GREMLIN Database
YEEO - Uncharacterized transporter YeeO
UniProt: P76352 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13383
Length: 495 (425)
Sequences: 17732 (13294)
Seq/√Len: 644.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_D114_R4.7141.00
173_A235_Y3.9051.00
162_T224_V3.3581.00
79_G309_F3.1521.00
104_A334_G3.1501.00
375_A388_V3.0781.00
142_E161_L3.0111.00
370_F373_V2.9831.00
270_W274_G2.8441.00
189_N192_I2.7821.00
140_F143_Q2.7131.00
142_E146_D2.6891.00
341_Q344_Q2.6811.00
203_L236_I2.5381.00
99_T122_S2.5301.00
166_L224_V2.5281.00
266_F270_W2.4951.00
210_I215_L2.4291.00
66_L212_I2.4041.00
73_D155_E2.3881.00
161_L165_E2.3471.00
153_T302_T2.3061.00
66_L209_G2.3061.00
417_D469_R2.2801.00
106_S114_R2.2711.00
77_G159_L2.2511.00
40_R44_P2.2171.00
200_L237_G2.1681.00
176_I238_A2.1141.00
196_I240_A2.0981.00
159_L162_T2.0801.00
350_R354_W2.0631.00
382_P386_H2.0351.00
166_L227_G2.0211.00
329_S352_V2.0141.00
71_G74_A1.9881.00
117_V265_N1.9771.00
307_G387_V1.9721.00
447_G450_G1.9661.00
63_S230_L1.9601.00
390_I449_V1.9501.00
224_V228_L1.9461.00
371_A393_W1.9291.00
67_V226_A1.9211.00
50_F324_A1.9181.00
158_A162_T1.9141.00
170_S231_T1.9021.00
212_I226_A1.8891.00
221_L228_L1.8651.00
210_I214_G1.8411.00
126_M179_I1.8391.00
383_Q386_H1.8301.00
66_L208_S1.8221.00
72_K381_D1.7851.00
372_G389_V1.7821.00
47_V51_M1.7721.00
336_R344_Q1.7641.00
303_S383_Q1.7491.00
106_S111_D1.7251.00
141_G161_L1.6921.00
239_V243_W1.6901.00
106_S109_K1.6891.00
215_L220_G1.6851.00
146_D157_K1.6811.00
191_K195_L1.6751.00
166_L228_L1.6701.00
169_L172_P1.6671.00
332_I348_Q1.6631.00
337_L415_A1.6621.00
371_A389_V1.6611.00
401_I460_A1.6601.00
214_G220_G1.6561.00
196_I241_I1.6481.00
173_A238_A1.6281.00
368_A393_W1.6281.00
265_N268_I1.6171.00
46_A328_A1.6121.00
202_I206_I1.5941.00
349_L408_L1.5871.00
356_S403_S1.5841.00
102_V118_A1.5821.00
209_G215_L1.5731.00
347_I350_R1.5681.00
209_G213_Y1.5511.00
155_E302_T1.5501.00
62_L205_I1.5491.00
208_S226_A1.5331.00
346_E350_R1.5301.00
143_Q146_D1.5291.00
157_K161_L1.5161.00
337_L345_A1.5031.00
155_E158_A1.5001.00
207_I229_G1.4731.00
166_L231_T1.4711.00
372_G376_S1.4671.00
141_G165_E1.4661.00
134_A172_P1.4661.00
364_A368_A1.4651.00
211_L215_L1.4581.00
347_I351_H1.4551.00
146_D154_T1.4551.00
203_L207_I1.4541.00
39_W351_H1.4531.00
81_A164_L1.4391.00
417_D420_Y1.4351.00
154_T158_A1.4341.00
142_E158_A1.4301.00
180_G241_I1.4241.00
206_I210_I1.4211.00
145_I157_K1.4111.00
343_A347_I1.4101.00
349_L411_G1.4071.00
67_V78_V1.4061.00
63_S204_N1.4041.00
336_R341_Q1.4001.00
373_V376_S1.3861.00
446_W450_G1.3771.00
206_I209_G1.3741.00
106_S118_A1.3681.00
38_F332_I1.3571.00
394_L453_M1.3571.00
112_R116_R1.3511.00
243_W247_I1.3511.00
373_V377_F1.3481.00
376_S385_K1.3471.00
211_L221_L1.3411.00
36_V40_R1.3371.00
467_Y471_V1.3311.00
195_L199_S1.3161.00
105_F334_G1.3161.00
51_M194_L1.3141.00
464_V468_W1.3121.00
468_W471_V1.3071.00
368_A396_A1.3041.00
137_I168_V1.2941.00
389_V393_W1.2881.00
107_L335_R1.2851.00
107_L115_A1.2801.00
224_V227_G1.2791.00
354_W358_L1.2781.00
356_S407_V1.2751.00
114_R117_V1.2731.00
108_G338_G1.2721.00
468_W472_T1.2611.00
439_V443_M1.2601.00
105_F109_K1.2581.00
55_C198_G1.2581.00
113_R117_V1.2581.00
427_L431_G1.2561.00
196_I244_V1.2511.00
438_Y442_I1.2511.00
142_E157_K1.2471.00
74_A159_L1.2451.00
386_H390_I1.2441.00
143_Q147_F1.2391.00
207_I232_I1.2381.00
432_C461_V1.2351.00
70_L213_Y1.2261.00
267_S270_W1.2241.00
64_T313_S1.2201.00
73_D302_T1.2171.00
365_W369_P1.2121.00
76_A306_A1.2101.00
314_I374_M1.2091.00
419_R423_W1.2021.00
149_A152_A1.1991.00
39_W355_L1.1981.00
208_S229_G1.1981.00
114_R268_I1.1951.00
342_I346_E1.1931.00
375_A385_K1.1921.00
72_K303_S1.1891.00
420_Y469_R1.1871.00
204_N230_L1.1841.00
64_T75_M1.1641.00
450_G454_G1.1551.00
105_F416_R1.1531.00
277_I281_V1.1531.00
77_G156_V1.1521.00
209_G212_I1.1501.00
446_W453_M1.1501.00
199_S240_A1.1491.00
78_V223_F1.1421.00
326_G410_A1.1371.00
69_W380_Q1.1361.00
138_H165_E1.1321.00
121_Q264_L1.1291.00
69_W213_Y1.1221.00
211_L232_I1.1211.00
145_I160_A1.1191.00
264_L269_I1.1131.00
209_G214_G1.1091.00
121_Q269_I1.0921.00
253_L257_L1.0821.00
469_R472_T1.0791.00
405_S459_W1.0781.00
119_T183_A1.0771.00
73_D159_L1.0761.00
333_T345_A1.0721.00
387_V390_I1.0701.00
189_N193_P1.0691.00
42_I352_V1.0691.00
103_V186_G1.0681.00
134_A138_H1.0641.00
63_S208_S1.0571.00
431_G435_V1.0521.00
311_A391_L1.0501.00
37_L40_R1.0451.00
304_V448_V1.0391.00
125_I269_I1.0391.00
211_L214_G1.0361.00
214_G221_L1.0351.00
443_M446_W1.0291.00
349_L470_M1.0251.00
303_S387_V1.0231.00
203_L233_S1.0201.00
423_W427_L1.0181.00
435_V439_V1.0161.00
424_V466_F1.0161.00
358_L362_A1.0121.00
385_K388_V1.0051.00
139_H143_Q1.0041.00
192_I244_V1.0031.00
43_T47_V0.9981.00
198_G202_I0.9971.00
440_L446_W0.9891.00
108_G339_V0.9871.00
126_M175_A0.9841.00
228_L231_T0.9821.00
165_E169_L0.9801.00
351_H355_L0.9771.00
188_G335_R0.9771.00
386_H389_V0.9721.00
215_L221_L0.9711.00
127_T176_I0.9701.00
295_M299_G0.9671.00
118_A268_I0.9671.00
122_S272_V0.9651.00
117_V268_I0.9571.00
134_A169_L0.9541.00
116_R259_S0.9541.00
256_S259_S0.9461.00
314_I367_T0.9451.00
458_D462_R0.9431.00
60_G82_D0.9431.00
139_H165_E0.9401.00
107_L187_A0.9381.00
271_E274_G0.9361.00
105_F337_L0.9341.00
324_A328_A0.9281.00
394_L449_V0.9251.00
251_P254_R0.9251.00
180_G238_A0.9251.00
361_T365_W0.9231.00
208_S230_L0.9221.00
336_R348_Q0.9181.00
372_G386_H0.9141.00
107_L112_R0.9141.00
141_G164_L0.9131.00
124_V264_L0.9101.00
285_L426_M0.9091.00
401_I463_A0.9091.00
294_Q298_A0.9041.00
35_K341_Q0.9021.00
375_A389_V0.8991.00
362_A366_L0.8981.00
231_T235_Y0.8971.00
184_L245_L0.8931.00
391_L448_V0.8921.00
301_G304_V0.8901.00
80_L152_A0.8881.00
128_L132_L0.8861.00
307_G384_V0.8861.00
41_E44_P0.8851.00
408_L470_M0.8831.00
310_I378_Y0.8801.00
235_Y239_V0.8771.00
207_I211_L0.8751.00
49_I327_S0.8731.00
92_F175_A0.8711.00
412_F469_R0.8711.00
345_A349_L0.8691.00
62_L204_N0.8671.00
353_F404_A0.8661.00
298_A305_I0.8641.00
189_N244_V0.8611.00
362_A365_W0.8551.00
385_K389_V0.8521.00
65_F68_S0.8521.00
70_L220_G0.8521.00
162_T165_E0.8511.00
436_V457_A0.8501.00
333_T414_G0.8491.00
296_F437_G0.8461.00
66_L213_Y0.8461.00
345_A415_A0.8451.00
159_L223_F0.8451.00
308_N452_W0.8411.00
296_F438_Y0.8381.00
368_A372_G0.8371.00
55_C201_N0.8371.00
76_A156_V0.8361.00
62_L201_N0.8361.00
383_Q387_V0.8301.00
85_N167_T0.8301.00
45_L190_T0.8281.00
199_S203_L0.8271.00
105_F271_E0.8261.00
99_T103_V0.8251.00
369_P373_V0.8211.00
177_T237_G0.8201.00
204_N208_S0.8191.00
322_G360_L0.8141.00
281_V422_M0.8111.00
132_L136_L0.8111.00
138_H142_E0.8111.00
195_L198_G0.8101.00
333_T411_G0.8101.00
135_T139_H0.8101.00
240_A243_W0.8091.00
228_L232_I0.8091.00
379_T384_V0.8071.00
454_G458_D0.8061.00
274_G419_R0.8051.00
297_V448_V0.8041.00
180_G245_L0.8031.00
325_L352_V0.8031.00
304_V387_V0.8031.00
313_S378_Y0.8021.00
194_L198_G0.8011.00
236_I240_A0.7981.00
307_G388_V0.7971.00
169_L231_T0.7941.00
154_T157_K0.7941.00
449_V453_M0.7921.00
336_R339_V0.7901.00
189_N248_G0.7881.00
136_L140_F0.7871.00
72_K384_V0.7821.00
103_V183_A0.7781.00
432_C435_V0.7781.00
296_F299_G0.7781.00
254_R257_L0.7781.00
428_S462_R0.7751.00
347_I354_W0.7731.00
91_F280_S0.7711.00
73_D76_A0.7711.00
404_A463_A0.7711.00
156_V305_I0.7691.00
149_A153_T0.7681.00
382_P385_K0.7671.00
184_L241_I0.7671.00
67_V212_I0.7661.00
166_L169_L0.7661.00
73_D156_V0.7651.00
41_E335_R0.7641.00
257_L260_Y0.7621.00
41_E332_I0.7621.00
300_M441_G0.7601.00
243_W246_A0.7591.00
436_V440_L0.7581.00
102_V275_I0.7561.00
55_C58_L0.7541.00
352_V407_V0.7521.00
42_I351_H0.7511.00
394_L456_F0.7491.00
310_I388_V0.7491.00
184_L192_I0.7491.00
104_A186_G0.7481.00
343_A350_R0.7471.00
39_W354_W0.7471.00
204_N233_S0.7451.00
440_L450_G0.7431.00
158_A161_L0.7421.00
59_M230_L0.7411.00
460_A464_V0.7381.00
437_G441_G0.7381.00
307_G391_L0.7381.00
358_L361_T0.7361.00
162_T223_F0.7351.00
52_E197_N0.7341.00
141_G168_V0.7341.00
299_G442_I0.7321.00
39_W43_T0.7311.00
297_V451_V0.7291.00
208_S212_I0.7291.00
271_E416_R0.7271.00
185_R193_P0.7271.00
397_L400_P0.7251.00
101_V105_F0.7241.00
344_Q347_I0.7241.00
109_K338_G0.7231.00
77_G223_F0.7191.00
122_S179_I0.7181.00
357_T361_T0.7171.00
124_V128_L0.7171.00
46_A324_A0.7141.00
351_H354_W0.7131.00
361_T400_P0.7121.00
220_G224_V0.7111.00
61_V317_L0.7111.00
102_V106_S0.7111.00
268_I271_E0.7101.00
242_L246_A0.7081.00
58_L62_L0.7071.00
68_S75_M0.7071.00
325_L359_G0.7061.00
441_G450_G0.7051.00
132_L135_T0.7011.00
432_C436_V0.7011.00
371_A392_I0.7001.00
62_L66_L0.7001.00
203_L232_I0.6991.00
296_F441_G0.6971.00
227_G231_T0.6941.00
336_R345_A0.6921.00
42_I328_A0.6911.00
381_D385_K0.6911.00
155_E159_L0.6891.00
232_I235_Y0.6861.00
370_F374_M0.6851.00
333_T349_L0.6841.00
65_F377_F0.6821.00
192_I240_A0.6811.00
354_W357_T0.6811.00
276_G280_S0.6791.00
103_V115_A0.6771.00
371_A375_A0.6761.00
453_M456_F0.6751.00
142_E165_E0.6731.00
199_S236_I0.6711.00
168_V171_Y0.6711.00
145_I164_L0.6681.00
325_L356_S0.6681.00
292_L434_V0.6671.00
163_Y208_S0.6671.00
116_R256_S0.6671.00
77_G160_A0.6631.00
357_T403_S0.6631.00
450_G453_M0.6631.00
360_L403_S0.6621.00
329_S333_T0.6621.00
140_F144_I0.6621.00
420_Y424_V0.6611.00
293_T451_V0.6611.00
67_V223_F0.6601.00
372_G385_K0.6591.00
130_A172_P0.6581.00
410_A414_G0.6561.00
114_R118_A0.6491.00
368_A371_A0.6481.00
284_V288_S0.6461.00
164_L168_V0.6441.00
170_S173_A0.6441.00
252_A255_I0.6441.00
152_A298_A0.6421.00
120_R260_Y0.6401.00
425_S428_S0.6391.00
275_I418_A0.6381.00
233_S236_I0.6381.00
113_R259_S0.6381.00
434_V438_Y0.6371.00
169_L173_A0.6371.00
278_P422_M0.6371.00
296_F442_I0.6361.00
369_P372_G0.6361.00
67_V74_A0.6341.00
65_F69_W0.6331.00
135_T138_H0.6321.00
307_G452_W0.6311.00
94_A280_S0.6291.00
359_G363_I0.6251.00
70_L74_A0.6251.00
59_M200_L0.6251.00
221_L224_V0.6231.00
213_Y221_L0.6231.00
74_A222_G0.6231.00
101_V275_I0.6231.00
273_M277_I0.6211.00
448_V452_W0.6211.00
297_V308_N0.6191.00
343_A346_E0.6181.00
117_V120_R0.6171.00
75_M310_I0.6171.00
170_S234_R0.6171.00
303_S306_A0.6151.00
393_W397_L0.6151.00
315_A399_M0.6131.00
168_V172_P0.6121.00
59_M234_R0.6071.00
342_I345_A0.6061.00
321_P359_G0.6041.00
211_L226_A0.6041.00
58_L201_N0.6021.00
113_R116_R0.6021.00
437_G451_V0.6011.00
198_G201_N0.6001.00
433_R458_D0.6001.00
127_T131_V0.6001.00
255_I258_K0.5981.00
366_L370_F0.5981.00
156_V159_L0.5971.00
330_T413_K0.5951.00
180_G242_L0.5941.00
54_A58_L0.5941.00
379_T382_P0.5941.00
255_I260_Y0.5941.00
240_A244_V0.5931.00
117_V121_Q0.5931.00
411_G415_A0.5921.00
177_T238_A0.5921.00
136_L139_H0.5921.00
440_L443_M0.5911.00
379_T385_K0.5911.00
300_M304_V0.5911.00
163_Y226_A0.5891.00
296_F451_V0.5891.00
157_K160_A0.5871.00
204_N229_G0.5871.00
165_E224_V0.5871.00
337_L342_I0.5851.00
318_I363_I0.5831.00
181_S185_R0.5801.00
41_E344_Q0.5801.00
111_D117_V0.5801.00
138_H169_L0.5801.00
76_A79_G0.5781.00
203_L206_I0.5781.00
152_A157_K0.5771.00
408_L466_F0.5771.00
355_L358_L0.5771.00
211_L228_L0.5771.00
101_V334_G0.5761.00
408_L467_Y0.5751.00
357_T400_P0.5741.00
38_F351_H0.5741.00
319_N402_W0.5741.00
120_R259_S0.5731.00
412_F417_D0.5721.00
131_V135_T0.5721.00
335_R339_V0.5711.00
424_V465_L0.5701.00
42_I355_L0.5701.00
138_H141_G0.5681.00
109_K340_G0.5681.00
199_S202_I0.5671.00
384_V388_V0.5661.00
396_A400_P0.5651.00
277_I280_S0.5641.00
436_V439_V0.5631.00
145_I161_L0.5631.00
353_F357_T0.5631.00
418_A422_M0.5621.00
357_T404_A0.5601.00
130_A168_V0.5601.00
131_V134_A0.5581.00
100_T182_G0.5581.00
465_L468_W0.5571.00
74_A77_G0.5571.00
315_A395_N0.5541.00
162_T166_L0.5541.00
60_G167_T0.5521.00
254_R260_Y0.5501.00
427_L465_L0.5501.00
311_A392_I0.5501.00
196_I237_G0.5451.00
316_A319_N0.5421.00
110_R339_V0.5411.00
127_T130_A0.5411.00
82_D86_M0.5411.00
439_V442_I0.5401.00
304_V307_G0.5401.00
405_S462_R0.5391.00
130_A134_A0.5391.00
38_F347_I0.5391.00
131_V172_P0.5371.00
453_M457_A0.5371.00
247_I251_P0.5360.99
172_P235_Y0.5350.99
322_G403_S0.5350.99
300_M447_G0.5350.99
97_L327_S0.5350.99
156_V302_T0.5350.99
49_I324_A0.5340.99
438_Y441_G0.5340.99
254_R258_K0.5340.99
447_G454_G0.5330.99
244_V248_G0.5320.99
205_I209_G0.5310.99
173_A231_T0.5300.99
120_R124_V0.5300.99
210_I220_G0.5290.99
95_I129_F0.5290.99
95_I280_S0.5280.99
75_M379_T0.5280.99
38_F348_Q0.5280.99
72_K306_A0.5270.99
428_S465_L0.5270.99
364_A400_P0.5260.99
436_V461_V0.5250.99
156_V160_A0.5210.99
182_G185_R0.5190.99
229_G233_S0.5190.99
435_V438_Y0.5190.99
330_T410_A0.5180.99
461_V465_L0.5180.99
303_S384_V0.5180.99
185_R190_T0.5170.99
115_A119_T0.5160.99
293_T437_G0.5160.99
238_A242_L0.5160.99
94_A330_T0.5150.99
80_L305_I0.5150.99
121_Q268_I0.5140.99
37_L41_E0.5140.99
62_L65_F0.5140.99
253_L256_S0.5130.99
66_L229_G0.5130.99
353_F408_L0.5110.99
80_L160_A0.5110.99
283_S287_T0.5100.99
192_I248_G0.5100.99
404_A467_Y0.5100.99
329_S407_V0.5100.99
267_S271_E0.5100.99
177_T181_S0.5090.99
269_I273_M0.5090.99
49_I190_T0.5080.99
98_G275_I0.5070.99
246_A254_R0.5060.99
138_H168_V0.5060.99
98_G276_G0.5060.99
134_A139_H0.5040.99
43_T355_L0.5040.99
221_L225_G0.5030.99
58_L61_V0.5010.99
297_V391_L0.5000.99
148_V291_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9192 100 0.359 Contact Map
4humA 1 0.9273 100 0.371 Contact Map
4lz6A 1 0.897 100 0.394 Contact Map
3w4tA 1 0.8929 100 0.437 Contact Map
3wdoA 1 0.8121 85.2 0.946 Contact Map
4ikvA 1 0.8444 83.6 0.947 Contact Map
4zw9A 1 0.8444 78.8 0.95 Contact Map
1pw4A 1 0.8384 75.5 0.951 Contact Map
4j05A 3 0.796 75.4 0.951 Contact Map
4tphA 2 0.7576 68.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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