GREMLIN Database
YEDV - Probable sensor-like histidine kinase YedV
UniProt: P76339 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14044
Length: 452 (435)
Sequences: 47343 (40674)
Seq/√Len: 1950.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
385_D443_V4.1721.00
386_I390_G4.0141.00
423_K427_E3.8081.00
310_L344_A3.5751.00
434_T445_R3.4301.00
258_N278_N3.2691.00
383_N443_V3.1801.00
373_T383_N2.9381.00
381_Y447_T2.9221.00
383_N445_R2.8831.00
364_S387_A2.8681.00
396_P436_H2.8611.00
335_K371_H2.8381.00
381_Y445_R2.7991.00
344_A429_H2.7431.00
309_S343_F2.7051.00
375_F381_Y2.6801.00
371_H385_D2.6681.00
255_L283_E2.6661.00
335_K369_R2.6481.00
437_Y440_K2.6361.00
369_R387_A2.6301.00
435_Y444_F2.6281.00
392_K395_E2.5651.00
262_L279_I2.5611.00
213_R216_K2.5551.00
262_L276_A2.5151.00
352_M426_A2.4891.00
422_V433_A2.4811.00
373_T385_D2.4631.00
337_E373_T2.4431.00
309_S341_Q2.4391.00
375_F383_N2.4321.00
426_A431_G2.3681.00
400_F433_A2.3451.00
311_S314_K2.3451.00
391_T399_L2.3381.00
396_P435_Y2.2861.00
225_M229_L2.2721.00
395_E398_K2.2591.00
268_I271_Y2.1691.00
318_N350_Q2.1441.00
337_E371_H2.1351.00
308_D346_K2.0981.00
426_A446_I2.0731.00
333_C369_R2.0651.00
432_S447_T2.0591.00
436_H442_N2.0561.00
398_K401_R2.0041.00
212_P216_K1.9771.00
255_L282_L1.9751.00
323_L354_S1.9691.00
352_M425_I1.9621.00
255_L286_S1.9451.00
238_Q242_D1.9381.00
434_T447_T1.9231.00
344_A349_L1.9091.00
327_S361_I1.8821.00
286_S290_E1.8741.00
307_L343_F1.8731.00
364_S368_S1.8651.00
234_E238_Q1.8631.00
267_S271_Y1.8521.00
352_M422_V1.8501.00
393_I396_P1.8311.00
27_W31_N1.8121.00
425_I429_H1.8071.00
196_A201_D1.7871.00
395_E404_W1.7821.00
358_V362_R1.7601.00
368_S387_A1.7561.00
353_L382_L1.7431.00
226_H229_L1.7341.00
236_L240_A1.7301.00
391_T442_N1.7261.00
398_K404_W1.7231.00
427_E432_S1.7021.00
259_Q279_I1.6911.00
391_T395_E1.6861.00
191_S217_P1.6641.00
386_I441_H1.6421.00
345_D348_L1.6331.00
313_N317_E1.6261.00
267_S270_E1.6211.00
85_D89_K1.6161.00
258_N279_I1.6111.00
371_H387_A1.6041.00
215_L219_G1.6031.00
355_N422_V1.5811.00
262_L272_Q1.5711.00
348_L351_R1.5611.00
395_E406_G1.5561.00
382_L446_I1.5561.00
197_L226_H1.5501.00
257_Q274_T1.5411.00
364_S370_I1.5231.00
379_N447_T1.5121.00
191_S195_E1.4901.00
400_F435_Y1.4791.00
426_A433_A1.4601.00
176_S180_I1.4591.00
436_H439_N1.4521.00
261_T275_I1.4401.00
279_I283_E1.4281.00
219_G223_N1.4041.00
352_M446_I1.4021.00
311_S341_Q1.3961.00
318_N346_K1.3911.00
254_L282_L1.3851.00
346_K350_Q1.3831.00
324_E328_D1.3751.00
322_Y350_Q1.3751.00
313_N374_S1.3681.00
392_K438_L1.3611.00
246_E351_R1.3601.00
396_P400_F1.3391.00
253_A257_Q1.3381.00
401_R404_W1.3331.00
424_A427_E1.3311.00
254_L278_N1.3271.00
436_H440_K1.3151.00
205_P227_H1.3121.00
196_A204_E1.2981.00
210_A216_K1.2901.00
348_L425_I1.2891.00
231_K235_R1.2881.00
348_L428_L1.2801.00
101_L104_I1.2801.00
264_Q271_Y1.2781.00
255_L279_I1.2751.00
400_F444_F1.2581.00
431_G448_L1.2581.00
435_Y442_N1.2521.00
313_N338_C1.2411.00
363_Y405_R1.2401.00
223_N226_H1.2381.00
239_F243_L1.2351.00
201_D204_E1.2341.00
253_A281_E1.2341.00
261_T271_Y1.2341.00
320_L336_V1.2321.00
159_I163_I1.2221.00
276_A280_E1.2191.00
317_E336_V1.2191.00
242_D402_R1.2101.00
194_T222_L1.1991.00
315_E319_L1.1971.00
258_N262_L1.1921.00
360_A370_I1.1861.00
188_K191_S1.1811.00
326_L329_E1.1761.00
400_F423_K1.1661.00
268_I272_Q1.1601.00
399_L435_Y1.1601.00
258_N282_L1.1581.00
338_C374_S1.1501.00
212_P215_L1.1461.00
316_V374_S1.1431.00
365_P368_S1.1391.00
193_V206_V1.1371.00
233_F236_L1.1351.00
34_A38_K1.1321.00
195_E217_P1.1291.00
319_L354_S1.1281.00
28_T32_G1.1251.00
230_V234_E1.1111.00
257_Q277_G1.1111.00
385_D437_Y1.1081.00
248_R290_E1.0971.00
253_A256_G1.0951.00
393_I436_H1.0931.00
181_R185_R1.0851.00
180_I184_L1.0851.00
386_I442_N1.0821.00
155_E159_I1.0761.00
287_R347_I1.0761.00
391_T396_P1.0741.00
349_L429_H1.0731.00
194_T221_A1.0701.00
9_R213_R1.0641.00
405_R412_S1.0591.00
26_V30_Y1.0541.00
307_L429_H1.0531.00
48_R51_Q1.0511.00
208_V220_Q1.0481.00
356_L444_F1.0451.00
7_T181_R1.0411.00
84_G90_I1.0401.00
256_G260_V1.0391.00
205_P223_N1.0361.00
59_G63_D1.0281.00
272_Q276_A1.0271.00
191_S221_A1.0251.00
215_L218_L1.0251.00
232_D236_L1.0241.00
194_T197_L1.0201.00
255_L259_Q1.0141.00
183_G186_E1.0141.00
46_I50_A1.0061.00
319_L323_L1.0041.00
305_V345_D1.0031.00
30_Y158_K1.0031.00
238_Q402_R0.9961.00
353_L384_I0.9961.00
224_K228_A0.9941.00
290_E294_F0.9921.00
273_K277_G0.9881.00
60_V64_T0.9851.00
310_L315_E0.9841.00
265_T271_Y0.9781.00
230_V233_F0.9761.00
246_E355_N0.9761.00
31_N34_A0.9741.00
339_N375_F0.9741.00
353_L357_I0.9731.00
42_D46_I0.9721.00
49_T53_K0.9701.00
291_N348_L0.9671.00
174_V178_L0.9651.00
320_L324_E0.9621.00
293_L296_A0.9611.00
173_S177_P0.9601.00
356_L433_A0.9601.00
61_N64_T0.9491.00
314_K318_N0.9471.00
258_N275_I0.9461.00
319_L350_Q0.9421.00
355_N358_V0.9391.00
198_N224_K0.9351.00
216_K219_G0.9331.00
207_E223_N0.9311.00
402_R424_A0.9301.00
417_L421_L0.9301.00
391_T435_Y0.9291.00
147_A151_H0.9281.00
281_E284_N0.9261.00
323_L357_I0.9251.00
356_L422_V0.9241.00
363_Y389_P0.9221.00
278_N282_L0.9211.00
222_L225_M0.9191.00
332_I364_S0.9131.00
212_P219_G0.9121.00
40_R44_T0.9121.00
317_E321_D0.9111.00
221_A224_K0.9081.00
312_L382_L0.9081.00
277_G281_E0.9031.00
356_L446_I0.9031.00
41_D44_T0.8971.00
180_I183_G0.8961.00
42_D126_D0.8961.00
269_A272_Q0.8941.00
315_E344_A0.8941.00
322_Y354_S0.8901.00
139_L143_V0.8891.00
216_K220_Q0.8861.00
391_T397_E0.8851.00
225_M228_A0.8841.00
426_A448_L0.8771.00
31_N35_S0.8771.00
390_G442_N0.8771.00
399_L444_F0.8751.00
311_S340_Q0.8711.00
205_P226_H0.8711.00
280_E318_N0.8711.00
350_Q354_S0.8701.00
131_N140_T0.8701.00
354_S358_V0.8681.00
53_K57_I0.8651.00
287_R291_N0.8641.00
234_E237_S0.8641.00
273_K276_A0.8631.00
178_L182_T0.8631.00
38_K42_D0.8631.00
347_I350_Q0.8621.00
326_L358_V0.8591.00
194_T218_L0.8561.00
195_E221_A0.8561.00
357_I372_I0.8551.00
282_L286_S0.8531.00
305_V348_L0.8521.00
319_L357_I0.8521.00
40_R43_T0.8511.00
323_L358_V0.8501.00
245_H249_T0.8481.00
240_A243_L0.8461.00
423_K432_S0.8451.00
249_T253_A0.8441.00
159_I162_I0.8371.00
158_K162_I0.8371.00
422_V426_A0.8361.00
283_E286_S0.8301.00
140_T144_A0.8291.00
271_Y274_T0.8281.00
133_D136_S0.8251.00
44_T47_N0.8241.00
135_V138_S0.8241.00
156_Q160_N0.8211.00
197_L225_M0.8211.00
226_H230_V0.8171.00
246_E250_P0.8161.00
102_N105_P0.8131.00
245_H355_N0.8121.00
193_V204_E0.8101.00
235_R238_Q0.8101.00
376_L380_S0.8081.00
36_E40_R0.8071.00
312_L380_S0.8071.00
424_A428_L0.8061.00
307_L430_G0.8061.00
393_I397_E0.8051.00
218_L222_L0.8031.00
194_T198_N0.8021.00
313_N340_Q0.8011.00
192_G196_A0.7991.00
348_L352_M0.7991.00
217_P220_Q0.7981.00
49_T52_I0.7981.00
252_N256_G0.7971.00
332_I336_V0.7961.00
372_I384_I0.7961.00
206_V219_G0.7951.00
41_D45_L0.7951.00
129_R140_T0.7951.00
316_V353_L0.7951.00
276_A279_I0.7951.00
191_S194_T0.7911.00
206_V223_N0.7881.00
96_V99_G0.7881.00
177_P181_R0.7871.00
421_L425_I0.7811.00
45_L49_T0.7801.00
260_V264_Q0.7781.00
321_D324_E0.7761.00
377_D381_Y0.7741.00
431_G446_I0.7741.00
231_K234_E0.7731.00
295_L420_S0.7721.00
17_L21_A0.7711.00
188_K192_G0.7711.00
352_M429_H0.7691.00
294_F351_R0.7691.00
306_K345_D0.7661.00
44_T48_R0.7631.00
59_G62_P0.7631.00
79_I82_I0.7611.00
126_D129_R0.7571.00
232_D235_R0.7551.00
208_V219_G0.7551.00
248_R286_S0.7521.00
82_I142_T0.7511.00
327_S334_F0.7511.00
251_I289_T0.7511.00
307_L344_A0.7511.00
198_N228_A0.7501.00
126_D131_N0.7491.00
182_T185_R0.7491.00
392_K406_G0.7491.00
98_D101_L0.7481.00
233_F237_S0.7471.00
310_L346_K0.7471.00
190_L194_T0.7461.00
23_A27_W0.7431.00
327_S370_I0.7431.00
154_L158_K0.7421.00
316_V372_I0.7411.00
247_L285_I0.7411.00
277_G280_E0.7391.00
186_E190_L0.7391.00
124_E127_A0.7381.00
351_R425_I0.7381.00
57_I61_N0.7331.00
210_A213_R0.7321.00
317_E320_L0.7301.00
374_S380_S0.7291.00
66_P70_N0.7281.00
356_L426_A0.7281.00
333_C336_V0.7281.00
43_T46_I0.7251.00
125_I129_R0.7251.00
195_E199_Y0.7211.00
185_R189_K0.7211.00
30_Y34_A0.7201.00
162_I166_I0.7171.00
243_L292_I0.7171.00
257_Q281_E0.7171.00
331_E367_K0.7171.00
386_I389_P0.7171.00
193_V196_A0.7161.00
60_V63_D0.7091.00
395_E408_N0.7081.00
433_A444_F0.7071.00
52_I55_L0.7061.00
328_D331_E0.7061.00
85_D91_V0.7051.00
39_W42_D0.6991.00
405_R414_G0.6991.00
305_V428_L0.6981.00
389_P412_S0.6961.00
319_L322_Y0.6961.00
129_R142_T0.6951.00
362_R412_S0.6951.00
218_L221_A0.6951.00
400_F403_F0.6931.00
189_K193_V0.6921.00
327_S330_K0.6901.00
320_L334_F0.6901.00
110_I113_A0.6901.00
213_R217_P0.6871.00
325_Y329_E0.6871.00
360_A384_I0.6871.00
54_Q58_D0.6861.00
195_E198_N0.6851.00
326_L330_K0.6851.00
50_A54_Q0.6841.00
69_F72_M0.6831.00
391_T436_H0.6821.00
317_E338_C0.6821.00
217_P221_A0.6801.00
189_K192_G0.6801.00
401_R423_K0.6791.00
312_L342_I0.6791.00
385_D439_N0.6791.00
45_L48_R0.6781.00
325_Y328_D0.6781.00
393_I437_Y0.6771.00
291_N351_R0.6741.00
237_S299_D0.6721.00
374_S382_L0.6691.00
150_R154_L0.6681.00
321_D325_Y0.6681.00
257_Q278_N0.6671.00
310_L343_F0.6661.00
38_K41_D0.6661.00
55_L58_D0.6651.00
47_N50_A0.6651.00
348_L429_H0.6651.00
7_T188_K0.6641.00
365_P389_P0.6641.00
396_P444_F0.6641.00
127_A130_I0.6631.00
364_S367_K0.6621.00
219_G222_L0.6621.00
37_L40_R0.6601.00
331_E366_E0.6601.00
240_A244_A0.6591.00
80_L93_R0.6581.00
27_W30_Y0.6571.00
262_L275_I0.6561.00
318_N322_Y0.6541.00
35_S39_W0.6491.00
274_T278_N0.6491.00
237_S242_D0.6481.00
270_E274_T0.6481.00
257_Q261_T0.6481.00
54_Q57_I0.6481.00
155_E158_K0.6451.00
127_A144_A0.6451.00
68_Y73_M0.6451.00
80_L144_A0.6441.00
422_V425_I0.6431.00
42_D45_L0.6421.00
281_E322_Y0.6421.00
284_N350_Q0.6421.00
190_L219_G0.6411.00
151_H155_E0.6371.00
377_D447_T0.6371.00
125_I128_L0.6361.00
187_I218_L0.6341.00
294_F297_R0.6341.00
399_L404_W0.6321.00
370_I384_I0.6321.00
279_I282_L0.6321.00
24_G28_T0.6311.00
265_T268_I0.6311.00
62_P65_L0.6301.00
100_M103_N0.6281.00
252_N255_L0.6281.00
362_R414_G0.6271.00
241_D244_A0.6241.00
43_T47_N0.6241.00
32_G35_S0.6231.00
35_S38_K0.6231.00
314_K346_K0.6221.00
399_L420_S0.6211.00
210_A219_G0.6211.00
420_S424_A0.6201.00
337_E375_F0.6191.00
50_A53_K0.6171.00
84_G142_T0.6171.00
327_S332_I0.6161.00
156_Q159_I0.6161.00
294_F348_L0.6161.00
36_E39_W0.6151.00
381_Y434_T0.6151.00
434_T446_I0.6141.00
247_L250_P0.6141.00
390_G441_H0.6121.00
32_G36_E0.6121.00
293_L297_R0.6111.00
357_I370_I0.6101.00
239_F246_E0.6091.00
274_T277_G0.6081.00
166_I170_V0.6081.00
58_D61_N0.6061.00
186_E213_R0.6061.00
90_I93_R0.6061.00
182_T186_E0.6041.00
323_L361_I0.6041.00
239_F242_D0.6041.00
15_I18_L0.6021.00
320_L372_I0.6011.00
13_L17_L0.6001.00
396_P442_N0.6001.00
253_A277_G0.6001.00
254_L258_N0.5991.00
118_S121_N0.5991.00
332_I361_I0.5981.00
110_I114_G0.5981.00
299_D402_R0.5971.00
70_N74_D0.5971.00
365_P387_A0.5971.00
55_L59_G0.5921.00
85_D88_N0.5921.00
204_E208_V0.5901.00
9_R182_T0.5891.00
391_T444_F0.5881.00
242_D246_E0.5881.00
160_N163_I0.5851.00
49_T143_V0.5851.00
194_T225_M0.5821.00
185_R188_K0.5811.00
68_Y71_R0.5801.00
431_G449_P0.5801.00
14_F176_S0.5791.00
82_I90_I0.5781.00
28_T31_N0.5761.00
397_E401_R0.5761.00
246_E421_L0.5731.00
8_V12_L0.5721.00
163_I167_V0.5721.00
172_C176_S0.5711.00
125_I144_A0.5691.00
70_N73_M0.5691.00
121_N124_E0.5681.00
245_H250_P0.5671.00
409_S413_V0.5671.00
285_I289_T0.5661.00
224_K227_H0.5651.00
136_S139_L0.5651.00
141_V146_L0.5651.00
339_N373_T0.5651.00
315_E349_L0.5641.00
218_L223_N0.5631.00
275_I279_I0.5631.00
220_Q224_K0.5631.00
187_I215_L0.5601.00
405_R413_V0.5591.00
39_W43_T0.5581.00
48_R52_I0.5571.00
16_L23_A0.5571.00
238_Q424_A0.5561.00
264_Q274_T0.5561.00
295_L424_A0.5561.00
339_N374_S0.5551.00
16_L19_S0.5551.00
260_V274_T0.5541.00
209_S212_P0.5531.00
192_G195_E0.5511.00
61_N65_L0.5501.00
50_A130_I0.5501.00
357_I361_I0.5501.00
68_Y72_M0.5491.00
227_H231_K0.5481.00
207_E210_A0.5471.00
246_E249_T0.5471.00
139_L145_K0.5461.00
349_L448_L0.5451.00
56_L60_V0.5451.00
208_V216_K0.5441.00
239_F244_A0.5441.00
283_E287_R0.5441.00
236_L244_A0.5441.00
261_T274_T0.5431.00
190_L222_L0.5421.00
389_P442_N0.5401.00
360_A364_S0.5401.00
197_L202_S0.5391.00
342_I380_S0.5391.00
19_S23_A0.5391.00
67_V70_N0.5381.00
187_I191_S0.5381.00
286_S289_T0.5361.00
202_S226_H0.5351.00
121_N125_I0.5351.00
146_L149_A0.5351.00
120_I123_T0.5341.00
98_D103_N0.5341.00
257_Q282_L0.5341.00
67_V71_R0.5321.00
189_K207_E0.5311.00
133_D137_P0.5311.00
314_K317_E0.5311.00
33_L36_E0.5301.00
193_V223_N0.5301.00
259_Q262_L0.5291.00
262_L265_T0.5291.00
292_I296_A0.5281.00
184_L188_K0.5281.00
392_K396_P0.5251.00
49_T130_I0.5251.00
256_G282_L0.5241.00
318_N321_D0.5241.00
322_Y326_L0.5231.00
252_N257_Q0.5221.00
222_L226_H0.5221.00
426_A432_S0.5221.00
305_V429_H0.5211.00
181_R188_K0.5201.00
51_Q55_L0.5201.00
196_A199_Y0.5201.00
228_A231_K0.5201.00
246_E288_L0.5181.00
260_V265_T0.5181.00
135_V139_L0.5181.00
316_V319_L0.5181.00
330_K361_I0.5181.00
98_D102_N0.5161.00
310_L349_L0.5151.00
150_R153_M0.5141.00
371_H374_S0.5131.00
18_L21_A0.5131.00
14_F17_L0.5121.00
51_Q54_Q0.5101.00
441_H444_F0.5081.00
152_N156_Q0.5081.00
128_L132_I0.5071.00
330_K366_E0.5071.00
251_I257_Q0.5071.00
291_N347_I0.5061.00
237_S241_D0.5051.00
285_I293_L0.5041.00
208_V213_R0.5041.00
71_R75_V0.5021.00
99_G103_N0.5021.00
18_L172_C0.5021.00
361_I364_S0.5011.00
26_V165_C0.5011.00
201_D205_P0.5001.00
219_G226_H0.5001.00
47_N51_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5929 100 0.355 Contact Map
4bixA 2 0.4934 100 0.406 Contact Map
4ctiA 2 0.5022 100 0.431 Contact Map
4q20A 2 0.5 100 0.468 Contact Map
3jz3A 2 0.3496 100 0.484 Contact Map
3a0rA 2 0.7212 100 0.486 Contact Map
4gczA 2 0.7721 100 0.492 Contact Map
4mpcA 2 0.646 100 0.492 Contact Map
4e01A 3 0.6261 100 0.501 Contact Map
2c2aA 2 0.5066 100 0.504 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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