GREMLIN Database
HIUH - 5-hydroxyisourate hydrolase
UniProt: P76341 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14046
Length: 137 (111)
Sequences: 1773 (1110)
Seq/√Len: 105.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_I45_V3.3951.00
115_K118_E3.1951.00
66_D72_K3.1181.00
86_R110_E2.6011.00
42_A45_V2.5661.00
48_T90_K2.5581.00
90_K93_D2.3271.00
36_Q130_G2.3211.00
57_W86_R2.2791.00
50_E88_V2.2491.00
59_Q62_T2.2151.00
48_T62_T2.1901.00
68_D137_S2.1821.00
52_K57_W1.9531.00
46_T90_K1.9171.00
48_T88_V1.8071.00
88_V106_E1.8041.00
103_F122_V1.7241.00
48_T59_Q1.7141.00
63_A71_I1.7041.00
38_T98_Q1.6551.00
46_T64_K1.6311.00
91_T107_I1.6241.00
46_T62_T1.6121.00
53_A58_L1.6081.00
50_E59_Q1.5471.00
35_N38_T1.4801.00
47_V87_V1.4591.00
89_F124_L1.4171.00
37_Q130_G1.4161.00
86_R108_P1.4091.00
31_V87_V1.4061.00
84_D112_H1.3120.99
44_D64_K1.3040.99
93_D96_K1.2930.99
53_A56_G1.2910.99
88_V108_P1.2700.99
43_A67_K1.2250.99
27_N30_S1.2220.99
96_K102_S1.2200.99
87_V122_V1.2100.99
50_E86_R1.1380.98
63_A73_A1.1330.98
32_H70_R1.1110.98
45_V126_L1.0950.98
68_D125_L1.0940.98
95_F126_L1.0560.97
91_T126_L1.0520.97
51_K58_L1.0470.97
28_I77_E1.0330.97
101_E114_N1.0310.97
36_Q104_F1.0260.97
71_I74_L1.0130.96
124_L131_Y1.0060.96
106_E110_E1.0020.96
50_E57_W0.9840.96
28_I75_W0.9820.96
46_T93_D0.9810.96
28_I74_L0.9690.95
127_S130_G0.9670.95
33_I65_T0.9320.94
96_K105_P0.9250.94
71_I76_P0.9220.94
90_K106_E0.9120.94
111_F132_S0.9100.93
32_H121_H0.8970.93
89_F122_V0.8950.93
95_F129_Y0.8770.92
92_G102_S0.8670.92
92_G96_K0.8440.91
45_V91_T0.8370.90
113_I116_V0.8310.90
29_L80_A0.8250.90
74_L80_A0.8240.90
123_P135_R0.8240.90
41_P137_S0.8110.89
91_T105_P0.8090.89
95_F107_I0.8070.89
103_F129_Y0.7890.87
30_S125_L0.7830.87
30_S37_Q0.7790.87
30_S75_W0.7780.87
105_P108_P0.7750.87
91_T104_F0.7730.86
31_V122_V0.7720.86
37_Q127_S0.7720.86
52_K86_R0.7700.86
34_L70_R0.7680.86
95_F102_S0.7670.86
100_L128_Q0.7630.86
40_K118_E0.7540.85
51_K83_G0.7520.85
107_I122_V0.7500.85
84_D110_E0.7360.84
70_R134_Y0.7360.84
107_I124_L0.7340.83
51_K81_T0.7310.83
104_F108_P0.7200.82
129_Y132_S0.7150.82
61_N79_T0.7100.81
38_T100_L0.7070.81
30_S74_L0.7010.81
28_I119_H0.7000.80
38_T129_Y0.6950.80
113_I118_E0.6890.79
47_V65_T0.6840.79
102_S126_L0.6730.78
31_V130_G0.6680.77
57_W110_E0.6560.76
103_F127_S0.6550.76
80_A85_Y0.6530.76
89_F103_F0.6430.75
32_H134_Y0.6410.74
114_N118_E0.6360.74
70_R121_H0.6340.73
32_H68_D0.6310.73
102_S112_H0.6300.73
104_F109_V0.6280.73
84_D106_E0.6250.72
60_L74_L0.6230.72
82_T116_V0.6180.72
104_F133_T0.6170.71
99_N112_H0.6140.71
57_W88_V0.6130.71
75_W80_A0.6080.70
53_A81_T0.6070.70
48_T106_E0.6050.70
51_K57_W0.6020.70
45_V95_F0.6010.69
65_T71_I0.5980.69
71_I130_G0.5970.69
93_D97_K0.5970.69
47_V71_I0.5940.69
36_Q132_S0.5930.68
68_D122_V0.5820.67
53_A79_T0.5780.67
61_N76_P0.5660.65
92_G112_H0.5650.65
45_V65_T0.5640.65
96_K100_L0.5590.64
64_K101_E0.5550.63
70_R135_R0.5470.62
74_L95_F0.5420.62
102_S105_P0.5410.61
78_Q81_T0.5400.61
68_D124_L0.5390.61
30_S119_H0.5380.61
95_F130_G0.5370.61
29_L51_K0.5370.61
43_A97_K0.5340.60
126_L130_G0.5320.60
46_T102_S0.5280.60
37_Q128_Q0.5260.59
52_K59_Q0.5200.58
121_H134_Y0.5180.58
37_Q129_Y0.5180.58
91_T95_F0.5150.58
38_T92_G0.5130.57
78_Q92_G0.5120.57
35_N42_A0.5080.57
42_A137_S0.5070.57
61_N73_A0.5070.57
94_Y114_N0.5050.56
40_K43_A0.5030.56
49_L87_V0.5020.56
85_Y94_Y0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iwvA 4 0.8394 100 0.11 Contact Map
2g2nA 5 0.8175 100 0.126 Contact Map
4q14A 2 0.8175 100 0.148 Contact Map
2h0eA 4 0.7956 100 0.174 Contact Map
4pweA 4 0.8102 100 0.176 Contact Map
3qvaA 4 0.8175 100 0.187 Contact Map
1oo2A 4 0.8175 100 0.193 Contact Map
1f86A 4 0.8102 100 0.194 Contact Map
4zjhA 1 0.6277 98.5 0.799 Contact Map
3e8vA 1 0.5985 96.3 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.