GREMLIN Database
WZZB - Chain length determinant protein
UniProt: P76372 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13406
Length: 326 (302)
Sequences: 5947 (5127)
Seq/√Len: 295.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_G144_A3.8531.00
145_Q286_L3.1291.00
28_W31_K3.1241.00
57_T291_D3.0891.00
45_A302_A3.0551.00
97_G108_E3.0261.00
60_A152_I2.9911.00
57_T137_V2.9451.00
149_A284_P2.8511.00
145_Q149_A2.5421.00
98_R150_Q2.4631.00
49_L298_T2.4451.00
216_Q219_Q2.4401.00
48_Y52_A2.3881.00
159_V162_E2.3751.00
138_G143_G2.3521.00
174_G177_N2.2241.00
142_E146_M2.1731.00
191_E195_L2.1491.00
237_L241_I2.1471.00
19_D22_D2.1321.00
136_Y147_K2.0311.00
264_D267_S2.0051.00
136_Y148_L1.9641.00
150_Q154_Q1.9621.00
58_S144_A1.9411.00
310_G314_V1.9191.00
57_T135_S1.9171.00
294_K297_I1.9101.00
93_E97_G1.8691.00
30_G317_R1.8611.00
179_Q183_R1.8501.00
55_K137_V1.8311.00
187_V191_E1.7901.00
192_Q196_R1.7831.00
98_R154_Q1.7301.00
204_L208_N1.7111.00
41_A302_A1.7021.00
153_Q157_D1.7011.00
223_D226_Q1.6871.00
37_S41_A1.6781.00
49_L299_L1.6731.00
59_T133_T1.6661.00
137_V292_S1.6651.00
233_G236_A1.6601.00
184_T188_V1.6431.00
201_Q204_L1.6341.00
134_V148_L1.6331.00
42_I303_V1.6111.00
255_Y258_T1.6011.00
92_Q115_E1.5921.00
302_A306_G1.5721.00
221_G245_A1.5371.00
118_K136_Y1.5321.00
38_V307_G1.5151.00
227_D230_F1.5041.00
46_I50_A1.5001.00
180_D184_T1.4961.00
224_I238_E1.4931.00
49_L302_A1.4881.00
234_S238_E1.4801.00
150_Q153_Q1.4741.00
34_I38_V1.4661.00
83_Q86_P1.4631.00
60_A148_L1.4501.00
238_E242_K1.4411.00
46_I299_L1.4371.00
89_S282_M1.4241.00
154_Q157_D1.4211.00
224_I234_S1.4201.00
82_G86_P1.4181.00
306_G310_G1.4181.00
53_K139_Q1.4121.00
253_P257_Q1.4051.00
266_E269_K1.3891.00
61_I131_P1.3811.00
94_T154_Q1.3761.00
41_A306_G1.3591.00
231_L235_E1.3581.00
185_Q188_V1.3561.00
217_I220_T1.3541.00
124_S133_T1.3531.00
94_T98_R1.3491.00
252_S255_Y1.3481.00
205_Q208_N1.3441.00
190_Q194_D1.3431.00
172_A176_K1.3241.00
169_D173_L1.3221.00
172_A265_I1.3211.00
252_S256_Y1.3201.00
232_L235_E1.3131.00
249_L252_S1.3121.00
58_S145_Q1.3091.00
45_A49_L1.2871.00
94_T97_G1.2861.00
242_K245_A1.2801.00
81_Y85_A1.2661.00
177_N181_S1.2461.00
208_N212_V1.2461.00
140_T143_G1.2441.00
182_L186_E1.2411.00
232_L248_P1.2381.00
93_E108_E1.2371.00
251_F254_N1.2371.00
146_M150_Q1.2361.00
137_V291_D1.2361.00
89_S93_E1.2311.00
224_I241_I1.2171.00
254_N258_T1.2121.00
31_K35_I1.1991.00
58_S287_P1.1931.00
149_A153_Q1.1921.00
41_A45_A1.1911.00
164_E167_L1.1851.00
119_L136_Y1.1801.00
185_Q189_A1.1791.00
176_K179_Q1.1711.00
165_K169_D1.1681.00
77_M80_I1.1621.00
212_V215_P1.1581.00
61_I133_T1.1541.00
34_I314_V1.1521.00
198_R201_Q1.1521.00
55_K292_S1.1511.00
33_T37_S1.1491.00
131_P281_V1.1471.00
224_I227_D1.1421.00
153_Q283_K1.1361.00
241_I245_A1.1341.00
183_R187_V1.1331.00
253_P256_Y1.1321.00
38_V42_I1.1261.00
249_L255_Y1.1221.00
92_Q151_Y1.1121.00
122_E133_T1.1121.00
26_Q318_N1.1071.00
265_I269_K1.0981.00
59_T135_S1.0941.00
49_L52_A1.0901.00
125_V128_Q1.0811.00
176_K180_D1.0811.00
214_K220_T1.0671.00
96_I111_D1.0671.00
254_N257_Q1.0661.00
143_G147_K1.0551.00
92_Q116_R1.0511.00
30_G314_V1.0491.00
61_I282_M1.0461.00
214_K217_I1.0451.00
108_E112_N1.0421.00
115_E136_Y1.0411.00
166_D169_D1.0371.00
148_L152_I1.0331.00
217_I241_I1.0141.00
91_L151_Y1.0141.00
44_L48_Y1.0141.00
297_I301_L1.0071.00
245_A248_P1.0011.00
240_M243_H0.9951.00
92_Q147_K0.9931.00
89_S285_M0.9901.00
42_I299_L0.9891.00
76_A81_Y0.9861.00
251_F256_Y0.9851.00
242_K246_T0.9851.00
80_I85_A0.9811.00
90_D282_M0.9811.00
234_S237_L0.9801.00
244_E248_P0.9791.00
243_H246_T0.9781.00
148_L284_P0.9741.00
153_Q156_D0.9731.00
253_P258_T0.9731.00
152_I280_Y0.9731.00
215_P219_Q0.9681.00
238_E241_I0.9621.00
143_G146_M0.9621.00
251_F258_T0.9611.00
93_E112_N0.9611.00
38_V41_A0.9611.00
217_I221_G0.9471.00
114_E118_K0.9411.00
145_Q284_P0.9401.00
34_I311_A0.9391.00
231_L234_S0.9391.00
54_E295_K0.9361.00
26_Q315_L0.9361.00
79_V83_Q0.9321.00
235_E238_E0.9301.00
236_A240_M0.9261.00
315_L319_A0.9251.00
98_R153_Q0.9241.00
226_Q229_L0.9201.00
49_L295_K0.9191.00
178_L181_S0.9111.00
52_A55_K0.9101.00
181_S184_T0.9091.00
313_I317_R0.9031.00
180_D183_R0.9021.00
152_I284_P0.8931.00
241_I248_P0.8901.00
218_Q221_G0.8861.00
41_A309_V0.8811.00
243_H247_R0.8761.00
81_Y84_A0.8761.00
48_Y298_T0.8761.00
37_S313_I0.8731.00
218_Q222_E0.8721.00
134_V152_I0.8681.00
40_V47_G0.8681.00
90_D283_K0.8671.00
199_Q202_E0.8671.00
210_A213_T0.8631.00
33_T36_I0.8631.00
198_R207_A0.8611.00
249_L258_T0.8601.00
214_K221_G0.8601.00
115_E151_Y0.8601.00
78_N82_G0.8551.00
95_L99_F0.8511.00
55_K139_Q0.8461.00
47_G51_V0.8401.00
99_F150_Q0.8391.00
260_Q264_D0.8361.00
199_Q207_A0.8331.00
82_G85_A0.8311.00
202_E207_A0.8281.00
224_I237_L0.8271.00
45_A306_G0.8271.00
295_K298_T0.8261.00
235_E239_S0.8261.00
172_A269_K0.8241.00
37_S310_G0.8241.00
94_T158_K0.8221.00
96_I115_E0.8181.00
113_Q117_E0.8181.00
205_Q211_Q0.8181.00
30_G33_T0.8161.00
175_R262_L0.8151.00
244_E247_R0.8131.00
188_V191_E0.8111.00
214_K218_Q0.8081.00
89_S112_N0.8051.00
45_A298_T0.8041.00
92_Q112_N0.8001.00
119_L148_L0.7990.99
144_A148_L0.7950.99
238_E245_A0.7950.99
26_Q30_G0.7940.99
60_A134_V0.7940.99
152_I156_D0.7930.99
38_V303_V0.7900.99
50_A295_K0.7880.99
40_V44_L0.7870.99
95_L154_Q0.7860.99
290_R295_K0.7840.99
92_Q95_L0.7800.99
95_L147_K0.7760.99
207_A210_A0.7720.99
295_K299_L0.7710.99
24_L28_W0.7690.99
118_K138_G0.7650.99
38_V310_G0.7650.99
209_Q212_V0.7630.99
55_K291_D0.7620.99
107_A110_L0.7610.99
175_R261_N0.7610.99
96_I112_N0.7600.99
191_E194_D0.7600.99
249_L253_P0.7560.99
175_R265_I0.7560.99
262_L266_E0.7550.99
252_S258_T0.7540.99
163_L167_L0.7510.99
261_N270_V0.7500.99
205_Q209_Q0.7490.99
21_I28_W0.7450.99
21_I25_V0.7440.99
28_W32_M0.7430.99
42_I49_L0.7410.99
62_I152_I0.7410.99
113_Q116_R0.7390.99
233_G237_L0.7390.99
54_E290_R0.7330.99
48_Y51_V0.7310.99
239_S243_H0.7280.99
58_S286_L0.7280.99
95_L150_Q0.7260.99
141_A287_P0.7260.99
142_E286_L0.7230.99
95_L151_Y0.7200.99
30_G318_N0.7200.99
96_I99_F0.7190.99
27_L311_A0.7190.99
241_I244_E0.7170.99
251_F255_Y0.7170.99
77_M83_Q0.7100.99
91_L95_L0.7090.99
76_A84_A0.7090.99
249_L257_Q0.7080.99
120_T137_V0.7080.99
305_L312_G0.7040.99
106_L111_D0.7040.99
155_V278_Y0.7010.99
197_I202_E0.7000.99
34_I41_A0.6990.99
42_I46_I0.6950.99
42_I307_G0.6940.99
223_D229_L0.6930.99
80_I84_A0.6890.99
292_S295_K0.6890.99
77_M81_Y0.6870.98
305_L309_V0.6870.98
223_D227_D0.6870.98
77_M84_A0.6840.98
29_R318_N0.6840.98
200_I203_A0.6830.98
239_S242_K0.6820.98
183_R186_E0.6810.98
81_Y86_P0.6800.98
55_K118_K0.6790.98
33_T317_R0.6730.98
236_A239_S0.6680.98
170_N270_V0.6670.98
173_L176_K0.6670.98
50_A299_L0.6650.98
78_N81_Y0.6630.98
120_T135_S0.6620.98
80_I83_Q0.6610.98
119_L151_Y0.6590.98
142_E145_Q0.6580.98
260_Q263_L0.6580.98
250_V253_P0.6530.98
115_E147_K0.6520.98
87_K121_I0.6510.98
52_A298_T0.6420.98
292_S298_T0.6410.98
98_R157_D0.6410.98
117_E289_R0.6400.98
289_R296_A0.6400.98
111_D115_E0.6390.98
90_D158_K0.6330.97
79_V82_G0.6320.97
124_S129_Q0.6310.97
34_I310_G0.6310.97
250_V255_Y0.6300.97
171_I261_N0.6300.97
307_G310_G0.6290.97
173_L177_N0.6230.97
76_A83_Q0.6230.97
65_P130_L0.6220.97
216_Q220_T0.6210.97
199_Q203_A0.6200.97
123_P130_L0.6180.97
207_A211_Q0.6170.97
79_V84_A0.6160.97
203_A210_A0.6150.97
71_A74_N0.6140.97
311_A315_L0.6100.97
26_Q314_V0.6100.97
30_G321_R0.6090.97
146_M149_A0.6080.97
220_T240_M0.6080.97
113_Q289_R0.6060.97
263_L267_S0.6050.97
62_I134_V0.6050.97
177_N180_D0.6050.97
103_F106_L0.6040.97
200_I213_T0.6030.97
298_T301_L0.6010.97
151_Y155_V0.6010.97
249_L254_N0.5990.96
200_I204_L0.5990.96
37_S40_V0.5980.96
249_L256_Y0.5960.96
198_R202_E0.5960.96
43_A47_G0.5940.96
184_T187_V0.5940.96
149_A283_K0.5930.96
312_G316_G0.5930.96
77_M82_G0.5920.96
198_R203_A0.5870.96
107_A111_D0.5850.96
208_N211_Q0.5820.96
264_D273_L0.5820.96
91_L154_Q0.5810.96
122_E135_S0.5800.96
199_Q204_L0.5780.96
206_Y210_A0.5760.96
44_L47_G0.5750.96
223_D231_L0.5740.95
58_S285_M0.5720.95
220_T241_I0.5710.95
72_G75_N0.5690.95
89_S92_Q0.5670.95
270_V273_L0.5660.95
178_L261_N0.5660.95
32_M36_I0.5640.95
223_D240_M0.5630.95
36_I40_V0.5630.95
99_F146_M0.5630.95
36_I43_A0.5630.95
30_G310_G0.5620.95
163_L168_K0.5600.95
110_L114_E0.5580.95
267_S271_D0.5570.95
178_L182_L0.5560.95
58_S284_P0.5550.95
260_Q267_S0.5540.95
29_R32_M0.5520.94
296_A300_I0.5520.94
298_T302_A0.5520.94
22_D26_Q0.5490.94
169_D172_A0.5490.94
280_Y283_K0.5480.94
121_I132_L0.5470.94
174_G178_L0.5460.94
42_I45_A0.5430.94
237_L244_E0.5430.94
190_Q193_K0.5380.94
52_A293_P0.5370.94
220_T224_I0.5370.94
76_A79_V0.5360.94
300_I303_V0.5360.94
27_L34_I0.5350.93
261_N264_D0.5350.93
92_Q96_I0.5350.93
197_I203_A0.5320.93
223_D233_G0.5310.93
181_S185_Q0.5290.93
170_N174_G0.5280.93
303_V308_M0.5270.93
52_A292_S0.5260.93
100_S104_S0.5250.93
303_V307_G0.5220.93
112_N116_R0.5210.93
201_Q208_N0.5200.92
173_L191_E0.5170.92
309_V312_G0.5160.92
199_Q208_N0.5140.92
139_Q143_G0.5130.92
115_E119_L0.5120.92
37_S306_G0.5110.92
202_E206_Y0.5110.92
33_T313_I0.5100.92
220_T223_D0.5100.92
250_V254_N0.5080.92
106_L110_L0.5040.91
141_A144_A0.5030.91
158_K161_Q0.5030.91
93_E285_M0.5000.91
167_L193_K0.5000.91
78_N83_Q0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wl1A 3 0.6104 100 0.362 Contact Map
3b8mA 3 0.6933 99 0.798 Contact Map
3b8oA 3 0.6074 99 0.799 Contact Map
4e29A 3 0.7025 99 0.8 Contact Map
4cgkA 3 0.7546 87.3 0.917 Contact Map
4iloA 3 0.5644 85 0.92 Contact Map
3ghgA 2 0.4479 83.5 0.921 Contact Map
4rsiA 1 0.3528 80.2 0.924 Contact Map
3na7A 1 0.638 72.8 0.929 Contact Map
4rsiB 1 0.5307 65.7 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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