GREMLIN Database
ZINT - Metal-binding protein ZinT
UniProt: P76344 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14049
Length: 216 (195)
Sequences: 323 (232)
Seq/√Len: 16.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_V135_I4.6531.00
52_N130_Y4.2261.00
73_K206_S4.0201.00
200_Y212_E3.4590.99
115_V162_I3.1940.99
68_L209_V2.9000.98
162_I179_I2.7750.97
109_G118_H2.7350.97
78_F94_K2.7310.97
168_I172_R2.4750.95
61_V107_M2.3930.94
27_H30_G2.3040.93
148_L186_Q2.2790.92
113_G127_K2.2750.92
121_N208_E2.2520.92
140_S143_K2.2400.92
139_K208_E2.1620.90
205_S208_E2.1480.90
107_M118_H2.1420.90
22_F26_H2.0120.86
126_C183_N2.0060.86
25_G29_H1.9790.85
126_C151_C1.9770.85
180_F193_M1.9720.85
20_P26_H1.9680.85
39_K42_N1.9600.85
129_D152_K1.9480.84
41_A99_K1.8580.81
131_D150_E1.8520.81
20_P24_H1.8350.81
151_C158_A1.8050.80
107_M202_Y1.7020.75
200_Y213_M1.6840.74
71_S206_S1.6650.74
68_L206_S1.6570.73
151_C154_P1.6290.72
35_E38_Q1.6050.71
116_E123_T1.5990.70
48_A68_L1.5730.69
44_V140_S1.5640.69
24_H27_H1.5610.69
184_D188_S1.5540.68
58_W180_F1.5420.68
180_F189_L1.5400.67
210_V214_M1.5330.67
28_S31_K1.5260.67
148_L193_M1.5230.67
138_Y163_Q1.5100.66
78_F90_F1.5030.66
80_K83_D1.5000.65
27_H31_K1.4980.65
189_L193_M1.4840.64
106_E120_N1.4740.64
41_A180_F1.4500.63
24_H29_H1.4280.61
80_K84_A1.3900.59
76_P207_E1.3640.58
204_L212_E1.3530.57
44_V143_K1.3500.57
158_A183_N1.3400.56
44_V142_K1.3320.56
21_A28_S1.3280.56
126_C158_A1.2940.54
59_D120_N1.2930.54
27_H32_P1.2750.53
134_K180_F1.2600.52
21_A26_H1.2500.51
162_I181_M1.2330.50
115_V179_I1.2270.50
22_F25_G1.1960.48
95_D187_Q1.1940.48
180_F195_N1.1860.47
20_P23_S1.1810.47
150_E186_Q1.1770.47
23_S26_H1.1520.45
145_V163_Q1.1440.45
46_D92_E1.1390.45
208_E211_E1.1220.44
40_A49_N1.1190.43
35_E39_K1.1140.43
24_H31_K1.0770.41
94_K98_H1.0540.40
23_S30_G1.0490.39
26_H29_H1.0490.39
32_P37_E1.0430.39
124_T157_K1.0400.39
147_Y170_A1.0250.38
21_A24_H1.0250.38
48_A51_Q1.0190.38
61_V202_Y1.0060.37
53_R72_G1.0050.37
114_I127_K1.0040.37
151_C156_S0.9940.36
63_Q67_P0.9840.36
138_Y165_S0.9830.36
21_A25_G0.9800.36
131_D186_Q0.9790.36
106_E119_R0.9680.35
61_V118_H0.9660.35
126_C156_S0.9560.34
144_G163_Q0.9450.34
100_G163_Q0.9420.34
69_L74_L0.9400.33
128_Y132_G0.9380.33
154_P158_A0.9370.33
119_R147_Y0.9370.33
78_F154_P0.9360.33
180_F194_E0.9220.32
51_Q170_A0.9190.32
59_D111_E0.9130.32
204_L208_E0.9040.32
37_E120_N0.9020.31
168_I175_S0.9010.31
28_S32_P0.8930.31
35_E204_L0.8820.30
68_L71_S0.8770.30
58_W179_I0.8760.30
168_I174_S0.8750.30
100_G138_Y0.8730.30
153_D156_S0.8730.30
77_V165_S0.8710.30
22_F29_H0.8690.30
57_D171_P0.8650.30
20_P25_G0.8610.29
43_G136_L0.8590.29
58_W70_Q0.8570.29
131_D184_D0.8560.29
25_G30_G0.8550.29
52_N94_K0.8530.29
106_E112_D0.8490.29
95_D207_E0.8420.28
89_T120_N0.8410.28
65_V200_Y0.8350.28
35_E78_F0.8210.27
159_P211_E0.8040.27
59_D118_H0.8020.27
87_T93_I0.7990.26
25_G34_T0.7950.26
77_V138_Y0.7930.26
83_D210_V0.7920.26
89_T191_N0.7910.26
134_K186_Q0.7910.26
118_H202_Y0.7880.26
23_S28_S0.7790.26
115_V184_D0.7770.25
90_F94_K0.7770.25
152_K208_E0.7730.25
119_R122_E0.7720.25
80_K159_P0.7690.25
44_V47_D0.7650.25
129_D134_K0.7610.25
179_I186_Q0.7490.24
31_K183_N0.7490.24
26_H31_K0.7460.24
76_P84_A0.7450.24
40_A44_V0.7420.24
77_V163_Q0.7270.23
43_G138_Y0.7180.23
20_P31_K0.7140.23
65_V105_I0.7100.23
61_V109_G0.7100.23
58_W174_S0.7090.23
76_P158_A0.7050.22
127_K170_A0.7050.22
138_Y144_G0.7040.22
70_Q95_D0.6970.22
50_V96_Y0.6940.22
25_G28_S0.6920.22
76_P79_Q0.6920.22
160_K194_E0.6910.22
102_A173_K0.6790.21
188_S191_N0.6730.21
115_V181_M0.6730.21
146_R163_Q0.6660.21
146_R165_S0.6650.21
124_T187_Q0.6650.21
29_H34_T0.6630.21
63_Q73_K0.6600.21
20_P29_H0.6570.20
133_Y191_N0.6560.20
191_N205_S0.6520.20
98_H102_A0.6420.20
163_Q192_E0.6420.20
61_V66_Y0.6400.20
200_Y204_L0.6390.20
103_T199_Y0.6370.20
101_Y164_F0.6340.20
46_D49_N0.6330.20
49_N215_S0.6320.20
53_R166_D0.6300.19
43_G47_D0.6300.19
21_A33_L0.6290.19
106_E118_H0.6210.19
23_S27_H0.6210.19
113_G206_S0.6130.19
111_E214_M0.6130.19
115_V168_I0.6100.19
178_H197_P0.6100.19
56_S113_G0.6070.19
27_H58_W0.6060.19
138_Y145_V0.6060.19
77_V146_R0.6020.18
206_S210_V0.6020.18
203_Q207_E0.5980.18
68_L205_S0.5980.18
78_F153_D0.5950.18
31_K36_V0.5950.18
94_K172_R0.5950.18
91_A215_S0.5940.18
126_C159_P0.5940.18
172_R188_S0.5880.18
30_G111_E0.5870.18
43_G196_W0.5870.18
72_G132_G0.5870.18
140_S215_S0.5860.18
190_L194_E0.5840.18
64_S67_P0.5820.18
148_L190_L0.5810.18
81_K100_G0.5800.18
116_E213_M0.5800.18
122_E205_S0.5790.18
136_L145_V0.5790.18
91_A121_N0.5790.18
83_D211_E0.5790.18
58_W140_S0.5770.18
89_T92_E0.5730.17
65_V136_L0.5720.17
134_K148_L0.5710.17
37_E111_E0.5700.17
22_F27_H0.5700.17
189_L214_M0.5700.17
121_N172_R0.5700.17
136_L144_G0.5690.17
21_A88_K0.5680.17
139_K191_N0.5670.17
56_S112_D0.5650.17
112_D179_I0.5630.17
34_T39_K0.5600.17
72_G97_Y0.5590.17
36_V156_S0.5590.17
104_D120_N0.5590.17
96_Y100_G0.5590.17
45_F143_K0.5580.17
139_K183_N0.5560.17
104_D175_S0.5550.17
138_Y192_E0.5540.17
57_D97_Y0.5540.17
94_K109_G0.5530.17
54_T95_D0.5520.17
51_Q171_P0.5520.17
99_K188_S0.5510.17
97_Y101_Y0.5500.17
157_K183_N0.5500.17
177_F193_M0.5490.17
24_H32_P0.5450.16
145_V165_S0.5450.16
79_Q83_D0.5410.16
48_A54_T0.5410.16
151_C161_Y0.5400.16
138_Y146_R0.5390.16
113_G203_Q0.5360.16
160_K173_K0.5330.16
32_P59_D0.5320.16
43_G144_G0.5320.16
136_L142_K0.5310.16
53_R146_R0.5310.16
151_C155_E0.5300.16
24_H118_H0.5240.16
188_S193_M0.5240.16
75_D94_K0.5190.16
116_E202_Y0.5180.16
146_R180_F0.5180.16
150_E161_Y0.5160.16
21_A27_H0.5150.16
119_R150_E0.5140.16
49_N177_F0.5130.15
77_V195_N0.5130.15
48_A122_E0.5110.15
127_K187_Q0.5100.15
38_Q188_S0.5090.15
36_V79_Q0.5080.15
42_N212_E0.5080.15
48_A121_N0.5070.15
142_K215_S0.5070.15
34_T54_T0.5060.15
106_E172_R0.5040.15
112_D139_K0.5030.15
183_N207_E0.5030.15
34_T37_E0.5020.15
37_E172_R0.5020.15
199_Y215_S0.5000.15
84_A139_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1txlA 1 0.8704 100 0.077 Contact Map
3oiqB 1 0.1389 14.3 0.967 Contact Map
1z1sA 1 0.6204 11.2 0.968 Contact Map
2ab9A 1 0.1065 10.1 0.969 Contact Map
2f73A 1 0.5 6.3 0.972 Contact Map
2lwxA 1 0.3287 5.6 0.972 Contact Map
4f82A 2 0.6574 5.4 0.972 Contact Map
3vg7A 1 0.4676 3.8 0.974 Contact Map
4a60A 1 0.5278 3.4 0.975 Contact Map
3zfjA 1 0.3796 3.2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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