GREMLIN Database
CBEA - Cytoskeleton bundling-enhancing protein CbeA
UniProt: P76364 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13388
Length: 122 (104)
Sequences: 164 (54)
Seq/√Len: 5.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_L87_Q4.8800.97
98_T117_T3.6470.87
75_L93_Y2.5640.60
43_Y50_I2.2150.49
43_Y107_C2.1320.46
64_Q68_L2.1050.45
76_M83_N2.0700.44
59_A68_L2.0150.42
23_P26_V1.9860.41
35_V42_H1.9400.40
19_W29_C1.9380.40
38_G54_F1.8380.36
30_F116_P1.7800.35
69_L87_Q1.7490.34
50_I117_T1.7240.33
68_L97_L1.7220.33
43_Y49_G1.7100.33
35_V84_P1.6540.31
64_Q70_M1.6200.30
42_H84_P1.5810.29
103_T110_V1.5560.28
71_K87_Q1.4940.27
36_Q77_L1.4870.26
69_L95_K1.4070.24
30_F71_K1.4040.24
64_Q97_L1.3480.23
104_L113_A1.3400.23
68_L87_Q1.3100.22
92_L116_P1.2670.21
100_K104_L1.2390.20
50_I75_L1.2330.20
42_H77_L1.2330.20
63_D107_C1.2220.20
36_Q55_S1.2050.20
48_A110_V1.2000.20
39_N43_Y1.1890.19
107_C118_P1.1620.19
94_A104_L1.1590.19
65_A94_A1.1550.19
85_R91_T1.1420.18
18_P112_L1.1380.18
50_I57_A1.1350.18
37_E42_H1.1150.18
23_P29_C1.0950.18
69_L73_L1.0850.17
29_C60_Y1.0840.17
86_H93_Y1.0440.17
18_P38_G1.0400.16
24_C113_A1.0100.16
28_P52_G0.9880.16
78_T90_V0.9810.15
43_Y59_A0.9800.15
44_L52_G0.9800.15
28_P44_L0.9620.15
58_D116_P0.9540.15
89_T104_L0.9460.15
67_P81_E0.9410.15
54_F72_Q0.9410.15
23_P53_L0.9380.15
55_S113_A0.9350.15
84_P110_V0.9350.15
64_Q72_Q0.9330.15
70_M97_L0.9280.15
70_M91_T0.9260.14
43_Y83_N0.9210.14
26_V89_T0.9090.14
24_C50_I0.9060.14
83_N93_Y0.9060.14
58_D83_N0.9000.14
58_D72_Q0.8910.14
63_D96_G0.8860.14
61_H69_L0.8830.14
58_D94_A0.8810.14
75_L88_H0.8760.14
22_L109_Y0.8720.14
21_G52_G0.8610.13
72_Q107_C0.8510.13
21_G28_P0.8420.13
24_C89_T0.8370.13
21_G44_L0.8300.13
54_F84_P0.8230.13
50_I59_A0.8090.13
41_L52_G0.8040.13
32_A102_D0.7980.12
91_T98_T0.7920.12
92_L104_L0.7910.12
77_L110_V0.7880.12
61_H97_L0.7860.12
28_P41_L0.7830.12
29_C76_M0.7830.12
36_Q84_P0.7830.12
18_P50_I0.7800.12
89_T114_V0.7740.12
41_L44_L0.7690.12
48_A63_D0.7610.12
15_H43_Y0.7610.12
24_C31_G0.7570.12
35_V77_L0.7530.12
58_D95_K0.7430.12
24_C57_A0.7370.12
21_G41_L0.7350.12
112_L118_P0.7260.11
35_V59_A0.7240.11
52_G115_Y0.7230.11
49_G57_A0.7220.11
62_L82_L0.7070.11
28_P115_Y0.7030.11
60_Y95_K0.7030.11
58_D69_L0.6960.11
17_R49_G0.6950.11
44_L115_Y0.6910.11
48_A67_P0.6880.11
60_Y92_L0.6860.11
89_T94_A0.6790.11
76_M81_E0.6640.11
50_I70_M0.6630.11
84_P97_L0.6570.11
94_A97_L0.6460.10
62_L105_S0.6430.10
32_A48_A0.6400.10
20_W109_Y0.6370.10
77_L82_L0.6310.10
38_G79_S0.6280.10
69_L94_A0.6150.10
26_V62_L0.6070.10
23_P89_T0.6070.10
92_L100_K0.6030.10
17_R87_Q0.5990.10
37_E45_A0.5910.10
64_Q71_K0.5850.10
76_M88_H0.5620.09
30_F92_L0.5620.09
43_Y57_A0.5610.09
36_Q42_H0.5590.09
27_T38_G0.5540.09
30_F97_L0.5530.09
21_G115_Y0.5530.09
78_T86_H0.5530.09
51_R116_P0.5470.09
61_H70_M0.5440.09
92_L114_V0.5380.09
93_Y118_P0.5370.09
69_L104_L0.5290.09
75_L92_L0.5250.09
75_L95_K0.5240.09
43_Y104_L0.5230.09
104_L112_L0.5230.09
50_I85_R0.5220.09
19_W30_F0.5220.09
25_T78_T0.5210.09
29_C51_R0.5150.09
41_L83_N0.5070.09
61_H64_Q0.5040.09
56_D60_Y0.5020.09
40_R58_D0.5000.09
39_N65_A0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2inwA 1 0.959 100 0.085 Contact Map
2ea9A 1 0.8443 100 0.132 Contact Map
3h2tA 2 0.3607 25.2 0.954 Contact Map
1dquA 4 0.9098 18.1 0.957 Contact Map
4jm1A 1 0.3033 13.5 0.959 Contact Map
4ekfA 1 0.7213 13.3 0.959 Contact Map
1xv2A 2 0.6475 7.2 0.964 Contact Map
3neaA 1 0.5738 6 0.965 Contact Map
4wghA 1 0.5656 5.5 0.966 Contact Map
1rybA 1 0.6148 5.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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