GREMLIN Database
YEEY - Uncharacterized HTH-type transcriptional regulator YeeY
UniProt: P76369 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13392
Length: 309 (282)
Sequences: 79766 (57785)
Seq/√Len: 3441.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_E76_T3.5621.00
17_E26_K3.2881.00
162_S290_L2.5971.00
69_K83_Q2.4321.00
13_A26_K2.4081.00
98_G143_A2.3601.00
163_R268_P2.2151.00
166_D268_P2.1931.00
163_R166_D2.1881.00
94_E125_K2.1791.00
177_H194_Y2.1621.00
114_A292_N2.1351.00
47_I62_T2.1261.00
232_Q239_G2.1101.00
10_I37_T2.0581.00
12_D71_R2.0551.00
94_E123_R2.0291.00
168_E243_R2.0191.00
166_D266_F2.0181.00
12_D16_K1.9831.00
114_A288_E1.9821.00
69_K76_T1.9791.00
233_I254_A1.9731.00
170_V243_R1.9721.00
187_N190_I1.9721.00
22_A25_A1.9301.00
13_A17_E1.9281.00
96_V125_K1.9131.00
13_A16_K1.8721.00
229_L249_F1.8531.00
12_D67_L1.8471.00
15_E59_F1.8181.00
16_K71_R1.8111.00
173_V258_K1.7991.00
73_V77_V1.7981.00
10_I34_L1.7911.00
67_L71_R1.7811.00
197_I237_G1.7751.00
170_V257_E1.7521.00
233_I249_F1.7201.00
161_F270_W1.6891.00
195_R219_A1.6891.00
51_D58_K1.6691.00
65_M83_Q1.6631.00
15_E67_L1.6461.00
137_A142_R1.6391.00
66_L80_L1.6081.00
17_E22_A1.5941.00
134_S146_I1.5561.00
160_G275_E1.5471.00
69_K72_E1.5431.00
20_F38_V1.5331.00
12_D70_G1.5321.00
162_S273_W1.5051.00
136_D140_Q1.5041.00
16_K26_K1.4821.00
19_S22_A1.4771.00
7_V44_D1.4741.00
7_V37_T1.4551.00
7_V40_K1.4441.00
286_R290_L1.4371.00
90_G121_V1.4331.00
48_Q51_D1.4171.00
273_W286_R1.4171.00
115_F285_W1.4151.00
10_I29_K1.4131.00
160_G273_W1.4081.00
13_A27_L1.4021.00
11_L67_L1.4001.00
69_K79_E1.3941.00
148_G272_G1.3931.00
53_S58_K1.3881.00
105_F226_K1.3871.00
30_T33_A1.3871.00
182_E190_I1.3861.00
209_T213_L1.3831.00
150_M270_W1.3691.00
278_A282_S1.3641.00
21_A31_P1.3631.00
137_A143_A1.3631.00
118_H288_E1.3601.00
115_F122_T1.3511.00
76_T79_E1.3511.00
4_L7_V1.3401.00
284_W287_D1.3391.00
96_V127_I1.3381.00
92_E121_V1.3301.00
206_G213_L1.3271.00
138_L146_I1.3251.00
73_V80_L1.3181.00
61_R64_K1.3081.00
12_D74_L1.2961.00
167_L244_Y1.2931.00
114_A118_H1.2921.00
271_I286_R1.2831.00
68_E72_E1.2781.00
175_P254_A1.2771.00
66_L81_E1.2761.00
139_T158_E1.2671.00
5_L77_V1.2651.00
145_I271_I1.2601.00
69_K80_L1.2461.00
175_P256_I1.2461.00
194_Y238_C1.2371.00
228_K239_G1.2291.00
163_R270_W1.2241.00
173_V238_C1.2231.00
206_G210_A1.2211.00
116_Y219_A1.2201.00
230_E233_I1.2191.00
243_R257_E1.2091.00
29_K33_A1.2021.00
65_M68_E1.1991.00
116_Y195_R1.1911.00
113_E117_Q1.1741.00
145_I282_S1.1741.00
113_E234_S1.1731.00
36_Y40_K1.1681.00
249_F254_A1.1661.00
44_D81_E1.1641.00
11_L50_L1.1601.00
243_R247_Q1.1471.00
161_F272_G1.1441.00
11_L15_E1.1441.00
65_M69_K1.1421.00
185_P261_V1.1381.00
110_P234_S1.1051.00
195_R217_Q1.1051.00
36_Y39_H1.0931.00
173_V177_H1.0931.00
177_H180_A1.0921.00
64_K68_E1.0911.00
39_H43_S1.0861.00
72_E79_E1.0851.00
119_H284_W1.0841.00
288_E292_N1.0831.00
162_S286_R1.0791.00
247_Q251_D1.0781.00
257_E260_V1.0761.00
125_K221_T1.0731.00
186_L190_I1.0711.00
287_D290_L1.0701.00
8_L70_G1.0661.00
172_A257_E1.0581.00
139_T156_S1.0571.00
13_A23_A1.0571.00
114_A117_Q1.0531.00
274_N277_T1.0471.00
230_E234_S1.0441.00
20_F57_A1.0411.00
73_V76_T1.0411.00
283_G287_D1.0351.00
111_L289_I1.0311.00
248_R252_S1.0241.00
229_L233_I1.0201.00
37_T40_K1.0201.00
6_D9_M1.0191.00
11_L49_L1.0161.00
35_S39_H1.0161.00
168_E266_F1.0151.00
127_I137_A1.0131.00
81_E85_I1.0081.00
188_R262_A1.0071.00
75_H79_E0.9961.00
288_E291_A0.9941.00
222_V228_K0.9871.00
115_F288_E0.9831.00
174_A235_G0.9811.00
14_L23_A0.9801.00
197_I228_K0.9521.00
95_L285_W0.9501.00
14_L20_F0.9481.00
66_L70_G0.9451.00
172_A246_A0.9451.00
40_K43_S0.9421.00
115_F119_H0.9411.00
29_K34_L0.9401.00
78_R81_E0.9321.00
9_M78_R0.9311.00
207_A210_A0.9311.00
208_S212_Q0.9301.00
15_E50_L0.9241.00
198_V218_E0.9211.00
59_F63_G0.9191.00
23_A34_L0.9181.00
222_V231_L0.9171.00
137_A140_Q0.9161.00
22_A26_K0.9151.00
210_A213_L0.9141.00
10_I27_L0.9131.00
171_F238_C0.9121.00
207_A211_S0.9111.00
11_L41_L0.9101.00
78_R82_K0.9091.00
72_E75_H0.9071.00
11_L59_F0.8981.00
101_D224_D0.8951.00
65_M87_L0.8941.00
279_G282_S0.8881.00
118_H291_A0.8821.00
209_T214_L0.8791.00
18_G58_K0.8741.00
173_V179_L0.8731.00
77_V81_E0.8721.00
150_M268_P0.8671.00
68_E71_R0.8601.00
111_L288_E0.8591.00
160_G163_R0.8591.00
143_A146_I0.8531.00
180_A256_I0.8511.00
50_L57_A0.8471.00
47_I84_A0.8461.00
62_T65_M0.8431.00
205_A208_S0.8411.00
6_D37_T0.8411.00
21_A25_A0.8371.00
98_G148_G0.8331.00
135_W139_T0.8301.00
196_A216_E0.8291.00
190_I193_R0.8291.00
192_K214_L0.8271.00
205_A209_T0.8261.00
113_E236_L0.8241.00
98_G134_S0.8231.00
123_R217_Q0.8231.00
62_T87_L0.8211.00
127_I143_A0.8201.00
27_L34_L0.8191.00
93_N281_A0.8171.00
79_E83_Q0.8171.00
116_Y236_L0.8141.00
97_I145_I0.8131.00
53_S56_R0.8111.00
111_L292_N0.8111.00
246_A249_F0.8051.00
187_N261_V0.8051.00
62_T84_A0.8041.00
233_I252_S0.8021.00
17_E23_A0.7991.00
18_G56_R0.7981.00
76_T80_L0.7971.00
31_P35_S0.7971.00
195_R218_E0.7971.00
176_H180_A0.7951.00
15_E63_G0.7951.00
98_G146_I0.7921.00
278_A283_G0.7911.00
122_T281_A0.7911.00
15_E18_G0.7911.00
159_F272_G0.7901.00
16_K67_L0.7891.00
77_V80_L0.7891.00
189_R192_K0.7881.00
11_L66_L0.7871.00
249_F252_S0.7871.00
174_A177_H0.7811.00
280_L284_W0.7801.00
18_G64_K0.7791.00
5_L74_L0.7741.00
9_M13_A0.7731.00
39_H48_Q0.7721.00
172_A239_G0.7691.00
287_D291_A0.7651.00
174_A236_L0.7601.00
71_R75_H0.7601.00
168_E264_T0.7571.00
168_E259_K0.7541.00
14_L50_L0.7531.00
20_F34_L0.7491.00
99_V104_P0.7481.00
7_V10_I0.7481.00
133_G136_D0.7451.00
231_L236_L0.7431.00
80_L84_A0.7421.00
64_K67_L0.7401.00
250_L253_G0.7361.00
139_T159_F0.7351.00
158_E275_E0.7311.00
208_S211_S0.7311.00
118_H284_W0.7271.00
141_G274_N0.7261.00
145_I285_W0.7261.00
51_D60_T0.7261.00
284_W288_E0.7261.00
70_G73_V0.7231.00
115_F284_W0.7191.00
93_N122_T0.7171.00
14_L34_L0.7161.00
172_A241_L0.7151.00
61_R65_M0.7061.00
173_V256_I0.7051.00
144_D282_S0.7031.00
242_P245_L0.7021.00
176_H235_G0.7001.00
9_M12_D0.6971.00
114_A291_A0.6971.00
224_D227_T0.6931.00
172_A250_L0.6931.00
85_I88_H0.6881.00
14_L38_V0.6861.00
62_T66_L0.6821.00
151_H154_P0.6791.00
179_L194_Y0.6731.00
91_W119_H0.6721.00
179_L182_E0.6671.00
177_H195_R0.6641.00
51_D56_R0.6641.00
200_G221_T0.6621.00
105_F230_E0.6621.00
66_L84_A0.6611.00
59_F64_K0.6601.00
6_D40_K0.6571.00
96_V144_D0.6571.00
69_K73_V0.6561.00
177_H182_E0.6551.00
199_V228_K0.6551.00
187_N262_A0.6521.00
96_V143_A0.6521.00
196_A238_C0.6521.00
250_L257_E0.6451.00
58_K64_K0.6451.00
133_G137_A0.6451.00
33_A37_T0.6431.00
25_A28_Y0.6401.00
9_M74_L0.6401.00
220_I231_L0.6381.00
171_F240_Y0.6371.00
185_P259_K0.6341.00
246_A250_L0.6341.00
110_P113_E0.6341.00
182_E185_P0.6341.00
75_H78_R0.6331.00
209_T212_Q0.6311.00
79_E82_K0.6301.00
11_L63_G0.6271.00
248_R251_D0.6251.00
123_R221_T0.6241.00
280_L283_G0.6231.00
42_E52_R0.6201.00
182_E195_R0.6191.00
176_H256_I0.6141.00
193_R217_Q0.6121.00
110_P114_A0.6101.00
149_A267_E0.6101.00
206_G209_T0.6011.00
145_I286_R0.6011.00
42_E47_I0.6011.00
104_P131_L0.5961.00
82_K86_K0.5941.00
45_L66_L0.5901.00
95_L281_A0.5881.00
171_F191_I0.5871.00
108_L111_L0.5851.00
6_D10_I0.5841.00
38_V42_E0.5831.00
208_S213_L0.5821.00
205_A213_L0.5821.00
273_W283_G0.5811.00
70_G74_L0.5801.00
14_L19_S0.5791.00
74_L78_R0.5771.00
99_V108_L0.5761.00
23_A27_L0.5761.00
65_M84_A0.5731.00
15_E64_K0.5721.00
200_G223_F0.5721.00
45_L84_A0.5711.00
95_L145_I0.5701.00
119_H122_T0.5691.00
285_W289_I0.5691.00
175_P253_G0.5671.00
92_E123_R0.5621.00
192_K215_D0.5601.00
173_V180_A0.5601.00
20_F31_P0.5551.00
222_V227_T0.5541.00
50_L59_F0.5541.00
167_L267_E0.5541.00
47_I51_D0.5511.00
33_A36_Y0.5501.00
164_L271_I0.5491.00
169_Q240_Y0.5491.00
177_H238_C0.5481.00
150_M161_F0.5461.00
228_K232_Q0.5431.00
165_G269_V0.5431.00
138_L159_F0.5421.00
45_L48_Q0.5401.00
241_L246_A0.5391.00
32_S36_Y0.5371.00
98_G127_I0.5341.00
138_L272_G0.5341.00
30_T36_Y0.5321.00
93_N121_V0.5301.00
231_L237_G0.5291.00
110_P230_E0.5291.00
201_D221_T0.5281.00
82_K85_I0.5251.00
86_K91_W0.5231.00
59_F67_L0.5221.00
109_A113_E0.5221.00
83_Q86_K0.5211.00
18_G57_A0.5191.00
171_F196_A0.5181.00
225_F242_P0.5171.00
136_D142_R0.5171.00
29_K37_T0.5171.00
139_T142_R0.5161.00
141_G277_T0.5131.00
282_S286_R0.5111.00
273_W278_A0.5101.00
10_I38_V0.5091.00
48_Q62_T0.5091.00
107_L111_L0.5091.00
160_G276_Q0.5081.00
80_L83_Q0.5081.00
99_V126_F0.5081.00
103_F107_L0.5071.00
112_I124_L0.5051.00
20_F56_R0.5041.00
147_V289_I0.5011.00
134_S141_G0.5011.00
105_F224_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fzvA 4 0.9223 100 0.116 Contact Map
2esnA 3 0.9417 100 0.123 Contact Map
3fxqA 3 0.9385 100 0.131 Contact Map
1uthA 2 0.7184 100 0.131 Contact Map
1ixcA 4 0.932 100 0.131 Contact Map
4x6gA 4 0.9644 100 0.137 Contact Map
2h98A 2 0.6731 100 0.138 Contact Map
2h9bA 2 0.6764 100 0.141 Contact Map
1al3A 1 0.7055 100 0.142 Contact Map
3hhgA 3 0.9353 100 0.144 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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