GREMLIN Database
MTFA - Protein MtfA
UniProt: P76346 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13377
Length: 265 (239)
Sequences: 774 (561)
Seq/√Len: 36.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_S242_Y5.8001.00
58_F64_R5.2481.00
68_I92_I4.4961.00
147_I217_S4.3061.00
46_F73_C4.0721.00
54_P60_L4.0351.00
141_S222_S3.5571.00
60_L64_R3.4821.00
95_A132_L3.4081.00
32_T35_E3.1781.00
53_V89_E3.0971.00
61_D64_R2.9191.00
15_T19_W2.7601.00
54_P150_V2.5591.00
201_I216_L2.4201.00
184_M188_Q2.4121.00
38_K78_E2.3961.00
62_S65_S2.3050.99
58_F131_W2.2990.99
183_A234_L2.2920.99
228_A247_L2.2450.99
93_Y128_V2.1980.99
84_L150_V2.1970.99
83_W241_F2.1600.99
151_A213_F2.1020.99
20_Q40_V2.0970.99
158_N165_V2.0760.99
186_N231_F2.0070.98
220_F235_W2.0030.98
130_N133_D2.0020.98
93_Y97_F1.9300.98
183_A186_N1.9170.98
97_F128_V1.8910.98
75_P147_I1.8730.98
35_E78_E1.8410.97
64_R131_W1.7760.97
23_L36_Q1.7750.97
97_F117_Q1.7380.96
156_T162_A1.6890.96
102_E112_N1.6760.95
186_N190_E1.6530.95
180_L238_F1.6030.94
43_A69_A1.6030.94
79_L244_Q1.5360.93
101_D117_Q1.5230.92
219_Y223_A1.4800.91
221_F244_Q1.4560.90
155_D164_G1.4500.90
55_L91_L1.4480.90
155_D166_P1.4290.90
99_V117_Q1.4220.89
66_C70_L1.4190.89
46_F72_F1.4140.89
20_Q24_S1.3710.87
175_G179_D1.3710.87
179_D237_R1.3460.87
169_P243_Q1.3450.86
190_E197_N1.3450.86
236_Q240_Q1.3320.86
148_H152_H1.3210.85
54_P68_I1.2990.84
62_S66_C1.2880.84
225_E247_L1.2850.84
149_E152_H1.2820.84
7_K49_Q1.2810.84
193_L196_E1.2770.83
129_L134_I1.2760.83
238_F242_Y1.2730.83
178_H182_A1.2690.83
155_D176_W1.2660.83
151_A242_Y1.2400.82
83_W157_R1.2360.81
75_P121_S1.2310.81
60_L92_I1.2290.81
16_A19_W1.2120.80
14_Q44_E1.1830.78
8_V114_R1.1660.77
52_L65_S1.1640.77
183_A231_F1.1490.76
215_V218_E1.1460.76
226_L230_R1.1400.76
61_D189_E1.1370.76
105_D111_H1.1340.75
235_W244_Q1.1300.75
134_I146_I1.1230.75
182_A233_S1.1190.74
142_G222_S1.1190.74
15_T18_P1.1150.74
44_E66_C1.1130.74
42_L80_G1.1110.74
21_E47_L1.0940.73
61_D131_W1.0930.73
64_R92_I1.0880.72
34_Q37_S1.0840.72
171_R237_R1.0780.72
42_L73_C1.0570.70
72_F84_L1.0500.70
14_Q18_P1.0280.68
162_A167_F1.0210.67
100_D114_R1.0190.67
64_R68_I1.0140.67
18_P22_A1.0110.67
200_S219_Y1.0100.66
137_S222_S1.0100.66
155_D210_A1.0090.66
126_P153_K1.0060.66
141_S223_A1.0030.66
235_W245_D1.0020.66
183_A227_F0.9960.65
220_F245_D0.9860.65
87_F150_V0.9800.64
165_V177_E0.9770.64
176_W206_A0.9760.64
97_F130_N0.9740.64
193_L197_N0.9660.63
121_S156_T0.9620.63
216_L227_F0.9550.62
159_G166_P0.9470.61
47_L69_A0.9440.61
151_A238_F0.9410.61
87_F221_F0.9330.60
43_A70_L0.9260.60
174_A178_H0.9240.59
205_A216_L0.9240.59
39_L73_C0.9200.59
166_P176_W0.9180.59
57_G131_W0.9130.59
75_P217_S0.9090.58
190_E230_R0.8990.57
126_P156_T0.8900.57
220_F244_Q0.8890.57
223_A226_L0.8880.56
237_R240_Q0.8820.56
16_A36_Q0.8820.56
16_A40_V0.8780.56
143_F207_S0.8700.55
151_A217_S0.8700.55
38_K73_C0.8700.55
188_Q192_E0.8690.55
96_P133_D0.8670.55
205_A219_Y0.8660.55
177_E209_P0.8610.54
9_Q13_H0.8470.53
44_E158_N0.8440.53
101_D120_Q0.8360.52
234_L237_R0.8300.51
76_V79_L0.8120.50
39_L77_L0.8110.50
28_L147_I0.8090.50
87_F97_F0.8080.49
153_K156_T0.8080.49
158_N163_S0.8070.49
121_S127_I0.8060.49
132_L136_D0.8040.49
177_E181_H0.7970.49
26_P141_S0.7940.48
155_D159_G0.7890.48
200_S205_A0.7880.48
27_L89_E0.7830.47
164_G176_W0.7800.47
181_H185_N0.7750.47
75_P84_L0.7750.47
159_G164_G0.7730.46
181_H184_M0.7710.46
57_G61_D0.7680.46
47_L65_S0.7680.46
60_L163_S0.7650.46
137_S141_S0.7620.45
207_S245_D0.7580.45
46_F69_A0.7570.45
29_T233_S0.7540.45
128_V157_R0.7500.44
151_A214_A0.7480.44
98_V116_V0.7480.44
87_F153_K0.7480.44
14_Q40_V0.7460.44
187_I191_I0.7390.43
97_F217_S0.7380.43
178_H228_A0.7360.43
12_A44_E0.7330.43
138_F242_Y0.7310.43
118_S196_E0.7300.43
217_S241_F0.7300.43
96_P143_F0.7280.43
117_Q130_N0.7270.42
7_K129_L0.7270.42
60_L80_G0.7270.42
106_D247_L0.7270.42
67_R71_L0.7270.42
7_K127_I0.7260.42
45_R83_W0.7260.42
235_W239_C0.7180.42
100_D112_N0.7150.41
71_L138_F0.7130.41
28_L40_V0.7110.41
52_L68_I0.7080.41
34_Q234_L0.7070.41
228_A236_Q0.7070.41
227_F235_W0.7050.41
97_F101_D0.7030.40
7_K10_E0.7030.40
101_D113_Q0.7020.40
75_P80_G0.7000.40
236_Q239_C0.6990.40
90_V150_V0.6940.40
216_L238_F0.6880.39
176_W221_F0.6870.39
79_L157_R0.6860.39
28_L70_L0.6860.39
213_F238_F0.6850.39
57_G226_L0.6840.39
199_A231_F0.6820.39
57_G146_I0.6810.39
92_I236_Q0.6810.39
88_H150_V0.6790.38
190_E198_A0.6790.38
166_P213_F0.6770.38
21_E95_A0.6760.38
82_E241_F0.6750.38
36_Q66_C0.6750.38
51_R190_E0.6740.38
210_A214_A0.6740.38
224_P246_P0.6710.38
133_D145_L0.6680.38
154_L246_P0.6660.37
157_R167_F0.6650.37
50_K157_R0.6640.37
16_A62_S0.6630.37
122_W128_V0.6610.37
73_C77_L0.6540.36
145_L208_D0.6540.36
34_Q225_E0.6540.36
63_L193_L0.6530.36
77_L241_F0.6520.36
23_L67_R0.6520.36
163_S237_R0.6520.36
32_T184_M0.6470.36
71_L134_I0.6450.36
201_I219_Y0.6450.36
28_L134_I0.6440.36
21_E170_L0.6420.35
28_L71_L0.6390.35
196_E199_A0.6360.35
12_A36_Q0.6360.35
179_D233_S0.6330.35
201_I226_L0.6320.35
53_V178_H0.6310.35
224_P235_W0.6310.35
34_Q38_K0.6250.34
95_A214_A0.6230.34
107_I115_I0.6220.34
50_K72_F0.6170.33
86_G153_K0.6170.33
92_I151_A0.6160.33
163_S208_D0.6160.33
11_S45_R0.6130.33
110_V146_I0.6130.33
191_I203_A0.6130.33
84_L159_G0.6110.33
79_L169_P0.6090.33
173_V184_M0.6070.33
182_A229_P0.6060.33
55_L205_A0.6060.33
133_D185_N0.6040.32
151_A246_P0.5990.32
8_V185_N0.5980.32
8_V95_A0.5980.32
75_P87_F0.5970.32
32_T40_V0.5950.32
52_L201_I0.5940.32
165_V173_V0.5930.32
33_E37_S0.5930.32
33_E36_Q0.5900.31
15_T20_Q0.5890.31
112_N116_V0.5830.31
164_G213_F0.5830.31
157_R234_L0.5810.31
7_K20_Q0.5800.31
81_L84_L0.5790.31
76_V81_L0.5730.30
220_F239_C0.5730.30
155_D242_Y0.5720.30
203_A212_C0.5700.30
229_P233_S0.5680.30
42_L83_W0.5670.30
87_F145_L0.5660.30
51_R89_E0.5650.30
36_Q64_R0.5630.29
127_I150_V0.5620.29
90_V162_A0.5620.29
65_S93_Y0.5610.29
211_E218_E0.5590.29
201_I231_F0.5580.29
125_G246_P0.5570.29
55_L75_P0.5570.29
204_Y215_V0.5560.29
45_R243_Q0.5550.29
31_L238_F0.5550.29
193_L229_P0.5550.29
99_V116_V0.5540.29
26_P66_C0.5530.29
94_P125_G0.5500.28
219_Y226_L0.5500.28
88_H126_P0.5480.28
74_L206_A0.5470.28
53_V206_A0.5470.28
188_Q191_I0.5460.28
49_Q230_R0.5460.28
225_E228_A0.5450.28
92_I193_L0.5440.28
15_T40_V0.5410.28
18_P66_C0.5400.28
210_A217_S0.5400.28
21_E154_L0.5390.28
231_F234_L0.5380.28
50_K77_L0.5360.27
91_L99_V0.5360.27
24_S228_A0.5340.27
158_N180_L0.5340.27
35_E170_L0.5340.27
191_I206_A0.5330.27
54_P131_W0.5320.27
233_S237_R0.5310.27
121_S153_K0.5300.27
35_E244_Q0.5270.27
205_A223_A0.5260.27
59_E245_D0.5260.27
9_Q43_A0.5260.27
42_L81_L0.5250.27
73_C150_V0.5240.27
90_V118_S0.5240.27
43_A153_K0.5230.27
21_E24_S0.5230.27
142_G223_A0.5210.26
62_S225_E0.5210.26
42_L77_L0.5190.26
23_L66_C0.5190.26
163_S201_I0.5190.26
192_E229_P0.5180.26
184_M187_I0.5170.26
192_E198_A0.5150.26
30_C68_I0.5130.26
7_K24_S0.5130.26
109_L241_F0.5120.26
220_F246_P0.5120.26
65_S128_V0.5110.26
163_S166_P0.5100.26
93_Y122_W0.5100.26
19_W62_S0.5090.26
36_Q118_S0.5090.26
82_E163_S0.5090.26
18_P26_P0.5070.25
199_A203_A0.5050.25
118_S208_D0.5030.25
191_I199_A0.5030.25
136_D178_H0.5020.25
8_V11_S0.5010.25
50_K242_Y0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3khiA 1 0.8415 100 0.098 Contact Map
4dv8A 1 0.766 100 0.708 Contact Map
5a0rA 1 0.6415 99.9 0.742 Contact Map
1j7nA 2 0.7358 99.9 0.748 Contact Map
4jiuA 1 0.3811 62.1 0.958 Contact Map
4jixA 2 0.4038 61.6 0.958 Contact Map
4l7aA 2 0.8226 45 0.962 Contact Map
4qhjA 2 0.4 19 0.969 Contact Map
2ejqA 1 0.4226 12.9 0.971 Contact Map
4in9A 1 0.5736 11.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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