GREMLIN Database
YEES - UPF0758 protein YeeS
UniProt: P76362 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13386
Length: 148 (141)
Sequences: 4037 (2945)
Seq/√Len: 248.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_F145_H2.7821.00
82_I121_L2.6541.00
64_E84_R2.5251.00
95_L128_V2.4491.00
55_N59_Q2.4081.00
111_R142_F2.3601.00
46_R68_T2.0811.00
37_L96_A2.0311.00
62_A88_H1.9741.00
118_V128_V1.9011.00
108_K112_L1.8931.00
95_L117_L1.8891.00
28_T32_A1.8741.00
71_I91_A1.8301.00
27_F60_L1.7811.00
50_R65_T1.7121.00
65_T68_T1.7031.00
56_N72_N1.6881.00
53_Y84_R1.6661.00
114_T131_H1.6591.00
48_E68_T1.6531.00
115_E119_Q1.6471.00
48_E65_T1.6411.00
83_K89_N1.6251.00
111_R147_L1.5941.00
33_A94_V1.5751.00
44_L48_E1.5521.00
67_F74_T1.5421.00
31_R35_E1.5331.00
50_R63_G1.5021.00
12_A16_L1.5011.00
52_L60_L1.4901.00
104_V138_Q1.4811.00
30_T144_E1.4771.00
53_Y88_H1.4341.00
84_R87_Y1.4331.00
119_Q122_G1.4211.00
81_V117_L1.4141.00
40_N63_G1.3871.00
76_V113_I1.3841.00
49_F76_V1.3441.00
41_M44_L1.3411.00
108_K111_R1.3401.00
85_A93_V1.3201.00
83_K87_Y1.3041.00
45_E83_K1.3031.00
104_V140_F1.3011.00
14_K18_R1.2941.00
34_R139_V1.2871.00
85_A126_I1.2861.00
58_N92_A1.2851.00
132_L139_V1.2781.00
82_I124_V1.2731.00
84_R88_H1.2721.00
57_Q103_E1.2691.00
118_V122_G1.2571.00
14_K17_D1.2451.00
140_F147_L1.2211.00
34_R38_I1.2191.00
49_F128_V1.1971.00
53_Y85_A1.1841.00
120_A123_L1.1611.00
37_L52_L1.1511.00
41_M50_R1.1061.00
54_L92_A1.1001.00
105_T145_H1.0901.00
93_V121_L1.0861.00
49_F74_T1.0841.00
121_L124_V1.0801.00
27_F33_A1.0701.00
58_N129_P1.0681.00
12_A15_T1.0531.00
70_T80_E1.0471.00
46_R67_F1.0401.00
142_F147_L1.0391.00
36_W63_G1.0321.00
38_I42_A1.0291.00
13_L16_L1.0281.00
120_A124_V1.0151.00
8_L12_A1.0151.00
80_E83_K1.0081.00
51_V95_L1.0071.00
52_L63_G1.0051.00
70_T77_H1.0031.00
42_A136_G0.9981.00
27_F36_W0.9851.00
29_S32_A0.9731.00
16_L19_H0.9721.00
44_L65_T0.9651.00
133_I140_F0.9641.00
11_R14_K0.9541.00
53_Y90_A0.9531.00
53_Y64_E0.9531.00
70_T75_E0.9431.00
27_F32_A0.9401.00
119_Q123_L0.9381.00
71_I79_R0.9341.00
121_L128_V0.9301.00
50_R96_A0.9241.00
31_R144_E0.9151.00
104_V135_G0.8971.00
115_E118_V0.8871.00
92_A129_P0.8831.00
34_R144_E0.8700.99
34_R132_L0.8680.99
51_V66_L0.8670.99
49_F95_L0.8600.99
35_E38_I0.8580.99
46_R80_E0.8540.99
13_L19_H0.8490.99
93_V128_V0.8480.99
26_A59_Q0.8370.99
38_I136_G0.8310.99
42_A135_G0.8300.99
33_A96_A0.8290.99
62_A84_R0.8260.99
64_E88_H0.8150.99
61_I90_A0.8020.99
106_P140_F0.7990.99
33_A132_L0.7960.99
49_F113_I0.7820.99
53_Y62_A0.7780.99
104_V133_I0.7770.99
11_R15_T0.7750.99
56_N91_A0.7740.99
8_L11_R0.7720.99
122_G127_R0.7710.99
142_F145_H0.7650.99
67_F75_E0.7640.99
53_Y66_L0.7620.99
44_L68_T0.7590.99
79_R91_A0.7560.99
116_R125_D0.7540.99
25_V32_A0.7520.99
13_L17_D0.7520.99
106_P133_I0.7500.98
77_H80_E0.7490.98
111_R115_E0.7470.98
46_R64_E0.7440.98
40_N65_T0.7370.98
109_A112_L0.7350.98
11_R16_L0.7210.98
92_A127_R0.7200.98
7_S11_R0.7190.98
37_L63_G0.7100.98
116_R119_Q0.6990.98
12_A19_H0.6950.98
139_V144_E0.6890.97
72_N91_A0.6810.97
134_V139_V0.6800.97
38_I137_N0.6580.97
81_V95_L0.6560.96
54_L94_V0.6560.96
76_V81_V0.6540.96
21_H40_N0.6460.96
40_N50_R0.6440.96
112_L115_E0.6370.96
133_I147_L0.6340.96
20_L39_L0.6270.95
74_T113_I0.6270.95
121_L126_I0.6200.95
30_T34_R0.6180.95
10_Q15_T0.6180.95
8_L17_D0.6110.95
45_E89_N0.6100.95
8_L15_T0.6010.94
10_Q13_L0.5920.94
11_R18_R0.5910.94
112_L116_R0.5910.94
41_M134_V0.5900.94
25_V60_L0.5900.94
130_D141_S0.5900.94
26_A60_L0.5880.94
32_A35_E0.5820.93
117_L128_V0.5820.93
78_P117_L0.5810.93
54_L58_N0.5780.93
82_I128_V0.5780.93
71_I89_N0.5770.93
66_L81_V0.5740.93
17_D21_H0.5670.92
16_L20_L0.5660.92
78_P82_I0.5640.92
27_F52_L0.5630.92
7_S14_K0.5590.92
53_Y93_V0.5560.92
30_T33_A0.5530.91
45_E87_Y0.5510.91
122_G125_D0.5490.91
86_L120_A0.5480.91
96_A132_L0.5430.91
135_G138_Q0.5350.90
38_I135_G0.5330.90
13_L20_L0.5300.90
8_L16_L0.5300.90
138_Q145_H0.5290.90
9_I12_A0.5270.89
10_Q16_L0.5270.89
61_I88_H0.5250.89
25_V59_Q0.5240.89
38_I134_V0.5240.89
15_T19_H0.5230.89
41_M96_A0.5170.88
25_V35_E0.5150.88
78_P120_A0.5140.88
103_E106_P0.5070.88
56_N71_I0.5060.87
67_F113_I0.5040.87
7_S16_L0.5030.87
79_R126_I0.5020.87
30_T143_A0.5010.87
39_L42_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlcA 1 0.8514 100 0.151 Contact Map
1oi0A 1 0.6757 87.6 0.892 Contact Map
2kcqA 1 0.7635 86.1 0.894 Contact Map
2kksA 1 0.7703 82.7 0.899 Contact Map
3k13A 1 0.9865 60.1 0.915 Contact Map
3oqpA 2 0.6554 58.9 0.916 Contact Map
2znrA 1 0.8716 54.9 0.918 Contact Map
1jvnA 1 0.9189 48.7 0.921 Contact Map
3rzvA 1 0.8514 46.9 0.922 Contact Map
4jxeA 1 0.8986 44 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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