Y154_H2.1191.00
224_N227_Q2.1111.00
76_Y174_L2.1021.00
24_E60_H2.0651.00
24_E62_N2.0451.00
8_T27_A2.0081.00
299_V330_V2.0051.00
333_I360_A1.9821.00
67_K103_D1.9791.00
88_K91_Y1.9771.00
32_P65_L1.9711.00
102_K130_K1.9301.00
23_H177_G1.9181.00
77_V111_A1.8711.00
202_T210_Y1.8561.00
33_S36_A1.8441.00
200_A232_V1.8131.00
86_D91_Y1.8091.00
188_T196_I1.8031.00
352_D355_T1.7561.00
43_S54_L1.7481.00
357_K380_Y1.7391.00
135_N164_S1.7371.00
266_Q274_S1.7161.00
31_L34_R1.7021.00
195_A218_A1.6921.00
21_Q57_D1.6821.00
99_S102_K1.6771.00
300_G356_F1.6751.00
206_M276_I1.6671.00
376_A379_V1.6551.00
98_E102_K1.6451.00
269_P274_S1.6251.00
110_Y135_N1.6201.00
112_V170_F1.6031.00
172_A187_F1.5941.00
2_K73_D1.5881.00
3_I174_L1.5761.00
4_T77_V1.5681.00
286_F290_A1.5531.00
98_E126_A1.5491.00
17_L61_F1.5391.00
29_D35_V1.5341.00
370_E373_K1.5261.00
262_L274_S1.5021.00
203_Y207_R1.4991.00
274_S278_D1.4991.00
18_L21_Q1.4961.00
36_A39_N1.4841.00
17_L54_L1.4741.00
333_I350_E1.4731.00
49_E52_Q1.4721.00
216_S286_F1.4721.00
308_S368_M1.4661.00
37_M44_P1.4471.00
28_L67_K1.4451.00
304_L334_I1.4341.00
324_R327_A1.4291.00
38_L63_A1.4251.00
169_R186_L1.4251.00
324_R328_K1.4241.00
52_Q56_S1.4191.00
76_Y112_V1.4071.00
19_I174_L1.4051.00
203_Y241_H1.3931.00
216_S283_R1.3911.00
135_N166_R1.3781.00
354_A379_V1.3761.00
219_E286_F1.3751.00
35_V65_L1.3671.00
51_Q55_Q1.3661.00
325_I330_V1.3651.00
162_E166_R1.3581.00
98_E127_M1.3521.00
169_R173_L1.3481.00
70_A73_D1.3451.00
319_Q323_K1.3311.00
33_S37_M1.3301.00
206_M210_Y1.3251.00
66_D70_A1.3221.00
17_L53_F1.2981.00
18_L153_L1.2931.00
62_N70_A1.2911.00
227_Q230_E1.2891.00
126_A130_K1.2871.00
107_I111_A1.2821.00
220_S268_V1.2791.00
35_V63_A1.2751.00
338_V371_E1.2701.00
288_A321_I1.2611.00
172_A176_E1.2551.00
110_Y166_R1.2491.00
211_F229_I1.2291.00
50_I54_L1.2201.00
217_Y270_N1.2171.00
2_K26_V1.2161.00
196_I231_G1.2121.00
21_Q153_L1.2101.00
95_S99_S1.1981.00
123_F127_M1.1961.00
300_G363_I1.1941.00
288_A324_R1.1921.00
147_K150_Y1.1831.00
129_K133_T1.1821.00
216_S220_S1.1791.00
38_L61_F1.1661.00
298_V359_Q1.1631.00
344_F347_S1.1631.00
272_L279_A1.1581.00
272_L275_A1.1571.00
357_K363_I1.1561.00
299_V362_V1.1551.00
37_M40_D1.1531.00
218_A225_S1.1521.00
249_Y277_V1.1491.00
26_V74_A1.1471.00
53_F149_L1.1451.00
72_R108_N1.1391.00
300_G333_I1.1391.00
206_M272_L1.1361.00
101_I105_V1.1341.00
125_A129_K1.1241.00
26_V62_N1.1241.00
199_F214_L1.1221.00
39_N62_N1.1221.00
189_D227_Q1.1221.00
102_K131_Y1.1171.00
302_Y375_V1.1161.00
102_K106_E1.1141.00
344_F349_L1.1091.00
57_D60_H1.1041.00
6_S100_V1.1041.00
236_P241_H1.0981.00
292_L330_V1.0941.00
76_Y170_F1.0931.00
320_G323_K1.0921.00
370_E374_D1.0891.00
226_R244_N1.0891.00
165_E169_R1.0881.00
192_E223_L1.0761.00
6_S77_V1.0761.00
135_N163_R1.0711.00
226_R230_E1.0711.00
223_L228_I1.0691.00
139_S175_Q1.0691.00
34_R44_P1.0681.00
331_E348_R1.0681.00
323_K326_K1.0641.00
285_D289_D1.0641.00
26_V73_D1.0631.00
69_E72_R1.0631.00
271_N282_T1.0621.00
99_S103_D1.0611.00
26_V64_T1.0571.00
164_S167_A1.0561.00
73_D108_N1.0521.00
173_L176_E1.0471.00
128_H132_R1.0471.00
84_D93_N1.0421.00
112_V137_I1.0401.00
105_V134_E1.0371.00
151_D154_H1.0361.00
35_V39_N1.0351.00
115_I124_T1.0241.00
322_M326_K1.0211.00
75_D111_A1.0181.00
320_G324_R1.0181.00
170_F173_L1.0091.00
160_I171_A1.0041.00
4_T28_L0.9941.00
218_A228_I0.9931.00
154_H180_K0.9891.00
298_V360_A0.9891.00
8_T16_G0.9831.00
216_S282_T0.9821.00
192_E228_I0.9811.00
214_L225_S0.9801.00
69_E73_D0.9771.00
103_D106_E0.9731.00
297_Q361_D0.9701.00
16_G61_F0.9671.00
92_F120_P0.9651.00
302_Y363_I0.9541.00
21_Q52_Q0.9481.00
124_T190_S0.9451.00
284_K320_G0.9431.00
127_M131_Y0.9411.00
128_H163_R0.9411.00
3_I19_I0.9401.00
289_D293_S0.9381.00
16_G27_A0.9371.00
22_N177_G0.9361.00
270_N273_I0.9341.00
113_M131_Y0.9321.00
230_E240_N0.9281.00
62_N69_E0.9251.00
79_I104_V0.9161.00
125_A190_S0.9151.00
114_V171_A0.9081.00
323_K327_A0.9061.00
304_L316_S0.9051.00
53_F56_S0.9011.00
104_V113_M0.8991.00
169_R172_A0.8991.00
205_A277_V0.8961.00
291_I299_V0.8941.00
153_L180_K0.8941.00
8_T61_F0.8921.00
101_I115_I0.8911.00
64_T70_A0.8901.00
247_F366_N0.8901.00
282_T285_D0.8871.00
18_L152_N0.8841.00
355_T358_Q0.8831.00
296_P331_E0.8821.00
299_V364_I0.8811.00
107_I132_R0.8801.00
349_L352_D0.8781.00
333_I359_Q0.8781.00
28_L70_A0.8751.00
304_L313_F0.8711.00
98_E130_K0.8681.00
4_T26_V0.8681.00
15_N152_N0.8621.00
290_A293_S0.8590.99
126_A129_K0.8490.99
316_S319_Q0.8460.99
101_I128_H0.8430.99
67_K106_E0.8420.99
3_I23_H0.8360.99
346_N349_L0.8350.99
169_R187_F0.8340.99
128_H190_S0.8320.99
259_K277_V0.8290.99
326_K347_S0.8290.99
291_I325_I0.8290.99
79_I113_M0.8270.99
288_A328_K0.8270.99
4_T71_Y0.8260.99
105_V131_Y0.8190.99
344_F348_R0.8170.99
318_I366_N0.8140.99
300_G357_K0.8130.99
302_Y357_K0.8110.99
207_R243_N0.8090.99
350_E356_F0.8060.99
26_V70_A0.8050.99
217_Y261_L0.8050.99
79_I97_V0.8040.99
166_R171_A0.8030.99
186_L234_L0.8020.99
249_Y258_T0.8010.99
161_G167_A0.7980.99
308_S370_E0.7980.99
30_I103_D0.7830.99
233_C242_Y0.7810.99
76_Y114_V0.7780.99
281_R320_G0.7780.99
217_Y268_V0.7780.99
368_M373_K0.7760.99
143_L152_N0.7750.99
282_T289_D0.7740.99
172_A185_M0.7740.99
262_L277_V0.7720.99
101_I131_Y0.7710.99
54_L61_F0.7700.99
28_L64_T0.7690.99
76_Y171_A0.7670.99
112_V166_R0.7650.99
265_Y270_N0.7620.99
5_I16_G0.7610.99
114_V174_L0.7610.99
313_F339_M0.7600.99
262_L273_I0.7570.99
42_I50_I0.7540.99
302_Y372_L0.7530.99
304_L322_M0.7510.99
92_F260_Q0.7500.99
313_F343_S0.7480.99
59_I62_N0.7470.99
129_K132_R0.7460.99
156_S236_P0.7450.99
326_K332_V0.7450.99
247_F287_I0.7450.99
203_Y243_N0.7430.99
101_I130_K0.7420.99
263_A266_Q0.7410.99
105_V113_M0.7400.98
353_L371_E0.7400.98
207_R211_F0.7370.98
348_R351_R0.7350.98
302_Y365_S0.7340.98
137_I162_E0.7330.98
313_F319_Q0.7320.98
34_R37_M0.7300.98
333_I348_R0.7280.98
345_F351_R0.7260.98
225_S229_I0.7210.98
144_R147_K0.7190.98
192_E227_Q0.7130.98
363_I372_L0.7130.98
15_N19_I0.7130.98
301_I364_I0.7110.98
34_R38_L0.7110.98
77_V104_V0.7110.98
159_V196_I0.7100.98
202_T273_I0.7090.98
97_V123_F0.7090.98
233_C240_N0.7070.98
162_E187_F0.7060.98
285_D320_G0.7050.98
345_F349_L0.7030.98
116_K175_Q0.7020.98
350_E355_T0.7000.98
188_T192_E0.6960.98
101_I127_M0.6950.98
4_T70_A0.6940.98
322_M334_I0.6940.98
28_L103_D0.6910.98
71_Y77_V0.6890.98
28_L65_L0.6890.98
230_E233_C0.6860.98
220_S269_P0.6860.98
8_T29_D0.6820.97
124_T138_F0.6800.97
214_L261_L0.6790.97
363_I380_Y0.6780.97
376_A380_Y0.6770.97
172_A186_L0.6750.97
375_V380_Y0.6740.97
377_D380_Y0.6730.97
213_E279_A0.6730.97
46_V338_V0.6720.97
18_L149_L0.6720.97
159_V172_A0.6700.97
78_I174_L0.6700.97
353_L357_K0.6680.97
15_N157_R0.6660.97
229_I233_C0.6630.97
5_I15_N0.6620.97
357_K374_D0.6610.97
355_T359_Q0.6600.97
339_M343_S0.6590.97
176_E182_N0.6580.97
97_V101_I0.6580.97
106_E134_E0.6570.97
130_K133_T0.6550.97
247_F308_S0.6550.97
52_Q55_Q0.6520.97
102_K133_T0.6510.97
281_R284_K0.6510.97
6_S67_K0.6510.97
229_I244_N0.6500.97
179_I182_N0.6490.97
340_K349_L0.6470.97
232_V240_N0.6470.97
167_A186_L0.6450.96
24_E73_D0.6450.96
217_Y265_Y0.6450.96
288_A292_L0.6430.96
163_R190_S0.6420.96
6_S71_Y0.6400.96
42_I55_Q0.6370.96
258_T277_V0.6360.96
115_I127_M0.6350.96
118_T253_C0.6350.96
348_R359_Q0.6340.96
164_S169_R0.6330.96
116_K139_S0.6330.96
290_A294_R0.6330.96
283_R286_F0.6330.96
10_Y314_R0.6330.96
210_Y214_L0.6320.96
166_R170_F0.6320.96
275_A278_D0.6320.96
23_H76_Y0.6320.96
30_I96_S0.6320.96
302_Y353_L0.6310.96
205_A249_Y0.6290.96
141_E253_C0.6290.96
326_K346_N0.6280.96
211_F214_L0.6270.96
121_V132_R0.6270.96
158_I196_I0.6260.96
259_K281_R0.6260.96
143_L148_A0.6260.96
262_L270_N0.6240.96
49_E53_F0.6230.96
71_Y111_A0.6180.95
43_S51_Q0.6160.95
79_I115_I0.6160.95
67_K71_Y0.6150.95
235_D238_I0.6140.95
229_I245_P0.6130.95
313_F318_I0.6110.95
118_T257_D0.6110.95
337_P372_L0.6100.95
75_D170_F0.6080.95
145_E306_M0.6060.95
96_S100_V0.6050.95
270_N274_S0.6050.95
42_I51_Q0.6030.95
304_L344_F0.6030.95
289_D328_K0.6020.95
162_E190_S0.6010.95
304_L318_I0.6000.95
357_K360_A0.6000.95
97_V115_I0.5980.95
126_A264_N0.5980.95
216_S268_V0.5970.95
22_N60_H0.5970.95
48_K53_F0.5960.95
81_T96_S0.5950.94
209_A272_L0.5950.94
135_N170_F0.5940.94
266_Q269_P0.5920.94
74_A77_V0.5920.94
284_K321_I0.5910.94
114_V137_I0.5910.94
294_R362_V0.5910.94
199_F202_T0.5900.94
262_L266_Q0.5900.94
94_T98_E0.5890.94
21_Q53_F0.5880.94
271_N275_A0.5880.94
86_D98_E0.5870.94
85_Y259_K0.5870.94
192_E196_I0.5860.94
152_N178_A0.5860.94
291_I294_R0.5850.94
157_R200_A0.5840.94
326_K331_E0.5830.94
137_I160_I0.5810.94
201_N257_D0.5810.94
252_Y256_K0.5790.94
28_L100_V0.5790.94
105_V132_R0.5760.93
29_D65_L0.5740.93
159_V167_A0.5720.93
8_T38_L0.5680.93
132_R136_I0.5680.93
295_K329_G0.5670.93
288_A291_I0.5660.93
75_D109_P0.5640.93
247_F321_I0.5630.93
335_Y353_L0.5630.93
216_S219_E0.5620.93
85_Y90_N0.5610.93
284_K317_S0.5600.92
333_I356_F0.5600.92
258_T273_I0.5590.92
203_Y211_F0.5580.92
299_V332_V0.5580.92
334_I340_K0.5570.92
20_A60_H0.5570.92
195_A214_L0.5540.92
179_I184_P0.5540.92
154_H181_Q0.5520.92
83_T117_S0.5510.92
253_C256_K0.5500.92
334_I349_L0.5490.92
288_A364_I0.5460.92
23_H173_L0.5450.91
215_D283_R0.5430.91
249_Y276_I0.5430.91
289_D292_L0.5420.91
235_D239_G0.5410.91
142_F200_A0.5410.91
354_A357_K0.5400.91
214_L218_A0.5400.91
275_A279_A0.5390.91
17_L21_Q0.5390.91
187_F231_G0.5380.91
130_K134_E0.5350.91
271_N274_S0.5350.91
84_D315_A0.5350.91
145_E256_K0.5340.91
53_F57_D0.5340.91
51_Q54_L0.5330.91
62_N73_D0.5330.91
95_S98_E0.5320.90
372_L375_V0.5310.90
233_C241_H0.5310.90
35_V38_L0.5300.90
179_I185_M0.5300.90
170_F174_L0.5290.90
322_M332_V0.5290.90
116_K256_K0.5290.90
98_E131_Y0.5280.90
217_Y221_L0.5280.90
23_H174_L0.5270.90
201_N253_C0.5270.90
209_A279_A0.5270.90
266_Q270_N0.5260.90
240_N244_N0.5240.90
121_V264_N0.5230.90
116_K157_R0.5220.90
353_L356_F0.5210.90
336_E339_M0.5200.89
91_Y263_A0.5180.89
116_K145_E0.5180.89
277_V281_R0.5180.89
160_I185_M0.5170.89
84_D312_N0.5170.89
226_R245_P0.5150.89
259_K315_A0.5140.89
141_E314_R0.5130.89
215_D219_E0.5120.89
151_D155_P0.5120.89
202_T206_M0.5110.89
135_N162_E0.5110.89
115_I136_I0.5110.89
285_D328_K0.5100.89
316_S320_G0.5100.89
287_I364_I0.5100.89
273_I276_I0.5100.89
201_N307_K0.5100.89
39_N42_I0.5090.88
272_L276_I0.5080.88
25_V61_F0.5070.88
268_V279_A0.5070.88
325_I332_V0.5070.88
322_M366_N0.5060.88
301_I334_I0.5060.88
167_A187_F0.5050.88
49_E149_L0.5050.88
46_V311_D0.5030.88
157_R175_Q0.5020.88
9_G253_C0.5010.88
20_A56_S0.5010.88
23_H176_E0.5000.88
300_G352_D0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9974 100 0.265 Contact Map
3pidA 2 0.9562 100 0.277 Contact Map
3gg2A 3 0.9974 100 0.28 Contact Map
2q3eA 5 0.9974 100 0.284 Contact Map
2o3jA 4 0.9974 100 0.289 Contact Map
1dljA 2 1 100 0.289 Contact Map
3ojoA 2 0.9588 100 0.298 Contact Map
3g79A 2 0.982 100 0.3 Contact Map
4a7pA 2 0.9845 100 0.309 Contact Map
3vtfA 2 0.9871 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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