WZZB - ECOLI - GREMLIN Contacts

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WZZB - Chain length determinant protein

UniProt:	P76372	Sequences: MRVENNNVSGQNHDPEQIDLIDLLVQLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSDLQETLIGRFSSAFSALAETLDNQEEREKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKLAQYIQQVDDKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEALQYANQAQVTKPQIQQTGEDITQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLLDIESLKVDDLDIHAYRYVMKPMLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13406
Length:	326 (302)
Sequences:	5947 (5127)
Seq/√Len:	295.0

ECOLI - WZZB WZZE FEPE ETK WZC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
138_G	144_A	3.853	1.00
145_Q	286_L	3.129	1.00
28_W	31_K	3.124	1.00
57_T	291_D	3.089	1.00
45_A	302_A	3.055	1.00
97_G	108_E	3.026	1.00
60_A	152_I	2.991	1.00
57_T	137_V	2.945	1.00
149_A	284_P	2.851	1.00
145_Q	149_A	2.542	1.00
98_R	150_Q	2.463	1.00
49_L	298_T	2.445	1.00
216_Q	219_Q	2.440	1.00
48_Y	52_A	2.388	1.00
159_V	162_E	2.375	1.00
138_G	143_G	2.352	1.00
174_G	177_N	2.224	1.00
142_E	146_M	2.173	1.00
191_E	195_L	2.149	1.00
237_L	241_I	2.147	1.00
19_D	22_D	2.132	1.00
136_Y	147_K	2.031	1.00
264_D	267_S	2.005	1.00
136_Y	148_L	1.964	1.00
150_Q	154_Q	1.962	1.00
58_S	144_A	1.941	1.00
310_G	314_V	1.919	1.00
57_T	135_S	1.917	1.00
294_K	297_I	1.910	1.00
93_E	97_G	1.869	1.00
30_G	317_R	1.861	1.00
179_Q	183_R	1.850	1.00
55_K	137_V	1.831	1.00
187_V	191_E	1.790	1.00
192_Q	196_R	1.783	1.00
98_R	154_Q	1.730	1.00
204_L	208_N	1.711	1.00
41_A	302_A	1.702	1.00
153_Q	157_D	1.701	1.00
223_D	226_Q	1.687	1.00
37_S	41_A	1.678	1.00
49_L	299_L	1.673	1.00
59_T	133_T	1.666	1.00
137_V	292_S	1.665	1.00
233_G	236_A	1.660	1.00
184_T	188_V	1.643	1.00
201_Q	204_L	1.634	1.00
134_V	148_L	1.633	1.00
42_I	303_V	1.611	1.00
255_Y	258_T	1.601	1.00
92_Q	115_E	1.592	1.00
302_A	306_G	1.572	1.00
221_G	245_A	1.537	1.00
118_K	136_Y	1.532	1.00
38_V	307_G	1.515	1.00
227_D	230_F	1.504	1.00
46_I	50_A	1.500	1.00
180_D	184_T	1.496	1.00
224_I	238_E	1.493	1.00
49_L	302_A	1.488	1.00
234_S	238_E	1.480	1.00
150_Q	153_Q	1.474	1.00
34_I	38_V	1.466	1.00
83_Q	86_P	1.463	1.00
60_A	148_L	1.450	1.00
238_E	242_K	1.441	1.00
46_I	299_L	1.437	1.00
89_S	282_M	1.424	1.00
154_Q	157_D	1.421	1.00
224_I	234_S	1.420	1.00
82_G	86_P	1.418	1.00
306_G	310_G	1.418	1.00
53_K	139_Q	1.412	1.00
253_P	257_Q	1.405	1.00
266_E	269_K	1.389	1.00
61_I	131_P	1.381	1.00
94_T	154_Q	1.376	1.00
41_A	306_G	1.359	1.00
231_L	235_E	1.358	1.00
185_Q	188_V	1.356	1.00
217_I	220_T	1.354	1.00
124_S	133_T	1.353	1.00
94_T	98_R	1.349	1.00
252_S	255_Y	1.348	1.00
205_Q	208_N	1.344	1.00
190_Q	194_D	1.343	1.00
172_A	176_K	1.324	1.00
169_D	173_L	1.322	1.00
172_A	265_I	1.321	1.00
252_S	256_Y	1.320	1.00
232_L	235_E	1.313	1.00
249_L	252_S	1.312	1.00
58_S	145_Q	1.309	1.00
45_A	49_L	1.287	1.00
94_T	97_G	1.286	1.00
242_K	245_A	1.280	1.00
81_Y	85_A	1.266	1.00
177_N	181_S	1.246	1.00
208_N	212_V	1.246	1.00
140_T	143_G	1.244	1.00
182_L	186_E	1.241	1.00
232_L	248_P	1.238	1.00
93_E	108_E	1.237	1.00
251_F	254_N	1.237	1.00
146_M	150_Q	1.236	1.00
137_V	291_D	1.236	1.00
89_S	93_E	1.231	1.00
224_I	241_I	1.217	1.00
254_N	258_T	1.212	1.00
31_K	35_I	1.199	1.00
58_S	287_P	1.193	1.00
149_A	153_Q	1.192	1.00
41_A	45_A	1.191	1.00
164_E	167_L	1.185	1.00
119_L	136_Y	1.180	1.00
185_Q	189_A	1.179	1.00
176_K	179_Q	1.171	1.00
165_K	169_D	1.168	1.00
77_M	80_I	1.162	1.00
212_V	215_P	1.158	1.00
61_I	133_T	1.154	1.00
34_I	314_V	1.152	1.00
198_R	201_Q	1.152	1.00
55_K	292_S	1.151	1.00
33_T	37_S	1.149	1.00
131_P	281_V	1.147	1.00
224_I	227_D	1.142	1.00
153_Q	283_K	1.136	1.00
241_I	245_A	1.134	1.00
183_R	187_V	1.133	1.00
253_P	256_Y	1.132	1.00
38_V	42_I	1.126	1.00
249_L	255_Y	1.122	1.00
92_Q	151_Y	1.112	1.00
122_E	133_T	1.112	1.00
26_Q	318_N	1.107	1.00
265_I	269_K	1.098	1.00
59_T	135_S	1.094	1.00
49_L	52_A	1.090	1.00
125_V	128_Q	1.081	1.00
176_K	180_D	1.081	1.00
214_K	220_T	1.067	1.00
96_I	111_D	1.067	1.00
254_N	257_Q	1.066	1.00
143_G	147_K	1.055	1.00
92_Q	116_R	1.051	1.00
30_G	314_V	1.049	1.00
61_I	282_M	1.046	1.00
214_K	217_I	1.045	1.00
108_E	112_N	1.042	1.00
115_E	136_Y	1.041	1.00
166_D	169_D	1.037	1.00
148_L	152_I	1.033	1.00
217_I	241_I	1.014	1.00
91_L	151_Y	1.014	1.00
44_L	48_Y	1.014	1.00
297_I	301_L	1.007	1.00
245_A	248_P	1.001	1.00
240_M	243_H	0.995	1.00
92_Q	147_K	0.993	1.00
89_S	285_M	0.990	1.00
42_I	299_L	0.989	1.00
76_A	81_Y	0.986	1.00
251_F	256_Y	0.985	1.00
242_K	246_T	0.985	1.00
80_I	85_A	0.981	1.00
90_D	282_M	0.981	1.00
234_S	237_L	0.980	1.00
244_E	248_P	0.979	1.00
243_H	246_T	0.978	1.00
148_L	284_P	0.974	1.00
153_Q	156_D	0.973	1.00
253_P	258_T	0.973	1.00
152_I	280_Y	0.973	1.00
215_P	219_Q	0.968	1.00
238_E	241_I	0.962	1.00
143_G	146_M	0.962	1.00
251_F	258_T	0.961	1.00
93_E	112_N	0.961	1.00
38_V	41_A	0.961	1.00
217_I	221_G	0.947	1.00
114_E	118_K	0.941	1.00
145_Q	284_P	0.940	1.00
34_I	311_A	0.939	1.00
231_L	234_S	0.939	1.00
54_E	295_K	0.936	1.00
26_Q	315_L	0.936	1.00
79_V	83_Q	0.932	1.00
235_E	238_E	0.930	1.00
236_A	240_M	0.926	1.00
315_L	319_A	0.925	1.00
98_R	153_Q	0.924	1.00
226_Q	229_L	0.920	1.00
49_L	295_K	0.919	1.00
178_L	181_S	0.911	1.00
52_A	55_K	0.910	1.00
181_S	184_T	0.909	1.00
313_I	317_R	0.903	1.00
180_D	183_R	0.902	1.00
152_I	284_P	0.893	1.00
241_I	248_P	0.890	1.00
218_Q	221_G	0.886	1.00
41_A	309_V	0.881	1.00
243_H	247_R	0.876	1.00
81_Y	84_A	0.876	1.00
48_Y	298_T	0.876	1.00
37_S	313_I	0.873	1.00
218_Q	222_E	0.872	1.00
134_V	152_I	0.868	1.00
40_V	47_G	0.868	1.00
90_D	283_K	0.867	1.00
199_Q	202_E	0.867	1.00
210_A	213_T	0.863	1.00
33_T	36_I	0.863	1.00
198_R	207_A	0.861	1.00
249_L	258_T	0.860	1.00
214_K	221_G	0.860	1.00
115_E	151_Y	0.860	1.00
78_N	82_G	0.855	1.00
95_L	99_F	0.851	1.00
55_K	139_Q	0.846	1.00
47_G	51_V	0.840	1.00
99_F	150_Q	0.839	1.00
260_Q	264_D	0.836	1.00
199_Q	207_A	0.833	1.00
82_G	85_A	0.831	1.00
202_E	207_A	0.828	1.00
224_I	237_L	0.827	1.00
45_A	306_G	0.827	1.00
295_K	298_T	0.826	1.00
235_E	239_S	0.826	1.00
172_A	269_K	0.824	1.00
37_S	310_G	0.824	1.00
94_T	158_K	0.822	1.00
96_I	115_E	0.818	1.00
113_Q	117_E	0.818	1.00
205_Q	211_Q	0.818	1.00
30_G	33_T	0.816	1.00
175_R	262_L	0.815	1.00
244_E	247_R	0.813	1.00
188_V	191_E	0.811	1.00
214_K	218_Q	0.808	1.00
89_S	112_N	0.805	1.00
45_A	298_T	0.804	1.00
92_Q	112_N	0.800	1.00
119_L	148_L	0.799	0.99
144_A	148_L	0.795	0.99
238_E	245_A	0.795	0.99
26_Q	30_G	0.794	0.99
60_A	134_V	0.794	0.99
152_I	156_D	0.793	0.99
38_V	303_V	0.790	0.99
50_A	295_K	0.788	0.99
40_V	44_L	0.787	0.99
95_L	154_Q	0.786	0.99
290_R	295_K	0.784	0.99
92_Q	95_L	0.780	0.99
95_L	147_K	0.776	0.99
207_A	210_A	0.772	0.99
295_K	299_L	0.771	0.99
24_L	28_W	0.769	0.99
118_K	138_G	0.765	0.99
38_V	310_G	0.765	0.99
209_Q	212_V	0.763	0.99
55_K	291_D	0.762	0.99
107_A	110_L	0.761	0.99
175_R	261_N	0.761	0.99
96_I	112_N	0.760	0.99
191_E	194_D	0.760	0.99
249_L	253_P	0.756	0.99
175_R	265_I	0.756	0.99
262_L	266_E	0.755	0.99
252_S	258_T	0.754	0.99
163_L	167_L	0.751	0.99
261_N	270_V	0.750	0.99
205_Q	209_Q	0.749	0.99
21_I	28_W	0.745	0.99
21_I	25_V	0.744	0.99
28_W	32_M	0.743	0.99
42_I	49_L	0.741	0.99
62_I	152_I	0.741	0.99
113_Q	116_R	0.739	0.99
233_G	237_L	0.739	0.99
54_E	290_R	0.733	0.99
48_Y	51_V	0.731	0.99
239_S	243_H	0.728	0.99
58_S	286_L	0.728	0.99
95_L	150_Q	0.726	0.99
141_A	287_P	0.726	0.99
142_E	286_L	0.723	0.99
95_L	151_Y	0.720	0.99
30_G	318_N	0.720	0.99
96_I	99_F	0.719	0.99
27_L	311_A	0.719	0.99
241_I	244_E	0.717	0.99
251_F	255_Y	0.717	0.99
77_M	83_Q	0.710	0.99
91_L	95_L	0.709	0.99
76_A	84_A	0.709	0.99
249_L	257_Q	0.708	0.99
120_T	137_V	0.708	0.99
305_L	312_G	0.704	0.99
106_L	111_D	0.704	0.99
155_V	278_Y	0.701	0.99
197_I	202_E	0.700	0.99
34_I	41_A	0.699	0.99
42_I	46_I	0.695	0.99
42_I	307_G	0.694	0.99
223_D	229_L	0.693	0.99
80_I	84_A	0.689	0.99
292_S	295_K	0.689	0.99
77_M	81_Y	0.687	0.98
305_L	309_V	0.687	0.98
223_D	227_D	0.687	0.98
77_M	84_A	0.684	0.98
29_R	318_N	0.684	0.98
200_I	203_A	0.683	0.98
239_S	242_K	0.682	0.98
183_R	186_E	0.681	0.98
81_Y	86_P	0.680	0.98
55_K	118_K	0.679	0.98
33_T	317_R	0.673	0.98
236_A	239_S	0.668	0.98
170_N	270_V	0.667	0.98
173_L	176_K	0.667	0.98
50_A	299_L	0.665	0.98
78_N	81_Y	0.663	0.98
120_T	135_S	0.662	0.98
80_I	83_Q	0.661	0.98
119_L	151_Y	0.659	0.98
142_E	145_Q	0.658	0.98
260_Q	263_L	0.658	0.98
250_V	253_P	0.653	0.98
115_E	147_K	0.652	0.98
87_K	121_I	0.651	0.98
52_A	298_T	0.642	0.98
292_S	298_T	0.641	0.98
98_R	157_D	0.641	0.98
117_E	289_R	0.640	0.98
289_R	296_A	0.640	0.98
111_D	115_E	0.639	0.98
90_D	158_K	0.633	0.97
79_V	82_G	0.632	0.97
124_S	129_Q	0.631	0.97
34_I	310_G	0.631	0.97
250_V	255_Y	0.630	0.97
171_I	261_N	0.630	0.97
307_G	310_G	0.629	0.97
173_L	177_N	0.623	0.97
76_A	83_Q	0.623	0.97
65_P	130_L	0.622	0.97
216_Q	220_T	0.621	0.97
199_Q	203_A	0.620	0.97
123_P	130_L	0.618	0.97
207_A	211_Q	0.617	0.97
79_V	84_A	0.616	0.97
203_A	210_A	0.615	0.97
71_A	74_N	0.614	0.97
311_A	315_L	0.610	0.97
26_Q	314_V	0.610	0.97
30_G	321_R	0.609	0.97
146_M	149_A	0.608	0.97
220_T	240_M	0.608	0.97
113_Q	289_R	0.606	0.97
263_L	267_S	0.605	0.97
62_I	134_V	0.605	0.97
177_N	180_D	0.605	0.97
103_F	106_L	0.604	0.97
200_I	213_T	0.603	0.97
298_T	301_L	0.601	0.97
151_Y	155_V	0.601	0.97
249_L	254_N	0.599	0.96
200_I	204_L	0.599	0.96
37_S	40_V	0.598	0.96
249_L	256_Y	0.596	0.96
198_R	202_E	0.596	0.96
43_A	47_G	0.594	0.96
184_T	187_V	0.594	0.96
149_A	283_K	0.593	0.96
312_G	316_G	0.593	0.96
77_M	82_G	0.592	0.96
198_R	203_A	0.587	0.96
107_A	111_D	0.585	0.96
208_N	211_Q	0.582	0.96
264_D	273_L	0.582	0.96
91_L	154_Q	0.581	0.96
122_E	135_S	0.580	0.96
199_Q	204_L	0.578	0.96
206_Y	210_A	0.576	0.96
44_L	47_G	0.575	0.96
223_D	231_L	0.574	0.95
58_S	285_M	0.572	0.95
220_T	241_I	0.571	0.95
72_G	75_N	0.569	0.95
89_S	92_Q	0.567	0.95
270_V	273_L	0.566	0.95
178_L	261_N	0.566	0.95
32_M	36_I	0.564	0.95
223_D	240_M	0.563	0.95
36_I	40_V	0.563	0.95
99_F	146_M	0.563	0.95
36_I	43_A	0.563	0.95
30_G	310_G	0.562	0.95
163_L	168_K	0.560	0.95
110_L	114_E	0.558	0.95
267_S	271_D	0.557	0.95
178_L	182_L	0.556	0.95
58_S	284_P	0.555	0.95
260_Q	267_S	0.554	0.95
29_R	32_M	0.552	0.94
296_A	300_I	0.552	0.94
298_T	302_A	0.552	0.94
22_D	26_Q	0.549	0.94
169_D	172_A	0.549	0.94
280_Y	283_K	0.548	0.94
121_I	132_L	0.547	0.94
174_G	178_L	0.546	0.94
42_I	45_A	0.543	0.94
237_L	244_E	0.543	0.94
190_Q	193_K	0.538	0.94
52_A	293_P	0.537	0.94
220_T	224_I	0.537	0.94
76_A	79_V	0.536	0.94
300_I	303_V	0.536	0.94
27_L	34_I	0.535	0.93
261_N	264_D	0.535	0.93
92_Q	96_I	0.535	0.93
197_I	203_A	0.532	0.93
223_D	233_G	0.531	0.93
181_S	185_Q	0.529	0.93
170_N	174_G	0.528	0.93
303_V	308_M	0.527	0.93
52_A	292_S	0.526	0.93
100_S	104_S	0.525	0.93
303_V	307_G	0.522	0.93
112_N	116_R	0.521	0.93
201_Q	208_N	0.520	0.92
173_L	191_E	0.517	0.92
309_V	312_G	0.516	0.92
199_Q	208_N	0.514	0.92
139_Q	143_G	0.513	0.92
115_E	119_L	0.512	0.92
37_S	306_G	0.511	0.92
202_E	206_Y	0.511	0.92
33_T	313_I	0.510	0.92
220_T	223_D	0.510	0.92
250_V	254_N	0.508	0.92
106_L	110_L	0.504	0.91
141_A	144_A	0.503	0.91
158_K	161_Q	0.503	0.91
93_E	285_M	0.500	0.91
167_L	193_K	0.500	0.91
78_N	83_Q	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wl1A	3	0.6104	100	0.362	Contact Map
3b8mA	3	0.6933	99	0.798	Contact Map
3b8oA	3	0.6074	99	0.799	Contact Map
4e29A	3	0.7025	99	0.8	Contact Map
4cgkA	3	0.7546	87.3	0.917	Contact Map
4iloA	3	0.5644	85	0.92	Contact Map
3ghgA	2	0.4479	83.5	0.921	Contact Map
4rsiA	1	0.3528	80.2	0.924	Contact Map
3na7A	1	0.638	72.8	0.929	Contact Map
4rsiB	1	0.5307	65.7	0.932	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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