GREMLIN Database
YEEL - Putative uncharacterized protein YeeL
UniProt: P76349 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13380
Length: 350 (304)
Sequences: 5698 (4648)
Seq/√Len: 266.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_L111_P4.5451.00
210_A283_A4.1371.00
29_F58_H3.2951.00
233_K340_A3.2821.00
79_T107_Q3.2011.00
285_I343_L3.1101.00
211_F231_I2.8771.00
52_E78_Q2.8751.00
237_E344_K2.8471.00
226_I336_L2.8351.00
228_E260_C2.6551.00
294_L306_A2.5711.00
272_S275_R2.5081.00
224_L256_A2.4061.00
58_H78_Q2.3821.00
30_V57_K2.3581.00
210_A280_I2.3571.00
227_A289_P2.3521.00
58_H79_T2.2901.00
251_E255_R2.2861.00
197_E275_R2.2781.00
41_A71_F2.2371.00
210_A245_V2.2311.00
164_A172_F2.2151.00
230_L340_A2.2031.00
223_S226_I2.1671.00
323_E345_S2.1101.00
199_R282_D2.1031.00
222_F339_F2.0881.00
276_S293_I2.0831.00
195_L281_K2.0671.00
208_Y282_D2.0621.00
207_S284_Y2.0331.00
68_L72_N2.0321.00
230_L287_I2.0141.00
288_T294_L1.9761.00
254_A268_S1.9641.00
60_L78_Q1.9311.00
206_G241_P1.8891.00
209_I234_I1.8761.00
222_F226_I1.8471.00
244_I254_A1.8391.00
337_D341_K1.7921.00
31_V62_V1.7701.00
233_K337_D1.7461.00
235_Q263_N1.7361.00
194_V274_K1.7181.00
47_V117_G1.7151.00
29_F60_L1.7131.00
60_L79_T1.7111.00
232_A261_Y1.6991.00
208_Y283_A1.6921.00
287_I343_L1.6891.00
60_L81_L1.6801.00
44_I117_G1.6801.00
208_Y284_Y1.6491.00
232_A262_N1.6351.00
335_S338_E1.6251.00
277_A296_M1.6111.00
209_I285_I1.6061.00
172_F175_R1.6011.00
233_K237_E1.5961.00
65_T84_V1.5891.00
209_I240_I1.5621.00
222_F227_A1.5611.00
29_F107_Q1.5521.00
226_I229_N1.5341.00
174_M179_F1.5191.00
69_E72_N1.5021.00
286_A302_T1.4931.00
246_H269_L1.4831.00
208_Y243_V1.4811.00
255_R259_D1.4771.00
98_K102_K1.4611.00
107_Q111_P1.4251.00
229_N232_A1.4161.00
241_P265_Y1.4151.00
32_I48_I1.3801.00
212_N288_T1.3741.00
342_A345_S1.3711.00
329_Q333_N1.3611.00
201_E275_R1.3571.00
134_A137_N1.3541.00
255_R266_R1.3241.00
215_G221_T1.3201.00
212_N291_T1.2991.00
213_L244_I1.2951.00
60_L107_Q1.2941.00
280_I300_Y1.2921.00
49_R53_L1.2871.00
114_C129_I1.2831.00
223_S332_D1.2781.00
49_R187_E1.2441.00
207_S240_I1.2411.00
328_G331_I1.2401.00
307_I334_I1.2271.00
254_A266_R1.2231.00
93_T96_E1.2151.00
191_S194_V1.2101.00
222_F230_L1.2101.00
113_L138_F1.2071.00
234_I340_A1.2001.00
323_E342_A1.1991.00
52_E59_L1.1971.00
208_Y241_P1.1741.00
286_A297_A1.1701.00
61_I71_F1.1681.00
130_S137_N1.1581.00
43_A315_W1.1551.00
233_K336_L1.1541.00
214_E250_G1.1501.00
47_V174_M1.1501.00
245_V276_S1.1441.00
221_T253_K1.1421.00
194_V275_R1.1421.00
49_R76_L1.1331.00
266_R269_L1.1321.00
224_L257_L1.1281.00
256_A260_C1.1281.00
233_K236_S1.1251.00
31_V111_P1.1241.00
210_A279_I1.1191.00
48_I61_I1.1191.00
114_C134_A1.1171.00
220_R290_D1.1141.00
192_E196_D1.1121.00
52_E57_K1.1051.00
229_N336_L1.1001.00
338_E341_K1.0901.00
229_N233_K1.0871.00
319_A322_S1.0821.00
228_E232_A1.0681.00
229_N337_D1.0641.00
168_M318_M1.0571.00
285_I305_V1.0531.00
331_I334_I1.0451.00
245_V283_A1.0381.00
185_I301_N1.0351.00
37_Q216_S1.0351.00
73_A274_K1.0331.00
211_F287_I1.0331.00
338_E342_A1.0321.00
45_F74_L1.0321.00
280_I302_T1.0301.00
136_T150_P1.0301.00
68_L82_T1.0151.00
30_V113_L1.0151.00
230_L336_L1.0131.00
251_E270_P1.0121.00
305_V343_L1.0081.00
28_D112_D1.0061.00
246_H266_R1.0051.00
232_A236_S1.0031.00
198_V278_A1.0031.00
258_V266_R1.0031.00
41_A67_N0.9941.00
248_P251_E0.9921.00
30_V59_L0.9911.00
222_F336_L0.9851.00
127_L131_Q0.9761.00
231_I261_Y0.9741.00
101_A105_T0.9701.00
340_A344_K0.9691.00
54_H179_F0.9681.00
228_E257_L0.9671.00
95_K99_D0.9631.00
214_E253_K0.9631.00
288_T306_A0.9611.00
41_A61_I0.9601.00
231_I244_I0.9581.00
228_E261_Y0.9561.00
230_L233_K0.9551.00
334_I338_E0.9531.00
234_I343_L0.9521.00
38_I67_N0.9521.00
252_D255_R0.9511.00
175_R180_P0.9491.00
256_A259_D0.9481.00
150_P153_K0.9471.00
33_H62_V0.9431.00
148_F151_L0.9391.00
212_N286_A0.9391.00
34_I37_Q0.9321.00
113_L136_T0.9281.00
68_L80_K0.9271.00
305_V346_V0.9251.00
197_E201_E0.9221.00
219_E330_K0.9201.00
221_T289_P0.9191.00
50_A54_H0.9171.00
225_S332_D0.9141.00
215_G289_P0.9121.00
50_A53_L0.9121.00
75_K189_P0.9101.00
208_Y240_I0.9081.00
212_N245_V0.9061.00
42_M296_M0.9021.00
28_D56_I0.9021.00
214_E221_T0.8981.00
65_T68_L0.8971.00
220_R311_Y0.8961.00
307_I339_F0.8961.00
250_G253_K0.8961.00
69_E274_K0.8931.00
63_T80_K0.8871.00
237_E340_A0.8831.00
149_S153_K0.8791.00
29_F111_P0.8781.00
226_I335_S0.8751.00
255_R258_V0.8731.00
147_C150_P0.8721.00
305_V342_A0.8711.00
196_D200_E0.8661.00
280_I286_A0.8651.00
72_N274_K0.8621.00
271_P279_I0.8621.00
225_S256_A0.8591.00
294_L308_Y0.8591.00
29_F112_D0.8511.00
164_A168_M0.8501.00
102_K106_Q0.8471.00
146_N149_S0.8431.00
165_P318_M0.8431.00
145_M148_F0.8431.00
38_I273_I0.8390.99
243_V279_I0.8360.99
337_D340_A0.8320.99
61_I77_E0.8290.99
261_Y264_V0.8270.99
231_I257_L0.8240.99
197_E200_E0.8220.99
281_K302_T0.8190.99
36_D118_M0.8170.99
96_E99_D0.8140.99
233_K344_K0.8110.99
217_S310_D0.8020.99
116_E123_L0.8010.99
201_E205_L0.8000.99
210_A286_A0.7970.99
200_E204_S0.7950.99
235_Q242_I0.7880.99
165_P316_P0.7850.99
214_E289_P0.7850.99
277_A300_Y0.7850.99
309_A330_K0.7760.99
34_I41_A0.7750.99
95_K98_K0.7710.99
252_D256_A0.7690.99
336_L340_A0.7690.99
46_P171_A0.7680.99
167_P318_M0.7670.99
168_M172_F0.7670.99
278_A281_K0.7640.99
222_F335_S0.7630.99
31_V114_C0.7630.99
266_R270_P0.7610.99
322_S325_V0.7580.99
149_S152_C0.7510.99
166_V169_T0.7510.99
166_V314_R0.7440.99
94_L98_K0.7430.99
209_I287_I0.7380.99
57_K112_D0.7370.99
287_I305_V0.7320.99
79_T103_N0.7290.99
51_L57_K0.7290.99
240_I284_Y0.7280.99
309_A331_I0.7270.99
290_D308_Y0.7260.99
201_E204_S0.7240.98
239_D242_I0.7180.98
327_V330_K0.7130.98
247_G250_G0.7070.98
52_E76_L0.7060.98
37_Q118_M0.7060.98
181_A184_P0.7040.98
254_A258_V0.7020.98
45_F299_A0.7020.98
48_I76_L0.7010.98
133_K137_N0.7000.98
224_L228_E0.7000.98
50_A171_A0.6980.98
39_G295_H0.6970.98
74_L189_P0.6950.98
73_A278_A0.6940.98
191_S274_K0.6890.98
217_S220_R0.6870.98
271_P275_R0.6860.98
227_A231_I0.6850.98
206_G239_D0.6850.98
222_F307_I0.6850.98
196_D199_R0.6840.98
310_D328_G0.6830.98
244_I264_V0.6690.97
114_C132_L0.6670.97
226_I230_L0.6640.97
97_I101_A0.6620.97
32_I51_L0.6590.97
323_E346_V0.6590.97
152_C155_A0.6570.97
123_L220_R0.6570.97
129_I134_A0.6550.97
37_Q41_A0.6530.97
101_A131_Q0.6520.97
235_Q264_V0.6490.97
34_I44_I0.6480.97
52_E55_K0.6480.97
37_Q43_A0.6470.97
294_L304_V0.6470.97
41_A63_T0.6440.97
267_L270_P0.6420.97
226_I332_D0.6410.97
42_M299_A0.6390.97
246_H270_P0.6390.97
341_K344_K0.6380.97
168_M184_P0.6380.97
343_L346_V0.6380.97
137_N149_S0.6360.97
213_L291_T0.6340.97
192_E195_L0.6330.96
78_Q107_Q0.6290.96
140_V173_M0.6280.96
40_D220_R0.6280.96
213_L257_L0.6270.96
304_V319_A0.6260.96
51_L59_L0.6250.96
118_M314_R0.6240.96
70_V296_M0.6210.96
246_H271_P0.6200.96
197_E272_S0.6180.96
140_V143_I0.6130.96
65_T82_T0.6110.96
39_G292_S0.6100.96
222_F289_P0.6090.96
144_T151_L0.6060.96
284_Y303_P0.6060.96
214_E247_G0.6050.95
221_T227_A0.6040.95
118_M315_W0.6040.95
64_S67_N0.6010.95
310_D331_I0.6010.95
228_E231_I0.6010.95
33_H114_C0.5980.95
190_L195_L0.5970.95
212_N315_W0.5960.95
45_F186_Y0.5950.95
267_L271_P0.5900.95
99_D102_K0.5890.95
144_T149_S0.5890.95
298_S318_M0.5840.95
212_N293_I0.5840.95
329_Q332_D0.5830.94
104_I132_L0.5830.94
37_Q291_T0.5820.94
198_V279_I0.5820.94
53_L185_I0.5790.94
214_E246_H0.5790.94
129_I132_L0.5780.94
313_T326_V0.5780.94
126_M139_Q0.5760.94
64_S122_N0.5760.94
52_E56_I0.5760.94
112_D135_K0.5750.94
283_A302_T0.5750.94
105_T133_K0.5730.94
129_I137_N0.5720.94
148_F152_C0.5720.94
281_K300_Y0.5710.94
278_A282_D0.5710.94
165_P168_M0.5690.94
245_V293_I0.5670.94
103_N106_Q0.5660.94
234_I240_I0.5660.94
340_A343_L0.5650.94
148_F153_K0.5610.93
216_S315_W0.5600.93
146_N150_P0.5590.93
58_H111_P0.5580.93
198_V201_E0.5560.93
211_F242_I0.5540.93
323_E326_V0.5520.93
145_M149_S0.5510.93
49_R183_R0.5510.93
36_D116_E0.5500.93
209_I242_I0.5480.92
78_Q111_P0.5480.92
251_E266_R0.5480.92
248_P252_D0.5480.92
76_L187_E0.5480.92
305_V339_F0.5460.92
283_A286_A0.5450.92
129_I133_K0.5450.92
147_C154_N0.5440.92
46_P49_R0.5440.92
230_L343_L0.5440.92
120_K123_L0.5440.92
116_E129_I0.5410.92
246_H268_S0.5400.92
266_R271_P0.5390.92
193_D197_E0.5360.92
172_F176_E0.5340.92
171_A174_M0.5320.91
210_A243_V0.5320.91
211_F230_L0.5310.91
215_G291_T0.5300.91
195_L278_A0.5300.91
74_L77_E0.5300.91
34_I166_V0.5300.91
195_L282_D0.5300.91
48_I77_E0.5280.91
48_I59_L0.5260.91
253_K256_A0.5250.91
150_P155_A0.5250.91
61_I120_K0.5240.91
310_D330_K0.5220.91
107_Q110_T0.5200.90
243_V265_Y0.5200.90
304_V322_S0.5200.90
195_L199_R0.5200.90
117_G173_M0.5200.90
118_M169_T0.5190.90
231_I239_D0.5190.90
193_D196_D0.5190.90
280_I293_I0.5190.90
83_L93_T0.5160.90
132_L137_N0.5160.90
39_G220_R0.5160.90
115_I177_A0.5160.90
84_V96_E0.5160.90
49_R74_L0.5160.90
50_A174_M0.5150.90
223_S289_P0.5140.90
36_D64_S0.5140.90
294_L298_S0.5140.90
259_D262_N0.5140.90
166_V170_W0.5130.90
185_I320_D0.5130.90
116_E120_K0.5120.90
213_L254_A0.5100.90
37_Q315_W0.5090.89
320_D325_V0.5090.89
232_A235_Q0.5080.89
190_L198_V0.5080.89
342_A346_V0.5080.89
225_S229_N0.5080.89
202_M208_Y0.5080.89
51_L174_M0.5070.89
325_V339_F0.5070.89
258_V264_V0.5060.89
36_D120_K0.5050.89
62_V104_I0.5040.89
38_I296_M0.5030.89
79_T111_P0.5030.89
232_A260_C0.5030.89
271_P276_S0.5000.89
81_L107_Q0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gt1A 1 0.8771 100 0.337 Contact Map
1pswA 1 0.8714 100 0.354 Contact Map
3tovA 1 0.9114 100 0.357 Contact Map
4rapA 3 0.8143 100 0.521 Contact Map
3ot5A 2 0.86 99.1 0.823 Contact Map
4nesA 2 0.8714 98.9 0.835 Contact Map
4rifA 2 0.8514 98.8 0.84 Contact Map
3s2uA 1 0.8286 98.8 0.84 Contact Map
3h4tA 1 0.8514 98.8 0.841 Contact Map
4fkzA 2 0.8771 98.7 0.844 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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