GREMLIN Database
SHIA - Shikimate transporter
UniProt: P76350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20205
Length: 438 (377)
Sequences: 153921 (110993)
Seq/√Len: 5716.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_P127_L4.3141.00
110_L131_L3.9261.00
103_M138_A3.6981.00
112_G203_L3.5791.00
93_R152_E3.5281.00
76_F133_A3.3901.00
84_F141_G3.0491.00
154_A162_Y3.0311.00
100_T141_G2.8981.00
105_G209_V2.8501.00
107_A131_L2.8101.00
325_I356_A2.6561.00
158_K161_F2.6251.00
89_D378_Y2.5201.00
332_P349_S2.5141.00
260_L392_G2.4771.00
107_A138_A2.4531.00
116_S127_L2.4451.00
155_P158_K2.4061.00
107_A134_I2.3931.00
298_L351_M2.3721.00
372_F380_G2.3701.00
196_W200_I2.3681.00
94_K98_M2.3541.00
160_A311_D2.3521.00
284_P287_L2.3461.00
302_T355_I2.3011.00
80_G137_F2.2631.00
264_L396_T2.2511.00
88_G145_G2.2011.00
344_W348_F2.1911.00
315_R370_E2.0921.00
28_F169_G2.0641.00
256_I387_V2.0091.00
242_I246_L2.0061.00
240_P243_E1.9731.00
109_A206_I1.9711.00
373_G376_Y1.9601.00
114_L127_L1.9511.00
92_G95_R1.9321.00
314_G317_R1.8551.00
308_W312_R1.8431.00
416_I420_A1.8281.00
72_V133_A1.8241.00
72_V129_V1.8041.00
111_I131_L1.7921.00
107_A135_Q1.7911.00
86_H90_R1.7811.00
117_F129_V1.7621.00
69_T128_L1.7211.00
402_A406_Y1.6991.00
268_I400_A1.6921.00
243_E246_L1.6841.00
114_L131_L1.6811.00
65_A117_F1.6801.00
54_F65_A1.6621.00
98_M216_R1.6511.00
76_F80_G1.6481.00
413_S416_I1.6181.00
54_F117_F1.5971.00
317_R320_I1.5891.00
161_F311_D1.5841.00
203_L207_V1.5831.00
283_L287_L1.5781.00
344_W347_F1.5741.00
112_G206_I1.5651.00
47_L50_N1.5641.00
118_S130_T1.5571.00
243_E376_Y1.5551.00
329_S356_A1.5511.00
322_G359_M1.5351.00
329_S349_S1.5241.00
95_R99_L1.5201.00
83_I86_H1.5031.00
95_R98_M1.5021.00
80_G140_G1.5021.00
80_G83_I1.4941.00
200_I203_L1.4371.00
278_T285_R1.4341.00
411_W414_V1.4291.00
179_G293_L1.4161.00
316_R320_I1.4081.00
306_F359_M1.4011.00
87_F91_L1.4011.00
49_F66_A1.4001.00
127_L131_L1.3981.00
105_G206_I1.3961.00
87_F96_M1.3881.00
334_F416_I1.3871.00
412_H416_I1.3761.00
342_I345_I1.3751.00
305_C308_W1.3741.00
99_L103_M1.3661.00
250_G254_K1.3651.00
331_F335_M1.3571.00
186_M195_S1.3461.00
295_V354_N1.3411.00
239_I243_E1.3411.00
214_W218_G1.3351.00
151_V159_K1.3341.00
89_D379_S1.3261.00
109_A113_I1.3181.00
47_L51_R1.3031.00
239_I242_I1.3011.00
111_I128_L1.3011.00
265_T422_C1.2911.00
240_P245_L1.2861.00
35_W170_Y1.2841.00
91_L95_R1.2821.00
225_F229_Q1.2751.00
150_S166_V1.2751.00
376_Y379_S1.2711.00
317_R321_T1.2711.00
240_P244_A1.2681.00
302_T305_C1.2651.00
287_L290_N1.2641.00
267_Y393_G1.2601.00
85_G89_D1.2511.00
329_S352_L1.2491.00
278_T288_F1.2471.00
309_L313_F1.2411.00
179_G183_L1.2391.00
105_G210_L1.2391.00
75_L394_G1.2391.00
103_M107_A1.2361.00
88_G93_R1.2211.00
45_A66_A1.2201.00
249_P253_L1.2191.00
334_F419_L1.2171.00
186_M286_E1.2101.00
91_L96_M1.2021.00
100_T138_A1.1911.00
63_T405_T1.1841.00
299_S358_D1.1831.00
290_N294_L1.1791.00
68_A398_F1.1751.00
226_E229_Q1.1731.00
277_S283_L1.1651.00
156_K159_K1.1571.00
104_M138_A1.1501.00
49_F54_F1.1481.00
343_F347_F1.1471.00
238_R241_V1.1461.00
308_W311_D1.1391.00
197_G200_I1.1341.00
73_G136_G1.1251.00
298_L302_T1.1221.00
30_G142_E1.1181.00
92_G96_M1.1161.00
252_F256_I1.1151.00
414_V418_L1.1121.00
238_R242_I1.1121.00
110_L113_I1.1091.00
321_T325_I1.1041.00
253_L257_A1.1041.00
226_E230_H1.0991.00
307_A311_D1.0981.00
242_I245_L1.0961.00
327_T426_A1.0911.00
327_T331_F1.0851.00
403_L407_F1.0831.00
241_V245_L1.0831.00
76_F136_G1.0771.00
320_I426_A1.0721.00
301_L304_P1.0711.00
276_Y281_M1.0711.00
215_V219_M1.0691.00
240_P246_L1.0681.00
71_G398_F1.0621.00
21_R25_L1.0591.00
348_F351_M1.0571.00
332_P335_M1.0571.00
49_F63_T1.0561.00
106_I110_L1.0541.00
417_Y421_G1.0531.00
118_S127_L1.0501.00
93_R148_L1.0501.00
64_L68_A1.0481.00
215_V218_G1.0481.00
237_K240_P1.0441.00
144_G147_A1.0291.00
420_A424_I1.0251.00
259_R384_G1.0251.00
184_I200_I1.0251.00
236_K240_P1.0241.00
71_G394_G1.0211.00
78_P386_Q1.0201.00
23_A153_S1.0191.00
329_S353_A1.0151.00
130_T134_I1.0141.00
113_I203_L1.0131.00
213_L217_N1.0121.00
161_F165_G1.0121.00
286_E290_N1.0111.00
241_V244_A1.0091.00
207_V211_G1.0071.00
214_W217_N1.0021.00
94_K221_E1.0021.00
73_G139_V0.9961.00
110_L127_L0.9941.00
304_P308_W0.9941.00
112_G199_R0.9931.00
152_E377_R0.9921.00
413_S417_Y0.9921.00
72_V76_F0.9901.00
127_L130_T0.9871.00
161_F308_W0.9861.00
392_G396_T0.9801.00
217_N220_E0.9791.00
68_A72_V0.9751.00
324_L328_L0.9731.00
423_L427_M0.9711.00
183_L195_S0.9701.00
65_A129_V0.9661.00
95_R221_E0.9641.00
239_I245_L0.9641.00
236_K239_I0.9601.00
36_Y177_S0.9591.00
345_I348_F0.9581.00
67_F71_G0.9531.00
320_I324_L0.9461.00
301_L305_C0.9361.00
225_F230_H0.9341.00
227_Q230_H0.9281.00
44_T185_S0.9271.00
99_L102_W0.9191.00
326_G422_C0.9161.00
225_F228_Q0.9151.00
96_M99_L0.9151.00
104_M209_V0.9151.00
322_G360_V0.9091.00
402_A405_T0.9081.00
324_L426_A0.9081.00
98_M102_W0.9071.00
195_S199_R0.9071.00
257_A261_C0.9041.00
421_G425_S0.9021.00
234_A240_P0.9011.00
67_F272_F0.8981.00
37_D40_L0.8981.00
320_I323_T0.8971.00
78_P394_G0.8931.00
250_G253_L0.8931.00
24_A154_A0.8931.00
327_T423_L0.8921.00
418_L422_C0.8911.00
241_V246_L0.8881.00
313_F317_R0.8871.00
407_F413_S0.8861.00
151_V377_R0.8851.00
65_A68_A0.8841.00
320_I430_L0.8821.00
325_I329_S0.8821.00
82_V86_H0.8821.00
159_K370_E0.8791.00
132_R136_G0.8791.00
51_R198_W0.8771.00
70_F271_A0.8741.00
359_M363_V0.8731.00
321_T324_L0.8671.00
362_C365_Q0.8651.00
258_L429_A0.8621.00
297_G301_L0.8591.00
348_F352_L0.8541.00
366_P370_E0.8541.00
149_L153_S0.8521.00
81_G385_Y0.8521.00
223_A228_Q0.8511.00
368_F384_G0.8501.00
323_T425_S0.8491.00
374_A377_R0.8451.00
330_A334_F0.8441.00
115_P118_S0.8371.00
44_T201_P0.8371.00
327_T422_C0.8351.00
291_I347_F0.8301.00
313_F318_V0.8281.00
336_A349_S0.8261.00
176_L179_G0.8261.00
262_E360_V0.8251.00
369_T381_A0.8251.00
30_G97_L0.8251.00
92_G221_E0.8201.00
401_A405_T0.8191.00
239_I246_L0.8191.00
329_S332_P0.8191.00
65_A69_T0.8171.00
415_A419_L0.8161.00
276_Y280_N0.8161.00
89_D93_R0.8151.00
237_K243_E0.8121.00
130_T133_A0.8111.00
416_I419_L0.8091.00
196_W199_R0.8061.00
259_R263_L0.8051.00
32_V173_G0.8031.00
322_G356_A0.7991.00
318_V321_T0.7991.00
273_A350_I0.7971.00
22_R218_G0.7971.00
108_T135_Q0.7971.00
216_R220_E0.7961.00
40_L201_P0.7961.00
64_L398_F0.7961.00
108_T206_I0.7921.00
175_L297_G0.7911.00
263_L388_A0.7891.00
324_L327_T0.7891.00
36_Y205_S0.7881.00
108_T205_S0.7871.00
251_A254_K0.7861.00
298_L301_L0.7851.00
305_C309_L0.7831.00
203_L206_I0.7821.00
182_S289_L0.7811.00
411_W415_A0.7811.00
234_A237_K0.7811.00
46_A50_N0.7761.00
275_N279_Q0.7731.00
111_I135_Q0.7721.00
283_L343_F0.7691.00
331_F419_L0.7671.00
171_G299_S0.7651.00
49_F52_E0.7651.00
200_I204_F0.7651.00
277_S346_V0.7641.00
427_M430_L0.7641.00
51_R199_R0.7631.00
275_N278_T0.7621.00
26_G215_V0.7591.00
22_R25_L0.7571.00
220_E223_A0.7561.00
222_S225_F0.7561.00
207_V210_L0.7531.00
37_D132_R0.7521.00
237_K242_I0.7501.00
149_L219_M0.7481.00
328_L332_P0.7481.00
367_M371_M0.7461.00
336_A345_I0.7461.00
182_S290_N0.7451.00
86_H379_S0.7441.00
362_C366_P0.7411.00
79_L83_I0.7401.00
223_A226_E0.7381.00
151_V163_S0.7371.00
398_F402_A0.7371.00
64_L405_T0.7351.00
102_W106_I0.7351.00
154_A158_K0.7351.00
391_V395_F0.7341.00
259_R388_A0.7321.00
331_F334_F0.7311.00
98_M213_L0.7301.00
141_G145_G0.7291.00
287_L291_I0.7271.00
224_E227_Q0.7241.00
157_N161_F0.7241.00
115_P199_R0.7221.00
68_A129_V0.7191.00
80_G84_F0.7191.00
226_E231_Y0.7181.00
73_G77_R0.7171.00
33_V37_D0.7161.00
93_R221_E0.7161.00
183_L186_M0.7131.00
180_L183_L0.7121.00
69_T129_V0.7111.00
97_L149_L0.7101.00
50_N53_F0.7091.00
46_A49_F0.7091.00
419_L423_L0.7071.00
332_P336_A0.7071.00
338_E344_W0.7051.00
206_I210_L0.7011.00
102_W105_G0.7001.00
235_A238_R0.6971.00
256_I384_G0.6931.00
252_F372_F0.6891.00
101_V212_A0.6891.00
174_L296_G0.6891.00
79_L82_V0.6881.00
113_I127_L0.6881.00
32_V176_L0.6871.00
105_G213_L0.6831.00
326_G356_A0.6831.00
171_G300_C0.6831.00
283_L291_I0.6791.00
44_T48_V0.6781.00
200_I207_V0.6781.00
253_L256_I0.6771.00
296_G300_C0.6771.00
272_F401_A0.6751.00
293_L297_G0.6751.00
249_P371_M0.6711.00
100_T145_G0.6711.00
225_F231_Y0.6701.00
414_V417_Y0.6701.00
168_V304_P0.6691.00
132_R135_Q0.6651.00
345_I349_S0.6651.00
417_Y420_A0.6631.00
109_A203_L0.6631.00
106_I109_A0.6601.00
168_V171_G0.6601.00
399_I402_A0.6601.00
199_R203_L0.6591.00
382_G386_Q0.6561.00
48_V198_W0.6551.00
204_F207_V0.6551.00
310_A363_V0.6541.00
151_V369_T0.6521.00
77_R389_S0.6511.00
163_S366_P0.6501.00
111_I202_F0.6461.00
302_T306_F0.6451.00
251_A371_M0.6451.00
84_F140_G0.6441.00
326_G329_S0.6431.00
256_I383_V0.6421.00
168_V300_C0.6401.00
277_S281_M0.6371.00
294_L347_F0.6351.00
185_S201_P0.6341.00
147_A166_V0.6341.00
255_I384_G0.6331.00
183_L290_N0.6331.00
98_M217_N0.6291.00
347_F351_M0.6281.00
78_P389_S0.6251.00
361_V365_Q0.6241.00
43_I181_V0.6221.00
150_S162_Y0.6221.00
144_G148_L0.6221.00
386_Q391_V0.6211.00
223_A227_Q0.6201.00
320_I429_A0.6171.00
287_L343_F0.6151.00
257_A260_L0.6141.00
74_F393_G0.6141.00
114_L117_F0.6121.00
305_C355_I0.6111.00
235_A245_L0.6111.00
268_I418_L0.6101.00
249_P376_Y0.6101.00
314_G318_V0.6091.00
30_G101_V0.6091.00
140_G144_G0.6081.00
116_S199_R0.6061.00
168_V172_V0.6031.00
238_R243_E0.6011.00
392_G395_F0.6001.00
38_F77_R0.6001.00
85_G378_Y0.5991.00
277_S291_I0.5981.00
383_V387_V0.5971.00
148_L378_Y0.5961.00
31_A166_V0.5961.00
24_A162_Y0.5951.00
163_S369_T0.5941.00
212_A216_R0.5941.00
368_F371_M0.5921.00
23_A26_G0.5911.00
294_L351_M0.5911.00
41_Y70_F0.5881.00
205_S208_L0.5881.00
286_E289_L0.5871.00
424_I428_T0.5851.00
261_C421_G0.5841.00
178_T293_L0.5831.00
111_I132_R0.5831.00
173_G177_S0.5821.00
395_F399_I0.5811.00
178_T292_G0.5791.00
327_T419_L0.5791.00
111_I114_L0.5791.00
171_G303_I0.5791.00
330_A353_A0.5781.00
81_G386_Q0.5781.00
64_L67_F0.5771.00
306_F309_L0.5771.00
369_T377_R0.5751.00
243_E375_S0.5731.00
422_C426_A0.5701.00
377_R381_A0.5701.00
404_I407_F0.5701.00
43_I47_L0.5691.00
182_S186_M0.5681.00
256_I260_L0.5681.00
277_S288_F0.5661.00
159_K369_T0.5631.00
37_D104_M0.5621.00
104_M139_V0.5611.00
47_L185_S0.5601.00
39_L174_L0.5601.00
73_G132_R0.5591.00
105_G109_A0.5591.00
158_K162_Y0.5571.00
245_L253_L0.5561.00
302_T358_D0.5551.00
309_L318_V0.5551.00
235_A240_P0.5541.00
181_V201_P0.5521.00
182_S293_L0.5521.00
394_G398_F0.5501.00
295_V350_I0.5481.00
351_M354_N0.5481.00
354_N358_D0.5441.00
426_A430_L0.5441.00
28_F165_G0.5431.00
75_L78_P0.5431.00
227_Q231_Y0.5421.00
175_L293_L0.5421.00
81_G382_G0.5411.00
31_A35_W0.5391.00
67_F401_A0.5391.00
403_L406_Y0.5391.00
309_L312_R0.5381.00
37_D205_S0.5371.00
104_M142_E0.5371.00
291_I294_L0.5371.00
88_G96_M0.5321.00
265_T268_I0.5311.00
29_A33_V0.5301.00
412_H415_A0.5291.00
366_P369_T0.5281.00
335_M416_I0.5281.00
294_L297_G0.5261.00
54_F66_A0.5261.00
234_A241_V0.5211.00
290_N293_L0.5211.00
98_M101_V0.5201.00
263_L267_Y0.5191.00
271_A274_L0.5181.00
165_G168_V0.5181.00
101_V213_L0.5151.00
255_I368_F0.5151.00
210_L214_W0.5151.00
40_L181_V0.5151.00
323_T426_A0.5131.00
108_T132_R0.5131.00
320_I327_T0.5131.00
228_Q231_Y0.5121.00
97_L146_A0.5111.00
381_A385_Y0.5111.00
261_C425_S0.5111.00
169_G173_G0.5111.00
131_L135_Q0.5101.00
179_G182_S0.5101.00
338_E343_F0.5081.00
184_I201_P0.5081.00
71_G74_F0.5081.00
234_A238_R0.5051.00
24_A28_F0.5051.00
84_F96_M0.5051.00
28_F32_V0.5041.00
82_V386_Q0.5041.00
211_G214_W0.5041.00
272_F275_N0.5031.00
21_R24_A0.5031.00
63_T404_I0.5031.00
69_T117_F0.5021.00
425_S429_A0.5021.00
132_R143_W0.5011.00
294_L298_L0.5011.00
84_F87_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j05A 3 0.8836 100 0.179 Contact Map
1pw4A 1 0.9132 100 0.19 Contact Map
3o7qA 1 0.895 100 0.209 Contact Map
4pypA 1 0.9018 100 0.224 Contact Map
3wdoA 1 0.8881 100 0.235 Contact Map
4zw9A 1 0.9247 100 0.251 Contact Map
2gfpA 2 0.8539 100 0.267 Contact Map
4gc0A 1 0.9429 100 0.272 Contact Map
2cfqA 1 0.9041 100 0.276 Contact Map
4ldsA 2 0.8836 100 0.282 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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