GREMLIN Database
C56H - Cytochrome b561 homolog 1
UniProt: P76345 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14050
Length: 176 (168)
Sequences: 2650 (1956)
Seq/√Len: 150.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_F163_Q5.4241.00
157_L161_Y3.3321.00
103_I107_A3.0971.00
15_T57_M2.9461.00
19_V95_F2.7221.00
8_Q63_I2.6081.00
48_N116_L2.4871.00
5_S67_Y2.4601.00
77_P80_Q2.4331.00
9_I173_P2.2871.00
160_H169_L2.2811.00
7_T63_I2.2421.00
82_K85_S2.2061.00
15_T95_F2.1641.00
5_S63_I2.1431.00
160_H167_T2.1271.00
87_M151_A2.1161.00
89_I93_I2.0931.00
15_T56_L2.0261.00
10_Y14_I1.7991.00
26_M29_R1.7971.00
5_S8_Q1.7941.00
57_M95_F1.7631.00
52_F115_F1.7261.00
160_H168_L1.7191.00
136_N139_E1.6821.00
104_A134_I1.6161.00
8_Q67_Y1.6161.00
86_L89_I1.6151.00
22_T53_V1.5911.00
57_M96_L1.5731.00
78_A82_K1.5681.00
150_A154_G1.5561.00
97_A141_W1.5491.00
11_L59_S1.5091.00
47_Y106_M1.5061.00
149_I153_A1.5021.00
137_I141_W1.4851.00
3_R9_I1.4651.00
160_H166_N1.4611.00
147_F151_A1.4171.00
166_N169_L1.4011.00
54_W99_P1.3991.00
143_N147_F1.3981.00
82_K86_L1.3751.00
63_I67_Y1.3341.00
20_A24_A1.3271.00
98_L142_A1.3171.00
80_Q158_F1.3071.00
107_A123_F1.3051.00
87_M155_A1.2691.00
130_I133_L1.2641.00
78_A81_M1.2531.00
98_L141_W1.2441.00
28_L32_F1.2351.00
29_R43_R1.1801.00
81_M85_S1.1661.00
34_K39_Y1.1621.00
167_T170_R1.1611.00
103_I108_Y1.1471.00
72_I76_P1.1441.00
101_L142_A1.1421.00
23_Y149_I1.1421.00
105_L135_K1.1421.00
90_M148_L1.1371.00
151_A154_G1.1321.00
45_T48_N1.1271.00
98_L101_L1.1230.99
92_Y95_F1.1200.99
115_F118_F1.1160.99
43_R47_Y1.1130.99
151_A155_A1.1120.99
45_T49_A1.1120.99
86_L90_M1.1070.99
51_I115_F1.1040.99
54_W58_F1.1010.99
108_Y124_V1.0950.99
73_V167_T1.0920.99
73_V76_P1.0760.99
127_N130_I1.0720.99
7_T10_Y1.0680.99
101_L134_I1.0650.99
156_A160_H1.0560.99
101_L137_I1.0370.99
3_R173_P1.0280.99
95_F99_P1.0230.99
40_L43_R1.0170.99
24_A28_L1.0040.99
6_K9_I1.0010.99
103_I123_F0.9810.99
140_T144_I0.9810.99
79_W82_K0.9760.99
145_G149_I0.9750.99
93_I97_A0.9750.99
11_L63_I0.9740.99
103_I121_S0.9670.98
26_M142_A0.9650.98
139_E143_N0.9640.98
76_P80_Q0.9640.98
108_Y131_K0.9610.98
54_W103_I0.9490.98
64_K69_D0.9490.98
140_T143_N0.9410.98
58_F62_I0.9340.98
19_V145_G0.9330.98
114_S119_N0.9310.98
153_A156_A0.9290.98
26_M146_Y0.9070.98
57_M99_P0.9030.98
61_L96_L0.9020.98
162_I165_D0.9020.98
6_K10_Y0.9020.98
124_V127_N0.9010.98
73_V166_N0.8960.97
38_T42_M0.8960.97
132_A136_N0.8880.97
100_L104_A0.8770.97
91_L149_I0.8740.97
41_L45_T0.8690.97
147_F150_A0.8620.97
72_I85_S0.8610.97
106_M113_W0.8590.97
61_L89_I0.8490.97
129_E133_L0.8280.96
16_L20_A0.8280.96
21_I49_A0.8200.96
18_F53_V0.8110.95
19_V57_M0.8080.95
141_W144_I0.8050.95
8_Q69_D0.7980.95
53_V57_M0.7890.95
96_L100_L0.7860.95
9_I172_M0.7720.94
62_I66_R0.7720.94
40_L44_E0.7690.94
108_Y134_I0.7640.94
32_F42_M0.7530.93
25_A42_M0.7520.93
51_I55_V0.7510.93
18_F49_A0.7510.93
168_L171_M0.7490.93
55_V62_I0.7460.93
109_S131_K0.7360.93
107_A122_P0.7360.93
85_S89_I0.7330.92
8_Q11_L0.7320.92
104_A125_T0.7220.92
137_I140_T0.7200.92
113_W120_V0.7200.92
100_L103_I0.7130.91
6_K173_P0.7120.91
44_E117_G0.7110.91
84_A87_M0.7000.91
114_S117_G0.6990.91
98_L145_G0.6980.90
146_Y150_A0.6960.90
82_K164_K0.6950.90
46_H50_G0.6940.90
154_G158_F0.6920.90
22_T49_A0.6870.90
79_W83_A0.6760.89
128_S132_A0.6570.88
40_L109_S0.6560.88
23_Y27_E0.6530.87
115_F120_V0.6510.87
21_I25_A0.6450.87
132_A135_K0.6420.86
60_R92_Y0.6370.86
54_W57_M0.6340.86
161_Y164_K0.6330.86
101_L104_A0.6300.85
44_E106_M0.6260.85
58_F96_L0.6260.85
144_I148_L0.6220.85
25_A49_A0.6210.85
107_A121_S0.6170.84
43_R135_K0.6160.84
104_A124_V0.6140.84
72_I167_T0.6130.84
110_G122_P0.6110.84
28_L42_M0.6110.84
7_T67_Y0.6080.83
69_D85_S0.6070.83
28_L31_W0.6070.83
101_L105_L0.6060.83
27_E146_Y0.6060.83
16_L23_Y0.6060.83
40_L111_K0.6040.83
94_T145_G0.6030.83
143_N150_A0.6000.82
39_Y43_R0.6000.82
76_P167_T0.5980.82
161_Y165_D0.5980.82
7_T59_S0.5970.82
51_I120_V0.5960.82
55_V59_S0.5950.82
157_L165_D0.5900.81
51_I113_W0.5880.81
4_F8_Q0.5880.81
94_T144_I0.5860.81
127_N131_K0.5850.81
83_A155_A0.5810.80
167_T172_M0.5790.80
90_M94_T0.5780.80
52_F116_L0.5780.80
44_E48_N0.5740.80
62_I65_H0.5690.79
19_V98_L0.5680.79
74_P77_P0.5630.78
160_H164_K0.5610.78
83_A86_L0.5610.78
27_E31_W0.5600.78
32_F146_Y0.5580.78
30_G143_N0.5570.78
33_P39_Y0.5500.77
23_Y29_R0.5490.77
8_Q171_M0.5470.76
94_T141_W0.5460.76
169_L172_M0.5440.76
15_T22_T0.5420.76
73_V170_R0.5410.76
156_A171_M0.5410.76
130_I134_I0.5400.75
15_T92_Y0.5400.75
113_W122_P0.5380.75
91_L95_F0.5380.75
46_H138_H0.5380.75
18_F22_T0.5370.75
106_M110_G0.5350.75
26_M43_R0.5340.75
158_F162_I0.5300.74
97_A144_I0.5260.74
104_A108_Y0.5210.73
29_R42_M0.5200.73
25_A31_W0.5190.73
131_K135_K0.5180.72
104_A142_A0.5180.72
46_H165_D0.5160.72
112_S119_N0.5130.72
168_L172_M0.5130.72
101_L141_W0.5130.72
94_T148_L0.5120.72
43_R105_L0.5120.72
149_I154_G0.5110.71
143_N146_Y0.5090.71
48_N118_F0.5090.71
109_S135_K0.5080.71
72_I81_M0.5060.71
83_A87_M0.5050.71
88_H155_A0.5050.71
95_F104_A0.5040.70
30_G33_P0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gd3A 2 0.8466 100 0.466 Contact Map
1kqfC 3 0.8977 99.9 0.485 Contact Map
4o6yA 2 0.8068 49.8 0.927 Contact Map
1q16C 2 0.8977 27.3 0.937 Contact Map
3cx5C 2 0.6818 26.4 0.938 Contact Map
1pp9C 2 0.6136 13.9 0.945 Contact Map
2qjyA 2 0.7443 13.7 0.945 Contact Map
4bolA 2 0.3636 3.1 0.96 Contact Map
4i0uA 4 0.375 2.5 0.961 Contact Map
1jb0A 1 0.9375 2.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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